Prominent publications by Jelle F Homans

KOL Index score: 8379

OBJECTIVE: The 22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion syndrome in humans. It is characterised by wide phenotypic variability, including congenital heart disease (CHD), immunodeficiency and scoliosis. However, little is known regarding the prevalence and characteristics of scoliosis in patients with 22q11.2DS. The objective of this study is to assess the prevalence of scoliosis, its characteristics and the association with CHD in patients with ...

Known for Prevalence Scoliosis |  Deletion Syndrome |  Chd Patients |  Congenital Heart Disease |  Wide Phenotypic Variability
KOL Index score: 6189

BACKGROUND: The development of proximal junctional kyphosis (PJK) after posterior spinal fusion in adolescent idiopathic scoliosis is a major problem. Changes in the global sagittal parameters as they relate to PJK have been reported after surgery, however, the relationships between the changes in the upper-instrumented vertebra (UIV) during and after surgery as they relate to development of PJK have not been quantified. We hypothesize that the compensatory changes in the unfused ...

Known for Adolescent Idiopathic Scoliosis |  Proximal Junctional Kyphosis |  Posterior Spinal |  Cervical Lordosis |  Thoracic Vertebrae
KOL Index score: 5900

BACKGROUND CONTEXT: For over four decades, clinicians and researchers have suggested a relationship between congenital heart disease (CHD) and scoliosis, attributed to either the disease itself or to the long-term effects of cardiac surgery on the immature thoracic cage. However, no study has yet accounted for 22q11.2 deletion syndrome (22q11.2DS), the second most common cause of CHD after Down syndrome. 22q11.2DS has a scoliosis risk of 50%, but within 22q11.2DS a previous report found ...

Known for Deletion Syndrome |  Adults Chd |  Scoliosis 22q112ds |  Congenital Heart Disease |  Tetralogy Fallot
KOL Index score: 5566

22q11.2 deletion syndrome (22q11.2DS) is a disorder caused by recurrent, chromosome-specific, low copy repeat (LCR)-mediated copy-number losses of chromosome 22q11. The Children's Hospital of Philadelphia has been involved in the clinical care of individuals with what is now known as 22q11.2DS since our initial report of the association with DiGeorge syndrome in 1982. We reviewed the medical records on our continuously growing longitudinal cohort of 1,421 patients with molecularly ...

Known for Human Pair |  Digeorge Syndrome |  Congenital Heart Disease |  Childrens Hospital |  Chromosome Deletion
KOL Index score: 3914

BACKGROUND CONTEXT: Relative anterior spinal overgrowth was proposed as a generalized growth disturbance and a potential initiator of adolescent idiopathic scoliosis (AIS). However, anterior lengthening has also been observed in neuromuscular (NM) scoliosis and was shown to be restricted to the apical areas and located in the intervertebral discs, not in the bone. This suggests that relative anterior spinal overgrowth does not rightfully describe anterior lengthening in scoliosis, as it ...

Known for Compensatory Curves |  Vertebral Body |  Scoliosis Ais |  Thoracic Vertebrae |  Adolescent Idiopathic
KOL Index score: 3790

PurposeBlunt cerebrovascular injuries (BCVI), which can result in ischemic stroke, are identified in 1–2% of all blunt trauma patients. Computed tomography angiography (CTA) scanning has improved and is the diagnostic modality of choice in BCVI suspected patients. Data about long-term functional outcomes and the incidence of ischemic stroke after BCVI are limited. The aim of this study was to determine BCVI incidence in relation to imaging modality improvements and to determine long-term ...

Known for Ischemic Stroke |  Trauma Patients |  Blunt Cerebrovascular Injury |  Tomography Angiography |  Wounds Nonpenetrating
KOL Index score: 3110

PurposeThere are distinct differences in strategy amongst experienced surgeons from different ‘scoliosis schools’ around the world. This study aims to test the hypothesis that, due to the 3-D nature of AIS, different strategies can lead to different coronal, axial and sagittal curve correction.MethodsConsecutive patients who underwent posterior scoliosis surgery for primary thoracic AIS were compared between three major scoliosis centres (n = 193). Patients were treated according to the ...

Known for Implant Density |  Kyphosis Lordosis |  Curve Correction |  Spinal Fusion |  Thoracic Vertebrae
KOL Index score: 2940

Adolescent idiopathic scoliosis (AIS), defined as a lateral deviation of the spine of at least ten degrees, is a classic enigma in orthopaedics and affects 1-4% of the general population. Despite (over) a century of intensive research, the etiology is still largely unknown. One of the major problems in all existing AIS research is the fact that most patients come to medical attention after onset of the curve. Therefore, it is impossible to know whether current investigated parameters are ...

Known for Idiopathic Scoliosis |  Deletion Syndrome |  Patients 22q112ds |  Population 22q112
KOL Index score: 2359

Brace treatment is the most common noninvasive treatment in adolescent idiopathic scoliosis (AIS); however it is currently not fully known whether there is a difference in effectiveness between brace types/concepts. All studies on brace treatment for AIS were searched for in PubMed and EMBASE up to January 2021. Articles that did not report on maturity of the study population were excluded. Critical appraisal was performed using the Methodological Index for Non-Randomized Studies tool ...

Known for Brace Treatment |  Adolescent Idiopathic Scoliosis
KOL Index score: 2069

STUDY DESIGN: Cross-sectional.

OBJECTIVE: The aim of this study was to analyze the thoracic center of mass (COM) position of children at different ages and evaluate its relation with the previously reported pre-existent rotational pattern of the normal spine.

