• Disease
  • Chronic
  • Chronic Prostatitis
  • Richard B Alexander

    Prominent publications by Richard B Alexander

    KOL Index score: 14266

    PURPOSE: We examine whether leukocytes and bacteria correlate with symptom severity in men with chronic prostatitis/chronic pelvic pain syndrome.

    MATERIALS AND METHODS: All 488 men screened into the National Institutes of Health Chronic Prostatitis Cohort Study before close of recruitment on August 22, 2001 were selected for analysis. The National Institutes of Health Chronic Prostatitis Symptom Index, including subscores, were used to measure symptoms. Urethral inflammation was defined ...

    Also Ranks for: Chronic Prostatitis |  national institutes |  urine semen |  severity symptoms |  male pelvic
    KOL Index score: 13182

    OBJECTIVES: Chronic prostatitis/chronic pelvic pain syndrome is a common diagnosis, but the disease is poorly understood. The diagnosis is based only on symptoms, and no measurable parameter can help in defining the presence of the disease, its severity, or its cause. Cytokines are soluble proteins secreted by cells of the immune system that principally regulate inflammatory and immune responses. To provide an objective measure of inflammation in the genital tract, we measured levels of ...

    Also Ranks for: Pain Syndrome |  proinflammatory cytokines |  chronic prostatitis |  elevated levels |  semen patients
    KOL Index score: 12384

    PURPOSE: The molecular mechanisms underlying the therapeutic effect of the alpha1 blocker, doxazosin, on benign prostatic hyperplasia (BPH) are poorly understood. We evaluated the effect of doxazosin on cell proliferation and apoptosis in the prostatic glandular epithelium and stroma of patients with BPH.

    MATERIALS AND METHODS: We examined proliferative and apoptotic activities in prostate specimens of 22 men a mean of 65 years old with BPH before and after doxazosin treatment within the ...

    Also Ranks for: Prostate Apoptosis |  prostatic hyperplasia |  bph doxazosin |  cell proliferation |  smooth muscle
    KOL Index score: 12374

    Cytomegalovirus (CMV) is a highly immunogenic virus that results in a persistent, life-long infection in the host typically with no ill effects. Certain unique features of CMV, including its capacity to actively replicate in the presence of strong host CMV-specific immunity, may give CMV an advantage compared with other virus-based vaccine delivery platforms. In the present study, we tested the utility of mouse CMV (mCMV)-based vaccines expressing human prostate-specific antigen (PSA) ...

    Also Ranks for: Prostate Cancer |  tumor growth |  specific cd8 |  based vaccine |  murine model
    KOL Index score: 11092

    OBJECTIVES: To determine if proteins known to be expressed by both benign and malignant prostate epithelium can be recognized by T cells from patients with prostate cancer. We examined 7 HLA-A2 patients with prostate cancer for evidence of T cell reactivity with prostate-specific antigen (PSA).

    METHODS: Four peptides derived from PSA were chemically synthesized and shown to bind to HLA-A2. As a control, we also examined the immunogenic influenza matrix peptide Flu58-66 that binds to ...

    Also Ranks for: Prostate Cancer |  specific antigen |  psa peptides |  7 patients |  vitro stimulation
    KOL Index score: 10992

    PURPOSE: Chronic prostatitis has been traditionally characterized by inflammation and/or infection of the prostate gland, objectively categorized by white blood cells and cultured bacteria in prostate specific specimens. We compared leukocyte counts and localization rates for bacterial cultures of segmented urine samples (VB1, VB2, VB3), expressed prostatic secretion (EPS) and semen in men diagnosed with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) to men without pelvic ...

    Also Ranks for: Chronic Prostatitis |  pelvic pain |  asymptomatic controls |  bacterial cultures |  leukocyte counts
    KOL Index score: 10979

    Objectives: The NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to assess symptoms and quality of life in men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). We assessed the responsiveness of the NIH-CPSI to change over time and defined thresholds for changes perceptible to patients. Methods: We studied 174 men with CP/CPPS who participated in a placebo-controlled randomized clinical trial. Changes from baseline to six weeks in the NIH-CPSI total score and ...

    Also Ranks for: Quality Life |  national institutes |  chronic prostatitis |  nihcpsi total score |  guyatt statistics
    KOL Index score: 10872

    Cognitive/behavioral and environmental variables are significant predictors of patient adjustment in chronic pain. Using a biopsychosocial template and selecting several pain-relevant constructs from physical, cognitive/behavioral, and environmental predictors, outcomes of pain and disability in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) were explored. Men (n = 253) from a North American multi-institutional NIH-funded Chronic Prostatitis Cohort Study in 6 US and 1 ...

    Also Ranks for: Chronic Pelvic |  pain disability |  urinary symptoms |  helplessness catastrophizing |  cognitive behavioral
    KOL Index score: 10648

    Dendritic cells (DC) acquire antigens through a number of cell surface structures including receptors for the Fc portion of immunoglobulins and mannose. Little is known about the effects of antigen uptake via these receptors on antigen processing and presentation. We compared the capacity of DC to generate CD4(+) and CD8(+) T cell responses after exposure to prostate-specific antigen (PSA) alone, PSA targeted to the mannose receptor (mannosylated PSA (PSA-m)), or PSA targeted to Fc ...

    Also Ranks for: Dendritic Cells |  antigen psa |  cell responses |  prostate cancer |  mannose receptor
    KOL Index score: 10341

    BACKGROUND: Evidence suggests that the urogenital pain of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) may be neuropathic.

