Xiabin Chen: Influence Statistics

Xiabin Chen

Xiabin Chen

College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of ...

Xiabin Chen: Expert Impact

Concepts for which Xiabin Chen has direct influence: Cocaine hydrolase , Dendrobium officinale , Cocaine abuse , Cocaine overdose , Human butyrylcholinesterase , Clinical potential , Cocaine toxicity .

Xiabin Chen: KOL impact

Concepts related to the work of other authors for which for which Xiabin Chen has influence: Cocaine hydrolase , Tyrosine kinase , Lncrna hotair , Elemene injection , Human butyrylcholinesterase , Curcumae radix , Endophytic streptomyces .

KOL Resume for Xiabin Chen

Year
2021

College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.

Key Laboratory of Elemene Class Anti-Cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Holistic Integrative Pharmacy Institutes (HIPI), Hangzhou Normal University, Hangzhou, 311121, People’s Republic of China

2020

Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Holistic Integrative Pharmacy Institutes, School of Medicine, Hangzhou Normal University, Hangzhou, P. R. China

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, 40536, Lexington, Kentucky, USA

2019

Holistic Integrative Pharmacy Institutes (HIPI), School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China

Molecular Modeling and Biopharmaceutical Center and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA.

2018

School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China

Molecular Modeling and Biopharmaceutical Center (MMBC) and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, 40536, Lexington, KY, USA

2017

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536 USA

2016

Molecular Modeling and Biopharmaceutical Center, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, 40536, Lexington, KY, USA

2015

*Molecular Modeling and Biopharmaceutical Center and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, U.S.A.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536

2014

Molecular Modeling and Biopharmaceutical Center and Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky 40536, United States

