• Disease
  • Otitis
  • Otitis Media
  • Stephen I Wasserman

    Prominent publications by Stephen I Wasserman

    KOL Index score: 13613

    BACKGROUND: Some studies suggest that patients with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those homozygous for glycine (B16 Gly/Gly). We investigated whether there is a genotype-specific response to treatment with a longacting beta2 agonist in combination with inhaled corticosteroid.

    METHODS: In this multicentre, ...

    Also Ranks for: Inhaled Corticosteroid |  arg gly |  adrenergic receptor |  treatment salmeterol |  longacting β2
    KOL Index score: 12635

    To assess whether mast cell and eosinophil (EOS) degranulation occurs in the airway of subjects with moderately symptomatic asthma, we have measured levels of preformed mast cell-derived mediators (histamine and tryptase) and EOS-derived mediators (major basic protein and EOS-derived neurotoxin) in bronchoalveolar lavage fluid (BALF) obtained from patients with symptomatic (N = 14) and asymptomatic asthma (N = 9) and patients without asthma (N = 6). Both the FEV1 (1.52 +/- 0.33 L:55% +/- ...

    Also Ranks for: Mast Cell |  patients asthma |  eosinophil degranulation |  histamine release |  major basic protein
    KOL Index score: 12493

    BACKGROUND: Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled asthma are needed.

    METHODS: In a three-way, double-blind, triple-dummy crossover trial involving 210 patients with asthma, we evaluated the addition of tiotropium bromide (a long-acting anticholinergic agent approved for the treatment of chronic obstructive pulmonary disease but not ...

    Also Ranks for: Uncontrolled Asthma |  tiotropium bromide |  inhaled glucocorticoid |  p0001 addition |  doubling dose
    KOL Index score: 12367

    To determine whether cytokines are generated in vivo in subjects with asthma, we have measured cytokine levels (tumor necrosis factor [TNF], granulocyte-macrophage-colony-stimulating factor [GM-CSF], interleukin [IL]-1 alpha, IL-1 beta, IL-2, IL-4, and IL-6) in the airways of subjects with symptomatic (N = 24) and asymptomatic (N = 9) asthma with immunoassays (GM-CSF, IL-1 alpha, IL-1 beta, IL-2, and IL-4) or bioassays (TNF and IL-6) and the polymerase chain reaction (IL-1 beta and TNF). ...

    Also Ranks for: Symptomatic Asthma |  il1 beta |  levels tnf |  polymerase chain reaction |  balf patients
    KOL Index score: 11447

    The density and species prevalence of dust mites were determined at various times over a 5-year-period in 252 homes of dust mite sensitive people with asthma who lived in eight geographic areas of the United States (Cincinnati, Ohio; New Orleans, La.; Memphis, Tenn.; Galveston, Texas; Greenville, N.C.; Delray Beach, Fla.; San Diego and Los Angeles, Calif.). The most common dust mites found in the homes were Dermatophagoides farinae (DF), D. pteronyssinus (DP), Euroglyphus maynei (EM), ...

    Also Ranks for: United States |  dust mites |  new orleans |  geographic areas |  san diego
    KOL Index score: 11227

    CONTEXT: No consensus exists for adjusting inhaled corticosteroid therapy in patients with asthma. Approaches include adjustment at outpatient visits guided by physician assessment of asthma control (symptoms, rescue therapy, pulmonary function), based on exhaled nitric oxide, or on a day-to-day basis guided by symptoms.

    OBJECTIVE: To determine if adjustment of inhaled corticosteroid therapy based on exhaled nitric oxide or day-to-day symptoms is superior to guideline-informed, physician ...

    Also Ranks for: Inhaled Corticosteroid |  controlled trial |  adults asthma |  nitric oxide |  based adjustment
    KOL Index score: 10779

    Asthma has been recognized to consist of hyperresponsive airways and cellular inflammation. Allergen bronchoprovocation (BPC) may define the early (EAR) and late-phase asthmatic response (LAR). The LAR has now been associated with increased nonspecific airway hyperresponsiveness and cellular inflammation consisting of neutrophils and eosinophils. We used BPC to demonstrate EAR and LAR in 12 subjects with seasonal allergic asthma. One normal subject and one subject with asthma who had ...

    Also Ranks for: Chemotactic Activity |  eca nca |  eosinophils neutrophils |  ear lar |  asthmatic response
    KOL Index score: 10705

    Fluticasone propionate (FP) administered via metered-dose inhaler is a potent corticosteroid effective in the treatment of asthma. To evaluate the efficacy and safety of FP powder administered via a breath-activated inhaler (Diskhaler), a multicenter, double-blind, randomized, placebo-controlled, parallel-group study was conducted in adolescent and adult patients (n = 331) with mild-to-moderate asthma previously treated with beta 2-agonist therapy alone. Patients received FP powder 50, ...

    Also Ranks for: Treatment Asthma |  fluticasone propionate powder |  fp placebo |  inhalation adolescent adrenergic |  greater improvements
    KOL Index score: 10535

    BACKGROUND: Recent meta-analyses of genome-wide association studies in general populations of European descent have identified 28 loci for lung function.

    OBJECTIVE: We sought to identify novel lung function loci specifically for asthma and to confirm lung function loci identified in general populations.

