• Disease
  • Chronic
  • Chronic Pain
  • Chronic Pain Disorder
  • Harald O Guendel

    Prominent publications by Harald O Guendel

    KOL Index score: 12509

    BackgroundChild maltreatment (CM) has severe effects on psychological and physical health. The hypothalamic-pituitary-adrenal (HPA) axis, the major stress system of the body, is dysregulated after CM. The analysis of cortisol and dehydroepiandrosterone (DHEA) in scalp hair presents a new and promising methodological approach to assess chronic HPA axis activity. This study investigated the effects of CM on HPA axis activity in the last trimester of pregnancy by measuring the two important ...

    Also Ranks for: Hair Cortisol |  dehydroepiandrosterone dhea |  childhood maltreatment |  effects maternal |  hpa axis
    KOL Index score: 8143

    BACKGROUND: Without stimulation, the human brain spontaneously produces highly organized, low-frequency fluctuations of neural activity in intrinsic connectivity networks (ICNs). Furthermore, without adequate explanatory nociceptive input, patients with somatoform pain disorder experience pain symptoms, thus implicating a central dysregulation of pain homeostasis. The present study aimed to test whether interactions among pain-related ICNs, such as the default mode network (DMN), ...

    Also Ranks for: Pain Disorder |  functional network |  resting state |  fmri study |  posterior dmn
    KOL Index score: 7464

    BACKGROUND: Work related stress is associated with a range of debilitating health outcomes. However, no unanimously accepted assessment tool exists for the early identification of individuals suffering from chronic job stress. The psychological concept of self-perceived stress reactivity refers to the individual disposition of a person to answer stressors with immediate as well as long lasting stress reactions, and it could be a valid indicator of current as well as prospective adverse ...

    Also Ranks for: Stress Reactivity |  effort reward |  psychological surveys |  aged occupational |  health outcomes
    KOL Index score: 7021

    The postpartum period is a vulnerable period for women with a history of childhood maltreatment. This study investigated the association between childhood maltreatment and postnatal distress three months postpartum and examined the role of social support provided by different sources (intimate partner, parents, parents-in-law, and friends). Analyses are based on N=66 women, who were screened for maltreatment experiences shortly after parturition with the Childhood Trauma Questionnaire. ...

    Also Ranks for: Childhood Maltreatment |  social support |  postpartum period |  intimate partner |  depression anxiety
    KOL Index score: 6824

    BACKGROUND: Mental health issues are gaining in importance in society and the economic system. At the same time, the accessibility and stigmatisation of the mental health care system in Germany can obstruct help-seeking behavior and delay early psychotherapeutic interventions. Therefore, new models of care are being established at the interface of company-supported health promotion and conventional health insurance sponsored outpatient care for people developing mental illnesses. Two ...

    Also Ranks for: Mental Health |  psychosomatic consultation |  new model |  qualitative study |  work ability
    KOL Index score: 6226

    OBJECTIVE: Psychological and neural mechanisms of the affective dimension of pain are known to be disturbed in patients with chronic pain disorder. The aim of this functional magnetic resonance imaging study was to assess the neurofunctional and behavioral measures underlying the ability to construct pain-related affective meaning in a painful situation by comparing 21 clinically and psychometrically well-characterized patients with persistent non-nociceptive somatoform pain with 19 ...

    Also Ranks for: Chronic Pain Disorder |  neural correlates |  pain patients |  resonance imaging |  decreased activation
    KOL Index score: 5713

    BACKGROUND: Recent functional imaging studies on chronic pain of various organic etiologies have shown significant alterations in both the spatial and the temporal dimensions of the functional connectivity of the human brain in its resting state. However, it remains unclear whether similar changes in intrinsic connectivity networks (ICNs) also occur in patients with chronic pain disorder, defined as persistent, medically unexplained pain.

    METHODS: We compared 21 patients who suffered ...

    Also Ranks for: Chronic Pain Disorder |  salience network |  functional connectivity |  anterior default |  resting state
    KOL Index score: 4549

    There is considerable individual variability in vulnerability for developing posttraumatic stress disorder (PTSD); evidence suggests that this variability is related in part to genetic and environmental factors, including adverse early life experience. Interestingly, recent studies indicate that induction of chronic low-grade inflammation may be a common mechanism underlying gene and environment interactions that increase the risk for development of PTSD symptoms, and, therefore, may be ...

    Also Ranks for: Mouse Model |  subordinate colony |  ptsd symptoms |  housing animal |  posttraumatic stress disorder
    KOL Index score: 4254

    OBJECTIVE: This preliminary study investigates the neural substrates of empathy-induced pain in multisomatoform pain patients "with vs. without" a history of sexual abuse during childhood.

    METHODS: Using functional magnetic resonance imaging (fMRI) and behavioral measurements, we compared eight abused with eight nonabused patients using an established empathy-for-pain paradigm.

    RESULTS: Higher activations in left lateral and medial superior frontal gyrus as well as a nonsignificant ...

