• Disease
  • Chronic
  • Chronic Rhinosinusitis
  • Rodney J Schlosser

    Prominent publications by Rodney J Schlosser

    KOL Index score: 16120

    BACKGROUND: Appropriate indications for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) are currently poorly defined. The lack of clear surgical indications for ESS likely contributes to the large geographic variation in surgical rates and contributes to reduced quality of care. The objective of this study was to define appropriateness criteria for ESS during management of adult patients with uncomplicated CRS.

    METHODS: The RAND/UCLA appropriateness methodology was ...

    Also Ranks for: Appropriateness Criteria |  endoscopic sinus surgery |  ess study |  nasal polyps |  chronic rhinosinusitis
    KOL Index score: 13892

    Vitamin D(3) (VD(3) ) is a steroid hormone that regulates bone health and numerous aspects of immune function and may play a role in respiratory health. We hypothesized that T helper type 2 (Th2) disorders, chronic rhinosinusitis with nasal polyps (CRSwNP) and allergic fungal rhinosinusitis (AFRS) would have VD(3) deficiencies, resulting in increased mature dendritic cells (DCs) and bone erosion. We conducted a retrospective study examining VD(3) levels in patients with AFRS (n = 14), ...

    Also Ranks for: Nasal Polyps |  vitamin d3 |  chronic rhinosinusitis |  crswnp afrs |  dendritic cell
    KOL Index score: 12879

    BACKGROUND: Local tissue production of antigen-specific immunoglobulin E (IgE) has been shown in patients with allergic rhinitis and in patients with chronic rhinosinusitis (CRS) with nasal polyps. In allergic fungal rhinosinusitis (AFRS), specific IgE has been established in nasal lavage fluid and eosinophilic mucin. In this study, local production of antigen-specific IgE within sinus mucosa of AFRS patients was evaluated.

    METHODS: Sinus mucosa homogenates from 11 AFRS patients, 8 ...

    Also Ranks for: Specific Ige |  allergic fungal |  sinus mucosa |  afrs patients |  nasal polyps
    KOL Index score: 12536

    Given the relationship between allergic rhinitis (AR) and asthma, it can be hypothesized that reducing inflammation in the upper airway with intranasal corticosteroid (INCS) medications may improve asthma outcomes. The goal of this study was to perform a systematic review with meta-analysis of the efficacy of INCS medications on asthma outcomes in patients with AR and asthma. Asthma-specific outcomes from randomized, controlled studies evaluating INCS medications in patients with AR were ...

    Also Ranks for: Asthma Outcomes |  allergic rhinitis |  intranasal corticosteroids |  respiratory function |  cortex hormones
    KOL Index score: 12440

    BACKGROUND: Recent investigation has demonstrated that approximately 75% of patients with medically refractory chronic rhinosinusitis (CRS) report abnormal sleep quality, with strong correlation between worse sleep quality and more severe CRS disease severity. It remains unknown whether the treatment effect of endoscopic sinus surgery (ESS) for CRS results in appreciable sleep quality improvements.

    METHODS: Adult patients (aged ≥18 years) with a current diagnosis of recalcitrant chronic ...

    Also Ranks for: Sinus Surgery |  patients crs |  sleep quality |  ess life |  chronic disease
    KOL Index score: 12402

    OBJECTIVE: To report our outcomes with the repair of spontaneous cerebrospinal fluid (CSF) leaks and to demonstrate how management of underlying intracranial hypertension improves outcomes.

    STUDY DESIGN: Retrospective review of spontaneous CSF leaks treated at the University of Pennsylvania Health System from 1996 to 2006. Data collected included demographics, nature of presentation, body mass index (BMI), site of skull base defect, surgical approach, intracranial pressure, and clinical ...

    Also Ranks for: Spontaneous Csf Leaks |  intracranial hypertension |  retrospective review |  surgical approach |  ventriculoperitoneal shunt
    KOL Index score: 11597

    BACKGROUND: Topical therapies have become an integral component in the management plan for chronic rhinosinusitis (CRS). Several topical therapy strategies have been evaluated, but a formal comprehensive evaluation of the evidence has never been performed. The purpose of this article is to provide an evidence-based approach for the utilization of topical therapies in the management of CRS.

