Vaccinex; Inc., ; Rochester, NY 14620 | From the Departments of Family Medicine (Dr. Mueller), University of Medicine and Dentistry of New Jersey, Stratford. | Vaccinex, Inc., ...
KOL Resume for Loretta Mueller
Vaccinex; Inc., ; Rochester, NY 14620
From the Departments of Family Medicine (Dr. Mueller), University of Medicine and Dentistry of New Jersey, Stratford.
Vaccinex, Inc., Rochester, New York, USA
Loretta Mueller: Influence Statistics
|gaga factor proteins||#10|
|gaga transcription factor||#47|
|common nterminal region||#78|
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Prominent publications by Loretta Mueller
The GAGA transcription factor of Drosophila melanogaster is ubiquitous and plays multiple roles. Characterization of cDNA clones and detection by domain- specific antibodies has revealed that the 70-90 kDa major GAGA species are encoded by two open reading frames producing GAGA factor proteins of 519 amino acids (GAGA-519) and 581 amino acids (GAGA-581), which share a common N-terminal region that is linked to two different glutamine-rich C-termini. Purified recombinant GAGA-519 and ...
|Known for Chromatin Structure | Gaga Factor | Drosophila Melanogaster | Molecular Dna | Binding Proteins|
OBJECTIVE: The objective of this study was to determine whether differences in urinary proinflammatory cytokines, interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha), exist between migraineurs and nonheadache control subjects, and between nonhormonal migraine and menstrual migraine. Any differences noted would expand and clarify a neuroimmune hypothesis of migraine pathogenesis and lead to future diagnostic markers or therapeutic options or ...
|Known for Necrosis Factor | Proinflammatory Cytokines | Alpha Tnf | Il6 Levels | Migraine Disorders|
Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. Blocking the binding of SEMA4D to its receptors can result in physiologic changes that may have implications in cancer, autoimmune, and neurological disease. To study the effects of blocking SEMA4D, we generated, in SEMA4D-deficient mice, a panel of ...
|Known for Vx15 2503 | Semaphorin 4d | Multiple Sclerosis | Neurodegenerative Disorders | Huntingtons Disease|
Lethality-based selection of recombinant genes in mammalian cells: Application to identifying tumor antigens
[ PUBLICATION ]
Many biological processes result in either cell death or cessation of cell growth. However, plasmid- and retrovirus-based mammalian expression vectors in which it has been possible to construct representative cDNA libraries cannot be readily recovered from cells that are not actively dividing. This has limited the efficiency of selection of recombinant genes that mediate either lytic events or growth arrest. Examples include genes that encode the target antigens of cytotoxic T cells, ...
|Known for Mammalian Cells | Target Antigens | Cell Growth | Expression Vectors | Vaccinia Virus|
Key People For Chronic Migraine
Loretta Mueller:Expert Impact
Concepts for whichLoretta Muellerhas direct influence:Chronic migraine, Chromatin structure, Gaga factor, Vx15 2503, Target antigens, Semaphorin 4d, Drosophila melanogaster, Gaga transcription factor.
Loretta Mueller:KOL impact
Concepts related to the work of other authors for whichfor which Loretta Mueller has influence:Gaga factor, Migraine patients, Semaphorin 4d, Drosophila proteins, Dna binding, Vaccinia virus, Adh gene.
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