Frank H Gawin
Received November 15, 1999; revised December 7, 1999; accepted January 13, 2000. From the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los ...
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Frank H Gawin:Expert Impact
Concepts for whichFrank H Gawinhas direct influence:Cocaine abuse,Cocaine dependence,Cocaine abusers,Ambulatory cocaine abusers,Flupenthixol decanoate,Methamphetamine dependence,Cocaine craving,Cocaine addiction.
Frank H Gawin:KOL impact
Concepts related to the work of other authors for whichfor which Frank H Gawin has influence:Cocaine dependence,Substance abuse,Nucleus accumbens,Drug addiction,Gender differences,Psychiatric disorders.
KOL Resume for Frank H Gawin
Received November 15, 1999; revised December 7, 1999; accepted January 13, 2000. From the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California; Veterans Affairs Medical Center, West Los Angeles, California; Department of Psychiatry, Cornell University School of Medicine, New York, New York; Center for the Study of Addictions, UCLA School of Medicine; and Mood and Addiction Neuroscience Foundation, Los Angeles, California. Address correspondence to Dr. Kalechstein, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Room A7-372, Los Angeles, CA 90024; e-mail:, adk, ucla.edu
UCLA-VAMC Laboratory for the Study of Addictions, 90073, Los Angeles, California, USA
The Mood and Addiction Neuroscience Foundation, 7336 Santa Monica Blvd., #761 West Hollywood, CA-90046 USA
Mood and Addiction Neuroscience Foundation, West Los Angeles, CA 90025, USA.
University of California at Los Angeles, Los Angeles, CA, USA
From the Substance Abuse Treatment Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
Substance Abuse Treatment Unit, Department of Psychiatry, Yale University School of Medicine, New Haven; and Department of Psychiatry, University of California at Los Angeles.
Department of Psychiatry, University of California, Los Angeles 90024.
Substance Abuse Treatment Unit Departments of Psychiatry and Laboratory Medicine Yale University School of Medicine New Haven, Connecticut, 06519
Department of Psychiatry, Yale University School of Medicine, 06519, New Haven, CT, USA
Stimulant Abuse Treatment and Research Unit, Yale University School of Medicine, New Haven, Connecticut 06519.
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Yale University School of Medicine, New Haven, Connecticut.
Yale University, New Haven, Conn., USA
Departments of Psychiatry and Pharmacology, Yale University, School of Medicine, USA
Assistant Professor of Psychiatry, Yale University School of Medicine; Director of Cocaine Abuse Treatment Program, Addiction Prevention Treatment Foundation, New Haven, Connecticut
Yale University School of Medicine, Connecticut Mental Health Center and 34 Park Street, New Haven, Connecticut 06511, USA
Yale Medical School, USA
School of Medicine, Stanford University Medical Center
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Prominent publications by Frank H Gawin
BACKGROUND: At present, there is no consensus regarding effective treatment for cocaine abuse or the most productive roles for the two major forms of treatment, pharmacotherapy and psychotherapy. We conducted the first randomized clinical trial evaluating psychotherapy and pharmacotherapy, alone and in combination, as treatment for ambulatory cocaine abusers.
METHODS: One hundred thirty-nine subjects were assigned to one of four conditions offered over a 12-week abstinence initiation ...
|Known for Cocaine Abusers | Psychotherapy Pharmacotherapy | Relapse Prevention | 12 Weeks | Combination Treatment|
CONTEXT: Auricular acupuncture is widely used to treat cocaine addiction in the United States and Europe. However, evidence from controlled studies regarding this treatment's effectiveness has been inconsistent.
OBJECTIVE: To investigate the effectiveness of auricular acupuncture as a treatment for cocaine addiction.
DESIGN: Randomized, controlled, single-blind clinical trial conducted from November 1996 to April 1999.
SETTING: Six community-based clinics in the United States: 3 ...
|Known for Cocaine Addiction | Acupuncture Treatment | United States | Randomized Controlled | Ear Adult|
A Comparative Trial of Psychotherapies for Ambulatory Cocaine Abusers: Relapse Prevention and Interpersonal Psychotherapy
[ PUBLICATION ]
Despite the widespread use of psychotherapy as treatment for cocaine abuse, the effectiveness of psychotherapy has not been explored through clinical trials. Forty-two outpatients who met DSM-III criteria for cocaine abuse were randomly assigned to one of two forms of purely psychotherapeutic treatments of cocaine abuse, either relapse prevention (RPT) or interpersonal psychotherapy (IPT). Subjects assigned to relapse prevention were more likely than subjects in IPT to attain three or ...
|Known for Cocaine Abuse | Interpersonal Psychotherapy | Relapse Prevention | Treatment Subjects | Statistical Significance|
One-Year Follow-up of Psychotherapy and Pharmacotherapy for Cocaine Dependence: Delayed Emergence of Psychotherapy Effects
[ PUBLICATION ]
BACKGROUND: Neither the durability of brief ambulatory treatments for cocaine dependence nor the relative ability of psychotherapy vs pharmacotherapy to effect lasting change has been evaluated in well-controlled randomized trials.
