Michel Dominique Ferrari

Michel Dominique Ferrari

Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands | Department of Neurology, Leiden University Medical Center, Leiden, Netherlands | Department of ...

KOL Resume for Michel Dominique Ferrari  (cluster, headache, cluster headache syndrome, cluster syndrome, syndrome)


Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands


Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands


Department of Neurology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands

Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, USA

M.D.F. and C.A. contributed equally.


Leiden University Medical Centre, Leiden, Netherlands. Electronic address:


From the Departments of Neurology (W.P.J.v.O., G.G.S., G.M.T, M.D.F.), Medical Statistics (E.W.v.Z.), and Endocrinology (O.M.D.), Leiden University Medical Center, Rotterdam; Department of Neurology (W.P.J.v.O.), OLVG Hospital, Amsterdam; Department of Neurology (G.G.S.), Elisabeth Tweesteden Hospital, Tilburg; and Department of Internal Medicine (A.M.), Division of Vascular Medicine and Pharmacology, Erasmus Medical Centre, Rotterdam, the Netherlands.

Department of Neurology, Leiden University Medical Center, Leiden


From the Department of Neurology (H.J.A.v.O., I.A.M., G.M.T., M.D.F., M.J.H.W.), Radiology (A.B., M.A.A.v.W.), and Clinical Epidemiology (A.A.), Leiden University Medical Center, the Netherlands; Department of Radiology (I.C.v.d.S., B.K.V.), Neurology (L.J.K.), and Julius Center for Health Sciences and Primary Care (A.A.), University Medical Center Utrecht, the Netherlands; Department of Neurology, St Antonius Hospital, Nieuwegein, the Netherlands (W.J.S.); and Department of Neurology, VU Medical Center, Amsterdam, the Netherlands (M.C.V.).

Department of Neurology, Leiden University Medical Center, The Netherlands


From the Department of Neurology (H.J.A.v.O., I.A.M., G.M.T., M.D.F., M.J.H.W.) and Department of Radiology (M.A.A.v.W.), Division of Image Processing (A.B.), Leiden University Medical Center; Departments of Radiology (I.C.v.d.S., B.K.V.) and Neurology (L.J.K.), Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (A.A.), and Julius Center for Health Sciences and Primary Care (A.A.), University Medical Center Utrecht; and Department of Neurology (J.A.V., W.S.), St Antonius Hospital, Nieuwegein, Netherlands.

Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands


Leiden University Medical Center, the Netherlands

Departments of Neurology and.


Department of Neurology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, The Netherlands


Department of Neurology, Leiden University Medical Center, Albinusdreef 2, PO Box 9600, 2300 RC, Leiden, The Netherlands


Department of Neurology, Leiden University Medical Centre, 2300 RC Leiden, Netherlands;

Neurology LUMC, Leiden, the Netherlands


Leiden University, The Netherlands.

From the Stroke and Neurovascular Regulation Laboratory, Department of Radiology (K.E.-H., J.H.L., I.Y., Z.Z., H.K.S., Y.Z., T.Q., C.W., M.A.M., C.A.), Athinoula A. Martinos Center for Biomedical Imaging and Transcript Imaging and NeuroRepair Laboratory, Division of Neuroradiology (C.H.L.), and Stroke Service and Neuroscience Intensive Care Unit, Department of Neurology (C.A.), Massachusetts General Hospital, Harvard Medical School, Charlestown; Department of Radiology, Affiliated Hospital of Guilin...


Leiden University Medical Center, Netherlands.

Departments of Neurology,


Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands.

Leiden Centre for Translational Neuroscience, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, Netherlands


Leiden University Medical Center Department of Neurology Leiden The Netherlands


Prominent publications by Michel Dominique Ferrari

KOL Index score: 20419

BACKGROUND: A substantial proportion of patients with migraine does not respond to, or cannot tolerate, oral preventive treatments. Erenumab is a novel CGRP-receptor antibody with preventive efficacy in migraine. We assessed its efficacy and tolerability in patients with episodic migraine in whom previous treatment with two-to-four migraine preventives had been unsuccessful.

METHODS: LIBERTY was a 12-week, double-blind, placebo-controlled randomised study at 59 sites in 16 countries. ...

Known for Episodic Migraine |  Erenumab Patients |  Efficacy Tolerability |  Preventive Treatments |  Greater Reduction
KOL Index score: 18213

BACKGROUND: Antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor have shown efficacy in the prevention of migraine attacks. We investigated the efficacy and tolerability of fremanezumab, a fully humanised CGRP antibody, in patients with migraine who had previously not responded to two to four classes of migraine preventive medications.

METHODS: The randomised, double-blind, placebo-controlled, parallel-group, phase 3b FOCUS trial was done at 104 sites (including ...

Known for Migraine Prevention |  Placebo Fremanezumab |  12 Weeks |  Baseline Monthly Average |  Preventive Treatment
KOL Index score: 17552

CONTEXT: Clinical series have suggested an increased prevalence of cerebral infarction and white matter lesions (WMLs) in migraine patients. It is not known whether these lesions are prevalent in the general migraine population.

