• Disease
  • Structure
  • Structure Determination
  • Philip Hart

    Prominent publications by Philip Hart

    KOL Index score: 5653

    The ultrabright femtosecond X-ray pulses provided by X-ray free-electron lasers open capabilities for studying the structure and dynamics of a wide variety of systems beyond what is possible with synchrotron sources. Recently, this "probe-before-destroy" approach has been demonstrated for atomic structure determination by serial X-ray diffraction of microcrystals. There has been the question whether a similar approach can be extended to probe the local electronic structure by X-ray ...

    Also Ranks for: Ray Emission |  xes spectra |  room temperature |  oxidation states |  functional conditions
    KOL Index score: 4362

    Structure determination of proteins and other macromolecules has historically required the growth of high-quality crystals sufficiently large to diffract x-rays efficiently while withstanding radiation damage. We applied serial femtosecond crystallography (SFX) using an x-ray free-electron laser (XFEL) to obtain high-resolution structural information from microcrystals (less than 1 micrometer by 1 micrometer by 3 micrometers) of the well-characterized model protein lysozyme. The ...

    Also Ranks for: Structure Determination |  serial femtosecond |  resolution protein |  synchrotron data |  crystallography ray
    KOL Index score: 3770

    Single-particle diffraction from X-ray Free Electron Lasers offers the potential for molecular structure determination without the need for crystallization. In an effort to further develop the technique, we present a dataset of coherent soft X-ray diffraction images of Coliphage PR772 virus, collected at the Atomic Molecular Optics (AMO) beamline with pnCCD detectors in the LAMP instrument at the Linac Coherent Light Source. The diameter of PR772 ranges from 65–70 nm, which is ...

    Also Ranks for: Ray Diffraction |  coliphage pr772 |  light source |  reconstruction algorithms |  particle imaging
    KOL Index score: 3486

    BACKGROUND AND AIMS: Pancreatic ductal adenocarcinoma is an aggressive disease most often diagnosed after local progression or metastatic dissemination, precluding resection and resulting in a high mortality rate. For individuals with elevated personal risk of the development of pancreatic cancer, EUS is a frequently used advanced imaging and diagnostic modality. However, variability in the expertise and definition of EUS findings exists among gastroenterologists, as well as a lack of ...

    Also Ranks for: Consensus Statement |  risk individuals |  pancreatic cancer |  early detection |  reporting template
    KOL Index score: 3045

    X-ray magnetic circular dichroism spectroscopy using an X-ray free electron laser is demonstrated with spectra over the Fe L(3,2)-edges. The high brightness of the X-ray free electron laser combined with high accuracy detection of incident and transmitted X-rays enables ultrafast X-ray magnetic circular dichroism studies of unprecedented sensitivity. This new capability is applied to a study of all-optical magnetic switching dynamics of Fe and Gd magnetic sublattices in a GdFeCo thin ...

    Also Ranks for: Ray Magnetic |  circular dichroism |  free electron |  absorption spectroscopy |  laser demonstrated
    KOL Index score: 2575

    The dynamics of liquid water feature a variety of time scales, ranging from extremely fast ballistic-like thermal motion, to slower molecular diffusion and hydrogen-bond rearrangements. Here, we utilize coherent X-ray pulses to investigate the sub-100 fs equilibrium dynamics of water from ambient conditions down to supercooled temperatures. This novel approach utilizes the inherent capability of X-ray speckle visibility spectroscopy to measure equilibrium intermolecular dynamics with ...

    Also Ranks for: Liquid Water |  speckle contrast |  molecular dynamics simulations |  time scales |  coherent xray pulses
    KOL Index score: 1948

    A reduced-order model is used to derive a candidate energy function for a system that includes an infinite bus connected with a single frequency-droop-controlled inverter (a ‘MicroSource’) whose frequency command is actuated according to its low-pass-filtered active power measurement. The analysis of the large-signal stability of such a system is important in understanding the duration that a frequency-droop-controlled inverter can withstand a particular grid transient before islanding ...

    Also Ranks for: Controlled Inverter |  infinite bus |  energy function |  control parameters |  largesignal stability
    KOL Index score: 1648

    The possibility of imaging single proteins constitutes an exciting challenge for x-ray lasers. Despite encouraging results on large particles, imaging small particles has proven to be difficult for two reasons: not quite high enough pulse intensity from currently available x-ray lasers and, as we demonstrate here, contamination of the aerosolized molecules by nonvolatile contaminants in the solution. The amount of contamination on the sample depends on the initial droplet size during ...

