• Disease
  • Hyperthyroid
  • Hyperthyroid Cats
  • Harriet M Syme

    Prominent publications by Harriet M Syme

    KOL Index score: 12576

    BACKGROUND: Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required.

    OBJECTIVE: To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection of decreased GFR in clinically stable dogs, with or without chronic kidney disease (CKD).

    ANIMALS: Ninety-seven client-owned dogs: 67 dogs with a diagnosis or suspicion of CKD ...

    Also Ranks for: Symmetric Dimethylarginine |  creatinine sdma |  glomerular filtration |  chronic sensitivity |  diagnostic performance
    KOL Index score: 12094

    BACKGROUND: Iatrogenic hypothyroidism can occur after treatment of hyperthyroidism, and is correlated with a reduced glomerular filtration rate in humans and dogs.

    HYPOTHESIS: Cats with iatrogenic hypothyroidism after treatment for hyperthyroidism will have a greater incidence of azotemia than euthyroid cats.

    ANIMALS: Eighty client owned cats with hyperthyroidism.

    METHODS: Two retrospective studies. (1) Longitudinal study of 12 hyperthyroid cats treated with radioiodine (documented as ...

    Also Ranks for: Iatrogenic Hypothyroidism |  treatment hyperthyroidism |  euthyroid cats |  thyroid status |  retrospective studies
    KOL Index score: 11999

    BACKGROUND: Hypertension is a common problem in older cats, most often associated with chronic kidney disease (CKD). Cross-sectional studies have suggested that blood pressure in cats increases with age.

    HYPOTHESIS/OBJECTIVES: To determine whether blood pressure in cats increases with age and whether this occurs independently of the presence of CKD. To investigate risk factors for developing hypertension.

    ANIMALS/SUBJECTS: Two hundred and sixty-five cats with CKD and 133 healthy cats ≥9 ...

    Also Ranks for: Blood Pressure |  healthy cats |  chronic kidney disease |  ckd risk factors |  initial evaluation
    KOL Index score: 11270

    BACKGROUND: Systemic hypertension is a common clinical problem, often occurring in association with renal disease in cats. Limited information is available to assess the effect of blood pressure and the treatment of hypertension on survival.

    HYPOTHESIS: That adequacy of blood pressure control is associated with the duration of survival in cats with systolic hypertension.

    ANIMALS: One hundred and forty-one client-owned cats with systolic hypertension.

    METHODS: Hypertensive cats were ...

    Also Ranks for: Blood Pressure |  survival cats |  treatment hypertension |  amlodipine besylate |  mm hg
    KOL Index score: 11204

    BACKGROUND: Tubulointerstitial kidney disease is a common cause of illness and death in pet cats and is typically not associated with overt proteinuria.

    HYPOTHESIS: Proteinuria would be independently related to survival in cats with renal failure, with or without hypertension.

    ANIMALS: The study included 136 client-owned cats; 28 apparently normal, 14 hypertensive but not azotemic, 66 azotemic but not hypertensive, and 28 both hypertensive and azotemic.

    METHODS: Cox's proportional ...

    Also Ranks for: Renal Failure |  survival cats |  creatinine ratio |  death euthanasia |  systolic blood pressure
    KOL Index score: 11200

    BACKGROUND: Chronic kidney disease (CKD) is common in geriatric cats, but often appears to be stable for long periods of time.

    OBJECTIVES: To describe CKD progression and identify risk factors for progression in newly diagnosed azotemic cats.

    ANIMALS: A total of 213 cats with CKD (plasma creatinine concentration > 2 mg/dL, urine specific gravity < 1.035) were followed up until progression occurred or for at least 1 year; 132, 73, and 8 cats were in International Renal Interest Society ...

    Also Ranks for: Kidney Disease |  progression cats |  1 year |  creatinine concentration |  stage 2
    KOL Index score: 11087

    OBJECTIVES: In cats with concurrent hyperthyroidism and non-thyroidal illnesses such as chronic kidney disease, total thyroxine concentrations are often within the laboratory reference range (19 to 55 nmol/l). The objective of the study was to determine total thyroxine, free thyroxine and/or thyroid-stimulating hormone concentrations in cats with mild chronic kidney disease.

