Prominent publications by Johan Bohr

KOL Index score: 10302

BACKGROUND: Microscopic colitis (MC) is a chronic inflammatory bowel disorder of unknown aetiology comprising collagenous colitis (CC) and lymphocytic colitis (LC). Data on the local cytokine profile in MC is limited. This study investigated the T helper (Th) cell and cytotoxic T lymphocyte (CTL) mucosal cytokine profile at messenger and protein levels in MC patients.

METHODS: Mucosal biopsies from CC (n=10), LC (n=5), and CC or LC patients in histopathological remission (CC-HR, n=4), ...

Known for Colitis Patients |  Protein Levels |  Mucosal Cytokine |  Histopathological Remission |  Th1 Cells
KOL Index score: 9937

BACKGROUND: Microscopic colitis, including collagenous colitis and lymphocytic colitis, mainly affects middle aged and older subjects, with a female predominance in collagenous colitis. The diseases have previously been regarded as rare. We present an epidemiological study of microscopic colitis in a well defined Swedish population.

METHODS: Patients were retrospectively searched for in colonoscopy reports of those who had a colonoscopy in the period 1993-1998 for non-bloody diarrhoea. ...

Known for Microscopic Colitis |  Epidemiological Study |  Annual Incidence |  64 Years |  Female Predominance
KOL Index score: 9840

OBJECTIVES: The characteristic clinical symptoms of collagenous colitis are non-bloody diarrhoea, urgency and abdominal pain. Treatment is aimed at reducing the symptom burden and the disease impact on patients' health-related quality of life. The objective of this study was to analyse health-related quality of life in patients with collagenous colitis.

METHODS: In a cross-sectional, postal HRQL survey, 116 patients with collagenous colitis at four Swedish hospitals completed four ...

Known for Collagenous Colitis |  Healthrelated Quality |  Abdominal Pain |  Active Disease |  116 Patients
KOL Index score: 9129

BACKGROUND: The incidence of microscopic colitis (MC) has increased in several centers, but long-term epidemiologic data are missing. We report an epidemiologic study of collagenous colitis (CC) and lymphocytic colitis (LC) during 1999-2008, as a follow-up of our previous studies 1984-1998.

METHODS: Population-based study of residents of the catchment area of the hospital, with a new diagnosis of MC between 1999 and 2008. Patients were identified by diagnosis registers of the Departments ...

Known for Collagenous Colitis |  Incidence Mc |  Colonic Biopsies |  Epidemiologic Studies |  Catchment Area
KOL Index score: 8821

BACKGROUND: Collagenous colitis (CC) and lymphocytic colitis (LC) are chronic inflammatory bowel disorders of unknown etiology. This study investigated phenotypic characteristics of the mucosal lymphocytes in CC and LC.

METHODS: Lamina propria and intraepithelial lymphocytes (LPLs, IELs) isolated from mucosal biopsies from CC (n=7), LC (n=6), as well as LC or CC patients in histopathological remission, (LC-HR) (n=6) and CC-HR (n=4) and non-inflamed controls (n=10) were phenotypically ...

Known for Colitis Patients |  Mucosal Lymphocytes |  Iels Increased |  Compared Controls |  Cd4 Antigens
KOL Index score: 8637

OBJECTIVE: This 1-year study aimed to assess low-dose budesonide therapy for maintenance of clinical remission in patients with collagenous colitis.

DESIGN: A prospective, randomised, placebo-controlled study beginning with an 8-week open-label induction phase in which patients with histologically confirmed active collagenous colitis received budesonide (Budenofalk, 9 mg/day initially, tapered to 4.5 mg/day), after which 92 patients in clinical remission were randomised to budesonide ...

Known for Clinical Remission |  Collagenous Colitis |  Lowdose Budesonide |  Healthrelated Quality |  Primary Endpoint
KOL Index score: 7588

OBJECTIVES: Onset of microscopic colitis (MC) in patients with ulcerative colitis (UC) or Crohn's disease (CD), or vice versa, has been reported occasionally but the subject is not well described. We therefore report a retrospective observational study of such patients and review the literature.

METHODS: Forty-six Swedish gastroenterology clinics were contacted about patients with diagnoses of both inflammatory bowel disease (IBD) and MC. Publications were searched on PubMed.


Known for Ulcerative Colitis |  Ibd Mc |  Crohn Disease |  Uc Patients |  Vice Versa
KOL Index score: 7563

BACKGROUND: Microscopic colitis, comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhoea. The long-term prognosis is not well described.

AIM: To study outcome of symptoms and health-related quality of life (HRQoL).

METHODS: A case-control study using a postal questionnaire with three population-based controls per patient matched for age, sex and municipality. HRQoL was assessed by the Short Health Scale (SHS). Patients in clinical ...

Known for Microscopic Colitis |  Abdominal Pain |  Clinical Remission |  Faecal Incontinence |  Quality Life
KOL Index score: 7441

The incidence and prevalence of collagenous colitis are unknown. An epidemiological study was undertaken between 1984-93. All patients living in the immediate catchment area of Orebro Medical Center Hospital with the diagnosis collagenous colitis were identified. Biopsy specimens classified as unspecific intestinal fibrosis were re-examined to identify cases not correctly diagnosed at first. Medical records were scrutinised and colorectal biopsy specimens re-evaluated. Thirty patients ...

