• Disease
  • Chronic
  • Chronic Pancreatitis
  • Eugene P Dimagno

    Prominent publications by Eugene P DiMagno

    KOL Index score: 20973

    BACKGROUND: Hereditary pancreatitis is an autosomal-dominant disease, with a variable expression and an estimated penetrance of 80%. The gene for this disease has recently been mapped to chromosome 7q35, and the defect is believed to be caused by a mutation in the cationic trypsinogen gene. Acute attacks of abdominal pain begin early in life and the disease often progresses to chronic pancreatitis. Although the risk of pancreatic cancer is thought to be increased in more common types of ...

    Also Ranks for: Pancreatic Cancer |  hereditary pancreatitis |  patients onset |  age diagnosis
    KOL Index score: 15865

    To evaluate the cyclic patterns of interdigestive pancreatic and biliary flows into the duodenum and to correlate these and the plasma levels of pancreatic polypeptide and motilin with duodenal interdigestive motor activity, five dogs were surgically prepared with three indwelling duodenal catheters. Through the first catheter, located just distal to the pylorus, a nonabsorbable marker was perfused at 3 ml/min. The second catheter, opposite the main pancreatic duct orifice, was ...

    Also Ranks for: Pancreatic Polypeptide |  motor activity |  bile acids |  plasma levels |  motilin dogs
    KOL Index score: 12389

    BACKGROUND & AIMS: The aim of this study was to determine recurrence and long-term survival after resection of pancreatic intraductal papillary mucinous neoplasm and to correlate recurrence and survival with histology, extent of resection, and duration of follow-up.

    METHODS: A single pathologist, without knowledge of previous interpretations of histology or clinical data, retrospectively reviewed and classified 113 resected intraductal papillary mucinous neoplasms as invasive carcinoma ...

    Also Ranks for: Papillary Mucinous |  surgical resection |  neoplasm recurrence |  total pancreatectomy |  pancreatic intraductal
    KOL Index score: 11613

    We tested the hypothesis that the duodenum is necessary to coordinate interdigestive pancreatic trypsin secretion with gastrointestinal motility and determined whether duodenectomy altered interdigestive cycles of plasma motilin and pancreatic polypeptide and their relationship to trypsin secretion and motility. Consequently, in normal and duodenectomized dogs, we measured trypsin secretion, gastrointestinal motility, and plasma concentrations of motilin and pancreatic polypeptide during ...

    Also Ranks for: Gastrointestinal Motility |  pancreatic secretion |  plasma motilin |  interdigestive cycles |  normal duodenectomized dogs
    KOL Index score: 11483

    BACKGROUND/AIMS: Compared with alcoholic pancreatitis, little is known about the natural history of idiopathic pancreatitis. Two hundred forty-nine patients with alcoholic pancreatitis and 66 patients with idiopathic chronic pancreatitis seen at our institution between 1976 and 1982 were investigated.

    METHODS: Records were analyzed retrospectively from the onset of symptomatic disease, and patients were followed up prospectively until 1985. Patients with early-onset (n = 25) and ...

    Also Ranks for: Onset Idiopathic |  alcoholic pancreatitis |  patients late |  severe pain |  distribution age
    KOL Index score: 11386

    Interactions between bile acids (taurocholate, TC; taurochenodeoxycholate, TCDC; or taurodeoxycholate, TDC) and digestive products (essential amino acids, EAA or monoolein, MO) in the lumen of the proximal small bowel, affecting pancreatic enzyme secretion and gallbladder contraction, were studied in 77 healthy volunteers by a perfusion method. Perfusion of EAA or MO caused significant increases in pancreatic enzyme output together with gallbladder contraction; MO was more potent and ...

    Also Ranks for: Bile Acid |  gallbladder contraction |  pancreatic enzyme secretion |  cck pz |  stimulatory action
    KOL Index score: 11259

    An association exists between cigarette smoking and pancreatitis owing to alcohol. We determined whether cigarette smoking affected the course of pancreatic calcification and insufficiency in idiopathic chronic pancreatitis. Medical records were analyzed of 24 persons with early- and 42 with late-onset idiopathic chronic pancreatitis who were diagnosed between 1976 and 1982 and then followed prospectively until 1985. Smoking equaled >5 pack-years before calcification or insufficiency or ...

