Michaël H.J. Maes

Michaël H.J. Maes

From The Department Of Psychiatry, Case Western Reserve University, Cleveland, Ohio, Usa Biological Psychiatry/department Of Psychiatry, Case Western Reserve University, ...

Direct Impact

Concepts for which Michaël H J Maes has direct influence:

major depression
deficit schizophrenia
mood disorders
bipolar disorder
immune activation
chronic fatigue
insulin resistance

External impact

Concepts related to the work of other authors for which Michaël H J Maes has influence:

bipolar disorder
oxidative stress
major depression
depressive symptoms
chronic fatigue syndrome
rheumatoid arthritis
deficit schizophrenia

Prominent publications by Michaël H.J. Maes

KOL-Index: 270 Chronic systemic inflammation is associated with an increased risk of cardiovascular disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and with the pathophysiology of neuroprogressive disorders. The causes and consequences of this lipid paradox are explored. Circulating activated neutrophils can release inflammatory molecules such as myeloperoxidase and ...
Known for
Consequences Lipid | Atherosclerosis Cardiovascular | Activation Decreased | Paradox Neuroprogressive
KOL-Index: 175 The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro-psychiatric disorders including but not limited to schizophrenia, major depressive disorder and potentially bipolar disorder. The aim of this paper is to review mechanisms whereby both receptors may interact with neuro-immune ...
KOL-Index: 169 A model of the development and progression of chronic fatigue syndrome (myalgic encephalomyelitis), the aetiology of which is currently unknown, is put forward, starting with a consideration of the post-infection role of damage-associated molecular patterns and the development of chronic inflammatory, oxidative and nitrosative stress in genetically predisposed individuals. The consequences ...
Known for
Abnormalities Chronic | Immune Metabolic | Myalgic | Cells Endotoxin
KOL-Index: 160 The possibility is examined that immunomodulatory pharmacotherapy may be clinically useful in managing the pandemic coronavirus disease 2019 (COVID-19), known to result from infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive-sense single-stranded RNA virus. The dominant route of cell entry of the coronavirus is via phagocytosis, with ensconcement in ...
KOL-Index: 148 BACKGROUND: Potential routes whereby systemic inflammation, oxidative stress and mitochondrial dysfunction may drive the development of endothelial dysfunction and atherosclerosis, even in an environment of low cholesterol, are examined. MAIN TEXT: Key molecular players involved in the regulation of endothelial cell function are described, including PECAM-1, VE-cadherin, VEGFRs, SFK, Rho GEF ...
KOL-Index: 145 Lowered high-density lipoprotein (HDL) cholesterol has been reported in major depressive disorder, bipolar disorder, first episode of psychosis, and schizophrenia. HDL, its major apolipoprotein component, ApoA1, and the antioxidant enzyme paraoxonase (PON)1 (which is normally bound to ApoA1) all have anti-atherogenic, antioxidant, anti-inflammatory, and immunomodulatory roles, which are ...
Known for
Apoa1 Antioxidant | Function Hdl | S1p Signalling | Inflammation Oxidative
KOL-Index: 132 This paper reviews the potential role of glutathione (GSH) in autism spectrum disorder (ASD). GSH plays a key role in the detoxification of xenobiotics and maintenance of balance in intracellular redox pathways. Recent data showed that imbalances in the GSH redox system are an important factor in the pathophysiology of ASD. Furthermore, ASD is accompanied by decreased concentrations of ...
Known for
Interactions Glutamate | Gsh Autism | Effects Redox | Factor Pathophysiology
KOL-Index: 125 Abstract Coronavirus disease 2019 (COVID-19) is accompanied by activated immune-inflammatory pathways and oxidative stress, which both may induce indoleamine-2,3- dioxygenase (IDO), a key enzyme of the tryptophan (TRP) catabolite (TRYCAT) pathway. The aim of the current study was to systematically review and meta-analyze the TRYCAT pathway status including levels of TRP and kynurenine (KYN) ...
Known for
Kyn Ido | Trp Ratio | 1269 | Covid-19 Severe
KOL-Index: 112 The classical amyloid cascade model for Alzheimer’s disease (AD) has been challenged by several findings. Here, an alternative molecular neurobiological model is proposed. It is shown that the presence of the APOE ε4 allele, altered miRNA expression and epigenetic dysregulation in the promoter region and exon 1 of TREM2, as well as ANK1 hypermethylation and altered levels of histone ...
KOL-Index: 111 Myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS) is a common and disabling condition with a paucity of effective and evidence-based therapies, reflecting a major unmet need. Cognitive behavioural therapy and graded exercise are of modest benefit for only some ME/CFS patients, and many sufferers report aggravation of symptoms of fatigue with exercise. The presence of a ...
Known for
Fatigue Exercise | Encephalomyelitis Chronic | Abnormalities Include | Myalgic

From the Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA Biological Psychiatry/Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio USA

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