    METHODS: Genome-wide association studies of lung function (percent predicted FEV1 [ppFEV1], percent predicted forced vital capacity, and FEV1/forced vital capacity ratio) were performed ...

    Also Ranks for: Lung Function |  pathway genes |  asthmatic patients |  asthma susceptibility |  genomewide association studies
    KOL Index score: 10438

    Human nasal polyps from three ragweed-sensitive atopic patients released three chemical mediators: histamine, slow reacting substance of anaphylaxis, and eosinophil chemotactic factor of anaphylaxis on challenge with ragweed antigen. Polyps from four non-ragweed-sensitive subjects passively sensitized in vitro released the same chemical mediators. In a patient with chronic sinusitis and one with cystic fibrosis, dibutyryl cyclic adenosine 3′,5′-monophosphate and the beta adrenergic agent ...

    Also Ranks for: Chemical Mediators |  human nasal polyps |  immunologic release |  chronic sinusitis |  cystic fibrosis
    KOL Index score: 9634

    BACKGROUND: Improvement in lung function after macrolide antibiotic therapy has been attributed to reduction in bronchial infection by specific bacteria. However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present.

    OBJECTIVE: We sought to determine whether relationships exist between the composition of the airway bacterial microbiota and clinical features of asthma using ...

    Also Ranks for: Airway Microbiota |  bronchial hyperresponsiveness |  controlled asthma |  relative abundance |  bacterial diversity
    KOL Index score: 9541

    1-Alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase catalyzes the conversion of biologically inactive lysophospholipid to bioactive platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, PAF) by an acetylation reaction. The activity of this enzyme in eosinophils isolated from patients with eosinophilia is stimulated (up to 4-fold) in a dose-, time-, and Ca2+/Mg2+-dependent manner after exposure to the eosinophil chemotactic factor of anaphylaxis ...

    Also Ranks for: Paf Eosinophils |  eosinophil chemotaxis |  activating factor |  activity enzyme |  ionophore a23187
    KOL Index score: 9419

    BACKGROUND: Tiotropium has activity as an asthma controller. However, predictors of a positive response to tiotropium have not been described.

    OBJECTIVE: We sought to describe individual and differential responses of asthmatic patients to salmeterol and tiotropium when added to an inhaled corticosteroid, as well as predictors of a positive clinical response.

    METHODS: Data from the double-blind, 3-way, crossover National Heart, Lung, and Blood Institute's Asthma Clinical Research ...

    Also Ranks for: Tiotropium Salmeterol |  positive response |  inhaled corticosteroid |  agents asthma |  bromide treatment


    Stephen I Wasserman: Influence Statistics

    Sample of concepts for which Stephen I Wasserman is among the top experts in the world.
    Concept World rank
    vitro leukocyte migration #1
    involvement h1 receptor #1
    enzymes mast cell #1
    release receptor recognition #1
    pathogenesis exerciseinduced asthma #1
    substances leukocyte migration #1
    exerciseinduced asthma mediators #1
    cellular inflammation neutrophils #1
    regular treatment albuterol #1
    occasions cytarabine #1
    chloride secretion histamine #1
    analogs neca #1
    education immunotherapy #1
    frank austen #1
    t84 publication adenosine #1
    release generation #1
    case messengers #1
    death allergic events #1
    histamine t84 cell #1
    chemotaxis cold #1
    csf local accumulation #1
    aminophylline exposure #1
    infection typeable #1
    acu syndromes doxepin #1
    mucosa kinetics cell #1
    identification pf4 #1
    greater 3 minutes #1
    culture cell chlorides #1
    publication chemotaxis csf #1
    arac anaphylaxis cytarabine #1
    nonsteroidal nedocromil quinolones #1
    blood urticaria vibration #1
    1 10 20 #1
    csf meningitic csf #1
    immunoglobulin occasions #1
    coalescent wheal #1
    eca 28 #1
    alteration initial studies #1
    sides apical addition #1
    ecfa c5a #1
    longterm action aminophylline #1
    positive cstts #1
    chapter pathologic events #1
    morning chest tightness #1
    enzyme eosinophils #1

    Key People For Otitis Media

    Top KOLs in the world
    Charles D Bluestone
    otitis media eustachian tube middle ear
    Jerome O Klein
    otitis media middle ear newborn infant
    Jack L Paradise
    otitis media tympanostomy tubes cleft palate
    Richard M Rosenfeld
    otitis media clinical practice guideline cerumen impaction
    middle ear otitis media new zealand
    Bernard A Rosner
    breast cancer blood pressure nurses health study

    Stephen I Wasserman:Expert Impact

    Concepts for whichStephen I Wassermanhas direct influence:Otitis media,  Mast cells,  Mast cell,  Cold urticaria,  Middle ear,  Nedocromil sodium,  Animal ear,  Asthma control.

    Stephen I Wasserman:KOL impact

    Concepts related to the work of other authors for whichfor which Stephen I Wasserman has influence:Mast cells,  Otitis media,  Severe asthma,  Histamine release,  Middle ear,  Airway inflammation,  Nedocromil sodium.



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    Department of Medicine, University of California San Diego, USA | Medicine/Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, California, USA | Department of Medicine, Division of Rheumatology, Allergy and Immunology