    METHODS: A systematic review of the literature was performed and the guidelines for development of ...

    Also Ranks for: Topical Therapies |  chronic rhinosinusitis |  evidence‐based review |  crs evidence |  saline irrigation
    KOL Index score: 11592

    BACKGROUND: The aim of this study was to determine if there is a link between local dendritic cells (DCs) and various subtypes of chronic rhinosinusitis (CRS): CRS with nasal polyposis (CRSwNP), CRS without nasal polyposis (CRSsNP), and allergic fungal rhinosinusitis (AFRS). Once DC presence was established we considered possible mechanisms for DC recruitment to the sinuses.

    METHODS: Biopsy specimens were taken from the osteomeatal complex during endoscopic sinus surgery in patients with ...

    Also Ranks for: Dendritic Cells |  sinus mucosa |  nasal polyps |  crswnp afrs |  allergic fungal
    KOL Index score: 11445

    BACKGROUND: Volumetric analysis of the olfactory cleft by using computed tomography has been associated with olfaction in patients with chronic rhinosinusitis (CRS). However, existing studies have not comprehensively measured olfaction, and it thus remains unknown whether correlations differ across specific dimensions of odor perception.

    OBJECTIVE: To use comprehensive measures of patient-reported and objective olfaction to evaluate the relationship between volumetric olfactory cleft ...

    Also Ranks for: Olfactory Cleft |  computed tomography |  olfaction patients |  chronic rhinosinusitis |  nasal polyposis
    KOL Index score: 11382

    OBJECTIVE: Dendritic cells are professional antigen presenting cells, capable of initiating Th1 or Th2 responses, and have been implicated in the pathogenesis of a number of diseases, including sinusitis. Vitamin D(3) is a steroid hormone that acts on dendritic cells in a manner similar to corticosteroids. Investigators examined whether children with allergic fungal rhinosinusitis (AFRS) or chronic rhinosinusitis with nasal polyposis (CRSwNP) were vitamin D(3) deficient and the ...

    Also Ranks for: Vitamin D3 |  nasal polyps |  dendritic cells |  chronic rhinosinusitis |  crswnp afrs
    KOL Index score: 11359

    BACKGROUND: Chronic rhinosinusitis (CRS) significantly impacts olfaction. However, the relationship between objective olfaction and patient-reported olfactory-specific quality of life (QOL) is not well understood. Furthermore, objective olfactory testing can be time consuming, so we sought to determine if patient-reported olfactory QOL can be used as screening tool for olfactory dysfunction.

    METHODS: Olfactory dysfunction was evaluated in 109 patients with CRS using the Questionnaire of ...

    Also Ranks for: Chronic Rhinosinusitis |  patient factors |  olfactory dysfunction |  discrimination identification |  strongest correlation
    KOL Index score: 11012

    OBJECTIVE: Compare Eustachian tube balloon dilation versus continued medical therapy (control) for treating persistent Eustachian tube dysfunction (ETD).

    STUDY DESIGN: Prospective, multicenter, randomized controlled trial.

    SETTING: Tertiary care academic center and private practice.

    PATIENTS: Diagnosed with medically refractory persistent ETD.

    INTERVENTIONS: 1:1 Randomization to balloon dilation or control. After 6 weeks, control participants had the option to undergo balloon dilation if ...

    Also Ranks for: Balloon Dilation |  eustachian tube |  local anesthesia |  persistent etd |  6 weeks
    KOL Index score: 10995

    BACKGROUND: Cigarette smoke (CS) plays a role in the exacerbation of chronic rhinosinusitis (CRS); however, the mechanism for this is unknown. We hypothesize that CS impairs human sinonasal epithelial cell (HSNEC) conversion of 25(OH)D3 (25VD3) to 1,25-dihydroxyvitamin D3 (1,25VD3) and, furthermore, that supplementation with 1,25VD3 will reverse smoke-induced inflammatory responses by HSNECs.