OBJECTIVES: To compare the prevalence of brain infarcts and WMLs in migraine cases and controls from the general population and to identify migraine characteristics associated with these lesions.

DESIGN: Cross-sectional, prevalence study of population-based ...

Known for Brain Lesions |  Migraine Controls |  Aura Patients |  Attack Frequency |  Increased Prevalence
KOL Index score: 15632

BACKGROUND: Calcitonin gene-related peptide (CGRP) probably has a role in migraine pathophysiology, and antagonism of its receptors might provide treatment without the vasoconstrictor effects of triptans. We aimed to assess the clinical profile of MK-0974 (telcagepant), an orally bioavailable antagonist of CGRP receptor.

METHODS: In a randomised, parallel-treatment, placebo-controlled, double-blind, trial at 81 sites in the Europe and the USA, adults with migraine diagnosed by ...

Known for Peptide Receptor |  Calcitonin Gene |  Efficacy Telcagepant |  Zolmitriptan Placebo |  Pain Freedom
KOL Index score: 15302

OBJECTIVE: To compare the efficacy of oral rizatriptan 10 mg with oral doses of sumatriptan, naratriptan, and zolmitriptan on stringent outcome measures.

METHODS: Retrospective analysis of data from five randomized, placebo-controlled, double-masked clinical trials in which oral rizatriptan was directly compared with oral sumatriptan 100 mg (n = 772), 50 mg (n = 1116), 25 mg (n = 1183), naratriptan 2.5 mg (n = 413), and zolmitriptan 2.5 mg (n = 580) for the acute treatment of a moderate ...

Known for 2 Hours |  Patients Sumatriptan |  Oral Rizatriptan |  Naratriptan Zolmitriptan |  Pain Free
KOL Index score: 14585

BACKGROUND: The triptans, selective serotonin 5-HT(1B/1D) agonists, are very effective acute migraine drugs with a well- developed scientific rationale. Seven different triptans will soon be clinically available, making evidence-based selection guidelines necessary. Triptan trials have similar designs, facilitating meta-analysis; this will provide a foundation for using triptans in clinical practice.

METHOD: We asked pharmaceutical companies and the principal investigators of ...

Known for Oral Triptans |  53 Trials |  Serotonin 5 |  Acute Migraine Treatment |  Efficacy Consistency
KOL Index score: 14583

The triptans, selective serotonin 5-HT1B/1D agonists, are very effective acute migraine drugs. Soon, seven different triptans will be clinically available at 13 different oral doses, making evidence-based selection guidelines necessary. Triptan trials have similar designs, facilitating meta-analysis. We wished to provide an evidence-based foundation for using triptans in clinical practice, and to review the methodological issues surrounding triptan trials. We asked pharmaceutical ...

Known for Oral Triptans |  Efficacy Consistency |  Migraine Data |  Tolerability Sumatriptan |  53 Trials
KOL Index score: 13692

Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy in which brainstem spreading depolarization may play a pivotal role, as suggested by animal studies. However, patiotemporal details of spreading depolarization occurring in relation to fatal seizures have not been investigated. In addition, little is known about behavioural and neurophysiological features that may discriminate spontaneous fatal from non-fatal seizures. Transgenic mice carrying the missense ...

Known for Fatal Seizures |  Spreading Depolarization |  Cacna1as218l Mice |  Epilepsy Sudep |  Seizure Induced
KOL Index score: 13607

Rizatriptan (MK-462) is a potent 5HTID receptor agonist. This multicenter, double-blind, placebo-controlled, outpatient study investigated the clinical efficacy, safety, and tolerability of rizatriptan (2.5, 5, and 10 mg) as a function of dose for acute migraine. Patients with moderate or severe migraine (n = 417) were treated with placebo (n = 67), rizatriptan 2.5 mg (n = 75), 5 mg (n = 130), or rizatriptan 10 mg (n = 145). Headache severity, functional disability, and migraine symptoms ...

Known for Patients Rizatriptan |  Acute Treatment |  5 10 |  Pain Relief |  Adverse Experiences
KOL Index score: 13600

OBJECTIVE: To assess the involvement of the 19p13 familial hemiplegic migraine (FHM) locus in migraine with and without aura.

BACKGROUND: Migraine with and without aura are likely to be polygenetic multifactorial disorders. FHM is a rare dominantly inherited type of migraine with aura. In about 50% of families, FHM is caused by mutations in the P/Q-type calcium channel alpha(1A)-subunit (CACNA1A) gene on chromosome 19p13. The CACNA1A gene is thus a good candidate gene for "nonhemiplegic" ...

Known for Migraine Aura |  Cacna1a Gene |  Lod Score |  19p13 Locus |  Calcium Channels
KOL Index score: 13222

Trivial head trauma may be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval ("delayed cerebral edema"). Attacks of familial hemiplegic migraine (FHM) can be triggered by minor head trauma and are sometimes accompanied by coma. Mutations in the CACNA1A calcium channel subunit gene on chromosome 19 are associated with a wide spectrum of mutation-specific episodic and chronic neurological disorders, including FHM with or without coma. We ...

