• KOL
    • Chronic Pancreatitis
    • Tooru Shimosegawa
    • Tooru Shimosegawa: Influence Statistics

      Tooru Shimosegawa

      Tooru Shimosegawa

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      Department of Gastroenterology, South Miyagi Medical Center, Ohgawara, Japan | Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice ...

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      Tooru Shimosegawa:Expert Impact

      Concepts for whichTooru Shimosegawahas direct influence:Chronic pancreatitis,Pancreatic cancer,Autoimmune pancreatitis,Acute pancreatitis,Pylori infection,Nitric oxide,Gastric acid secretion,Japanese patients.

      Tooru Shimosegawa:KOL impact

      Concepts related to the work of other authors for whichfor which Tooru Shimosegawa has influence:Pancreatic cancer,Acute pancreatitis,Helicobacter pylori,Inflammatory bowel disease,Ulcerative colitis,Hepatocellular carcinoma,Gene expression.

      KOL Resume for Tooru Shimosegawa

      Year
      2022

      Department of Gastroenterology, South Miyagi Medical Center, Ohgawara, Japan

      2021

      Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Irritable Bowel Syndrome”, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, Tokyo 105-0004 Japan

      2020

      Department of Gastroenterology, South Miyagi Medical Centre, Miyagi, Japan

      2019

      Department of Gastroenterology, South Miyagi Medical Center, 28-1 Nishi, 9891253, Ohgawara, Miyagi, Japan

      South Miyagi Medical Center.

      Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai.

      2018

      Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan

      2017

      Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-cho, Aoba-ku, 980-8574, Sendai, Miyagi, Japan

      Department of Gastroenterology, Tohoku University

      2016

      a Division of Gastroenterology , Tohoku University Graduate School of Medicine , Sendai , Japan ;

      2015

      From the Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

      Division of Gastroenterology, Tohoku University Hospital, 1-1 Seiryo, Aoba, 980-8574, Sendai City, Miyagi, Japan

      Department of Gastroenterology, Graduate School of Medicine, Tohoku University

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      Sample of concepts for which Tooru Shimosegawa is among the top experts in the world.
      Concept World rank
      esem gerd #1
      cancer lesions ipmns #1
      u3148 c5907 #1
      map kinases pscs #1
      aip questionnaire #1
      chc patients pnalt #1
      ulcer location antrum #1
      eradication distribution #1
      mucin‐hypersecreting neoplasms #1
      tbetarii tgfbeta1 tbetari #1
      327 asian patients #1
      oct staging #1
      cdcp1 epithelial phenotype #1
      tgfbeta1 tbetari tbetarii #1
      subgenotypes b4 #1
      stat6 rna sox2 #1
      ab302942 #1
      aspirintakers controls #1
      n34s mutation ivs137tc #1
      stat3 pathway interaction #1
      expert panelists #1
      glutathione tissue #1
      cerulein pancreatitis #1
      acute pancreatitis role #1
      transcriptional activation tl1a #1
      igg4rd 1 serum #1
      rab5b hbv dna #1
      −215g #1
      hne activation #1
      9 prognostic factors #1
      japan spink1 #1
      ibd japanese population #1
      irs2 gluconeogenesis enzymes #1
      eusfna 22g needles #1
      rosiglitazone hbv #1
      ros production dpi #1
      msx2 expression malignancy #1
      “ecura #1
      kras itpns #1
      pscs mirnas #1
      80 ≤ 100 #1
      surgery interventionfree survival #1
      chronic pancreatitis development #1
      angiogenesis termination zone #1
      nudt15 east asian #1
      11 cqs #1
      cck8 01 nm #1
      health organization eusfna #1
      reactive increase #1
      sporadic pca cppca #1
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      Prominent publications by Tooru Shimosegawa

      KOL-Index: 23379

      OBJECTIVES: The acidity of the refluxate into the esophagus is a key factor for the pathogenesis of gastroesophageal reflux disease. Helicobacter pylori (H. pylori) infection can influence gastric acid secretion. We have reported that H. pylori infection prevents reflux esophagitis by decreasing gastric acid secretion in Japanese patients, but the role of this organism in Barrett's esophagus is unclear. The aim of this study was to investigate the prevalence of H. pylori infection and ...