    Also Ranks for: Cigarette Smoking |  chronic pancreatitis |  onset idiopathic |  pancreatic calcification |  endocrine insufficiency
    KOL Index score: 10432

    BACKGROUND & AIMS: Islet amyloid polypeptide (IAPP) levels are elevated in pancreatic cancer and may be a useful marker of pancreatic cancer-associated diabetes. The aim of this study was to compare the sensitivity and specificity for pancreatic cancer of IAPP with that of CA19-9, examine clinical characteristics of diabetes in pancreatic cancer, and define the relationship of IAPP to diabetes of pancreatic cancer.

    METHODS: Fasting serum glucose, IAPP, and CA 19-9 were measured in 130 ...

    Also Ranks for: Pancreatic Cancer |  islet amyloid |  sensitivity specificity |  tumor stage |  clinical characteristics
    KOL Index score: 10255

    OBJECTIVE: To determine whether the long-term behavior of cystic mucinous neoplasms of the pancreas could be predicted using a novel, precisely defined classification of benign mucinous cystadenomas, noninvasive proliferative cystic mucinous neoplasms, and invasive mucinous cystadenocarcinomas. The primary interest was to obtain long-term follow-up after complete resection to determine the recurrence rates based on this objective classification.

    BACKGROUND: Current understanding is that ...

    Also Ranks for: Mucinous Cystic |  recurrence rates |  neoplasms pancreas |  curative resection |  current understanding
    KOL Index score: 10203

    Whether commercial, bean-derived alpha-amylase inhibitor preparations failed to decrease starch digestion in humans because of insufficient antiamylase activity, destruction by gastrointestinal secretions, or decreased activity in the presence of starch is unknown. We used a simple partial purification procedure to markedly concentrate the inhibitor (sixfold to eightfold by total protein content, and 30-40-fold by dry weight). Compared with a commercial preparation and crude bean ...

    Also Ranks for: Starch Digestion |  amylase inhibitor |  partially purified |  duodenum humans |  specific activity
    KOL Index score: 10065

    Despite the old observations of Boldyreff that pancreatic and biliary secretions occur during periods of intestinal contraction, quantification of these secretions and their relationships to duodenal motor activity and pancreatic ductal pressures have not been reported. By utilizing a recently developed canine model, we simultaneously measured these events. Each of nine dogs was provided with a permanent indwelling pancreatodochal cutaneous catheter (to monitor pancreatic pressure) and ...

    Also Ranks for: Motor Activity |  phase iii |  pancreatic duct |  biliary secretions |  dogs duodenum
    KOL Index score: 9831

    BACKGROUND: To compare operative morbidity, mortality, quality of life, and survival after pancreatoduodenectomy (PD) versus pancreatoduodenectomy with extended lymphadenectomy (PD/ELND) in patients with resectable pancreatic cancer.

    METHODS: From May 1997 to July 2003 there were 132 patients with biopsy examination-proven or suspected adenocarcinoma of the pancreatic head who agreed to participate in a single-institution, prospective, randomized trial. If resectable at operation, ...

    Also Ranks for: Standard Pancreatoduodenectomy |  extended lymphadenectomy |  quality life |  resectable pancreatic |  prospective randomized
    KOL Index score: 9688

    OBJECTIVES: To determine the effect of endoscopic ultrasonography (EUS) on endoscopic drainage of pancreatic pseudocysts and to determine patency with fistula dilation and placement of multiple stents.

    PATIENTS AND METHODS: Between September 1995 and January 1999, 19 patients underwent endoscopic drainage of pancreatic pseudocysts, 17 of whom were assessed by EUS before drainage. Radial EUS scanning was used to detect an optimal site of apposition of pseudocyst and gut wall, free of ...

