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  • Jay A Nadel

    Prominent publications by Jay A Nadel

    KOL Index score: 16618

    Mucus hypersecretion is a prominent manifestation in patients with chronic inflammatory airway diseases and contributes to their morbidity and mortality by plugging airways and causing recurrent infections. Human neutrophil elastase (HNE) exists in high concentrations (1-20 microM) in airway secretions of these patients and induces overproduction of MUC5AC mucin, a major component of airway mucus. Previous studies showed that HNE induces MUC5AC mucin production involving reactive oxygen ...

    Also Ranks for: Muc5ac Mucin |  human airway |  oxygen species |  neutrophil elastase |  protein kinase
    KOL Index score: 16413

    Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death in the U.S. Because cigarette smoking is so importantly implicated in the pathogenesis of COPD and because mucus hypersecretion plays such an important role in COPD, understanding of the mechanisms of smoking-induced mucus hypersecretion could lead to new therapies for COPD. Cigarette smoke causes mucin overproduction via EGF receptor (EGFR) in airway epithelial cells, but the cellular mechanism remains ...

    Also Ranks for: Cigarette Smoke |  tumor necrosis factor |  human airway epithelial |  mucin overproduction |  ncih292 cells
    KOL Index score: 14911

    Mucus hypersecretion is a prominent manifestation in patients with chronic inflammatory airway diseases. MUC5AC mucin is a major component of airway mucus, and its expression is modulated by a TNF-alpha-converting enzyme (TACE)-EGF receptor pathway that can be activated by reactive oxygen species (ROS). Dual oxidase 1 (Duox1), a homologue of glycoprotein p91(phox), is expressed in airway epithelium and generates ROS. We hypothesize that Duox1 activates TACE, cleaving pro-TGF-alpha into ...

    Also Ranks for: Mucin Expression |  dual oxidase |  epithelial cells |  human airway |  tace activation
    KOL Index score: 14756

    Ectodomain shedding of epidermal growth factor receptor (EGFR) ligands [e.g., transforming growth factor type alpha (TGF-alpha)] and EGFR phosphorylation are implicated in mucin production in airway epithelial cells. Tumor necrosis factor alpha-converting enzyme (TACE) is reported to cleave precursor of TGF-alpha, with release of soluble mature TGF-alpha in various epithelial tissues. We hypothesized that TACE increases the shedding of TGF-alpha, resulting in EGFR phosphorylation and ...

    Also Ranks for: Mucin Expression |  egfr phosphorylation |  airway epithelial |  tumor necrosis |  converting enzyme
    KOL Index score: 14288

    Globule leukocytes in the epithelium of the rat trachea may be counterparts of mucosal mast cells that are located in the gastrointestinal tract. If they are indeed similar to mucosal mast cells, globule leukocytes would be expected to decrease in number in rats treated with dexamethasone but not in rats treated with compound 48/80, an agent which causes non-antigenic degranulation of connective tissue mast cells. In this study, we determined the number and compared the distribution of ...

    Also Ranks for: Mast Cells |  globule leukocytes |  rat trachea |  48 80 |  connective tissue
    KOL Index score: 14226

    Oxidative stress has been implicated in the pathogenesis of inflammatory diseases of airways. Here we show that oxidative stress causes ligand-independent activation of epidermal growth factor receptors (EGFR) and subsequent activation of mitogen-activated protein kinase kinase (MEK)-p44/42 mitogen-activated protein kinase (p44/42mapk), resulting in mucin synthesis in NCI-H292 cells. Exogenous hydrogen peroxide and neutrophils activated by IL-8, FMLP, or TNF-alpha increased EGFR tyrosine ...

    Also Ranks for: Mucin Synthesis |  oxidative stress |  growth factor |  protein kinase |  mitogen activated
    KOL Index score: 14026

    We examined the effects of acute exposure to cigarette smoke on the airway responses to substance P in anesthetized guinea pigs and on the activity of airway neutral endopeptidase (NEP). After exposure to air or to cigarette smoke we measured the change in total pulmonary resistance (RL) induced by increasing concentrations of aerosolized substance P in the absence or presence of the NEP inhibitor phosphoramidon. In the absence of phosphramidon the bronchoconstrictor responses to ...

    Also Ranks for: Cigarette Smoke |  free radicals |  guinea pig |  neutral endopeptidase |  nep activity
    KOL Index score: 13706

    The tachykinin, neurokinin A (NKA), contracts guinea-pig airways both in vitro and in vivo, preferentially activating smooth muscle NK(2) receptors, although smooth muscle NK(1) receptors may also contribute. In vitro evidence suggests that NKA activates epithelial NK(1) receptors, inducing the release of nitric oxide (NO) and subsequent smooth muscle relaxation. A number of selective NK(1) receptor agonists have been reported to activate both smooth muscle and epithelial NK(1) ...

    Also Ranks for: Nitric Oxide |  nk1 receptor |  bronchoconstriction induced |  smooth muscle |  neurokinin nka
    KOL Index score: 13668

    Toll-like receptors (TLRs) are critical for the recognition of inhaled pathogens that deposit on the airway epithelial surface. The epithelial response to pathogens includes signaling cascades that activate the EGF receptor (EGFR). We hypothesized that TLRs communicate with EGFR via epithelial signaling to produce certain innate immune responses. Airway epithelium expresses the highest levels of TLR2, TLR3, TLR5, and TLR6, and here we found that ligands for these TLRs increased IL-8 and ...