METHODS: We conducted a 1-year naturalistic follow-up of 121 ambulatory cocaine abusers who underwent psychotherapy (cognitive-behavioral relapse prevention or clinical management) and pharmacotherapy (desipramine hydrochloride or placebo) in a 2 x 2 design. ...
|Known for Treatment Cocaine | Psychotherapy Pharmacotherapy | Year Follow | Cognitive Behavioral | Relapse Prevention|
Cocaine is becoming a major drug of abuse among the general population and among opiate addicts. Reports from the early 1970s found that most abusers were older Black males with some antisocial characteristics. Cocaine abuse at that time was reported by about 17% of opiate addicts seeking treatment and by 7 to 11% of ex-addicts on methadone maintenance. However, that rate increased dramatically during the 1970s, and in our 1980 study of 533 addicts we found that 74% of opiate addicts ...
|Known for Cocaine Abuse | Opioid Addicts | Methadone Maintenance | Addiction Severity | Antisocial Personality|
[ PUBLICATION ]
In a sample of 298 cocaine abusers seeking inpatient (n = 149) or outpatient (n = 149) treatment, rates of psychiatric disorders were determined by means of the Schedule for Affective Disorders and Research Diagnostic Criteria. Overall, 55.7% met current and 73.5% met lifetime criteria for a psychiatric disorder other than a substance use disorder. In common with previous reports from clinical samples of cocaine abusers, these overall rates were largely accounted for by major depression, ...
|Known for Cocaine Abusers | Psychiatric Diagnoses | Anxiety Disorders | Antisocial Personality | Drug Abuse|
[ PUBLICATION ]
We conducted a double-blind, random assignment, six-week comparison of desipramine hydrochloride (n = 24), lithium carbonate (n = 24), and placebo (n = 24) treatments for cocaine dependence. Subjects were 72 outpatient cocaine abusers who met DSM-III-R dependence criteria for cocaine but not for other substance abuse. Subjects in each treatment group were similar in history of cocaine and other substance abuse, cocaine craving, sociodemographics, and other psychiatric comorbidity. ...
|Known for Cocaine Abstinence | Substance Abuse | Psychiatric Comorbidity | Subjects Treatment | Desipramine Hydrochloride|
The objective of this study was to examine the association between psychiatric symptoms and methamphetamine dependence. A four-hour survey was administered to 1,580 arrestees sampled from the 14 most populous counties in California. The survey included items assessing demographic profile, history of substance dependence, and psychiatric symptomatology. In the 12 months prior to the assessment, methamphetamine-dependent individuals were more likely to report depressive symptoms and ...
|Known for Methamphetamine Dependence | Psychiatric Comorbidity | Depressive Symptoms | Dependent Individuals | Amphetamine Disorders|
The authors describe the strategies and goals of Klerman et al.'s Interpersonal Psychotherapy (IPT) as revised for application to cocaine abusers. IPT is a brief, individual psychological treatment suitable for use by experienced psychotherapists. The goals are reduction or cessation of cocaine use and development of more productive strategies for dealing with social and interpersonal problems associated with the onset and perpetuation of cocaine use. The treatment has four definitive ...
|Known for Interpersonal Psychotherapy | Cocaine Abusers | Clinical Trial | Lithium Carbonate | Psychiatric Disorders|
[ PUBLICATION ]
Abstinence symptoms and psychiatric diagnoses were evaluated in 30 chronic cocaine abusers. Structured diagnostic interviews were done within an experimental design intended to maximize differentiation of enduring symptoms from symptoms linked to binges of cocaine use. Longitudinal evaluations showed a three-phase sequence of post-cocaine abuse abstinence symptoms. Over half the sample also met criteria for ed 3 DSM-III, axis I psychiatric disorders. The findings present specific ...
|Known for Psychiatric Diagnosis | Abstinence Symptomatology | Cocaine Abusers | Depressive Disorder | Clinical Observations|
We conducted an open clinical trial of desipramine hydrochloride or lithium carbonate as adjuncts to psychotherapy in cocaine abusers. Subjects who were treated with desipramine hydrochloride showed marked decreases in a measure of cocaine craving after two to three weeks of treatment and became abstinent regardless of whether an affective disorder was also present. Lithium carbonate was effective only in cyclothymic subjects. Other subjects treated with lithium carbonate, as well as ...
|Known for Lithium Carbonate | Cocaine Abuse Treatment | Desipramine Hydrochloride | Pilot Trial | Affective Disorder|
[ PUBLICATION ]
Because current studies have small sample sizes and limited controls, firm conclusions or treatment recommendations cannot be made at present, but pharmacologic approaches probably have a place in the treatment of cocaine abuse. Pharmacologic treatments of cocaine abusers may relate to underlying psychiatric diagnoses. Cocaine abusers with adult attention deficit disorder appear to respond well to methylphenidate, but other cocaine abusers have increased cocaine craving when getting this ...
|Known for Cocaine Abuse | Pharmacologic Treatments | Psychiatric Disorders | Attention Deficit | Bipolar Disorder|
[ PUBLICATION ]
"Crack" cocaine abuse often produces severe cocaine dependence that is refractory to available pharmacological and outpatient psychotherapeutic treatments. We conducted two preliminary investigations evaluating the efficacy of flupenthixol decanoate, a depot xanthene requiring infrequent intramuscular administration, in the treatment of cocaine withdrawal. Ten outpatient crack cocaine smokers with poor prognoses were administered flupenthixol decanoate in an open-label, open-ended trial. ...
|Known for Flupenthixol Decanoate | Outpatient Treatment | Preliminary Report | Cocaine Craving | Substance Disorders|