2013

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, United States of America

Prominent publications by Xiabin Chen

KOL-Index: 8910 . INTRODUCTION: Tyrosine kinase 2 (Tyk2) is a non-receptor tyrosine-protein kinase, an enzyme that in humans is encoded by the TYK2 gene. Tyk2, together with three other family subtypes, namely, Jak1, Jak2, and Jak3, belong to the JAK family. Before 2014, far more publications and patents appeared in public domain attributing to the development of selective Jak2 and Jak3 inhibitors than ...
Known for Tyk2 Inhibitors | Patent Review | Potential Therapeutic Agents | Tyrosine Kinase
KOL-Index: 7298 . Cocaine is a widely abused drug without an FDA (Food and Drug Administration)-approved medication. It has been recognized that an ideal anti-cocaine medication would accelerate cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e. human BChE (butyrylcholinesterase)-catalysed hydrolysis. However, the native human ...
Known for Human Butyrylcholinesterase | Cocaine Hydrolase | Vivo Characterization | Catalytic Activity
KOL-Index: 7118 . Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a comparable enzyme was created and tested in a conspecific host. Thus, similar mutations ...
Known for Gene Transfer | Mouse Bche | Cocaine Hydrolase | Viral Vectors
KOL-Index: 6202 . Cocaine is one of the most addictive drugs without a U.S. Food and Drug Administration (FDA)-approved medication. Enzyme therapy using an efficient cocaine-metabolizing enzyme is recognized as the most promising approach to cocaine overdose treatment. The actual enzyme, known as RBP-8000, under current clinical development for cocaine overdose treatment is our previously designed ...
Known for Cocaine Metabolite | Enzyme Therapy | Human Butyrylcholinesterase | Overdose Treatment
KOL-Index: 6174 . Cocaine abuse is a world-wide public health and social problem without a US Food and Drug Administration-approved medication. An ideal anticocaine medication would accelerate cocaine metabolism, producing biologically inactive metabolites by administration of an efficient cocaine-specific exogenous enzyme. Our recent studies have led to the discovery of the desirable, highly efficient ...
Known for Cocaine Metabolism | Molecular Rats | Catalytic Efficiency | Single Dose
KOL-Index: 5853 . Development of a truly effective medication for treatment of cocaine abuse has been a grand challenge. There is no FDA-approved therapeutic agent specific for cocaine addiction or overdose. An enzyme therapy using an efficient cocaine-metabolizing enzyme could be a promising treatment strategy for cocaine overdose and addiction. One of our previously designed cocaine hydrolases (CocHs), ...
Known for Cocaine Toxicity | Coch1 Hsa | Clinical Potential | Enzyme Therapy
KOL-Index: 5597 . β-elemene is a noncytotoxic Class II antitumor drug extracted from the traditional Chinese medicine Curcuma wenyujin Y. H. Chen et C. Ling. β-elemene exerts its effects by inhibiting cell proliferation, arresting the cell cycle, inducing cell apoptosis, exerting antiangiogenesis and antimetastasis effects, reversing multiple-drug resistance (MDR), and enhancing the immune system. Elemene ...
Known for Cancer Therapy | Drug Delivery | Elemene Injection | Cell Cycle
KOL-Index: 4951 . Cocaine esterase (CocE) is known as the most efficient natural enzyme for cocaine hydrolysis. The major obstacle to the clinical application of wild-type CocE is the thermoinstability with a half-life of only ∼12 min at 37 °C. The previously designed T172R/G173Q mutant (denoted as enzyme E172-173) with an improved in vitro half-life of ∼6 h at 37 °C is currently in clinical trial Phase II ...
Known for 37 °c | Crosssubunit Disulfide Bonds | Pegylated E196 | Catalytic Efficiency
KOL-Index: 4400 . Cocaine abuse is a worldwide public health and social problem without a US Food and Drug Administration (FDA)-approved medication. Accelerating cocaine metabolism that produces biologically inactive metabolites by administration of an efficient cocaine hydrolase (CocH) has been recognized as a promising strategy for cocaine abuse treatment. However, the therapeutic effects of CocH are ...
Known for Cocaine Hydrolase | Recombinant Proteins | Protein Domains | Addiction Treatment
KOL-Index: 4320 . It is a grand challenge to develop a truly effective medication for treatment of cocaine overdose. The current available, practical emergence treatment for cocaine overdose includes administration of a benzodiazepine anticonvulsant agent (e.g. diazepam) and/or physical cooling with an aim to relieve the symptoms. The inherent difficulties of antagonizing physiological effects of drugs in ...
Known for Cocaine Overdose | Clinical Potential | Grand Challenge | Effective Medication
KOL-Index: 4278 . Human butyrylcholinesterase (BChE) is known as a safe and effective protein for detoxification of organophosphorus (OP) nerve agents. Its rationally designed mutants with considerably improved catalytic activity against cocaine, known as cocaine hydrolases (CocHs), are recognized as the most promising drug candidates for the treatment of cocaine abuse. However, it is a grand challenge to ...
Known for Cocaine Abuse | Proteins Recombinant | Promising Candidate | Human Butyrylcholinesterase
KOL-Index: 3965 . As new metabolic pathways of cocaine were recently identified, a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed to simultaneously determine cocaine and nine cocaine-related metabolites in whole blood samples. One-step solid phase extraction was used to extract all of the ten compounds and corresponding internal standards from blood samples. ...
Known for Simultaneous Determination | Liquid Chromatography | Tandem Mass | Multiple Reaction Monitoring
KOL-Index: 3775 . Carboxylesterase-1 (CE-1) is a crucial enzyme responsible for metabolism/activation/inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and organophosphorus nerve agents etc.) and also involved in many other biological processes. In this study, we performed extensive computational modeling and simulations to understand the fundamental reaction mechanism of cocaine ...
Known for Cocaine Hydrolysis | Drug Metabolism | Transition States | Catalytic Mechanism
KOL-Index: 3701 . Accelerating cocaine metabolism through enzymatic hydrolysis at cocaine benzoyl ester is recognized as a promising therapeutic approach for cocaine abuse treatment. Our more recently designed A199S/F227A/S287G/A328W/Y332G mutant of human BChE, denoted as cocaine hydrolase-3 (CocH3), has a considerably improved catalytic efficiency against cocaine and has been proven active in blocking ...
Known for Human Butyrylcholinesterase | Cocaine Hydrolase | Protein Engineering | Tandem Mass
KOL-Index: 3209 . Mouse butyrylcholinesterase (mBChE) and an mBChE-based cocaine hydrolase (mCocH, i.e. the A¹⁹⁹S/S²²⁷A/S²⁸⁷G/A³²⁸W/Y³³²G mutant) have been characterized for their catalytic activities against cocaine, i.e. naturally occurring (-)-cocaine, in comparison with the corresponding human BChE (hBChE) and an hBChE-based cocaine hydrolase (hCocH, i.e. the A¹⁹⁹S/F²²⁷A/S²⁸⁷G/A³²⁸W/Y³³²G mutant). It ...
Known for Cocaine Hydrolase | Catalytic Efficiency | Human Bche | Mutant Proteins

Key People For Cocaine Hydrolase

Top KOLs in the world
#1
Stephen W Brimijoin
axonal transport cocaine hydrolase gene transfer
#2
Oksana Lockridge
human butyrylcholinesterase mass spectrometry active site
#3
Yuan Ping Pang
hydroxamic acids crystal structures small molecules
#4
Hong Sun
cocaine hydrolase milligram tissue molecular modeling
#5
Yang Gao
cocaine hydrolase gene transfer human butyrylcholinesterase
#6
Chang‐Guo Zhan
human butyrylcholinesterase energy barriers molecular dynamics

College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, China; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines; Engineering Laboratory of Development and Application of Traditional Chinese Medicines; Collaborative