    METHODS: Total thyroxine, free thyroxine and thyroid-stimulating hormone were measured in three groups. The ...

    Also Ranks for: Chronic Kidney Disease |  hyperthyroidism cats |  total thyroxine |  thyroidstimulating hormone |  clinical signs
    KOL Index score: 10307

    BACKGROUND: Fibroblast growth factor-23 (FGF-23) and parathyroid hormone (PTH) are commonly increased in cats with azotemic chronic kidney disease (CKD). Both are predictors of survival time in human patients, but these relationships have not previously been examined in the cat.

    OBJECTIVES: To investigate the relationship between plasma FGF-23 and PTH concentrations at diagnosis of CKD in cats with survival time and with disease progression over 12 months.

    ANIMALS: 214 azotemic, ...

    Also Ranks for: Fibroblast Growth |  cats ckd |  chronic kidney disease |  plasma fgf23 |  parathyroid hormone
    KOL Index score: 10181

    BACKGROUND: The efficacy and benefits of telmisartan in cats with chronic kidney disease (CKD) have not previously been reported.

    HYPOTHESIS: Long-term treatment of cats with CKD using telmisartan decreases urine protein-to-creatinine ratio (UP/C) similar to benazepril.

    ANIMALS: Two-hundred and twenty-four client-owned adult cats with CKD.

    METHODS: Prospective, multicenter, controlled, randomized, parallel group, blinded clinical trial with noninferiority design. Cats were allocated in a ...

    Also Ranks for: Chronic Kidney Disease |  cats ckd |  clinical trial |  proteinuria telmisartan |  primary endpoint
    KOL Index score: 10128

    BACKGROUND: Fibroblast growth factor (FGF-23) has an important role in phosphate regulation. Its clinical relevance in cats with CKD has not been explored previously.

    HYPOTHESIS/OBJECTIVES: The study objectives were (1) to determine whether FGF-23 concentrations are increased in nonazotemic cats, cats which developed azotemia within 12 months of screening compared with cats that remained non-azotemic, and (2) to evaluate the relationships between FGF-23 and PTH and FGF-23 and glomerular ...

    Also Ranks for: Fibroblast Growth Factor |  geriatric cats |  pth fgf23 |  12 months |  kidney disease
    KOL Index score: 9968

    INTRODUCTION AND OBJECTIVES: Hyperthyroidism in cats, caused by nodular hyperplasia or adenomas, is clinically and histologically similar to toxic nodular goiter in humans. Subclinical hyperthyroidism in humans is defined as low thyrotropin (TSH) in conjunction with within-reference-range thyroid hormone concentrations, but has not previously been defined in cats. The objective of this study was to test the hypothesis that euthyroid senior cats with low TSH have histological evidence of ...

    Also Ranks for: Subclinical Hyperthyroidism |  nodular goiter |  spontaneous model |  cats tsh |  thyroid disease
    KOL Index score: 9949

    BACKGROUND: Circulating natriuretic peptide concentrations are increased in cats with myocardial dysfunction.

    HYPOTHESIS: Serum N-terminal fragment of proatrial natriuretic peptide (NT-proANP) and NT-probrain natriuretic peptide (proBNP) concentrations may predict the presence of heart disease (HD) and congestive heart failure (CHF). A positive relationship is also predicted among natriuretic peptide (NP) concentrations, a noninvasive estimate of left ventricular filling pressure ...

    Also Ranks for: Heart Disease |  natriuretic peptides |  cats chf |  np concentrations |  atrial size
    KOL Index score: 9883

    BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a phosphaturic hormone involved in the pathogenesis of secondary renal hyperparathyroidism (SRHP) in humans. There are no published studies examining feline FGF-23.

    OBJECTIVES: Validation of a method for FGF-23 quantification in feline plasma and assessment of the associations among plasma FGF-23, PTH, creatinine, and phosphate concentrations in cats with chronic kidney disease (CKD).

    ANIMALS: One hundred nonazotemic and azotemic ...