    OBJECTIVE: We sought to determine the effect of CS on vitamin D3 (VD3) levels, conversion, and ...

    Also Ranks for: Chronic Rhinosinusitis |  cigarette smoke |  vitamin d3 |  patients crswnp |  nasal polyps
    KOL Index score: 10744

    BACKGROUND: Chronic rhinosinusitis with nasal polyps affects approximately 2-4% of the general population, and long-term use of systemic corticosteroids is associated with adverse effects. The aim of this study was to assess the efficacy and safety of mepolizumab in adults with recurrent, refractory severe bilateral chronic rhinosinusitis with nasal polyps.

    METHODS: SYNAPSE was a randomised, double-blind, placebo-controlled, parallel-group, phase 3 trial done at 93 centres, mainly ...

    Also Ranks for: Nasal Polyps |  chronic rhinosinusitis |  mepolizumab treatment |  systemic corticosteroids |  phase 3


    Rodney J Schlosser: Influence Statistics

    Sample of concepts for which Rodney J Schlosser is among the top experts in the world.
    Concept World rank
    sb defect factors #1
    humans nasal crs #1
    heart problems anxiety #1
    crswnp 1αhydroxylase #1
    tdi crs #1
    asthma qol control #1
    retronasal orthonasal olfaction #1
    syndrome encephalocele #1
    prior procedures ventilation #1
    proteins olfaction #1
    perforin grb #1
    base defects #1
    sinuses nasal cavity #1
    leaks success rates #1
    cytokine correlation #1
    afrs crs patients #1
    merafi #1
    cse complement activation #1
    surgical landmarks level #1
    antifungals herbals #1
    performance ess procedures #1
    sample crs patients #1
    delivery pressurized spray #1
    diagnosis patient quality #1
    sf36v2 sf6d #1
    contribution advanced presentation #1
    life sublingual immunotherapy #1
    gcrα afrs #1
    retronasal odors odors #1
    chronic rhinosinusitis spb #1
    literature quality evidence #1
    crswnp sinonasal tissue #1
    crs oces #1
    qol crs subset #1
    sella common pathophysiology #1
    topical steroids improvement #1
    afrs 8 patients #1
    pediatric patients esbs #1
    crssnp cxcl5 #1
    levels sinus tissue #1
    airway epithelium pathophysiology #1
    increased fibroblasts #1
    afrs chronic rhinosinusitis #1
    human sinus mucosa #1
    crssnp nasal polyps #1
    african americans lms #1
    leaks radiographic #1
    nasal obstruction osteoma #1
    oces score #1
    exposure crswnp #1

    Key People For Chronic Rhinosinusitis

    Top KOLs in the world
    Wytske Johanna Fokkens
    allergic rhinitis chronic rhinosinusitis nasal polyps
    Claus Bachert
    nasal polyps chronic rhinosinusitis allergic rhinitis
    Valerie Joan Lund
    chronic rhinosinusitis nasal polyps endoscopic sinus surgery
    Philippe Gevaert
    nasal polyps chronic rhinosinusitis allergic rhinitis
    allergic rhinitis chronic rhinosinusitis nasal challenge
    Rodney J Schlosser
    chronic rhinosinusitis nasal polyps endoscopic sinus surgery

    Rodney J Schlosser:Expert Impact

    Concepts for whichRodney J Schlosserhas direct influence:Chronic rhinosinusitis,  Nasal polyps,  Endoscopic sinus surgery,  Skull base,  Patients crs,  Nasal polyposis,  Chronic rhinosinusitis crs,  Vitamin d3.

    Rodney J Schlosser:KOL impact

    Concepts related to the work of other authors for whichfor which Rodney J Schlosser has influence:Chronic rhinosinusitis,  Nasal polyps,  Allergic rhinitis,  Endoscopic sinus surgery,  Skull base,  Olfactory dysfunction,  Patients crs.



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    Otolaryngology, Medical University of South Carolina, Mt Pleasant, South Carolina, USA | Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA | Department of Otolaryngology-Head an