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    • Pankaj Jay Pasricha
    • Pankaj Jay Pasricha

      Pankaj Jay Pasricha

      Departments of Epidemiology and Medicine, Johns Hopkins University, Baltimore, Maryland. | Center for Neurogastroenterology, Johns Hopkins Bayview Medical Center, Baltimore, ...



      KOL Resume for Pankaj Jay Pasricha


      Departments of Epidemiology and Medicine, Johns Hopkins University, Baltimore, Maryland.

      Center for Neurogastroenterology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA

      Johns Hopkins Medicine, United States of America


      Johns Hopkins University School of Medicine, Baltimore, Maryland


      Center for Neurogastroenterology and Division of Gastroenterology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

      Johns Hopkins University, Baltimore, Maryland


      Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

      Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland 21205.

      Johns Hopkins School of Medicine, Baltimore, Maryland.

      NIH Gastroparesis Clinical Research Consortium, Bethesda, MD, USA


      Division of Gastroenterology & Hepatology, Johns Hopkins School of Medicine, Baltimore, MD, United States of America

      Gastroenterology Section, Temple University School of Medicine, Philadelphia, Pennsylvania.

      Johns Hopkins Center for Neurogastroenterology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:


      Johns Hopkins School of Medicine Baltimore MD USA

      Division of Gastroenterology and Hepatology.


      Johns Hopkins Bayview Medical Center Center for Neurogastroenterology Baltimore MD USA


      Division of Gastroenterology and Hepatology, Department of Internal Medicine, Johns Hopkins University, Baltimore, Maryland

      Department of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD.


      Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; and.

      Gastroenterology, Johns Hopkins Hospital, Baltimore, MD

      Johns Hopkins Center for Neurogastroenterology, Johns Hopkins University School of Medicine, Ross 958, 21205, Baltimore, Maryland, USA


      Johns Hopkins University School of Medicine Division of Gastroenterology and Hepatology Baltimore Maryland USA

      Division of Gastroenterology and Hepatology, Stanford University, Stanford, California; and



      Pankaj Jay Pasricha: Influence Statistics

      Sample of concepts for which Pankaj Jay Pasricha is among the top experts in the world.
      Concept World rank
      blocking trpa1 chem5861528 #1
      ablation duodenal afferents #1
      gastroparesis severity investigator #1
      drg visceral pain #1
      porcine model gel #1
      colonic neurogenesis #1
      new devices instruments #1
      sns delayed gastric #1
      motility sibo #1
      tgfb1 tgfb #1
      lower icjp #1
      adult enteric nervous #1
      chronic phosphorylation rats #1
      female gastric electron #1
      autonomic function gastroparesis #1
      613 glucagon #1
      p2x receptor p2xr #1
      differences gastroparetics #1
      cd206‐positive macrophages #1
      neonatal irritation #1
      average density tnbstreated #1
      vitro effects tgfβ1 #1
      comorbidity tests recovery #1
      tgfβ chronic inflammation #1
      sensitivity crd #1
      trinitobenzene #1
      gel submucosal space #1
      65 patients nortriptyline #1
      symptoms gp marijuana #1
      wgt scintigraphy #1
      rtx trpa1 #1
      ano1 knockout muscle #1
      177 patients symptoms #1
      wlst dgp #1
      nutritional deficiencies body #1
      factors reduced symptoms #1
      neuronal phenotype transplantation #1
      ges 4 readers #1
      atropine sns #1
      test wlst #1
      pancreatic sensory #1
      40 patients gastroparesis #1
      nociceptors pancreatitis #1
      treatments symptom outcomes #1
      water tlr2 agonist #1
      pancreatitis messenger #1
      111in water #1
      neurons tnbstreated #1
      chem5861528 #1


      Prominent publications by Pankaj Jay Pasricha

      KOL-Index: 15081

      BACKGROUND: Perforation is an uncommon but potentially devastating complication of colonoscopy. Surgical closure is the standard of care. Immediate endoluminal closure of a perforation would avoid the morbidity and mortality associated with general anesthesia, laparotomy, and surgical repair.

      OBJECTIVES: To evaluate the feasibility and safety of full-thickness endoscopic closure of colonic perforations with a prototype endoscopic suturing device, the Eagle Claw, in a porcine ...

      Known for Endoscopic Closure | Colon Perforation | Porcine Model | Suturing Device | General Anesthesia
      KOL-Index: 14429

      AIMS: The aims of this study were to observe whether gastric motility was impaired in streptozotocin (STZ)-induced diabetic rats and whether gastric electrical stimulation was able to restore the impaired motility.

