• Chronic Rejection
    • Pekka J Häyry
    • Pekka J Häyry: Influence Statistics

      Pekka J Häyry

      Pekka J Häyry

      Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland | Rational Drug Design Programme, Biomedicum Helsinki and ...

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      Pekka J Häyry:Expert Impact

      Concepts for whichPekka J Häyryhas direct influence:Chronic rejection,Allograft arteriosclerosis,Graft rejection,Cytomegalovirus infection,Renal allografts,Endothelial cells,Allograft rejection,Inbred strains rats.

      Pekka J Häyry:KOL impact

      Concepts related to the work of other authors for whichfor which Pekka J Häyry has influence:Acute rejection,Kidney transplantation,Endothelial cells,Mycophenolate mofetil,Desmoid tumors,Graft survival,Cytomegalovirus infection.

      KOL Resume for Pekka J Häyry


      Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland


      Rational Drug Design Programme, Biomedicum Helsinki and Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland


      Haartman Institute, Transplantation Laboratory, University of Helsinki,


      Transplantation Laboratory and Rational Drug Design Programme, Biomedicum, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland


      Rational Drug Design Programme, Transplantation Laboratory, University of Helsinki, and Helsinki University Central Hospital, P. O. Box 63 (Haartmaninkatu 8), Helsinki, Finland


      Rational Drug Design Program Biomedicum Helsinki & Transplantation Laboratory University of Helsinki & Helsinki University Central Hospital Helsinki, Finland


      Department of Rational Drug Design Program, Biomedicum, University of Helsinki, Helsinki

      Juvantia Pharma Ltd., Turku, Finland


      Transplantation Laboratory, University of Helsinki, Helsinki, Finland


      Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland.


      Transplantation Laboratory, The Haartman Institute, University of Helsinki, Finland, 00014

      Department of Medical Nutrition, Karolinska Institute, NOVUM, S-141 86 Huddinge, Sweden


      Transplantation Laboratory, University of Helsinki, Finland.


      Transplantation Laboratory, University of Helsinki, P.O. Box 21, FIN‐00014 Helsinki, Finland


      Transplantation Laboratory. PO. Box 21 (Haartmaninkatu 3), FIN‐00014 University of Helsinki, Finland Tel.+ 358 0 434 6.590; Fax+ 358 0 2411 227

      Department of Medical Microbiology, University of Limburg, Maastricht, The Netherlands


      From the Transplantation Laboratory (K.L., P.K., L.K., P.H.), University of Helsinki (Finland), and the Departments of Medical Microbiology (C.B.) and Pathology (M.D.), University of Limburg, Maastricht, the Netherlands.

      Transplantation Laboratory, University of Helsinki and University of Helsinki Hospital, Helsinki, Finland


      Transplantation Laboratory, University of Helsinki, P.0. Box 21 (Haartmaninkatu 3). SF‐00014 Helsinki, Finland FAX:(358) 0–411227


      Transplantation Laboratory, University of Helsinki, Helsinki, Finland.


      Transplantation Laboratory, Helsinki, Finland


      Department of Anatomy, Laboratory for Biological Structure Research, Karolinska Institutet, S-104 01 Stockholm; Departments of Pathology and Transplantation Surgery, Huddinge Hospital, S-141 86 Huddinge, Sweden; and Transplantation Laboratory, Fourth Department of Surgery, University of Helsinki, SF-00290 Helsinki, Finland


      From the Transplantation Laboratory, University of Helsinki, Helsinki, Finland


      Transplantation Laboratory, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, Finland


      Department of Surgery, University of Helsinki, Finland.

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      Sample of concepts for which Pekka J Häyry is among the top experts in the world.
      Concept World rank
      episodes triple #1
      human lymphocytes percentage #1
      mobile bloodderived components #1
      recipient spleen receptor #1
      natural attachment capacities #1
      study cadi #1
      iellqar wf selectins #1
      infiltrating purified #1
      fold cell migration #1
      exclusive subtype #1
      emb histology angiography #1
      allograft destruction #1
      ctl specific cytotoxicity #1
      cmv antigens heart #1
      lymphocytes cord blood #1
      lymphoid cell subclasses #1
      blasts secondary lymphocytes #1
      vascular lymphocyte binding #1
      nkff #1
      needle creatinine #1
      immunogenic potential allograft #1
      kidney parenchymal cells #1
      cmi thyroid #1
      alloantiserum reactivity #1
      inhibition thromboxane cascade #1
      cadi homologous biopsy #1
      chronic banff score #1
      fungi1 prolongs #1
      precursor cell influx #1
      cmv kidney cells #1
      preexisting neointima injury #1
      growth factor transplantation #1
      agents aorta thoracic #1
      histological renal allografts #1
      patients azathioprine intolerance #1
      pge2 mp #1
      systemic local immunity #1
      igf1r pdgfrbeta #1
      renal allograft rat #1
      fungal tuberculosis #1
      arteriosclerosis rat #1
      aorta denudations #1
      txb2 adventitia #1
      graft components #1
      normal 7176 #1
      cardiac allografts rat #1
      infiltrating rat #1
      heterogeneity effector cells #1
      cadi 2 #1
      cold thymidine #1
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      Prominent publications by Pekka J Häyry

