![]() | David W KennedyDivision of Rhinology, Department of Otorhinolaryngology, Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA | Department of ... |
KOL Resume for David W Kennedy
Year | |
---|---|
2021 | Division of Rhinology, Department of Otorhinolaryngology, Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Department of Otorhinolaryngology—Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania |
2020 | Department of Otorhinolaryngology–Head and Neck Surgery, Division of Rhinology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA Editor-in-Chief, International Forum of Allergy & Rhinology |
2019 | Department of Otorhinolaryngology–Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA |
2018 | Department of Otorhinolaryngology-Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pa. International Forum of Allergy & Rhinology |
2017 | University of Pennsylvania, Perelman School of Medicine Department of Otorhinolaryngology–Head and Neck Surgery Philadelphia PA Department of Otorhinolaryngology-Head and Neck Surgery. |
2016 | Department of Otorhinolaryngology – Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA Perelman School of Medicine at the University of Pennsylvania Philadelphia PA |
2015 | The University of Pennsylvania Department of Otorhinolaryngology–Head and Neck Surgery Philadelphia PA Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pa., USA |
2014 | Department of Otorhinolaryngology: Head and Neck Surgery, Perelman School of Medicine of the University of Pennsylvania, University of Pennsylvania Medical Center, 5 Ravdin, Pavilion, 3400 Spruce Street, 19104, Philadelphia, PA, USA |
2013 | Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA International Forum of Allergy and Rhinology |
2012 | Department of Otolaryngology-Head and Neck Surgery, Georgia Health Science University, Augusta, Ga., USA |
2011 | Department of Otorhinolaryngology: Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A. Hospital of the University of Pennsylvania, Ravdin Building, 5th Floor, 3400 Spruce Street, Philadelphia, PA 19104 University of Pennsylvania, Philadelphia, PA |
2010 | Department of Otorhinolaryngology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania |
2009 | Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA |
2008 | University of Pennsylvania Medical Center, Philadelphia, PA. Department of Otorhinolaryngology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, New York |
2007 | Editor, The Laryngoscope (Johnson) Editor-in-Chief, Otology and Neurotology (Niparko) Editor, Archives of Otolaryngology–Head and Neck Surgery (Levine) Editor, American Journal of Rhinology (Kennedy) Editor-in-Chief, American Journal of Otolaryngology (Weber) Editor, Head and Neck (Weber) Past Editor-in-Chief, Otolaryngology–Head and Neck Surgery (Benninger) Editor-in-Chief, Otolaryngology–Head and Neck Surgery (Rosenfeld) Editor in Chief, International Journal of Pediatric Otorhinolaryngology (Ruben) Editor-in-Chief, Annals of Otology, Rhinology and Laryngology (Smith) Editor in Chief, The Journal of Voice , Editor in Chief, Ear , Nose and Throat Journal (Sataloff) Editor Emeritus, The Journal of Laryngology and Otology (Weir) Department of Otorhinolaryngology–Head and Neck Surgery,University of Pennsylvania School of Medicine, Philadelphia. |
2006 | Department of Otorhinolaryngology, Head and Neck Surgery, Division of Rhinology, University of Pennsylvania, Philadelphia, PA Division of Otolaryngology–Head and Neck Surgery, Philadelphia Veterans Administration Medical Center, Philadelphia, Pennsylvania American Journal of Rhinology |