      METHODS: Ten control rats and 30 STZ-induced diabetic rats were used in this study. Gastric slow waves were recorded at baseline and 0, 1, 2, 3 and 4 weeks after the injection of STZ or vehicle. Gastric emptying with (long or short pulses) or without gastric electrical ...

      Known for Diabetic Rats | Gastric Electrical Stimulation | Stz Injection | Slow Waves | Weight Loss
      KOL-Index: 13957

      Populations of interstitial cells of Cajal (ICC) are altered in several gastrointestinal neuromuscular disorders. ICC are identified typically by ultrastructure and expression of Kit (CD117), a protein that is also expressed on mast cells. No other molecular marker currently exists to independently identify ICC. The expression of ANO1 (DOG1, TMEM16A), a Ca(2+)-activated Cl(-) channel, in gastrointestinal stromal tumors suggests it may be useful as an ICC marker. The aims of this study ...

      Known for Kit Ano1 | Interstitial Cells | Gastrointestinal Tract | Cajal Icc | Muscularis Propria
      KOL-Index: 13411

      OBJECTIVE: Gastroparesis is a disorder of delayed gastric emptying that is often chronic in nature. Up to 50% of type 1 diabetic subjects have symptoms of gastroparesis, which include nausea, vomiting, and early satiety. Elevated pyloric pressures may be responsible for delayed gastric emptying in diabetic subjects. Botulinum toxin inhibits the release of acetylcholine and produces transient paralysis when injected into smooth muscle. The aim of this study was to determine whether ...

      Known for Diabetic Gastroparesis | Botulinum Toxin | Symptoms Patients | Injection Pylorus | Delayed Gastric
      KOL-Index: 13027

      BACKGROUND & AIMS: Paneth cells contribute to the small intestinal niche of Lgr5(+) stem cells. Although the colon also contains Lgr5(+) stem cells, it does not contain Paneth cells. We investigated the existence of colonic Paneth-like cells that have a distinct transcriptional signature and support Lgr5(+) stem cells.

      METHODS: We used multicolor fluorescence-activated cell sorting to isolate different subregions of colon crypts, based on known markers, from dissociated colonic ...

      Known for Stem Cells | Crypt Base | Gproteincoupled Receptors | Cell Types | Colonic Goblet
      KOL-Index: 12853

      Gastroparesis is a debilitating disease predominantly affecting young women. Recently, dysregulation of neuronal nitric oxide synthase (nNOS) in myenteric plexus neurons has been implicated for delayed solid gastric emptying/gastroparesis in diabetic patients. In this study, we have explored the role of tetrahydrobiopterin (BH4), a major cofactor for nNOS activity and NO synthesis in diabetic gastroparesis. Diabetes was induced with single injection of streptozotocin (55 mg/kg body wt, ...

      Known for Diabetic Rats | Gastric Emptying | Nitric Oxide | Nnos Expression | Tetrahydrobiopterin Bh4
      KOL-Index: 11857

      BACKGROUND: Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterised by abdominal pain and bloating in association with altered bowel movements. Its pathogenesis and the underlying molecular mechanisms of visceral hyperalgesia remain elusive. Recent studies of somatic and other visceral pain models suggest a role for purinergic signalling mediated by the P2X receptor (P2XR) family.

      AIMS: To examine the role of P2XR signalling in the pathogenesis in a rat model ...

      Known for Visceral Hyperalgesia | Rat Model | P2x Receptor | Drg Neurons | Abdominal Pain
      KOL-Index: 11733

      BACKGROUND: The pathogenesis of visceral hypersensitivity, a characteristic pathophysiological feature of irritable bowel syndrome (IBS), remains elusive. Recent studies suggest a role for hydrogen sulfide (H2S) in pain signaling but this has not been well studied in visceral models of hyperalgesia. We therefore determined the role for the endogenous H2S producing enzyme cystathionine-beta-synthetase (CBS) in a validated rat model of IBS-like chronic visceral hyperalgesia (CVH). CVH was ...

      Known for Visceral Hypersensitivity | Rat Model | Hydrogen Sulfide | Irritable Bowel | Drg Neurons
      KOL-Index: 11691

      BACKGROUND & AIMS: Diet has major effects on the intestinal microbiota, but the exact mechanisms that alter complex microbial communities have been difficult to elucidate. In addition to the direct influence that diet exerts on microbes, changes in microbiota composition and function can alter host functions such as gastrointestinal (GI) transit time, which in turn can further affect the microbiota.

      METHODS: We investigated the relationships among diet, GI motility, and the intestinal ...

      Known for Humanized Mice | Gastrointestinal Transit | Gut Microbiota | Complex Interactions | Germ Free
      KOL-Index: 11600

      BACKGROUND: Better pancreatic cyst fluid biomarkers are needed.

