• Chronic Pancreatitis
    • C N Mallinson
    • C N Mallinson: Influence Statistics

      C N Mallinson

      C N Mallinson

      Lewisham Hospital London, England | Lewisham Hospital, London SE13, United Kingdon | Dept. of Medicine, Royal Postgraduate Medical School, and Gastroenterology Unit, Lewisham ...

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      C N Mallinson:Expert Impact

      Concepts for whichC N Mallinsonhas direct influence:Chronic pancreatitis,Gut hormones,Plasma trypsin,Pancreatic polypeptide,Patients chronic pancreatitis,Pancreatic secretion,Pancreatic adenocarcinoma,Intestinal resection.

      C N Mallinson:KOL impact

      Concepts related to the work of other authors for whichfor which C N Mallinson has influence:Chronic pancreatitis,Glucagonoma syndrome,Pancreatic polypeptide,Celiac disease,Necrolytic migratory erythema,Growth hormone,Insulin secretion.

      KOL Resume for C N Mallinson


      Lewisham Hospital London, England


      Lewisham Hospital, London SE13, United Kingdon


      Dept. of Medicine, Royal Postgraduate Medical School, and Gastroenterology Unit, Lewisham Hospital, London, England; Service de Gastro-Enterologie, L'Hopital Saint-Lazare, Paris, France; and Ospedale San Giovanni Battista, Molinette, Torino, Italy


      Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London;, Gastrointestinal Unit, Greenwich District Hospital, London;, Division of Gastroenterology, Ospedale Mauriziano, Turin, Italy;, Hôpital St-Lazare, Paris, France;, Department of Surgery, St. George’s Hospital, London, England


      Lewisham Hospital, LondonU.K.

      and Salk Institute, San Diego, California, U.S.A..

      Department of Medicine, Hammersmith Hospital, London, United Kingdon


      West Middlesex Hospital, Isleworth, Middlesex, United Kingdom

      Greenwich District Hospital, London SE10, United Kingdon

      Inserm U54, Hopital Saint-Lazare, Paris, France


      Greenwich Hospital Gastrointestinal Unit, London SE10, United Kingdon

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      Sample of concepts for which C N Mallinson is among the top experts in the world.
      Concept World rank
      specific result hypersecretion #2
      stomatitis weight loss #2
      isletcell lesion tumours #2
      cases pancreatic tumours #2
      islet alpha2 cells #2
      syndrome specific result #2
      patients isletcell lesion #2
      humans aged amino #2
      hypersecretion pancreatic glucagon #3
      steatorrhoea contrast #4
      pancreatic adenocarcinoma trypsin #4
      food 10 patients #4
      steatorrhoea basal #4
      exocrine deficiency response #4
      test breakfast response #4
      pancreas circulates #4
      steatorrhoea pancreatic polypeptide #4
      chronic pancreatitis steatorrhoea #4
      deficient chronic pancreatitis #4
      steatorrhoea adenocarcinoma #4
      response test breakfast #4
      plasma trypsin concentrations #5
      isletcell lesion #5
      pancreatitis steatorrhoea #5
      basal trypsin concentrations #5
      intestinal resection role #6
      fourfold increase motilin #6
      resection threefold #6
      polypeptide postoperative period #6
      test breakfast patients #7
      fasting trypsin #7
      meal 10 patients #7
      pancreatic glucagon neurotensin #8
      glucagonlike peptides inhibitory #8
      gut hormones inhibitory #8
      polypeptide hpp concentrations #8
      normal hpp concentrations #8
      motilin contrast #9
      female humans trypsin #9
      mellitus erythema #9
      acute tropical sprue #10
      glucagonoma syndrome patients #10
      guthormone profile #11
      differential diagnosis steatorrhoea #11
      trypsin differential #12
      normal hpp #13
      motilin greater #13
      brochus #15
      diagnosis steatorrhoea #15
      basal trypsin #16
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      Prominent publications by C N Mallinson

      KOL-Index: 7493

      We have studied fasting levels and the response to a standard test breakfast of blood glucose and several gut hormones in 24 patients with ulcerative colitis, in 14 patients with Crohn's disease, and in 14 healthy control subjects. Patients with ulcerative colitis had significantly elevated fasting human pancreatic polypeptide (HPP) concentrations, and both basal and postprandial levels of gastrin, gastric inhibitory polypeptide (GIP), and motilin were greater than normal. In contrast, ...