2005 | From the Department of Otolaryngology (d.w.k.), University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A., the Georgia Nasal and Sinus Institute (f.a.k.), Savannah, Georgia, U.S.A., Massachusetts General Hospital (d.l.h.), Boston, Massachusetts, U.S.A., The Johns Hopkins Medical Institutions (s.j.z.), Baltimore, Maryland, U.S.A., University of California (d.b.), Los Angeles, California, U.S.A., Novartis Pharmaceuticals Corporation (g.w., a.t.), East Hanover, New Jersey, U.S.A., and Novartis Pharma AG (p.j.f.), Basel, Switzerland. Department of Otorhinolaryngology–Head and Neck Surgery, the University of Pennsylvania School of Medicine, Philadelphia. University of Pennsylvania Health System, Philadelphia Otolaryngology—Head and Neck Surgery (Benninger), Otology & Neurotology (Jackler), Laryngoscope (Johnson), Archives of Otolaryngology—Head and Neck Surgery (Johns), American Journal of Rhinology (Kennedy), International journal of Pediatric Otolaryngology (Ruben), Journal of Voice: Ear, Nose and Throat Journal (Sataloff), Annals of Otology, Rhinology and Laryngology (Smith), American Journal of Otolaryngology (P. C. Weber), Head and Neck (R. S. Weber), Journal of the Association for Research in Otolaryngology (Young) |
David W Kennedy: Influence Statistics
Concept | World rank |
---|---|
secondary manifestation obstruction | #1 |
patients ld complications | #1 |
7135 months | #1 |
understanding primary involvement | #1 |
cp110 cultures | #1 |
ciliary maturation | #1 |
average ebl | #1 |
osteomas endoscopic | #1 |
sinus surgery dramatic | #1 |
crs control specimens | #1 |
neuropathy article | #1 |
nonobstructed ostium | #1 |
cbf sites | #1 |
technological advancements renaissance | #1 |
pleuridirectional polytomography | #1 |
tomography staging systems | #1 |
primary auditory complaints | #1 |
ostioplasty | #1 |
denovo sccs | #1 |
cbf sinonasal | #1 |
48 total cultures | #1 |
qol questionaire | #1 |
t2rs sinonasal defense | #1 |
sinus headache literature | #1 |
sccs polyp | #1 |
relative sensitivity aeruginosa | #1 |
surgical navigational systems | #1 |
samples biofilm formation | #1 |
endoscopic approach nature | #1 |
longerterm postoperative data | #1 |
severe 729 ± | #1 |
pain sinus | #1 |
bony fragments attachment | #1 |
epithelium produces | #1 |
situ hybridization aspergillus | #1 |
longterm ostial obstruction | #1 |
sinonasal fluid | #1 |
x03c72 analysis | #1 |
indepth discussion physiology | #1 |
42 patients scans | #1 |
frs aspergillus | #1 |
work messerklinger | #1 |
variable ptc detection | #1 |
preoperative proptosis diplopia | #1 |
longterm success• | #1 |
aeruginosa flavones | #1 |
newer extended approaches | #1 |
performed frontal | #1 |
bone preliminary | #1 |
reverse transcriptase crs | #1 |
Open the FULL List in Excel | |
Prominent publications by David W Kennedy
OBJECTIVES/HYPOTHESIS: The aim of this study was to evaluate the associations between nasal nitric oxide and nasal symptoms, sinus opacification, and markers of allergic inflammation in allergic and in nonallergic rhinitis while taking into account the effect of sinus obstruction.
STUDY DESIGN: We studied 175 young adult subjects divided into three groups: 1) allergic rhinitis, 2) nonallergic rhinitis, and 3) controls.
METHODS: We measured nasal nitric oxide using the breath-holding ...
Known for Allergic Rhinitis | Nasal Nitric Oxide | Obstruction Nitric | Eosinophil Count | Case Control |
Spontaneous CSF leaks: A paradigm for definitive repair and management of intracranial hypertension
[ PUBLICATION ]
OBJECTIVE: To report our outcomes with the repair of spontaneous cerebrospinal fluid (CSF) leaks and to demonstrate how management of underlying intracranial hypertension improves outcomes.
STUDY DESIGN: Retrospective review of spontaneous CSF leaks treated at the University of Pennsylvania Health System from 1996 to 2006. Data collected included demographics, nature of presentation, body mass index (BMI), site of skull base defect, surgical approach, intracranial pressure, and clinical ...
Known for Spontaneous Csf Leaks | Intracranial Hypertension | Retrospective Review | Surgical Approach | Ventriculoperitoneal Shunt |
These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma and Immunology; the American College of Allergy, Asthma and Immunology; and the Joint Council of Allergy, Asthma and Immunology.The American Academy of Allergy, Asthma and Immunology (AAAAI) and the American College of Allergy, Asthma and Immunology (ACAAI) have jointly accepted responsibility for establishing “The diagnosis and management of sinusitis: a ...