      OBJECTIVE: To determine whether metabolomic profiling of pancreatic cyst fluid would yield clinically useful cyst fluid biomarkers.

      DESIGN: Retrospective study.

      SETTING: Tertiary-care referral center.

      PATIENTS: Two independent cohorts of patients (n = 26 and n = 19) with histologically defined pancreatic cysts.

      INTERVENTION: Exploratory analysis for differentially expressed metabolites between (1) nonmucinous and mucinous ...

      Known for Pancreatic Cysts | Cyst Fluid | Tumor Carcinoma | Roc Curve | Metabolomic Profiling
      KOL-Index: 11531

      BACKGROUND & AIMS: Idiopathic gastroparesis (IG) is a common but poorly understood condition with significant morbidity. We studied characteristics of patients with IG enrolled in the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Clinical Research Consortium Registry.

      METHODS: Data from medical histories, symptom questionnaires, and 4-hour gastric emptying scintigraphy studies were obtained from patients with IG.

      RESULTS: The mean age of 243 patients with ...

      Known for Gastric Emptying | Gastroparesis Severity | Symptom Onset | National Institute | Abdominal Pain
      KOL-Index: 11523

      BACKGROUND & AIMS: As in other tumor types, progression of pancreatic cancer may require a functionally unique population of cancer stem cells. Although such cells have been identified in many invasive cancers, it is not clear whether they emerge during early or late stages of tumorigenesis. Using mouse models and human pancreatic cancer cell lines, we investigated whether preinvasive pancreatic neoplasia contains a subpopulation of cells with distinct morphologies and cancer stem ...

      Known for Pancreatic Cancer | Stem Cell | Dclk1 Marks | Situ Carcinoma | Neoplastic Disease Models
      KOL-Index: 11396

      BACKGROUND: Transgastric cholecystectomy is thought to technically and anatomically challenge a single entry flexible endoscopic approach.

      OBJECTIVES: To examine the feasibility of a transgastric-only cholecystectomy, endoscope performance in an upper-abdominal operation, and the usefulness of an offset gastrotomy.

      STUDY DESIGN: Animal survival study.

      SETTING: Animal research laboratory.

      PATIENTS: Six domestic pigs.

      MAIN OUTCOME MEASUREMENTS: Transgastric access to the gallbladder and ...

      Known for Transgastric Cholecystectomy | Semf Method | Gastrointestinal Endoscopy | Peritoneal Cavity | Submucosal Space
      KOL-Index: 11289

      BACKGROUND & AIMS: There are few effective treatments for nausea and other symptoms in patients with gastroparesis and related syndromes. We performed a randomized trial of the ability of the neurokinin-1 receptor antagonist aprepitant to reduce symptoms in patients with chronic nausea and vomiting caused by gastroparesis or gastroparesis-like syndrome.

      METHODS: We conducted a 4-week multicenter, double-masked trial of 126 patients with at least moderate symptoms of chronic nausea and ...

      Known for Patients Gastroparesis | Nausea Vomiting | Symptom Severity | Chronic Disease | Method Female
      KOL-Index: 11189

      BACKGROUND & AIMS: The pathogenesis of pain in chronic pancreatitis (CP) is poorly understood and treatment remains difficult. We hypothesized that nerve growth factor (NGF) plays a key role in this process via its effects on the transient receptor potential vanilloid 1, TRPV1.

      METHODS: CP was induced by intraductal injection of trinitrobenzene sulfonic acid in rats. After 3 weeks, anti-NGF antibody or control serum was administered daily for 1 week. Pancreatic hyperalgesia was assessed ...

      Known for Chronic Pancreatitis | Trpv1 Expression | Nerve Growth Factor | Pancreatic Hyperalgesia | 1 Week

      Key People For Chronic Pancreatitis

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      pancreatic cancer chronic pancreatitis liver transplantation
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      acute pancreatitis pancreatic insufficiency organ failure

      Pankaj Jay Pasricha:Expert Impact

      Concepts for whichPankaj Jay Pasrichahas direct influence:Chronic pancreatitis,  Gastric emptying,  Diabetic gastroparesis,  Botulinum toxin,  Patients gastroparesis,  Idiopathic gastroparesis,  Functional dyspepsia,  Enteric nervous.

      Pankaj Jay Pasricha:KOL impact

      Concepts related to the work of other authors for whichfor which Pankaj Jay Pasricha has influence:Chronic pancreatitis,  Botulinum toxin,  Gut microbiota,  Visceral hypersensitivity,  Colorectal cancer,  Interstitial cells,  Enteric nervous.



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      Departments of Epidemiology and Medicine, Johns Hopkins University, Baltimore, Maryland. | Center for Neurogastroenterology, Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA | Johns Hopkins Medicine, United States of America | Johns Hop

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