Known for Minor Head Trauma |  Delayed Cerebral Edema |  Calcium Channel |  Cacna1a Gene |  Fatal Coma
KOL Index score: 13175

Oral sumatriptan in a dose of 100 mg aborts about 60% of migraine attacks within 2 h, but the headache may recur within 24 h. We investigated: (i) the incidence of headache recurrence after oral sumatriptan (ii) whether a second tablet of sumatriptan at 2 h increases initial efficacy and/or (iii) prevents headache recurrence and (iv) whether a further tablet of sumatriptan treats headache recurrence. In a randomized parallel-group clinical trial, 1246 patients treated one to three ...

Known for Headache Recurrence |  Oral Sumatriptan |  Migraine Attacks |  Dose Incidence |  Placebo Patients
KOL Index score: 13143

Migraine is an episodic neurovascular disorder that is clinically divided into two main subtypes that are based on the absence or presence of an aura: migraine without aura (MO) and migraine with aura (MA). Current molecular genetic insight into the pathophysiology of migraine predominantly comes from studies of a rare monogenic subtype of migraine with aura called familial hemiplegic migraine (FHM). Three FHM genes have been identified, which all encode ion transporters, suggesting that ...

Known for Migraine Aura |  Molecular Genetics |  Human Pair |  Fhm Genes |  Common Forms
KOL Index score: 13114

BACKGROUND: The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca2+ channels (Ca(v)2.1), is associated with familial hemiplegic migraine-1. We investigated whether this gain-of-function mutation changed the structure and function of trigeminal neuron P2X3 receptors that are thought to be important contributors to migraine pain.

RESULTS: Using in vitro trigeminal sensory neurons of a mouse genetic model knockin for the CACNA1A R192Q mutation, we ...

Known for P2x3 Receptor |  Familial Hemiplegic |  Ganglion Neurons |  Mice Migraine |  Trigeminal Pain


Michel Dominique Ferrari: Influence Statistics

Sample of concepts for which Michel Dominique Ferrari is among the top experts in the world.
Concept World rank
depolarization death #1
frovatriptan 30 #1
25 attack frequency #1
hypothetical ideal #1
cortical responsivity migraine #1
members fhm #1
lower efficacy tolerability #1
attacks median time #1
nonresponse sumatriptan #1
migraineurs controls #1
migraine alcoholic beverages #1
tcbf cvr #1
female humans cacna1a #1
rizatriptan attacks #1
4 patients cch #1
recurrence sumatriptan #1
p005 thalamus #1
mass spectrometry migraine #1
dihydroergotamine female #1
r192q ganglia respect #1
chest symptoms patients #1
migraine familial #1
erenumab functional outcomes #1
headache recurrences #1
migraine central sensitization #1
migraine adjustment #1
100mg sumatriptan succinate #1
placebo ly334370 #1
considerations gps #1
ahc mutations #1
hppd participants migraine #1
codon mutations ea2 #1
fhm shm #1
66 patients 30 #1
study populations studies #1
aura efficacy #1
25 311c90 #1
transcranial diameter #1
homozygous cacna1as218l mice #1
cadasil slls #1
tnaa tcre #1
cerebellum s218l mice #1
cacna1as218l mutant mice #1
lp migraine attacks #1
carotid vasoconstriction serotonin #1
enkephalin platelets enkephalin #1
forearm fibf #1
epigenetic mechanisms migraine #1
patients headaches auras #1
secondary humans bta #1

Key People For Cluster Headache

Top KOLs in the world
Peter James Goadsby
cluster headache chronic migraine acute treatment
Arne May
cluster headache migraine patients chronic pain
Gennaro Bussone
cluster headache chronic migraine medication overuse
Anish Bahra
cluster headache brain cancer hemicrania continua
Karl Ekbom
cluster headache basilar artery lifetime prevalence
Gian Camillo Manzoni
cluster headache chronic migraine psychiatric comorbidity

Michel Dominique Ferrari:Expert Impact

Concepts for whichMichel Dominique Ferrarihas direct influence:Cluster headache,  Migraine patients,  Migraine attacks,  Familial hemiplegic migraine,  Migraine aura,  Hemiplegic migraine,  Acute treatment,  Subcortical infarcts.

Michel Dominique Ferrari:KOL impact

Concepts related to the work of other authors for whichfor which Michel Dominique Ferrari has influence:Cluster headache,  Migraine patients,  Acute treatment,  Chronic rhinosinusitis,  Nasal polyps,  Psychiatric disorders,  Ischemic stroke.



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Department of Neurology, Leiden University Medical Centre, Leiden, Netherlands | Department of Neurology, Leiden University Medical Center, Leiden, Netherlands | Department of Neurology, Leiden University Medical Centre, Leiden, the Netherlands | Dep

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