Prominent publications by Arne May

KOL Index score: 12708

OBJECTIVES: The objective of phase 1 (reported here) of this two-phase study was to assess the efficacy of zolmitriptan 5 mg nasal spray, in terms of ability to provide relief from all migraine symptoms, in a controlled setting, designed to replicate clinical practice.

BACKGROUND: Zolmitriptan nasal spray has been shown to be fast acting and highly effective in the treatment of migraine, as assessed using standard endpoints, such as headache response and pain-free rates.

METHODS: In the ...

Also Ranks for: Nasal Spray |  zolmitriptan 5 |  treatment migraine |  headache response |  painfree status
KOL Index score: 11820

Primary headache syndromes, such as cluster headache and migraine, are widely described as vascular headaches, although considerable clinical evidence suggests that both are primarily driven from the brain. The shared anatomical and physiologic substrate for both of these clinical problems is the neural innervation of the cranial circulation. Functional imaging with positron emission tomography has shed light on the genesis of both syndromes, documenting activation in the midbrain and ...

Also Ranks for: Primary Headache Syndromes |  cluster headache |  neural influences |  cranial circulation |  trigeminal pain
KOL Index score: 11489

OBJECTIVE: To evaluate the effectiveness of transcranial direct current stimulation alone and in combination with cognitive behavioural management in patients with non-specific chronic low back pain.

DESIGN: Double blind parallel group randomised controlled trial with six months' follow-up conducted May 2011-March 2013. Participants, physiotherapists, assessors, and analyses were blinded to group allocation.

SETTING: Interdisciplinary chronic pain centre.

PARTICIPANTS: 135 participants ...

Also Ranks for: Current Stimulation |  transcranial direct |  chronic low |  controlled trial |  pain disability
KOL Index score: 11385

BACKGROUND: Cluster headache is a form of primary headache in which attacks are rapid in onset with very severe pain. The mainstays of acute therapy are inhaled oxygen and sumatriptan succinate injection.

OBJECTIVE: To evaluate zolmitriptan nasal spray in the acute treatment of cluster headache.

METHODS: Ninety-two patients, aged 40 +/- 10 years (mean +/- SD) (80 men and 12 women), with International Headache Society-defined cluster headache were randomized into a placebo-controlled, ...

Also Ranks for: Cluster Headache |  intranasal zolmitriptan |  30 minutes |  acute treatment |  severe pain
KOL Index score: 11012

Recently, local morphologic alterations of the brain in areas ascribable to the transmission of pain were reported in patients suffering from chronic pain. Although some authors discussed these findings as damage or loss of brain gray matter, one of the key questions is whether these structural alterations in the cerebral pain-transmitting network precede or succeed the chronicity of pain. We investigated 32 patients with chronic pain due to primary hip osteoarthritis and found a ...

Also Ranks for: Chronic Pain |  gray matter |  acc amygdala |  atrophy brain |  10 patients
KOL Index score: 10775

This population-based cross-sectional study examined the 3-month prevalence of headache, migraine and tension-type headache (TTH) among adolescents aged 12-15 years in Germany. Students (n = 3324) from 20 schools completed a questionnaire on general and headache-specific pain which included a sociodemographic module. The headache-specific questionnaire complied with the respective revised criteria of the International Headache Society (IHS). 'Modified criteria' changed the item ...

Also Ranks for: Headache Prevalence |  girls boys |  tth adolescents |  german dmkg |  tension type
KOL Index score: 10720

AIM: We aimed to conduct a systematic review evaluating the effectiveness of interventions used by physiotherapists on the intensity, frequency and duration of migraine, tension-type (TTH) and cervicogenic headache (CGH).

METHODS: We performed a systematic search of electronic databases and a hand search for controlled trials. A risk of bias analysis was conducted using the Cochrane risk of bias tool (RoB). Meta-analyses present the combined mean effects; sensitivity analyses evaluate ...

Also Ranks for: Migraine Tth |  frequency duration |  headache cgh |  pain intensity |  tension type
KOL Index score: 10379

BACKGROUND: The pain and autonomic symptoms of cluster headache (CH) result from activation of the trigeminal parasympathetic reflex, mediated through the sphenopalatine ganglion (SPG). We investigated the safety and efficacy of on-demand SPG stimulation for chronic CH (CCH).

METHODS: A multicenter, multiple CH attack study of an implantable on-demand SPG neurostimulator was conducted in patients suffering from refractory CCH. Each CH attack was randomly treated with full, ...