SUMMARY OF BACKGROUND DATA: The normal, nonscoliotic thoracic spine is known to have a rotational pattern that changes direction during growth, a transition from left-sided toward right-sided rotation with increasing age. This ...

Known for Vertebral Rotation |  Adolescent Age |  Thoracic Spine |  Idiopathic Scoliosis |  Existing Database
KOL Index score: 1707

The 22q11.2 Deletion Syndrome (22q11.2DS) is the most common microdeletion syndrome with an estimated prevalence of 1:4,000 live births. 22q11.2DS is known to have wide phenotypic variability, including orthopaedic manifestations. The purpose of this systematic review is to increase the awareness of orthopaedic manifestations associated with 22q11.2DS. This systematic review was performed according to the PRISMA Guidelines. Original epidemiological studies on the prevalence of ...

Known for Deletion Syndrome |  22q112ds Patients |  Skeletal Anomalies |  Scoliosis Prevalence |  Wide Phenotypic Variability
KOL Index score: 1462

Scoliosis is a deformation of the spine that may have several known causes, but humans are the only mammal known to develop scoliosis without any obvious underlying cause. This is called ‘idiopathic’ and is the most common type. Recent observations showed that human scoliosis, regardless of its cause, has a relatively uniform three-dimensional anatomy. We hypothesize that scoliosis is a universal compensatory mechanism of the spine, independent of cause and/or species. We had the ...

Known for Scoliosis Spine
KOL Index score: 1414

PurposeTo define the longitudinal rotation axis around which individual vertebrae rotate, and to establish the various extra- and intravertebral rotation patterns in thoracic adolescent idiopathic scoliosis (AIS) patients, for better understanding of the 3D development of the rotational deformity.MethodsSeventy high-resolution CT scans from an existing database of thoracic AIS patients (Cobb angle: 46°–109°) were included to determine the vertebral axial rotation, rotation radius, ...

Known for Idiopathic Scoliosis |  Ais Patients
KOL Index score: 1372

Scoliosis is a deformation of the spine that may have several known causes, but humans are the only mammal known to develop scoliosis without any obvious underlying cause. This is called ‘idiopathic’ scoliosis and is the most common type. Recent observations showed that human scoliosis, regardless of its cause, has a relatively uniform three-dimensional anatomy. We hypothesize that scoliosis is a universal compensatory mechanism of the spine, independent of cause and/or species. We had ...

Known for Idiopathic Scoliosis
KOL Index score: 850

Study designCross-sectional.ObjectivesTo determine semiautomatically the 3D position of the pedicle axis in operative adolescent idiopathic scoliosis (AIS) patients relative to the operating table and the lamina, as orientation for pedicle screw placement for better understanding and reference of spine surgeons.Summary of background dataPedicle morphology is well described as the angle between the convex and concave pedicle. However, the pedicle angle as relative to the neutral ...

Known for Adolescent Idiopathic |  Scoliosis Ais


Jelle F Homans: Influence Statistics

Sample of concepts for which Jelle F Homans is among the top experts in the world.
Concept World rank
euroqol sixdimensional eq6d #2
hospital cerebrovascular trauma #2
bcvi result #2
cta diagnostic modalities #2
result bcvi #2
period bcvi #2
bcvi suspected patients #2
modality improvements #2
ischemic stroke bcvi #2
resultsseventyone bcvi patients #2
period bcvi incidence #2
cervical trauma subgroups #2
determine bcvi #2
bcvi ischemic stroke #3
obvious called #4
universal compensatory #4
scoliosis whale #4
scoliosis obvious #4
scoliosis uniform #4
hypothesize scoliosis #4
scoliosis obvious underlying #4
humans universal mechanism #4
stranded whale scoliosis #4
necropsy imaging analysis #4
universal mechanism scoliosis #4
stranded july #4
suggests decompensation #4
mammal develop #4
scoliosis teach #4
taxidermists radiologists #4
acute lateral deviation #4
acutorostrata stranded #4
whale scoliosis #4
veterinarians taxidermists #4
scolioticlike deformities #5
bcvi long #5
shaped elastic rod #5
cohort 22q patients #5
backgroundthe sagittal curvature #5
32 patients spine #5
spine initiated #5
cohort 22q #5
curvature pediatric #5
sagittal curvature cohort #5
idiopathic suggests #5
spinal equilibrium #6
pathologists veterinarians #6
point lordosis #6
common type observations #7
taxidermists #7

Key People For Idiopathic Scoliosis

Top KOLs in the world
Lawrence G Lenke
adolescent idiopathic scoliosis spinal deformity pulmonary function
adolescent idiopathic scoliosis spinal deformity background data
Stuart L Weinstein
adolescent idiopathic scoliosis developmental dysplasia body image
lumbar supports idiopathic scoliosis intervertebral disc
Thomas G Lowe
idiopathic scoliosis pulmonary function surgical treatment
Peter O Newton
adolescent idiopathic scoliosis spinal fusion pulmonary function

Jelle F Homans:Expert Impact

Concepts for whichJelle F Homanshas direct influence:Idiopathic scoliosis,  Club foot,  Adolescent idiopathic scoliosis,  Deletion syndrome,  22q112 deletion syndrome,  Scoliosis chd,  Chd scoliosis,  Prevalence scoliosis.

Jelle F Homans:KOL impact

Concepts related to the work of other authors for whichfor which Jelle F Homans has influence:Idiopathic scoliosis,  22q112 deletion syndrome,  Club foot,  Spinal deformity,  Cervical spine,  Behavior problems,  Cnv genes.



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Department of Orthopaedic Surgery, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands. | Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands | Department of Orthopaedic Surgery, University M

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