Known for Allergy Asthma | Practice Parameter | Aaaai Acaai | Diagnosis Management | Immunology Academy |
Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps
[ PUBLICATION ]
BACKGROUND: IL-25 can function as an early signal for the respiratory type 2 response characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). In the mouse gut, tuft cells are the epithelial source of IL-25. However, the source of human airway epithelial IL-25 has remained elusive.
OBJECTIVE: In this study we sought to determine whether the solitary chemosensory cell (SCC) is the predominant source of IL-25 in the sinonasal epithelium.
METHOD: Flow ...
Known for Nasal Polyps | Chronic Rhinosinusitis | Patients Crswnp | Solitary Chemosensory Cells | Allergic Asthma |
Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many tissues outside the tongue, have recently become potential therapeutic targets. We have shown previously that airway epithelial cells express several T2Rs that activate innate immune responses that may be important for treatment of airway diseases such as chronic rhinosinusitis. It is imperative to more clearly understand what compounds activate airway T2Rs as well as their full range of functions. ...
Known for Nitric Oxide | Airway Epithelial | Taste Receptors | Pseudomonas Aeruginosa | Immune Responses |
Sphenoid Encephaloceles: Disease Management and Identification of Lesions Within the Lateral Recess of the Sphenoid Sinus
[ PUBLICATION ]
OBJECTIVES: Encephaloceles usually involve herniation of frontal lobe tissue through an anterior cranial fossa defect into the ethmoid sinus or nasal cavity. Encephaloceles can also result from temporal lobe herniation through a middle fossa defect into the sphenoid sinus. Within the sphenoid, encephaloceles are thought to occur most commonly in the central or midline aspect of the sinus. Lateral sphenoid encephaloceles, especially within the lateral aspect of the sphenoid sinus when the ...
Known for Sphenoid Sinus | Lateral Recess | Retrospective Review | Patients Lesions | Nasal Cavity |
BACKGROUND: The development of chronic rhinosinusitis, a mucocele, or persistent headaches is a common indication for the removal of a frontal sinus osteoma. The best surgical approach to ensure complete and safe removal of the lesion is less clearcut. The advent of specialized frontal sinus instruments, angled endoscopes, and surgical navigational systems has made removal of frontal sinus osteomas possible through an endoscopic approach. The aim of this study is to review our recent ...
Known for Frontal Sinus | Endoscopic Approach | Surgical Management | Retrospective Review | Aged Osteoma |
Mucociliary clearance (MCC) is the primary physical airway defense against inhaled pathogens and particulates. MCC depends on both proper fluid/mucus homeostasis and epithelial ciliary beating. Vasoactive intestinal peptide (VIP) is a neurotransmitter expressed in the sinonasal epithelium that is up-regulated in allergy. However, the effects of VIP on human sinonasal physiology are unknown, as are VIP's interactions with histamine, a major regulator of allergic disease. We imaged ciliary ...
Known for Vasoactive Intestinal Peptide | Mucociliary Clearance | Fluid Secretion | Ciliary Beat Frequency | Effects Vip |
In chronic sinusitis, culture-directed antibiotics are often recommended as a cornerstone of treatment. The significance of Gram-negative rods (GNRs), coagulase-negative Staphylococci (SCN), and Staphylococcus aureus has been controversial. In an effort to determine host factors which correlate with culture results, 507 endoscopically-guided cultures are reviewed from 265 patients. A history of asthma, allergic rhinitis, prior sinus surgery, and the concurrent use of antibiotics, ...