      KOL-Index: 14575

      We have recently demonstrated that rat cytomegalovirus (RCMV) infection induces an early inflammatory response in the adventitia (perivasculitis) and in the subendothelial space (endothelialitis) as well as doubles smooth muscle cell (SMC) proliferation and intimal thickening of rat aortic allografts performed from the DA (AG-B4, RT1a) to the WF (AG-B2, RT1v) strain. In this study, the impact of RCMV infection on the structure of inflammation in the allograft adventitia and on the ...

      Known for Growth Factor | Mrna Expression | Cytomegalovirus Infection | Rat Aortic Allografts | Intimal Thickening
      KOL-Index: 13871

      We have investigated the immunogenic potential of rat heart vascular endothelial cells by their ability to induce an accelerated rejection of a relevant heart allograft, and related the immunogenic potential to the expression of class II major histocompatibility complex (MHC) antigens on the endothelial cell surface. Only 12% of freshly isolated rat vascular endothelial cells express class II antigens in serum-free medium, and the level of expression is low as judged by immunoperoxidase ...

      Known for Endothelial Cells | Antigen Expression | Cell Surface | Major Histocompatibility | Graft Survival
      KOL-Index: 13578

      Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have been linked to vascular smooth muscle cell (SMC) migration and proliferation leading to atherosclerosis, restenosis, and chronic allograft rejection. This study describes the effect of CGP 53716, a specific PDGFR tyrosine kinase inhibitor on SMC proliferation and migration in vitro and in neointimal formation in vivo. CGP 53716 inhibited dose dependently tyrosine phosphorylation of both the known PDGFRs: the ...

      Known for Vascular Smooth | Cell Migration | Growth Factor | Tyrosine Kinase | Smc Proliferation
      KOL-Index: 13019

      Inbred DA (AG-B4, RT1a) and WF (AG-B2, RT1v) rats were used as donors and recipients of aortic allografts. The recipient rats were inoculated i.p. either on day 1 (early infection) or on day 60 (late infection) with 10(5) plaque-forming units of rat cytomegalovirus (RCMV). The control rats were left noninfected. The presence of viral infection was demonstrated by plaque assays from biopsies of the salivary glands, liver, and spleen at sacrifice. The rats received 300 microCi[3H]thymidine ...

      Known for Cytomegalovirus Infection | Aortic Allografts | Smooth Muscle | Intimal Thickening | Cell Proliferation
      KOL-Index: 12881

      This study is an investigation of whether a protocol biopsy may be used as surrogate to late graft survival in multicenter renal transplantation trials. During two mycophenolate mofetil trials, 621 representative protocol biopsies were obtained at baseline, 1 yr, and 3 yr. The samples were coded and evaluated blindly by two pathologists, and Chronic Allograft Damage Index (CADI) score was constructed. At 1 yr, only 20% of patients had elevated (>l.5 mg/100 ml) serum creatinine, whereas ...

      Known for Graft Survival | Needle Biopsy | Patients 1 | Serum Creatinine | Surrogate Point
      KOL-Index: 11964

      Human natural killer cells cytotoxic against cell-line target cells (NK-CLT) were isolated and characterized by utilizing adsorption-elution of the effector cells from the K-562 target cells. The cell associated with the cytotoxicity was a large lymphocyte with pale and characteristically granular cytoplasm. Thus, its morphology was identical with that of the large granular lymphocyte (LGL) previously shown to be the principal cytotoxic NK cell against fetal fibroblasts (NK-FF). The ...

      Known for Effector Cells | Natural Killer Activity | Cell Cytotoxicity | Fetal Fibroblasts | K562 Lgl
      KOL-Index: 11679

      Summary. The long-term success of coronary angioplasty is limited by restonosis. This study was undertaken to investigate whether and to what extent the enhanced proliferative response observed in a balloon reinjury model of rat aorta is regulated by the PDGF receptor (PDGF-R). Balloon injury was performed to 14-day-old pre-existing neointimal lesion in rat aorta. PDGF receptor and ligand immunoreactivity were measured at several time points after the first and second injury, and PDGF-R ...