    Also Ranks for: Endoscopic Drainage |  pancreatic pseudocysts |  ultrasonography eus |  pseudocyst retrospective |  antibiotic prophylaxis
    KOL Index score: 9515

    BACKGROUND: Smoking is a recognised risk factor for pancreatic cancer and has been associated with chronic pancreatitis and also with type II diabetes.

    AIMS: The aim of this study was to investigate the effect of tobacco on the age of diagnosis of pancreatitis and progression of disease, as measured by the appearance of calcification and diabetes.

    PATIENTS: We used data from a retrospective cohort of 934 patients with chronic alcoholic pancreatitis where information on smoking was ...

    Also Ranks for: Cigarette Smoking |  chronic pancreatitis |  age diagnosis |  alcohol consumption |  appearance calcification


    Eugene P DiMagno: Influence Statistics

    Sample of concepts for which Eugene P DiMagno is among the top experts in the world.
    Concept World rank
    ofin situ #1
    abolished ileal #1
    pancreatitis gallstones #1
    survival lipolytic #1
    pancreatic insufficency #1
    sprue severe #1
    genetic testing lieu #1
    casein triolein #1
    patient hypoalbuminemic edema #1
    epi confound interpretation #1
    enteropathies ménétrier #1
    eus digestive #1
    earlier diagnosis conditions #1
    lipolytic concentrations #1
    fecal balance #1
    digestive eus #1
    inhibitor pancreaticobiliary secretions #1
    refluxed duodenal secretions #1
    diameter routine ultrasonography #1
    trypsinogen pancreatic juice #1
    lumen esophagus #1
    eus computer pancreatic #1
    endoscopic ultrasonography origins #1
    lipase bicarbonate #1
    pancreatic cancer onset #1
    diets steatorrhea #1
    lateonset pancreatitis #1
    smoking pancreatic calcification #1
    inhibitor wai #1
    15 inhibitor #1
    polypeptide trypsin #1
    gastrointestinal polypeptide #1
    dogs echocardiography origins #1
    onset idiopathic #1
    ecp natural histories #1
    nondietary liquid starch #1
    compared pfc #1
    presentation duct anatomy #1
    fecal excretion tg #1
    late alcoholic #1
    duodenogastric reflux humans #1
    endoscopic ultrasonography background #1
    investigations elucidated #1
    examples pancreatic cancer #1
    clinical pancreatology #1
    enteral feeding antibiotics #1
    enzyme activities 56 #1
    increased carbohydrate delivery #1
    135000 iu #1
    pfc fac #1

    Key People For Chronic Pancreatitis

    Top KOLs in the world
    David C Whitcomb
    chronic pancreatitis pancreatic cancer united states
    Rudolf W Ammann
    chronic pancreatitis alveolar echinococcosis helicobacter pylori
    Helmut M Friess†
    pancreatic cancer chronic pancreatitis growth factor
    Markus Wolfgang Büchler†
    pancreatic cancer chronic pancreatitis liver transplantation
    Eugene P DiMagno
    chronic pancreatitis pancreatic cancer endoscopic ultrasonography
    Paul Georg Lankisch
    acute pancreatitis pancreatic insufficiency organ failure

    Eugene P DiMagno:Expert Impact

    Concepts for whichEugene P DiMagnohas direct influence:Chronic pancreatitis,  Pancreatic cancer,  Acute pancreatitis,  Pancreatic insufficiency,  Invasive cancer,  Amylase inhibitor,  Pancreatic secretion,  Endoscopic ultrasonography.

    Eugene P DiMagno:KOL impact

    Concepts related to the work of other authors for whichfor which Eugene P DiMagno has influence:Pancreatic cancer,  Chronic pancreatitis,  Helicobacter pylori,  Cystic fibrosis,  Papillary mucinous.



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    Emeritus Professor of Medicine, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mayo Medical School, Rochester, Minnesota, USA. | From the *Department of Internal Medicine, Division of Gastroenterology and Hepato