Gisela Marie Terwindt: Influence Statistics

Gisela Marie Terwindt

Gisela Marie Terwindt

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands | Department of Neurology (G.M.T., M.J.H.W.), Leiden University Medical Center, Leiden, the ...

Gisela Marie Terwindt: Expert Impact

Concepts for which Gisela Marie Terwindt has direct influence: Cluster headache , Familial hemiplegic migraine , Hemiplegic migraine , Migraine aura , Migraine patients , Aura migraine , Retinal vasculopathy .

Gisela Marie Terwindt: KOL impact

Concepts related to the work of other authors for which for which Gisela Marie Terwindt has influence: Migraine aura , Cluster headache , Psychiatric disorders , Bipolar disorder , Ischemic stroke , Calcium channels , Cortical spreading depression .

KOL Resume for Gisela Marie Terwindt

Year
2022

Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands

2021

Department of Neurology, Leiden University Medical Center, Leiden, Netherlands

Leiden University Medical Center: Leids Universitair Medisch Centrum

2020

From the Department of Neurology (E.A.K., S.V., I.R., E.S.v.E., M.J.H.W., G.M.T.), Leiden University Medical Center, the Netherlands.

Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, USA

Leiden University Medical Centre, Department of Neurology, PO Box 9600, 2300 RC Leiden, The Netherlands

2019

Department of Neurology.

Leiden University Medical Center, Leiden, the Netherlands.

2018

Wilhelmina Children’s Hospital Birth Center (G.A.Z., B.B.v.R., A.F.) Department of Reproductive Medicine and Gynaecology (B.C.J.M.G.) Julius Center for Health Sciences and Primary Care (Y.v.d.G.) Department of Vascular Medicine (F.L.V.) Department of Radiology (B.K.V.), University Medical Center Utrecht, Netherlands Department of Obstetrics and Gynaecology (L.B., E.A.P.S.) Department of Cardiology (E.B., R.P.J.B.) Department of Radiology (R.P.J.B.) Department of Internal Medicine (J.E.R.v.L.), Erasmus Medical Center, Rotterdam, Netherlands Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, Netherlands (G.J.M.d.G.) Department of Cardiology, Radboud University Medical Center, Nijmegen, Netherlands (A.H.E.M.M.) Academic Unit of Human Development and Health, University of Southampton, Southampton, United Kingdom (B.B.v.R.).

From the Departments of Neurology (N.P., J.H., A.H.S., A.S., M.D.F., A.M.J.M.v.d.M., G.M.T.) and Human Genetics (L.S.V., S.C.K., B.d.V., A.M.J.M.v.d.M.), Leiden University Medical Centre; and Department of Neurology (J.H.), Alrijne Hospital, Leiderdorp, the Netherlands.

Department of Neurology, LUMC, Leiden, The Netherlands

2017

Department of Neurology, Leiden University Medical Center, The Netherlands

2016

From the Departments of Neurology (E.S.v.E., J.H., G.M.T., M.J.H.W.), Radiology (J.v.d.G., M.A.v.B.), and Clinical Epidemiology (A.A.), Leiden University Medical Center; Department of Neurology (J.H.), Alrijne Hospital; Department of Neurology and Neurosurgery (A.A.), Brain Center Rudolf Magnus and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, the Netherlands; Hemorrhagic Stroke Research Program (M.E.G., A.V., K.M.S., A.M.A., S.M.G.), Department of Neurology, Massachusetts General Hospital Stroke Research Center; and Division of Neurocritical Care and Emergency Neurology (J.R.), Massachusetts General Hospital, Harvard Medical School, Boston.

Department of Neurology, Leiden University Medical Centre, the Netherlands

2015

Dept. Neurology, Leiden University Medical Centre, Leiden, The Netherlands

Departments of Neurology and

Author affiliations are provided at the end of the article.

2014

From the Division of Pharmacology and Vascular Medicine, Department of Internal Medicine (K.I., A.H.J.D., I.M.G., A.H.v.d.M., A.M.V.D.B.), and Departments of Gynaecology (W.v.D.), Psychiatry (S.A.K.), and Biostatistics (E.M.E.H.L.), Erasmus MC, Rotterdam; and Department of Neurology (W.P.J.v.O., G.M.T., M.D.F.), Leiden University Medical Center, the Netherlands.

Department of Neurology, Leiden University Medical Center (LUMC), the Netherlands

2013

Leiden University Medical Center Department of Neurology Leiden The Netherlands

2012

Departments of Radiology (Drs Palm-Meinders, Konishi, van Buchem, and Kruit and Ms Moonen), Division of Image Processing (Mr van Lew), Neurology (Drs Koppen, Terwindt, and Ferrari), and Neuropsychology (Dr Middelkoop), Leiden University Medical Center, the Netherlands

2011

Leiden University Medical Center, The Netherlands.