    Also Ranks for: Ray Lasers |  single proteins |  particle imaging |  sample delivery |  structure determination
    KOL Index score: 1075

    The Macromolecular Femtosecond Crystallography (MFX) instrument at the Linac Coherent Light Source (LCLS) is the seventh and newest instrument at the world's first hard X-ray free-electron laser. It was designed with a primary focus on structural biology, employing the ultrafast pulses of X-rays from LCLS at atmospheric conditions to overcome radiation damage limitations in biological measurements. It is also capable of performing various time-resolved measurements. The MFX design ...

    Also Ranks for: Femtosecond Crystallography |  light source |  structural biology |  time resolved |  linac coherent
    KOL Index score: 503

    The possibility of imaging single proteins constitutes an exciting challenge for X-ray lasers. Despite encouraging results on large particles, imaging small particles has proven to be difficult for two reasons: not quite high enough pulse intensity from currently available X-ray lasers and, as we demonstrate here, contamination of the aerosolised molecules by non-volatile contaminants in the solution. The amount of contamination on the sample depends on the initial droplet-size during ...

    Also Ranks for: Imaging Single |  structure determination |  free sample
    KOL Index score: 173

    The day-to-day operation of modern power systems is highly reliant on prompt and adequate situational-awareness. This can be achieved via various system monitoring functions such as anomaly detection, in which static thresholds are commonly utilized to distinguish the normal and the abnormal system states. However, a predetermined static threshold usually lacks the flexibility to adapt to unobserved scenarios. In this paper, we propose two self-adaptive synchrophasor data driven anomaly ...

    Also Ranks for: Chebyshev Inequality


    Philip Hart: Influence Statistics

    Sample of concepts for which Philip Hart is among the top experts in the world.
    Concept World rank
    timeresolved measurements location #18
    mfx instrument utilization #18
    location mfx instrument #18
    lcls multiple experiments #18
    primary techniques capabilities #18
    mfx design #18
    lcls primary focus #18
    ultrafast pulses rays #18
    user access lcls #18
    macromolecular femtosecond #18
    lcls atmospheric conditions #18
    measurements mfx #18
    multiple experiments mfx #18
    mfx instrument #20
    crystallography mfx #21
    multiple methods techniques #21
    radiation damage limitations #22
    intact electronic structure #34
    undamaged spectra #34
    rays lcls #35
    source macromolecular #37
    xray speckle visibility #39
    energydispersive xray emission #39
    redoxactive metal sites #40
    crystallography instrument #40
    complexes xes #41
    determination serial #46
    edih empirical #46
    serial xray diffraction #47
    singleparticle diffraction #54
    difficulttocrystallize molecules #62
    coliphage pr772 virus #63
    empirical dietary hyperinsulinemia #64
    versatile base #68
    metal catalytic sites #70
    coliphage pr772 #74
    lamp instrument #80
    dose synchrotron #85
    hyperinsulinemia edih #86
    dietary hyperinsulinemia #94
    sfx structure #95
    ultrafast xray #96
    experimental endstations #97

    Key People For Structure Determination

    Top KOLs in the world
    Randy J Read
    molecular replacement crystal structure density modification
    Paul David Adams
    crystal structure density modification escherichia coli
    Ralf W Grosse‐Kunstleve
    map quality molecular replacement structure refinement
    Adriaan Bax
    dipolar couplings solution structure chemical shift
    G Marius Clore
    solution structure magnetic resonance spectroscopy models
    Kurt Wüthrich
    nmr structure magnetic resonance aqueous solution

    Philip Hart:Expert Impact

    Concepts for whichPhilip Harthas direct influence:Structure determination,  Ray lasers,  Xray lasers,  Coliphage pr772,  Free electron laser,  Ray diffraction,  Free electron,  Light source.

    Philip Hart:KOL impact

    Concepts related to the work of other authors for whichfor which Philip Hart has influence:Radiation damage,  Serial crystallography,  Ray free,  European xfel,  Structure determination,  Structural biology,  Electron laser.



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    SLAC National Accelerator Lab. (United States) | GE Research, Niskayuna, New York, USA | Ohio State University Comprehensive Cancer Center – James; College of Medicine, The Ohio State University Wexner Medical Center | Linac Coherent Light Source, SL