Known for Chronic Sinusitis | Aerobic Bacteria | Scn Aureus | Endoscopically Guided Cultures | Systemic Steroids |
Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor
[ PUBLICATION ]
Chronic rhinosinusitis has a significant impact on patient quality of life, creates billions of dollars of annual healthcare costs, and accounts for ∼20% of adult antibiotic prescriptions in the United States. Because of the rise of resistant microorganisms, there is a critical need to better understand how to stimulate and/or enhance innate immune responses as a therapeutic modality to treat respiratory infections. We recently identified bitter taste receptors (taste family type 2 ...
Known for Innate Immunity | Respiratory Epithelial | Nitric Oxide | Protein Kinase | Antiinflammatory Effects |
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
[ PUBLICATION ]
Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway. Utilizing immunofluorescent and live cell imaging techniques in polarized primary human sinonasal cells, we demonstrate that T2R38 is expressed in human upper respiratory epithelium and is activated in response to acyl-homoserine lactone quorum-sensing molecules ...
Known for Respiratory Infection | Receptor Polymorphisms | T2r38 Taste | Pseudomonas Aeruginosa | Innate Defense |
Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention
[ PUBLICATION ]
BACKGROUND: We recently demonstrated the bitter taste receptor T2R38 upregulates sinonasal mucosal innate defense in response to gram-negative quorum-sensing molecules through increased nitric oxide production and mucociliary clearance. T2R38 was initially identified in the quest to understand the variability in bitter taste perception to the compound phenylthiocarbamide (PTC) and demonstrated to have polymorphisms generating diplotypes dividing people into PTC supertasters, ...
Known for Taste Receptor | Chronic Rhinosinusitis | Surgical Intervention | Mucociliary Clearance | Gram Negative |
BACKGROUND: Recently, biofilms have been implicated in the pathogenesis of recalcitrant chronic rhinosinusitis (CRS). We sought to determine the prevalence of biofilm-forming cultures obtained from patients with CRS and clinical factors that may contribute to biofilm formation.
METHODS: Endoscopically guided sinonasal cultures were obtained in duplicate from CRS patients with evidence of mucopurulence. Bacterial swabs were sent for microbiological characterization and were simultaneously ...
Known for Chronic Rhinosinusitis | Biofilm Formation | Crs Patients | Forming Bacteria | Staphylococcus Aureus Samples |
Rigid Nasal Endoscopy versus Sinus Puncture and Aspiration for Microbiologic Documentation of Acute Bacterial Maxillary Sinusitis
[ PUBLICATION ]
Sinus puncture and aspiration is an invasive procedure that hinders patient enrollment in studies of acute bacterial maxillary sinusitis (ABMS). Pain and minor bleeding also limit its potential diagnostic utility in clinical practice. Cultures obtained by rigid nasal endoscopy were compared with those from sinus puncture and aspiration in 53 patients with ABMS; 46 patients were assessable. Considering recovery of Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae ...
Known for Sinus Puncture | Acute Bacterial | Haemophilus Influenzae | Streptococcus Pneumoniae | Gold Standard |
Acoustic rhinometry is a recently developed method for the objective assessment of nasal patency. In this study, acoustic rhinometry was used to measure changes in nasal cavity dimensions in the immediate response to nasal allergen challenge in eight pollen-sensitive subjects. Acoustic rhinometric changes were compared with subjective symptoms, as well as histamine in nasal secretions, cytology of nasal mucosal scrapings, and changes in olfactory function. A significantly greater ...
Known for Acoustic Rhinometry | Olfactory Function | Allergen Challenge | Nasal Patency | Objective Assessment |
Key People For Chronic Rhinosinusitis
David W Kennedy:Expert Impact
Concepts for whichDavid W Kennedyhas direct influence:Chronic rhinosinusitis, Endoscopic sinus surgery, Frontal sinus, Inverted papilloma, Sinus surgery, Chronic sinusitis, Sphenoid sinus, Surgical management.
David W Kennedy:KOL impact
Concepts related to the work of other authors for whichfor which David W Kennedy has influence:Chronic rhinosinusitis, Nasal polyps, Endoscopic sinus surgery, Frontal sinus, Skull base, Inverted papilloma, Computed tomography.
Tools
Is this your profile? Claim your profile Copy URL Embed Link to your profile |