2010

From the Departments of Neurology (A.H.S., A.M.J.M.v.d.M., M.D.F., G.M.T.) and Human Genetics (B.d.V., K.R.J.V., P.H., R.R.F., A.M.J.M.v.d.M.), Leiden University Medical Centre, Leiden; and Department of Epidemiology (A.C.J.W.J.) and Genetic Epidemiology Unit, Departments of Epidemiology and Clinical Genetics (Y.S.A., B.A.O., C.M.v.D.), Erasmus University Medical Centre, the Netherlands.

2009

Department of Neurology, Leiden University Medical Centre, Leiden

2008

Department of Neurology and Clinical Genetic, Erasmus Medical Centre, Leiden, The Netherlands

2007

Department of Neurology, Leiden University Medical Centre, 2300 RC, Leiden, The Netherlands

2006

Department Neurology, Leiden University Medical Centre Leiden, Leiden

2005

From the Laboratory of Epidemiology, Demography, and Biometry (Drs. Scher and Launer), National Institute on Aging, National Institutes of Health, Bethesda, MD; Department of Neurology (Drs. Terwindt and Ferrari), Leiden University Medical Center, Leiden, The Netherlands; Center for Prevention and Health Services Research (Drs. Picavet, Verschuren, and Launer), National Institute of Public Health and the Environment, Bilthoven, The Netherlands.

Neurology, Leiden University Medical Center, Leiden, the Netherlands

2004

From the Department of Neurology and Clinical Neurophysiology, Leiden University Medical Center, The Netherlands.

Department of Neurology (K5Q), Leiden University Medical Centre, PO Box 9600, 2300, RC Leiden, The Netherlands

2003

Department of Neurology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands, e-mail: Tel.: +31-71-5262587, Fax: +31-71-5248253, , NL

2002

Department of Neurology, K5Q, Leiden University Medical Centre, P. O. Box 9600, 2300 RC Leiden, The Netherlands. NL

2001

From the Department of Neurology (Drs. Terwindt, Ophoff, Haan, and Ferrari, and M.N. Vergouwe) and MGC–Department of Human and Clinical Genetics (Drs. Ophoff, Frants, and Sandkuijl and R. van Eijk and M.N. Vergouwe), Leiden University Medical Centre; Rijnland Hospital (Dr. Haan), Leiderdorp; and MGC–Department of Clinical Genetics (Dr. Sandkuijl), Erasmus University Rotterdam, the Netherlands.

2000

Department of Neurology, Leiden University Medical Centre, The Netherlands.

1999

From the Department of Chronic Disease Epidemiology (Dr. Launer), National Institute of Public Health and the Environment, Bilthoven; and the Department of Neurology (Drs. Terwindt and Ferrari), Leiden University Medical Centre, the Netherlands.

Departments of Neurology, Leiden University Medical Centre

1998

Department of Human Genetics, Sylvius Laboratory, Leiden University Medical Center, Wassenaarseweg 72, 2333 RA Leiden, The Netherlands, and