      Known for Gut Hormones | Inflammatory Bowel Disease | Patients Ulcerative Colitis | Normal Levels | Gastric Inhibitory
      KOL-Index: 6165

      We have used a simple and precise radioimmunoassay to measure trypsin in human plasma. Fasting plasma trypsin concentrations were extremely low in patients with chronic pancreatitis with steatorrhoea (5 +/- 2 ng/ml) when compared to healthy controls (86 +/- 7 ng/ml, p less than 0.001). In patients with chronic pancreatitis but no steatorrhoea basal plasma trypsin levels were similar to those of the normal controls (99 +/- 25 ng/ml). A small but significant postprandial rise in plasma ...

      Known for Chronic Pancreatitis | Pancreatic Adenocarcinoma | Trypsin Concentrations | Healthy Subjects Patients | Normal Subjects
      KOL-Index: 4579

      A new long-acting octapeptide analogue of somatostatin, Des AA1,2,4,5,12,13 D Try8 somatostatin, has been tested in 8 patients with pancreatic endocrine tumours. The analogue given subcutaneously suppressed the tumour-derived hormones in patients with insulinomas, glucagonomas, and gastrinomas for up to 24 h. The prolonged action appeared to be the result of slow release from the injection site. No side-effects were observed. Studies of long-term administration of this new peptide are ...

      Known for Somatostatin Analogue | Pancreatic Endocrine | Ectopic Humans | Insulin Secretion | Longterm Administration
      KOL-Index: 4360

      Patients with coeliac disease have a highly significant reduction in the release of secretin and gastric inhibitory polypeptide from the upper small intestine, but a greatly increased release of enteroglucagon, and also of neurotensin, from the lower part of the small intestine. The release of gastrin and pancreatic polypeptide, from the antrum and pancreas respectively, is, however, normal. Thus the pattern of hormone release reflects the location of the mucosal lesion. The gut-hormone ...

      Known for Hormone Profile | Small Intestine | Disease Child | Highly Reduction | Gastric Inhibitory


      KOL-Index: 4306

      Nine patients presented with necrolytic migratory erythema, stomatitis, weight loss, and, in seven cases, diabetes. All nine were found to have pancreatic tumours. Pancreatic tissue was available from eight patients and invariably showed an islet-cell lesion. Four tumours were examined further and found to consist of islet alpha-2 cells and to contain glucagon. In these four patients very high plasma-glucagon and very low plasma-aminoacid concentrations were found. In the one case in ...

      Known for Glucagonoma Syndrome | Pancreatic Glucagon | Weight Loss | Aged Amino | Islet Cell
      KOL-Index: 4248

      To investigate the possible role of gut and pancreatic hormones in the adaptive responses to gut resection, plasma concentrations of the circulating hormones were measured, in response to a test breakfast, in patients with either small or large intestinal resection and in healthy control subjects. In 18 patients with partial ileal resection a significant threefold rise was found in basal and postprandial levels of pancreatic polypeptide, a fourfold increase in motilin, and more than a ...

      Known for Intestinal Resection | Pancreatic Polypeptide | Plasma Concentrations | Gut Hormone | 18 Patients
      KOL-Index: 4037

      Pancreatic polypeptide (PP) is a newly discovered hormonal peptide localised in a distinct endocrine cell type in the pancreas. PP circulates in plasma and in normal subjects levels rise substantially on the ingestion of food (mean rise 138 pmol/l). In 10 patients with chronic pancreatitis with exocrine deficiency the PP response to a test breakfast was greatly reduced (mean rise 20 pmol/l, P less than 0.001). PP response to the meal was normal in 10 patients with active coeliac disease ...

      Known for Pancreatic Polypeptide | Chronic Pancreatitis | 10 Patients | Exocrine Deficiency | Active Coeliac Disease
      KOL-Index: 3638

      The effect of PP on secretin-stimulated pancreatic secretion was assessed in five healthy subjects. During an intravenous infusion of BPP at a dose which produced plasma levels similar to those seen after meals in healthy young adults the volume and bicarbonate content of duodenal juice was reduced by 25% (p less than 0.05) and 24% (p less than 0.05) respectively, while protein and bilirubin concentrations were more markedly reduced by 68% (p less than 0.0005) and 67% (p less than ...

      Known for Pancreatic Secretion | Plasma Levels | Intravenous Infusion | Secretin Stimulated | Aged Pancreas
      KOL-Index: 3130
      Known for Growth Hormone | Fatty Acids | Circulating Glucagon | Glucose Tolerance | Insulin Male
      KOL-Index: 1418
      Known for Kaposis Sarcoma | Immunodeficiency Syndrome
      KOL-Index: 1102
      Known for Classification Pancreatitis | Terminology Topic

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      Lewisham Hospital London, England | Lewisham Hospital, London SE13, United Kingdon | Dept. of Medicine, Royal Postgraduate Medical School, and Gastroenterology Unit, Lewisham Hospital, London, England; Service de Gastro-Enterologie, L'Hopital Saint-L

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