    Also Ranks for: Sexual Abuse |  somatoform disorders |  pain patients |  clinical impression |  resonance imaging
    KOL Index score: 3794

    Introspective and self-referential in nature, the human brain's default mode network (DMN) is presumed to influence our behavior in response to the environment in predictive manner [Raichle ME, Gusnard DA (2005) J Comp Neurol 493:167-176; Bar M (2009) Philos Trans R Soc Lond B Biol Sci 364:1235-1243]. In the current study, we hypothesize that the strength of DMN-connectivity contributes to distinct introspective psychological processes in every-day social life such as the intuitive ...

    Also Ranks for: Independent Component Analysis |  models psychological |  brain default |  pain intensity |  imaging male
    KOL Index score: 1919

    Mental health problems have become one of the most common causes of incapacity for work, and engender high costs to society. Especially managerial behavior was found to have a great impact on employees' well-being. In order to support those in leading positions in dealing with their own, as well as their employees', psychological stress factors, we conducted a specific manager training. At the same time, we wanted to find out about the training's short- and long-term effects. ...

    Also Ranks for: Mental Health |  social distance scale |  knowledge schedule |  single day |  months training
    KOL Index score: 1677

    New tools for non-specific primary prevention strategies covering somatic and mental health in occupational medicine are urgently needed. Heart rate variability (HRV) reflects the capacity of the body to adapt to environmental challenges and of the mind to regulate emotions. Hence, a 24 h-measurement of HRV offers a unique possibility to quantify the interaction between situation-specific emotional regulation within a specific psychosocial environment and physiological state, thereby ...

    Also Ranks for: Heart Rate Variability |  occupational medicine |  24 hrv |  training program |  single arm

    The grapes of war

    KOL Index score: 1364

    Persistent pain is not a normal part of aging. Nevertheless, many older patients have long-lasting, more or less medically unexplained pain symptoms and, consequently, are often severely disabled, incur high health care costs, and have high comorbidity rates. Moreover, the effects of early traumatization, especially due to wars, and even below the level of posttraumatic stress disorder (PTSD) are apparent. However, the developmental and neurobiological underpinnings of somatoform pain ...

    KOL Index score: 1159

    OBJECTIVE: Posttraumatic stress disorder (PTSD) is associated with a higher rate of arterial hypertension. However, data about prevalence rates of PTSD in patients suffering from arterial hypertension as well as the relation to blood pressure (BP) control are lacking.

    METHODS: We recruited 145 patients with primary hypertension from March to November 2012 at the cardiologic outpatient clinic at Ulm University Medical Center. Symptoms of PTSD (assessed with the Posttraumatic Diagnostic ...

    Also Ranks for: Ptsd Patients |  traumatic stress |  disorders post |  depression anxiety


    Harald O Guendel: Influence Statistics

    Sample of concepts for which Harald O Guendel is among the top experts in the world.
    Concept World rank
    personal stress experience #1
    enrolled managers #1
    training cognitive stigma #1
    mentally employees #1
    theoretical mental #1
    cognitive stigma #2
    grapes persistent pain #4
    underpinnings somatoform #4
    older people special #4
    understanding disorders humans #4
    management strategy disorder #4
    industrial workplace patients #4
    early traumatization wars #4
    new models interface #4
    painprone elderly patients #4
    managers reduces #4
    normal older patients #4
    patients industrial workplace #4
    “psychosomatic consultation #4
    wars level #4
    outpatient qualitative #4
    workplace new model #4
    effects early traumatization #4
    persistent pain normal #4
    traumatization incident #4
    offer workplace #4
    comorbidity rates effects #5
    conventional psychosomatic #5
    disorder older people #5
    organic etiologies alterations #6
    fnc pain #6
    cingularinsular network #6
    cin smn #6
    fnc detected #6
    smn anterior #6
    ptsd somatoform #6
    smn somatoform pain #6
    posterior dmn smn #6
    incident management strategy #6
    icns somatoform #6
    pain icns #6
    020 024 hz #6
    painrelated icns #6
    neuroimaging data ica #6
    resting fnc #6
    smn posterior #6
    dmn smn fnc #6
    singleday training #7
    scale irritation #7
    regional outpatient #7

    Key People For Chronic Pain Disorder

    Top KOLs in the world
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    Select a search phrase   chronic pain disorders , chronic pain disorder

    Harald O Guendel:Expert Impact

    Concepts for whichHarald O Guendelhas direct influence:Chronic pain disorder,  Childhood maltreatment,  Pain disorder,  Posttraumatic stress,  Stress reactivity,  Nighttime sdann,  Sexual abuse,  Somatoform pain.

    Harald O Guendel:KOL impact

    Concepts related to the work of other authors for whichfor which Harald O Guendel has influence:Chronic pain,  Functional connectivity,  Hair cortisol,  Social support,  Default network,  Stress reactivity,  Childhood maltreatment.



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    Burnout Section, Privatklinik Meiringen, Hasliberg, Switzerland | Department of Psychosomatic Medicine and Psychotherapy, University Medical Center, 89081 Ulm, Germany;, michael.gast@uni-ulm.de, (M.G.);, janina.lehmann@uni-ulm.de, (J.L.);, elena.schw