Prominent publications by Gisela Marie Terwindt

KOL-Index: 17552 . CONTEXT: Clinical series have suggested an increased prevalence of cerebral infarction and white matter lesions (WMLs) in migraine patients. It is not known whether these lesions are prevalent in the general migraine population. OBJECTIVES: To compare the prevalence of brain infarcts and WMLs in migraine cases and controls from the general population and to identify migraine ...
Known for Brain Lesions | Migraine Controls | Aura Patients | Attack Frequency
KOL-Index: 14547 . BACKGROUND AND AIM: Monoclonal antibodies acting on the calcitonin gene-related peptide or on its receptor are new drugs to prevent migraine. Four monoclonal antibodies have been developed: one targeting the calcitonin gene-related peptide receptor (erenumab) and three targeting the calcitonin gene-related peptide (eptinezumab, fremanezumab, and galcanezumab). The aim of this document by ...
Known for Monoclonal Antibodies | Calcitonin Gene | European Headache Federation | Migraine Prevention
KOL-Index: 13600 . OBJECTIVE: To assess the involvement of the 19p13 familial hemiplegic migraine (FHM) locus in migraine with and without aura. BACKGROUND: Migraine with and without aura are likely to be polygenetic multifactorial disorders. FHM is a rare dominantly inherited type of migraine with aura. In about 50% of families, FHM is caused by mutations in the P/Q-type calcium channel alpha(1A)-subunit ...
Known for Migraine Aura | Cacna1a Gene | Lod Score | 19p13 Locus
KOL-Index: 13222 . Trivial head trauma may be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval ("delayed cerebral edema"). Attacks of familial hemiplegic migraine (FHM) can be triggered by minor head trauma and are sometimes accompanied by coma. Mutations in the CACNA1A calcium channel subunit gene on chromosome 19 are associated with a wide spectrum of ...
Known for Minor Head Trauma | Delayed Cerebral Edema | Calcium Channel | Cacna1a Gene
KOL-Index: 12786 . BACKGROUND: Rizatriptan (MK-462) is a new 5-hydroxytryptamine1D (serotonin1D; 5-HT1D) receptor agonist for the acute treatment of migraine that has improved pharmacokinetic properties compared with sumatriptan succinate. OBJECTIVE: To assess the efficacy and tolerability of 10-, 20-, and 40-mg doses of oral rizatriptan vs a 100-mg dose of oral sumatriptan succinate and placebo for the ...
Known for Acute Treatment | Rizatriptan Sumatriptan | Patients Migraine | 2 Hours
KOL-Index: 11883 . BACKGROUND: Familial (FHM) and sporadic (SHM) hemiplegic migraine are severe subtypes of migraine associated with transient hemiparesis. For FHM, three genes have been identified encoding subunits of a calcium channel (CACNA1A), a sodium-potassium pump (ATP1A2), and a sodium channel (SCN1A). Their role in SHM is unknown. Establishing a genetic basis for SHM may further the understanding of ...
Known for Fhm Genes | Shm Patients | Transient Hemiparesis | Sodium Channel
KOL-Index: 11805 . CONTEXT: A previous cross-sectional study showed an association of migraine with a higher prevalence of magnetic resonance imaging (MRI)-measured ischemic lesions in the brain. OBJECTIVE: To determine whether women or men with migraine (with and without aura) have a higher incidence of brain lesions 9 years after initial MRI, whether migraine frequency was associated with progression of ...
Known for Migraine Progression | Brain Lesions | White Matter | Higher Prevalence
KOL-Index: 11631 . BACKGROUND: Loss of cortical grey matter is a diagnostic marker of many neurodegenerative diseases, and is a key mediator of cognitive impairment. We postulated that cerebral amyloid angiopathy (CAA), characterised by cortical vascular amyloid deposits, is associated with cortical tissue loss independent of parenchymal Alzheimer's disease pathology. We tested this hypothesis in patients ...
Known for Cortical Atrophy | Cerebral Amyloid | Caa Patients | Vascular Dysfunction
KOL-Index: 11608 . OBJECTIVE: To investigate the co-occurrence of migraine and depression and assess whether shared genetic factors may underlie both diseases. METHODS: Subjects were 2,652 participants of the Erasmus Rucphen Family genetic isolate study. Migraine was diagnosed using a validated 3-stage screening method that included a telephone interview. Symptoms of depression were assessed using the Center ...
Known for Migraine Depression | Genetic Factors | Bidirectional Association | Depressive Disorder
KOL-Index: 11167 . BACKGROUND: Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura. Missense mutations in the chromosome 19 CACNA1A calcium channel gene have been found in approximately half of the families. The T666M mutation, replacing a threonine by a methionine at residue number 666, is the most frequent mutation, reported in 14 independent FHM families; other ...
Known for Familial Hemiplegic Migraine | Cacna1a Gene | Fhm Families | Phenotypic Spectrum
KOL-Index: 10896 . Migraine headache is widely believed to be associated with cerebral or meningeal vasodilatation. Human evidence for this hypothesis is lacking. 3 Tesla magnetic resonance angiography (3T MRA) allows for repetitive, non-invasive, sensitive assessment of intracranial vasodilatation and blood flow. Nitroglycerine (NTG) can faithfully induce migraine attacks facilitating pathophysiological ...
Known for Migraine Headache | Magnetic Resonance | Blood Flow | Infusion Ntg
KOL-Index: 10592 . Familial hemiplegic migraine (FHM) is a rare, severe, autosomal dominant subtype of migraine with aura. Up to 75% of FHM families have a mutation in the P/Q-type calcium channel Ca(v)2.1 subunit CACNA1A gene on chromosome 19p13. Some CACNA1A mutations also may cause epilepsy. Here, we describe novel missense mutations in the ATP1A2 Na(+),K(+)-ATPase pump gene on chromosome 1q23 in two ...
Known for Benign Familial | Gene Atp1a2 | Aura Mutation | Infantile Convulsions
KOL-Index: 10370 . BACKGROUND: Migraine, particularly with aura, is a risk factor for early-onset ischemic stroke. The underlying mechanisms are unknown, but may in part be due to migraineurs having an increased risk profile for cardiovascular disease. In this study, the authors compare the cardiovascular risk profile of adult migraineurs to that of nonmigraineurs. METHODS: Participants (n = 5,755, 48% men, ...
Known for Cardiovascular Risk | Aura Migraine | Myocardial Infarction | Oral Contraceptive
KOL-Index: 10055 . Familial hemiplegic migraine (FHM) is an autosomal dominant subtype of migraine with aura, with half of the families being assigned to chromosome 19p13. We identified missense mutations in a brain-specific calcium channel alpha1A-subunit (CACNA1A) gene on 19p13 segregating with FHM and truncating mutations in families with episodic ataxia type 2 (EA-2). Expansions of an intragenic CAG ...
Known for Familial Hemiplegic Migraine | Calcium Channel | Cerebellar Ataxia | Patients Fhm

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Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands | Department of Neurology (G.M.T., M.J.H.W.), Leiden University Medical Center, Leiden, the Netherlands. | Department of Neurology, Leiden University Medical Center, L