Todd Lencz

Todd Lencz

The Zucker-Hillside Hospital, Department Of Psychiatry Research 75-59 263rd Street, Glen Oaks, Ny, 11004, United States

Direct Impact

Concepts for which Todd Lencz has direct influence:

cognitive function
bipolar disorder
weight gain
first-episode schizophrenia
ashkenazi jewish
schizotypal personality
gray matter

External impact

Concepts related to the work of other authors for which Todd Lencz has influence:

bipolar disorder
infant head circumference
genetic effects
dopamine synthesis capacity
first-episode psychosis
ancestral tracks
tardive dyskinesia

Prominent publications by Todd Lencz

KOL-Index: 265 Evidence from both GWAS and clinical observation has suggested that certain psychiatric, metabolic, and autoimmune diseases are heterogeneous, comprising multiple subtypes with distinct genomic etiologies and Polygenic Risk Scores (PRS). However, the presence of subtypes within many phenotypes is frequently unknown. We present CLiP (Correlated Liability Predictors), a method to detect ...
Known for
Mega | Clip-X | Ascertainment | Predictors Method
KOL-Index: 173 Cognitive flexibility is a critical component of executive function and is strongly influenced by genetic factors. We conducted a genome-wide association study of cognitive flexibility (as measured by perseverative errors on the Wisconsin Card Sorting Test) in two sets of African American (AA) and European American (EA) subjects (Yale-Penn-1: 1,411 AAs/949 EAs; Yale-Penn-2: 1,178 AAs/1,335 ...
Known for
Cognitive Function-Associated Snps | Infant Head Circumference | Signalosome Ubiquitin-Specific Peptidase | -Linked Usp9x Subnetwork
KOL-Index: 122 The identification of rare variants associated with schizophrenia has proven challenging due to genetic heterogeneity, which is reduced in founder populations. In samples from the Ashkenazi Jewish population, we report that schizophrenia cases had a greater frequency of novel missense or loss of function (MisLoF) ultra-rare variants (URVs) compared to controls, and the MisLoF URV burden was ...
Known for
Missense | Genetic Heterogeneity | Founder Implicate Cadherins | Cadherin Gene Set
KOL-Index: 104 General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic ...
Known for
Variables | Gene-Based | 148 Genetic Loci | Prominent Stable Trait
KOL-Index: 87 Abstract Cognitive deficits are known to be related to most forms of psychopathology. Here, we perform local genetic correlation analysis as a means of identifying independent segments of the genome that show biologically interpretable pleiotropic associations between cognitive dimensions and psychopathology. We identified collective segments of the genome, which we call “meta-loci”, that ...
Known for
Segments Genome | Gca Relevant | Gene Sets
KOL-Index: 73 Abstract While antipsychotic medications have been utilized for decades, many patients experiencing psychosis do not demonstrate a satisfactory positive symptom response, even in the first episode of illness. Resting state functional magnetic resonance imaging (rs-fMRI) has increasingly been studied as a potential biomarker of antipsychotic treatment response, but studies to date remain ...
Known for
Cortex Prefrontal | Regions Responders | Psychosis Antipsychotic | Aripiprazole
KOL-Index: 63 Copy number variants (CNVs) are risk factors in neurodevelopmental disorders, including autism, epilepsy, intellectual disability (ID) and schizophrenia. Childhood onset schizophrenia (COS), defined as onset before the age of 13 years, is a rare and severe form of the disorder, with more striking array of prepsychotic developmental disorders and abnormalities in brain development. Because of ...
Known for
Well-Known Phenotypic Variability | Highest Rate | Well-Documented | Disease-Related Cnvs
KOL-Index: 61 Abstract Polygenic risk scores (PRSs) have been offered since 2019 to screen in vitro fertilization embryos for genetic liability to adult diseases, despite a lack of comprehensive modeling of expected outcomes. Here we predict, based on the liability threshold model, the expected reduction in complex disease risk following polygenic embryo screening for a single disease. Our main finding is ...
Known for
Sufficient Number | Potential Utility | “virtual” Couples | Theoretical Predictions
KOL-Index: 53 Abstract Nearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS) 1–4 . However, the impact of rare coding variants on depression remains poorly understood. Here, we present the largest to date exome analysis of depression based on 320,356 UK Biobank participants. We show that the burden of rare disruptive coding variants in ...
Known for
30 Genes | Fdr | Developmental Psychiatric Disorders | Blood-Brain Barrier Glucose Transporter
KOL-Index: 50 Susceptibility to schizophrenia is inversely correlated with general cognitive ability at both the phenotypic and the genetic level. Paradoxically, a modest but consistent positive genetic correlation has been reported between schizophrenia and educational attainment, despite the strong positive genetic correlation between cognitive ability and educational attainment. Here we leverage ...
Known for
Correlation Cognitive | Early Neurodevelopmental Synaptic Pathways | Schizophrenia Pleiotropic | Loci Identified

The Zucker-Hillside Hospital, Department of Psychiatry Research 75-59 263rd Street, Glen Oaks, NY, 11004, United States

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