AnneMarie M Kuijpers‐Jagtman

Bone has the capacity to alter its mass and structure to its mechanical environment. Osteocytes are the predominant bone cells and it is generally accepted that the osteocytes are the professional mechanosensors of bone. A strain-derived fluid flow through the lacuno-canalicular porosity seems to mechanically activate them, resulting in the production of signalling molecules such as nitric oxide (NO). We hypothesize that mechanically stimulated osteocytes modulate osteoclast formation ...

Orthodontic tooth movement requires extensive re-modelling of the periodontium. Matrix metalloproteinases (MMPs) degrade the extracellular matrix during re-modelling, while their activity is regulated by the tissue inhibitors of metalloproteinases (TIMPs). The aim of this study was to investigate differences in MMP and TIMP levels in the gingival crevicular fluid (GCF) at the resorption and apposition sides of orthodontically moved teeth, and to compare these with control teeth. GCF ...

OBJECTIVE: To assess dental age in children with a complete unilateral cleft lip and palate and to compare this with a noncleft control group.

DESIGN: Two-group, mixed-longitudinal cohort study.

SETTING: Cleft group from an academic center for cleft lip and palate treatment. Noncleft control group from the same population.

PATIENTS: Participants included 70 Caucasian children with a full complement of teeth and a complete unilateral cleft lip and palate (45 boys and 25 girls) from the ...

INTRODUCTION: The aim of this study was to determine the reproducibility and accuracy of linear measurements on 2 types of dental models derived from cone-beam computed tomography (CBCT) scans: CBCT images, and Anatomodels (InVivoDental, San Jose, Calif); these were compared with digital models generated from dental impressions (Digimodels; Orthoproof, Nieuwegein, The Netherlands). The Digimodels were used as the reference standard.

METHODS: The 3 types of digital models were made from ...

Superimposition of serial Cone Beam Computed Tomography (CBCT) scans has become a valuable tool for three dimensional (3D) assessment of treatment effects and stability. Voxel based image registration is a newly developed semi-automated technique for superimposition and comparison of two CBCT scans. The accuracy and reproducibility of CBCT superimposition on the anterior cranial base or the zygomatic arches using voxel based image registration was tested in this study. 16 pairs of 3D ...

OBJECTIVE: Evaluation of the effect of infant orthopedics on maxillary arch dimensions in the deciduous dentition in patients with unilateral cleft lip and palate.

DESIGN: Prospective two-arm randomized controlled clinical trial with three participating cleft palate centers.

SETTING: Cleft palate centers of the Radboud University Nijmegen Medical Center, Academic Center of Dentistry Amsterdam, and University Medical Center Rotterdam, the Netherlands.

PATIENTS: Children with complete ...

The effect of implantation of poly-(L-lactic) acid membranes on wound healing and wound contraction after palatal surgery was investigated macroscopically in beagle dogs. Thirty beagle dogs were randomly assigned to two experimental groups (group L and LM; both n = 12) and a control group (group C; n = 6). At 12 weeks of age, a soft-tissue defect was created in the median region of the palate by excising a standardized elliptical mucoperiosteal flap. This defect was closed according to ...

The aim of this study was to evaluate whether measurements performed on conventional frontal radiographs are comparable to measurements performed on three-dimensional (3D) models of human skulls derived from cone beam computed tomography (CBCT) scans and if the latter can be used in longitudinal studies. Cone beam computed tomography scans and conventional frontal cephalometric radiographs were made of 40 dry human skulls. From the CBCT scan a 3D model was constructed. Standard ...

Satellite cells are key cells for post-natal muscle growth and regeneration and they play a central role in the search for therapies to treat muscle injuries. In this study the proliferation and differentiation capacity of muscle progenitor cells was studied in 2D and 3D cultures with collagen type I and Matrigel, which contain the niche factors laminin and collagen type IV. Muscle progenitor cells were cultured to induce proliferation and differentiation in collagen- or Matrigel-coated ...

OBJECTIVE: To investigate the reliability of using photographs of study casts as an alternative to casts for rating dental arch relationships.

DESIGN: Repeated-measures study.

SETTING: Cleft Palate Center of the University Medical Center Nijmegen, Nijmegen, The Netherlands.

PATIENTS: Records of children with complete unilateral cleft lip and palate (UCLP) (n = 49) at the age of 9 years were included.

MEAN OUTCOME MEASURE(S): Statistics of intra- and interexaminer agreement.

RESULTS: No ...

Yardsticks have been developed to measure dental arch relations in cleft lip and palate (CLP) patients as diagnostic proxies for the underlying skeletal relationship. Travelling with plaster casts to compare results between CLP centres is inefficient so the aim of this study was to investigate the reliability of using digital models or photographs of dental casts instead of plaster casts for rating dental arch relationships in children with complete bilateral cleft lip and palate ...

Changes of maxillary arch dimensions were studied longitudinally until maturity, after palatal surgery was performed on 37 beagle dogs at different ages. The dogs were divided into three experimental groups, a sham group, and a control group. At the age of 6, 16, or 25 weeks in the experimental groups, we created a soft-tissue cleft in the medial region of the palate, made relaxation incisions, and elevated and closed the mucoperiosteum in the midline, thus leaving two areas of denuded ...