    Also Ranks for: Fibroblast Growth Factor |  feline chronic |  plasma fgf23 |  kidney disease |  concentrations cats
    KOL Index score: 9814

    BACKGROUND: Fibroblast growth factor 23 (FGF-23) is a phosphatonin, which is increased in cats with azotemic CKD. Dietary phosphate restriction decreases FGF-23 concentrations in humans and rodents, but this relationship has not previously been examined in the cat.

    OBJECTIVES: To investigate the effect of feeding renal diet on plasma FGF-23 concentrations in cats with stable azotemic CKD.

    ANIMALS: Azotemic, client-owned cats (≥ 9 years); 33 cats ate renal diet (RD group) and 11 cats did ...

    Also Ranks for: Renal Diet |  fibroblast growth |  plasma fgf23 |  cats azotemic ckd |  azotemic chronic
    KOL Index score: 9704

    BACKGROUND: Hyperthyroidism complicates the diagnosis of chronic kidney disease (CKD) as it increases glomerular filtration rate. No practical and reliable means for identifying those cats that will develop azotemia after treatment for hyperthyroidism has been identified. Hyperthyroidism is associated with proteinuria. Proteinuria has been correlated with decreased survival of cats with CKD and with progression of CKD.

    HYPOTHESIS: Proteinuria and other clinical parameters measured at ...

    Also Ranks for: Hyperthyroid Cats |  development azotemia |  progression ckd |  chronic kidney disease |  diagnosis survival


    Harriet M Syme: Influence Statistics

    Sample of concepts for which Harriet M Syme is among the top experts in the world.
    Concept World rank
    cystine male #1
    peptides cats #1
    odds ratio4·5 #1
    serum concentrations ntproanp #1
    chapter methimazole trials #1
    association cystine #1
    ntprobnp feline plasma #1
    serum np chf #1
    postal transportation samples #1
    cystine uroliths dogs #1
    increased cats #1
    generalised lymphadenomegaly #1
    ckd disease progression #1
    entire dogs #1
    simplest terms hyperthyroidism #1
    ninetyfive cats #1
    castration cystine #1
    preexisting azotaemia #1
    cats azotaemic #1
    progressive disease mortality #1
    cats proanp #1
    sodium retention activation #1
    control study cats #1
    hyperthyroid cats #1
    diagnostic accuracy rdchf #1
    523 fmol #1
    nopuc cats #1
    serum np rdnc #1
    subcutaneous ureteral bypass #1
    sterile cystitis #1
    temporal stability ntprobnp #1
    cystine urolithiasis #1
    np concentrations control #1
    hyperthyroidism clinical syndrome #1
    proteinuria cats #1
    specificity serum np #1
    urolithiasis entire #1
    multiple classified #1
    530 95 #1
    probnp animals #1
    optimum cutoff concentration #1
    986 fmol #1
    1 multiple cats #1
    nopuc #1
    cats systemic hypertension #1

    Key People For Hyperthyroid Cats

    Top KOLs in the world
    Mark E Peterson
    cats hyperthyroidism normal dogs plasma concentrations
    M E Peterson
    cats hyperthyroidism healthy dogs nonadrenal illness
    Jonathan Elliott
    chronic kidney disease hyperthyroid cats renal function
    Harriet M Syme
    hyperthyroid cats chronic kidney disease renal function
    Carmel T Mooney
    feline hyperthyroidism hong kong south africa
    Sylvie Daminet
    hyperthyroid cats adrenal glands thyroid function

    Harriet M Syme:Expert Impact

    Concepts for whichHarriet M Symehas direct influence:Hyperthyroid cats,  Chronic kidney disease,  Renal function,  Kidney disease,  Systolic hypertension,  Iatrogenic hypothyroidism,  Geriatric cats,  Chronic kidney.

    Harriet M Syme:KOL impact

    Concepts related to the work of other authors for whichfor which Harriet M Syme has influence:Chronic kidney disease,  Hyperthyroid cats,  Renal function,  Systemic hypertension,  Blood pressure,  Bartonella species,  Acute kidney injury.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Department of Clinical Science and Services, Royal Veterinary College, University of London, London, United Kingdom | Department of Clinical Science and Services, The Royal Veterinary College, Hawkshead Lane, AL7 9TA, UK | Clinical Sciences and Servi