    METHODS: This randomized, double-blind, placebo-controlled trial was conducted across 10 tertiary care centers in North America to determine whether pregabalin, which has been proved effective in other chronic pain syndromes, is effective in reducing CP/CPPS symptoms. In 2006-2007, 324 men with pelvic pain for at least 3 of the previous 6 months were ...

    Also Ranks for: Chronic Pelvic |  pregabalin placebo |  randomized controlled trial |  6 weeks |  pain syndrome
    KOL Index score: 10301

    BACKGROUND: Adrenocortical carcinoma (ACC) is rare, nearly always fatal, and to the authors' knowledge has few nonsurgical treatment options. Based on in vitro studies demonstrating the efficacy of mitotane as a P-glycoprotein (Pgp) antagonist, and expression of high levels of Pgp in ACC, the authors conducted a study of infusional doxorubicin, vincristine, and etoposide with oral mitotane +/- surgical resection in patients with metastatic ACC.

    METHODS: Thirty-six patients with ...

    Also Ranks for: Surgical Resection |  combination chemotherapy |  adrenocortical carcinoma |  metastatic acc |  mitotane treatment
    KOL Index score: 10285

    PURPOSE: We describe the study design of the National Institutes of Health Chronic Prostatitis Cohort (CPC) study characterizing men with chronic prostatitis/the chronic pelvic pain syndrome.

    MATERIALS AND METHODS: All 488 men screened into the CPC study before close of recruitment on August 22, 2001 were selected for analysis. The National Institutes of Health Chronic Prostatitis Symptom Index, including subscores, was used to measure symptoms. A comprehensive history, physical ...

    Also Ranks for: Chronic Prostatitis |  national institutes |  pain syndrome |  quality life |  physical examination
    KOL Index score: 9920

    PURPOSE: Prostate brachytherapy (PB) entails the placement of radioactive sources throughout the entire prostate gland to treat localized cancer. Typically, the target volume in PB encompasses the entire prostate gland because of the inability to localize the cancer and the multifocal nature of this malignancy. However, because of the unique biochemical nature of the prostate gland, recent advances in magnetic resonance spectroscopic imaging (MRSI) of the prostate have allowed precise ...

    Also Ranks for: Magnetic Resonance |  prostate cancer |  target volume |  spectroscopic imaging |  postimplant dosimetry


    Richard B Alexander: Influence Statistics

    Sample of concepts for which Richard B Alexander is among the top experts in the world.
    Concept World rank
    vlpvpsa vaccinated mice #1
    dr2b tumor #1
    automated leukopheresis #1
    155l vaccination #1
    agonist peptide psa #1
    psa derived peptides #1
    prostate candidate #1
    psa hladr2b #1
    proinflammatory cytokines semen #1
    human prostatespecific psa #1
    candidate self‐antigen #1
    tumor growth outcome #1
    editor cytotoxic #1
    rejection adenocarcinoma #1
    transgenic mouse adenocarcinoma #1
    human psa pap #1
    richard alexander #1
    selfprostatic proteins #1
    longstanding prostatitis #1
    intraprostatic cfa #1
    dr2bxpsa f1 #1
    normal il1 #1
    pap hla #1
    hla‐drb11503‐restricted t‐cell #1
    psa antigen #1
    hladrb11501 tg mice #1
    growth vlpv #1
    psa cd8 #1
    serum psa vaccine #1
    recognition psa #1
    autoimmunity prostate #1
    psa65 #1
    psa cd4 #1
    154 163 #1
    psa tramppsa #1
    psa hladr2b mice #1
    cancer alphavirus #1
    montanide isa51 psa #1
    richard alexander assumptions #1
    ongoing empiric administration #1
    drb11503 tg #1
    hladr2b mice #1
    hla drb11501 transgenes #1
    trampc1 tumor cells #1
    drb11501 dr2b #1
    hladrb11501 dr2b transgene #1
    pelvic pain plethora #1

    Key People For Chronic Prostatitis

    Top KOLs in the world
    John Curtis Nickel
    chronic prostatitis interstitial cystitis benign prostatic hyperplasia
    Richard B Alexander
    chronic prostatitis prostate cancer pelvic pain
    Michael P O'Leary
    chronic prostatitis prostate cancer sexual dysfunction
    Michel A Pontari
    chronic prostatitis pelvic pain interstitial cystitis
    John N Krieger
    chronic prostatitis male circumcision pelvic pain
    Anthony J Schaeffer
    pelvic pain chronic prostatitis urinary tract

    Richard B Alexander:Expert Impact

    Concepts for whichRichard B Alexanderhas direct influence:Chronic prostatitis,  Prostate cancer,  Chronic pelvic,  Pelvic pain,  Granulomatous prostatitis,  Renal lesions,  Pain syndrome,  Specific antigen.

    Richard B Alexander:KOL impact

    Concepts related to the work of other authors for whichfor which Richard B Alexander has influence:Chronic prostatitis,  Prostate cancer,  Pelvic pain,  Renal cell,  Benign prostatic hyperplasia,  Interstitial cystitis,  Cytoreductive nephrectomy.



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    Department of Surgery, Division of Urology, University of Maryland School of Medicine, USA | Department of Surgery, Division of Urology, University of Maryland, 10S Pine Street, MSTF-4, 21201, Baltimore, MD, USA | VA Maryland Health Care System, Depa