Also Ranks for: Cluster Headache |  sphenopalatine ganglion |  pain relief |  spg stimulation |  implanted female ganglia
KOL Index score: 10156

Migraine and the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome have some clinical features in common. First, cerebral infarctions, most often in the posterior cerebral regions, which are a main symptom of MELAS, may complicate migraine. Second, migrainous headache with vomiting is also a characteristic feature of the MELAS syndrome. Less frequently, hemicranial headache is present in another mitochondrial disease, myoclonic epilepsy ...

Also Ranks for: Mitochondrial Dna |  migraine aura |  melas syndrome |  point mutations |  myoclonic epilepsy
KOL Index score: 9340

BACKGROUND: A wide range of physical tests have been published for use in the assessment of musculoskeletal dysfunction in patients with headache. Which tests are used depends on a physiotherapist's clinical and scientific background as there is little guidance on the most clinically useful tests.

OBJECTIVES: To identify which physical examination tests international experts in physiotherapy consider the most clinically useful for the assessment of patients with headache.


Also Ranks for: Physical Examination |  patients headache |  musculoskeletal dysfunction |  delphi survey |  international experts
KOL Index score: 9145

BACKGROUND: In the recent Pathway CH-1 study, on-demand stimulation of the sphenopalatine ganglion (SPG) by means of an implantable neurostimulation system was proven to be a safe and effective therapy for the treatment of chronic cluster headache. Our objective was to assess the cost-effectiveness of SPG stimulation in the German healthcare system when compared to medical management.

METHODS: Clinical data from the Pathway CH-1 study were used as input for a model-based projection of ...

Also Ranks for: Cluster Headache |  sphenopalatine ganglion |  spg stimulation |  effective therapy |  quality life
KOL Index score: 8921

Migraine is a common neurological disease of two main types: migraine with aura and migraine without aura. Familial clustering suggests that genetic factors are involved in the etiology of migraine. Recently, a gene for familial hemiplegic migraine, a rare autosomal dominant subtype of migraine with aura, was mapped to chromosome 19p13. We tested the involvement of this chromosomal region in 28 unrelated families with the common forms of migraine with and without aura, by following the ...

Also Ranks for: Common Forms |  migraine aura |  familial hemiplegic |  genetic factors |  chromosomal region
KOL Index score: 8859

BACKGROUND AND PURPOSE: Trigeminal neuralgia (TN) is an extremely painful condition which can be difficult to diagnose and treat. In Europe, TN patients are managed by many different specialities. Therefore, there is a great need for comprehensive European guidelines for the management of TN. The European Academy of Neurology asked an expert panel to develop recommendations for a series of questions that are essential for daily clinical management of patients with TN.


Also Ranks for: Trigeminal Neuralgia |  neurovascular contact |  microvascular decompression |  european academy |  patients secondary
KOL Index score: 8791

BACKGROUND: Cluster headache, one of the most severe pain syndromes in human beings, is usually described as a vascular headache. However, the striking circadian rhythmicity of this strictly half-sided pain syndrome cannot be readily explained by the vascular hypothesis. We aimed to assess changes in regional cerebral blood flow (rCBF) in patients with cluster headache.

METHODS: We used positron emission tomography (PET) to assess the changes in rCBF, as an index of synaptic activity, ...

Also Ranks for: Cluster Headache |  hypothalamic activation |  rcbf patients |  pain state |  synaptic activity
KOL Index score: 8768

Functional imaging using positron emission tomography and later functional magnetic resonance imaging revealed a particular brainstem area that is believed to be specifically activated in migraine during, but not outside of the attack, and consequently has been coined the 'migraine generator'. However, the pathophysiological concept behind this term is not undisputed and typical migraine premonitory symptoms such as fatigue and yawning, but also a typical association of attacks to ...

Also Ranks for: Migraine Generator |  spontaneous attacks |  functional imaging |  pain onset |  hypothalamus magnetic

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Arne May:Expert Impact

Concepts for whichArne Mayhas direct influence:Cluster headache,  Migraine patients,  Chronic pain,  Trigeminal autonomic reflex,  Migraine attacks,  Facial pain,  Trigeminal pain,  Greater occipital nerve.

Arne May:KOL impact

Concepts related to the work of other authors for whichfor which Arne May has influence:Cluster headache,  Chronic pain,  Migraine patients,  Gray matter,  Cortical thickness,  Magnetic resonance,  Trigeminal neuralgia.



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Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. | Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany | Department of Systems Neuroscience, University Cl