Known for Collagenous Colitis |  Epidemiological Study |  Incidence Prevalence |  Catchment Area |  Medical Records
KOL Index score: 7295

BACKGROUND: The mechanisms behind increased fecal calprotectin (FC) in healthy relatives of patients with inflammatory bowel disease (IBD) are unknown. Our aims were to explore if there is a subclinical inflammation with increased neutrophil activity in healthy twin siblings in discordant twin pairs with IBD and to assess the influence of genetics in this context.

METHODS: Nuclear factor kappa B (NF-κB) and neutrophil activity, based on myeloperoxidase (MPO) and FC, were analyzed in ...

Known for Healthy Twin |  Bowel Disease |  Ulcerative Colitis |  Discordant Pairs |  Monozygotic Dizygotic
KOL Index score: 7217

OBJECTIVE: The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe whether smoking had any impact on the course of the disease.


Known for Collagenous Colitis |  Smoking Habits |  116 Patients |  Demographic Data |  62 Years
KOL Index score: 7211

BACKGROUND: Collagenous colitis is a chronic inflammatory bowel disease accompanied mainly by nonbloody diarrhea. The objectives of treatment are to alleviate the symptoms and minimize the deleterious effects on health-related quality of life (HRQOL). There is still no generally accepted clinical definition of remission or relapse. The purpose of this study was to analyze the impact of bowel symptoms on HRQOL and accordingly suggest criteria for remission and disease activity based on ...

Known for Collagenous Colitis |  Clinical Remission |  Watery Stools |  Life Hrqol |  Bowel Disease
KOL Index score: 6828

INTRODUCTION: Microscopic colitis is a chronic inflammatory bowel disease characterised by normal or almost normal endoscopic appearance of the colon, chronic watery, nonbloody diarrhoea and distinct histological abnormalities, which identify three histological subtypes, the collagenous colitis, the lymphocytic colitis and the incomplete microscopic colitis. With ongoing uncertainties and new developments in the clinical management of microscopic colitis, there is a need for ...

Known for Microscopic Colitis |  United European Gastroenterology |  Chronic Watery |  Recommendations Assessment |  Guidelines Improve
KOL Index score: 6746

BACKGROUND: Data on collagenous colitis have been based on a limited number of patients.

AIMS: To obtain more information on this disease from a register set up at Orebro Medical Center Hospital.

PATIENTS AND METHODS: Twenty five Swedish hospitals have contributed to this patient register, which comprises 163 histopathologically verified cases. Clinical data were retrospectively analysed.

RESULTS: Collagenous colitis followed a chronic intermittent course in most cases (85%) with a ...

Known for Collagenous Colitis |  Clinical Presentation |  Chronic Disease |  Swedish Hospitals |  Aged Prednisolone
KOL Index score: 6656

Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and protein expressions of different immune cell attracting chemokines and their receptors in colon biopsies from MC patients in active disease or histopathological remission (CC/LC-HR) with controls, using qRT-PCR and Luminex, respectively. ...

Known for Lymphocytic Colitis |  Chemokines Receptors |  Immune Cell |  Protein Expressions |  Mc Patients


Johan Bohr: Influence Statistics

Sample of concepts for which Johan Bohr is among the top experts in the world.
Concept World rank
observations fmt #1
life collagenous colitis #1
3 stools day #1
1 watery #1
11 faecal transplantation #1
mc ulcerative #1
faecal transplantation immunomodulatory #1
cd3 positive lymphocytes #1
watery stools #1
medical treatment fmt #1
microscopic colitis refractory #1
review collagenous colitis #1
study collagenous #1
patient collagenous #1
patient collagenous colitis #1
collagenous colitis #1
encompassing collagenous #1
comprising collagenous #1
mc immunopathology #2
myalgia years #2
cd45ro foxp3 cells #2
ki67 areas epithelium #2
nocturnal defecation #2
lpls observed #2
minor specific abnormalities #2
controls proportions #2
6070yearold individuals #2
remission collagenous #2
daily watery #2
background microscopic #2
colonic biopsies mc #2
mixed th17 tc17 #2
1 watery stool #2
colitis comprising #2
tcell lymphocytic colitis #2
proportions cd45ro cells #2
antigen lymphocytic colitis #2
increased proportions #2
lower diversity patients #2
patients lower diversity #2
iels p001 #2
fatigue 54 #2

Key People For Collagenous Colitis

Top KOLs in the world
Johan Bohr
collagenous colitis clinical remission colonic mucosa
Curt Tysk
collagenous colitis inflammatory bowel disease monozygotic twins
Francis M Giardiello
colorectal cancer familial adenomatous polyposis collagenous colitis
Sune Eriksson
collagenous colitis celiac disease epidemiological study
Theodore M Bayless
ulcerative colitis inflammatory bowel disease lactose intolerance
Gunnar Järnerot
ulcerative colitis crohns disease monozygotic twins

Johan Bohr:Expert Impact

Concepts for whichJohan Bohrhas direct influence:Collagenous colitis,  Microscopic colitis,  Lymphocytic colitis,  Clinical remission,  Colitis patients,  Colonic mucosa,  Ulcerative colitis,  Colonic perforation.

Johan Bohr:KOL impact

Concepts related to the work of other authors for whichfor which Johan Bohr has influence:Microscopic colitis,  Celiac disease,  Chronic diarrhea,  Irritable bowel syndrome,  Inflammatory bowel,  Patients mc,  Nitric oxide.



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Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Faculty of Medicine and Health, Örebro University, Örebro, Sweden | Department of Medicine, Örebro University Hospital, Örebro University, Örebro, Sweden | Division of

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