• Disease
  • Schizophrenia
  • Schizophrenia Patients
  • Rael David Strous

    Prominent publications by Rael David Strous

    KOL Index score: 13570

    BACKGROUND: Substance dependence is more common among trauma-exposed individuals; however, most studies suggest that Posttraumatic Stress Disorder (PTSD) accounts for the link between trauma exposure (TE) and substance dependence.

    OBJECTIVES: This study examined associations between TE and substance dependence (alcohol, nicotine, and marijuana), and whether PTSD accounted for this association.

    METHOD: 1317 Jewish Israeli household residents completed in-person structured interviews ...

    Also Ranks for: Trauma Exposure |  ptsd symptoms |  stress disorder |  nicotine dependence |  increased odds
    KOL Index score: 12348

    Dopamine is a major neurotransmitter in the central nervous system, and its receptors are associated with a number of neuropathological disorders such as Parkinson's disease and schizophrenia. Although the precise pathophysiology of schizophrenia remains unknown, the dopaminergic hypothesis of the illness assumes that the illness results from excessive activity at dopamine synapses in the brain. Because, at present, the diagnosis of schizophrenia relies on descriptive behavioral and ...

    Also Ranks for: D3 Dopamine |  peripheral marker |  messenger receptors |  blood lymphocytes |  receptor mrna
    KOL Index score: 11856

    CONTEXT: Negative symptoms of schizophrenia are a prominent feature of the illness, and frequently remain refractory to treatment. Dehydroepiandrosterone (DHEA), along with its sulfated form, DHEA-S, is an important circulating neurosteroid with several vital neurophysiological functions, including the regulation of neuronal excitability and function.

    OBJECTIVE: Since the administration of DHEA has demonstrated improvement in mood, sense of well-being, interest, activity, and energy in ...

    Also Ranks for: Anxiety Symptoms |  dehydroepiandrosterone dhea |  schizophrenic patients |  neuronal excitability |  sulfated form
    KOL Index score: 10946

    Substance use disorders, particularly those involving alcohol, marijuana, and cocaine, are highly prevalent among patients with schizophrenia and contribute markedly to its overall morbidity. Unfortunately, standard (typical) antipsychotic medications do not seem to reduce substance use in patients with schizophrenia and may even increase it. Recently, however, a few anecdotal case reports and two previous small "N" surveys have found that clozapine, an atypical antipsychotic medication, ...

    Also Ranks for: Schizoaffective Disorder |  substance patients |  treatment clozapine |  retrospective studies |  dual psychiatry
    KOL Index score: 10201

    BACKGROUND: Alcohol and cannabis use disorders worsen the course of schizophrenia. While the typical antipsychotics are of limited value in controlling substance use in schizophrenic patients, previous studies suggest that the novel antipsychotic clozapine (CLOZ) may decrease their substance use. We describe a retrospective study of the effects of the novel antipsychotics risperidone (RISP) and clozapine on alcohol and cannabis use in patients with schizophrenia or schizoaffective ...

    Also Ranks for: Clozapine Risperidone |  cannabis patients |  retrospective studies |  1 year |  schizoaffective disorder
    KOL Index score: 10065

    Patients with schizophrenia exhibit a decrease or loss of normal anatomical brain asymmetry that also extends to functional levels. We applied functional magnetic resonance imaging (fMRI) to investigate language lateralization in patients with schizophrenia during their first episode of illness, thus excluding effects of chronic illness and treatment. Brain regions activated during language tasks of verb generation and passive music listening were explored in 12 first-episode patients ...

    Also Ranks for: Language Lateralization |  patients schizophrenia |  brain regions |  functional asymmetry |  auditory cortex
    KOL Index score: 10055

    A variety of psychiatric illnesses, including schizophrenia and bipolar disorder, have been reported in patients with microdeletion on chromosome 22q11-a region which includes the catechol-O-methyltransferase (COMT) gene. The variety of psychiatric manifestations in patients with the 22q11 microdeletion and the role of COMT in the degradation of catecholamine neurotransmitters may thus suggest a general involvement of the COMT gene in psychiatric diseases. We have previously reported on ...

    Also Ranks for: Bipolar Disorder |  comt gene |  schizophrenia association |  psychiatric diseases |  catecholamine neurotransmitters
    KOL Index score: 9828

    Based on their metabolic inactivation of dopamine and norepinephrine, genes encoding the catechol-O-methyltransferase (COMT) enzyme are appropriate candidates to consider in the pathogenesis of schizophrenia. COMT enzyme activity is regulated by a common polymorphism causing substantial variations in enzymatic activity, and evidence for allelic or genotypic association with cognitive and behavioral features of schizophrenia has been noted. Since the role of COMT in schizophrenia remains ...

    Also Ranks for: Comt Polymorphism |  schizophrenia association |  clinical symptomatology |  metabolic inactivation |  enzymatic activity
    KOL Index score: 9769

    Methylphenidate is considered by many to be the treatment of choice for attention deficit hyperactivity disorder (ADHD). Methylphenidate exerts its therapeutic effects through the dopaminergic, serotonergic and noradrenergic systems, however its effects on other neurophysiological systems, such as the neurosteroidal system, remain unknown. Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEA-S) are neuroactive steroids with effects on several neurophysiological and behavioral ...