      Known for Pylori Infection | Reflux Esophagitis | Gastric Acid | Barretts Esophagus | Egt Patients
      KOL-Index: 19082

      BACKGROUND: We have previously reported that Helicobacter pylori infection prevents reflux esophagitis (RE) and Barrett's esophagus (BE) by decreasing gastric acid secretion. Gastroesophageal (GE) junction adenocarcinoma, including Barrett's adenocarcinoma, has been thought to be a complication of gastroesophageal reflux disease (GERD). However, the relationship between H. pylori infection, gastric acid secretion, and GE junction adenocarcinoma has not yet been investigated in Japan. The ...

      Known for Pylori Infection | Junction Adenocarcinoma | Gastric Acid Secretion | Japanese People | Patients Egc
      KOL-Index: 18357

      The efficacy of thiopurines, including azathioprine (AZA) and 6-mercaptopurine (6MP), has been demonstrated for the treatment of inflammatory bowel disease (IBD). The most common and serious adverse event of treatment with thiopurines altered by doctors is leukopenia. Hair loss is also a serious event that could be a critical reason for patients to decline thiopurine treatment. Thiopurine-induced severe hair loss causes cosmetic problems, and it takes a long time to recover. In a recent ...

      Known for Japanese Patients | Hair Loss | Thiopurine Treatment | Nudt15 R139c | Induced Early
      KOL-Index: 15880

      The interaction between pancreatic cancer cells and pancreatic stellate cells (PSCs), a major profibrogenic cell type in the pancreas, is receiving increasing attention. There is accumulating evidence that PSCs promote the progression of pancreatic cancer by increasing cancer cell proliferation and invasion as well as by protecting them from radiation- and gemcitabine-induced apoptosis. Because epithelial-mesenchymal transition (EMT) plays a critical role in the progression of pancreatic ...

      Known for Pancreatic Cancer Cells | Mesenchymal Transition | Pscs Emt | Tumor Cadherins Cell | Increasing Attention
      KOL-Index: 15391

      Periostin is a secretory protein that has been suggested to function as a cell adhesion molecule and promote the invasiveness or growth rate of tumors. However, little is known about the association of its expression and epithelial to mesenchymal transition (EMT), which is considered to play a crucial role in cancer cell metastasis. Thus, the authors investigated whether periostin could be involved in the process of EMT and the role of this gene in pancreatic cancer development. The ...

      Known for Cancer Cells | Cell Migration | Mesenchymal Transition | Expression Periostin | Secretory Protein
      KOL-Index: 15075

      BACKGROUND: Chronic pancreatitis is suggested to be one of the risk factors for the development of pancreatic cancer. The aim of this study was to confirm the high incidence of pancreatic cancer in patients with chronic pancreatitis in Japan and to determine the factors associated with the risk for pancreatic cancer in patients with chronic pancreatitis.

      METHODS: The working group of the Research Committee of Intractable Disease supported by the Ministry of Health, Labour and Welfare of ...

      Known for Chronic Pancreatitis | Pancreatic Cancer | Patients Surgery | Hazard Ratio | Retrospective Analysis
      KOL-Index: 14711

      BACKGROUND: In Japan, where the incidence of gastric cancer is high, Helicobacter pylori infection could affect gastric acid secretion differently from that in Western countries. The aim of this study was to investigate the relationship between H. pylori infection, acid secretion, aging, and gender in normal Japanese subjects.

      METHODS: The study comprised 193 Japanese subjects who had undergone routine endoscopy. Gastrin-stimulated acid output was performed during the routine endoscopic ...

      Known for Pylori Infection | Acid Secretion | Japanese Subjects | Gastric Cancer | Western Countries
      KOL-Index: 14603

      Activated pancreatic stellate cells (PSCs) have recently been implicated in the pathogenesis of pancreatic fibrosis and inflammation. However, the signal transduction pathways in PSCs remain largely unknown. We examined the role of p38 mitogen-activated protein (MAP) kinase in the activation of PSCs. PSCs were isolated from rat pancreas tissue and used in their culture-activated, myofibroblast-like phenotype. Activation of p38 MAP kinase was determined by Western blotting using ...

      Known for Activated Protein | P38 Mitogen | Activation Pscs | Map Kinase | Stellate Cells
      KOL-Index: 14426

      Alcohol is a major cause of both acute and chronic pancreatitis. Activated pancreatic stellate cells (PSCs) have recently been implicated in the pathogenesis of pancreatic inflammation and fibrosis. Herein, we examined the effect of ethanol and acetaldehyde on the activation of transcription factors and mitogen-activated protein (MAP) kinases in PSCs. PSCs were isolated from rat pancreas tissue and used in their culture-activated, myofibroblast-like phenotype. PSCs were treated with ...