    Also Ranks for: Airway Epithelium |  signaling cascade |  innate immune |  egfr epithelial cell |  growth factor tgfalpha
    KOL Index score: 12692

    Eosinophil recruitment and mucus hypersecretion are characteristic of asthmatic airway inflammation, but eosinophils have not been shown to induce mucin production. Because an epidermal growth factor receptor (EGFR) cascade induces MUC5AC mucin in airways, and because EGFR is up-regulated in asthmatic airways, we examined the effect of eosinophils on MUC5AC mucin production in NCI-H292 cells (a human airway epithelial cell line that produces mucins). Eosinophils were isolated from the ...

    Also Ranks for: Mucin Production |  epithelial cells |  growth factor |  human eosinophils |  egfr activation
    KOL Index score: 11988

    Viruses suppress host responses to increase infection, and understanding these mechanisms has provided insights into cellular signaling and led to novel therapies. Many viruses (e.g., Influenza virus, Rhinovirus [RV], Cytomegalovirus, Epstein-Barr virus, and Hepatitis C virus) activate epithelial epidermal growth factor receptor (EGFR), a tyrosine kinase receptor, but the role of EGFR in viral pathogenesis is not clear. Interferon (IFN) signaling is a critical innate antiviral host ...

    Also Ranks for: Egfr Activation |  respiratory virus |  airway epithelium |  antiviral defense |  viral infection
    KOL Index score: 11923

    Goblet-cell hyperplasia is a critical pathological feature in hypersecretory diseases of airways. However, the underlying mechanisms are unknown, and no effective therapy exists. Here we show that stimulation of epidermal growth factor receptors (EGF-R) by its ligands, EGF and transforming growth factor alpha (TGFalpha), causes MUC5AC expression in airway epithelial cells both in in vitro and in vivo. We found that a MUC5AC-inducing epithelial cell line, NCI-H292, expresses EGF-R ...

    Also Ranks for: Epidermal Growth |  mucin production |  goblet cells |  egfr ligands |  egf expression


    Jay A Nadel: Influence Statistics

    Sample of concepts for which Jay A Nadel is among the top experts in the world.
    Concept World rank
    endogenously produced ccl20 #1
    mucins clearance #1
    cp99994 sraw #1
    concentration 90 breaths #1
    efs phosphoramidon #1
    induced hyperresponsiveness substance #1
    plug instillation #1
    ici pr3 concentration #1
    clearance tantalum #1
    trachea neutral #1
    coldair inhalation #1
    cftr172 production #1
    egfr epithelial cell #1
    neutral endopeptidase modulation #1
    cough saline challenge #1
    cent 10 breaths #1
    airexposed animals presence #1
    glucocorticoids nep #1
    trachea animals #1
    infection potentiates #1
    pseudomonas supernatant expression #1
    fmlp regranulation #1
    ccr6 ncih292 cells #1
    rat airways #1
    hne ici #1
    sulfated products #1
    bradykinin vascular extravasation #1
    muc5ac production proteolytic #1
    induces mucin #1
    neutrophil proteases role #1
    absence bronchoconstrictor responses #1
    bronchiectasis secretagogue activity #1
    nasal response patients #1
    forskolin pde #1
    trachea nep activity #1
    control mucus secretion #1
    presence phosphoramidon #1
    blue periodic #1
    substance mucus secretion #1
    mucin production neutrophils #1
    icam1822 peptide #1
    exercise 6 subjects #1
    endogenous nep #1
    camp emax #1
    enzyme tachykinins #1
    mucus parasympathetic #1
    synthesis nci #1
    tiopronin trachea #1
    mucin production cells #1
    causing bronchoconstriction #1

    Key People For Cold Air

    Top KOLs in the world
    Edward R McFadden
    normal subjects acute asthma cold air
    Roland H Ingram
    normal subjects density dependence cold air
    Jay A Nadel
    cold air plasma extravasation neurogenic inflammation
    Sandra Doreen Anderson
    inhaled mannitol asthmatic subjects sodium cromoglycate
    E Chandler Deal
    ventral surface intermediate area cold air
    Kjell Åke Larsson
    swine dust bronchial responsiveness alveolar macrophages
    Select a search phrase   cold air

    Jay A Nadel:Expert Impact

    Concepts for whichJay A Nadelhas direct influence:Cold air,  Plasma extravasation,  Neurogenic inflammation,  Epithelial cells,  Mast cells,  Neutral endopeptidase,  Bronchial reactivity,  Smooth muscle.

    Jay A Nadel:KOL impact

    Concepts related to the work of other authors for whichfor which Jay A Nadel has influence:Cystic fibrosis,  Epithelial cells,  Guinea pigs,  Airway inflammation,  Smooth muscle,  Cigarette smoke,  Nitric oxide.



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    Division of Pulmonary, Critical Care, Allergy & Sleep Medicine, University of California San Francisco, San Francisco, California, USA | Cardiovascular Research Institute and Departments of Medicine (Pulmonary Division), Physiology, and Radiology, Un