      Known for Smooth Muscle | Tyrosine Kinase | Growth Factor | Cell Proliferation | Balloon Injury
      KOL-Index: 11267

      BACKGROUND: Porcine fetal pancreas is a potential source of beta cells for transplantation. The immaturity of the cells is a problem. We have defined the optimal conditions for in vitro propagation of this tissue before transplantation.

      METHODS: Porcine fetal pancreas tissue was obtained for tissue culture at various stages of development. Serum-containing and serum-free media and a variety of potential differentiation factors were tested. In vitro, the numbers of endocrine islet cells ...

      Known for Cells Transplantation | Nude Mice | Islets Langerhans | Islet Cell | Insulin Content
      KOL-Index: 11202

      Accelerated allograft arteriosclerosis (chronic rejection) has emerged as a major factor affecting long-term survival of human cardiac allografts. The underlying mechanism of this disorder remains unclear. The purpose of this study was to investigate the effect of cyclosporine on the development of cardiac allograft arteriosclerosis at the cellular and molecular level. Heterotopic rat cardiac allografts from DA donors to WF recipients, with a strong genetic disparity in major ...

      Known for Cardiac Allografts | Chronic Rejection | Cyclosporine Csa | Intimal Thickening | Inbred Strains Rats
      KOL-Index: 10752

      BACKGROUND: Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors.

      METHODS AND RESULTS: Our results in rat cardiac allografts established alloimmune response as an alternative stimulus capable of inducing vascular endothelial growth factor (VEGF) mRNA and protein expression in cardiomyocytes and graft-infiltrating mononuclear inflammatory ...

      Known for Endothelial Growth | Cardiac Allograft | Arteriosclerotic Lesions | Factor Vascular | Alloimmune Response
      KOL-Index: 10677

      In human kidney allografts, association of acute rejection and glomerulopathy with cytomegalovirus (CMV) infection has been demonstrated. To investigate the effect of CMV infection on the development of experimental chronic kidney allograft rejection, heterotopic kidney allografts from DA (Ag-B4, RT1a1) rat donors to WF (Ag-B2, RT1u) rat recipients were used. The animals received cyclosporine A (CsA) 5 mg/kg/day s.c. either for 1 or 12 weeks. Two groups of recipients were infected with ...

      Known for Chronic Kidney | Allograft Rejection | Rcmv Infection | Intercellular Adhesion | Immunosuppressive Agents
      KOL-Index: 9780

      A group of renal pathologists, nephrologists, and transplant surgeons met in Banff, Canada on August 2-4, 1991 to develop a schema for international standardization of nomenclature and criteria for the histologic diagnosis of renal allograft rejection. Development continued after the meeting and the schema was validated by the circulation of sets of slides for scoring by participant pathologists. In this schema intimal arteritis and tubulitis are the principal lesions indicative of acute ...

      Known for Histologic Diagnosis | Renal Allograft Rejection | Transplant Pathology | Grade Iii | Cyclosporine Toxicity
      KOL-Index: 9729

      We have isolated and identified the infiltrating inflammatory cells from rejecting rat kidney allografts. The first host cells to appear in the graft, already a few hours after the transplantation, are monocytes and lymphocytes. Both T and B lymphocytes contribute to the infiltrate: at early stages of rejection most of the infiltrating lymphocytes have the high electrophoretic mobility of (resting) T cells, whereas later during the rejection most of the infiltrating lymphocytes display ...

      Known for Allograft Rejection | Inflammatory Response | Rat Kidney | Killer Cells | Autologous Transplantation
      KOL-Index: 9439

      Chronic rejection has several histological appearances, depending on the type of organ graft. Common to all of them is transplant arteriosclerosis associated with an ongoing inflammatory response in the transplanted graft. To the contrary of classical atherosclerosis, in which the manifestations are mostly focal, proximal, and asymmetric, transplant arteriosclerosis is generalized, and the intimal thickening is concentric. In this article, we describe an experimental animal model whereby ...

      Known for Transplant Arteriosclerosis | Aortic Allografts | Experimental Model | Chronic Rejection | Inbred Rat

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      Transplantation Laboratory, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland | Rational Drug Design Programme, Biomedicum Helsinki and Transplantation Laboratory, University of Helsinki and Helsinki University Centra

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