      Known for Activated Protein | Ethanol Acetaldehyde | Map Kinases | Northern Blotting | Stellate Cells
      KOL-Index: 14365

      BACKGROUND: Helicobacter pylori infection is less prevalent and atrophic gastritis is less extensive in patients with reflux oesophagitis than those without it, but few studies have examined this relationship directly.

      AIMS: We investigated the relationship between H pylori infection, acid secretion, and reflux oesophagitis in Japanese subjects.

      SUBJECTS: A total of 105 patients with erosive reflux oesophagitis were compared with 105 sex and age matched patients without reflux ...

      Known for Reflux Oesophagitis | Acid Secretion | Pylori Infection | Patients Gastric | Japanese Subjects
      KOL-Index: 14320

      Intraductal tubulopapillary neoplasm (ITPN) is a recently recognized rare variant of intraductal neoplasms of the pancreas. Molecular aberrations underlying the neoplasm remain unknown. We investigated somatic mutations in PIK3CA, PTEN, AKT1, KRAS, and BRAF. We also investigated aberrant expressions of phosphorylated AKT, phosphatase and tensin homolog (PTEN), tumor protein 53 (TP53), SMAD4, and CTNNB1 in 11 cases of ITPNs and compared these data with those of 50 cases of intraductal ...

      Known for Somatic Mutations | Ipmns Itpns | Tumor Carcinoma | Tubulopapillary Neoplasm | Phosphorylated Akt
      KOL-Index: 14181

      In response to pancreatic injury and in cell culture, pancreatic stellate cells (PSCs) are transformed ("activated") into highly proliferative myofibroblast-like cells that express alpha-smooth muscle actin and produce extracellular matrix components. Activated PSCs are implicated in the pathogenesis of pancreatic fibrosis and inflammation. We here evaluated the effects of SP600125 (anthra[1,9-cd]pyrazole-6 (2H)-one), an inhibitor of c-Jun NH(2)-terminal kinase (JNK), on the activation ...

      Known for Pancreatic Stellate Cells | Activation Pscs | Jnk Sp600125 | Collagen Production | Activated Protein
      KOL-Index: 14069

      Although NF-kappaB plays an important role in pancreatitis, mechanisms underlying its activation remain unclear. We investigated the signaling pathways mediating NF-kappaB activation in pancreatic acinar cells induced by high-dose cholecystokinin-8 (CCK-8), which causes pancreatitis in rodent models, and TNF-alpha, which contributes to inflammatory responses of pancreatitis, especially the role of PKC isoforms. We determined subcellular distribution and kinase activities of PKC isoforms ...

      Known for Pancreatic Acinar Cells | Nfkappab Activation | Pkc Isoforms | Kinase Protein | Alpha Nf
      KOL-Index: 13860

      Cell-surface Toll-like receptors (TLRs) initiate innate immune responses, such as inducible nitric oxide synthase (iNOS) induction, to microorganisms' surface pathogens. TLR2 and TLR4 play important roles in gastric mucosa infected with Helicobacter pylori (H. pylori), which contains lipopolysaccharide (LPS) as a pathogen. The present study investigates their physiological roles in the innate immune response of gastric epithelial cells to H. pylori-LPS. Changes in the expression of iNOS, ...

      Known for Tlr2 Tlr4 | Helicobacter Pylori | Epithelial Cells | Gastric Mucosa | Tolllike Receptor
      KOL-Index: 13806

      BackgroundSocietal stress derived from an event that affects the whole society, e. g., a natural disaster, provides a unique, indirect way of determining the relationship between psychological stress and peptic ulcer disease in humans. In this study, we investigated the changing patterns of the incidence of peptic ulcers before and after the Great East Japan earthquake, which occurred on 11 March, 2011.MethodsClinical data of patients with peptic ulcers were retrospectively collected ...

      Known for Peptic Ulcers | Great East | Japan Earthquake | Psychological Stress | Antiinflammatory Agents

      Key People For Chronic Pancreatitis

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      Department of Gastroenterology, South Miyagi Medical Center, Ohgawara, Japan | Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Gastroesophageal Reflux Disease”, The Japanese Society of Gastroenter

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