    Also Ranks for: Hyperactivity Disorder |  attention deficit |  treatment methylphenidate |  plasma levels |  dehydroepiandrosterone dhea
    KOL Index score: 9685

    RGS2 (regulator of G-protein signaling 2) modulates dopamine receptor signal transduction. Functional variants in the gene may influence susceptibility to extrapyramidal symptoms (EPS) induced by antipsychotic drugs. To further investigate our previous report of association of the RGS2 gene with susceptibility to antipsychotic-induced EPS, we performed a replication study. EPS were rated in 184 US patients with schizophrenia (115 African Americans, 69 Caucasian) treated for at least a ...

    Also Ranks for: Rgs2 Gene |  functional polymorphism |  minor allele |  association rs4606 |  antipsychotic induced
    KOL Index score: 9450

    Comorbid schizophrenia and dementia is a common clinical phenomenon; however, management of the coexisting illnesses remains incomplete. Donepezil, a cholinesterase inhibitor, may be beneficial for the management of symptoms of Alzheimer's disease, a disease in which cholinergic pathways in the cerebral cortex and basal forebrain are well known to be compromised. Furthermore, impaired cognition in elderly schizophrenic patients has been observed to be more than two thirds; however, there ...

    Also Ranks for: Donepezil Augmentation |  patients schizophrenia |  comorbid dementia |  cholinesterase inhibitors |  combination female humans
    KOL Index score: 9275

    Electroconvulsive therapy (ECT) is an effective strategy in some treatment-resistant patients with schizophrenia. However, ECT is associated with cognitive adverse effects, most notably, memory loss. This study examined the effects of rivastigmine, a selective central nervous system acetylcholinesterase inhibitor, with benefits on cognition in Alzheimer disease, on memory performance in patients with schizophrenia treated with ECT. Thirty inpatients with Diagnostic and Statistical ...

    Also Ranks for: Electroconvulsive Therapy |  patients schizophrenia |  memory deficits |  ect cognitive |  alzheimer disease
    KOL Index score: 9186

    Dehydroepiandrosterone (DHEA) and its sulfate derivative DHEA-S are neurosteroids, produced in the brain, and neuroactive steroids, produced in the adrenals and affecting the brain. We compared the ratios of serum cortisol/DHEA or DHEA-S in schizophrenia patients with normal subjects, and determined the correlation of these ratios with psychopathology and distress. Early morning plasma concentrations of DHEA, DHEA-S, and cortisol were determined by radioimmunassay in 40 medicated ...

    Also Ranks for: Schizophrenia Patients |  cortisol dhea |  trait anxiety |  dehydroepiandrosterone ratio |  age onset


    Rael David Strous: Influence Statistics

    Sample of concepts for which Rael David Strous is among the top experts in the world.
    Concept World rank
    blatant flouting #1
    movement skills schizophrenia #1
    1200 names #1
    nazi policy misconceptions #1
    psychiatric genocide reflections #1
    neurosteroids aging brain #1
    healthy subjects inpatients #1
    physicians nazi #1
    neurosteroid levels dhea #1
    blood levels neurosteroids #1
    covid19 involuntary hospitalisation #1
    murderous process #1
    physician medical outreach #1
    higher treatment credibility #1
    paternalism physicians #1
    nazi period germany #1
    fate victims #1
    persons pandemics #1
    management schizophrenia symptoms #1
    list mentally #1
    reflections responsibilities #1
    ethical lessons #1
    video testimony #1
    neurosteroids age #1
    dhea administration schizophrenia #1
    terror security instability #1
    nazi #1
    powerreferences nazi #1
    endogenous neuroprotectors #1
    nazi eponyms #1
    dementia comorbid schizophrenia #1
    examples nazi germany #1
    international terror awareness #1
    dhea administration improvement #1
    donepezil augmentation management #1
    valueoriented considerations #1
    wellknown terror attacks #1
    medical murder #1
    holocaust homicide #1
    major leaders #1

    Key People For Schizophrenia Patients

    Top KOLs in the world
    Stanley R Kay
    negative syndrome tardive dyskinesia pineal calcification
    Danniel R Weinberger,
    prefrontal cortex patients schizophrenia magnetic resonance
    ABRAHAM Fiszbein
    negative syndrome spanish adaptation psychotic disorders
    Robin MacGregor Murray
    bipolar disorder episode psychosis obstetric complications
    Nancy C Andreasen
    negative symptoms patients schizophrenia magnetic resonance
    Jeffrey A MD Lieberman
    tardive dyskinesia weight gain episode schizophrenia

    Rael David Strous:Expert Impact

    Concepts for whichRael David Stroushas direct influence:Schizophrenia patients,  Chronic schizophrenia,  Rgs2 gene,  Autistic disorder,  Bipolar disorder,  Postpartum ptsd,  Postpartum depression,  Antipsychotic medication.

    Rael David Strous:KOL impact

    Concepts related to the work of other authors for whichfor which Rael David Strous has influence:Bipolar disorder,  Schizophrenia patients,  Negative symptoms,  Comt gene,  Tardive dyskinesia,  Neuroactive steroids,  Medical students.



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    Mayanei Hayeshua Medical Center, HaRav Povarsky, 17, Bnei Brak, Israel | Psychiatry Department, Mayanei Hayeshua Medical Center, Bnei Brak, Israel | Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel | Department of Psychiatry, Tel Avi