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    • Edward Luciano Giovannucci">
    • Edward Luciano Giovannucci">

      Edward Luciano Giovannucci">

      Department of Nutrition, Harvard T.H. School of Public Health, Boston, MA, USA 02115 | Harvard T.H. Chan School of Public Health, Boston, MA, United States | Department of ...



      KOL Resume for Edward Luciano Giovannucci">


      Department of Nutrition, Harvard T.H. School of Public Health, Boston, MA, USA 02115

      Harvard T.H. Chan School of Public Health, Boston, MA, United States



      Edward Luciano Giovannucci">: Influence Statistics

      Sample of concepts for which Edward Luciano Giovannucci"> is among the top experts in the world.
      Concept World rank
      fruit leukocyte mtdnacn #1
      activity prostate #1
      rs2855798 #1
      95 diverticulitis #1
      edih empirical lifestyle #1
      mortality proximal colon #1
      95 041 #1
      dietvegetables #1
      risk pancreatic #1
      17086 #1
      calculated cox #1
      week association #1
      physical activity pca #1
      risk btc #1
      adherence cancer #1
      lower crc #1
      95 diverticular bleeding #1
      95 dietary insulin #1
      tablets week #1
      neoplasms diabetes #1
      patients 25hydroxyvitamin sufficiency #1
      intake survival #1
      mass physical #1
      41458 #1
      ageadjusted #1
      marine ω3 #1
      tnfαr2 #1
      genes vitamin pathway #1
      crcspecific mortality 95 #1
      rs9461741 #1
      ptrend rectal cancer #1
      dietary intake adolescence #1
      heterogeneity052 #1
      lower endoscopy #1
      pheterogeneity063conclusions #1
      studies follow #1
      biomarkers involved #1
      biomarker correlation network #1
      bph trend #1
      shbg levels associations #1
      ci12–267 #1
      lower concentrations igfbp1 #1
      tea mvrr #1
      increased risk participants #1
      selenium antioxidant mixtures #1
      colorectal cancer let7a #1
      plant fat 95 #1
      31925 #1
      mtdnacn crc #1
      46398 #1


      Prominent publications by Edward Luciano Giovannucci">

      KOL-Index: 21618

      BACKGROUND: Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time.

      METHODS: We estimated deaths and disability-adjusted life years (DALYs; ...

      Known for Global Burden | 21 Regions | Comparative Risk Assessment | 67 Risk Factors | Leading Risk
      KOL-Index: 17947

      A cyclin-dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A methylation or loss of CDKN2A (p16) expression independent of CIMP status remains uncertain. Using a database of 902 colorectal cancers in 2 independent cohort studies (the Nurses' Health Study and the ...

      Known for Promoter Methylation | Cdkn2a P16 | Colorectal Cancer | Cellular Senescence | Tumor Suppressor
      KOL-Index: 17920

      BACKGROUND: Studies suggest that tooth loss and periodontal disease might increase the risk of developing various cancers; however, smoking might have confounded the reported associations. We aimed to assess whether periodontal disease or tooth loss is associated with cancer risk.

      METHODS: The analysis was done in a prospective study (the Health Professionals Follow-Up Study [HPFS]), which was initiated in 1986 when US male health professionals aged 40-75 years responded to ...

      Known for Periodontal Disease | Cancer Risk | Tooth Loss | Male Health Professionals | Prospective Cohort Study
      KOL-Index: 17701

      BACKGROUND: In several epidemiologic investigations, folate intake has appeared to reduce the elevated risk of breast cancer associated with moderate alcohol consumption. However, data relating plasma folate levels to breast cancer risk are sparse. We investigated the association between plasma folate and other vitamins with breast cancer in a prospective, nested case-control study.

      METHODS: Blood samples were obtained during 1989 and 1990 from 32 826 women in the Nurses' Health Study ...

      Known for Plasma Folate | Vitamin B12 | Breast Cancer | Lowest Quintile | Homocysteine Risk
      KOL-Index: 17668

      OBJECTIVE: Sex steroid hormones are thought to contribute to the growth, differentiation, and progression of prostate cancer. We investigated plasma levels of sex steroid hormones and length of the androgen receptor gene CAG repeat in relation to incident prostate cancer diagnosed in the prostate-specific antigen (PSA) era.

      METHODS: Using a nested case-control design, we included 460 prostate cancer cases diagnosed after providing a blood specimen in 1993 but before February 1998 among ...

      Known for Prostate Cancer | Sex Steroid Hormones | Cag Repeat | Androgen Receptor | Specific Antigen
      KOL-Index: 17169

      IMPORTANCE: Evidence indicates a complex link between gut microbiome, immunity, and intestinal tumorigenesis. To target the microbiota and immunity for colorectal cancer prevention and therapy, a better understanding of the relationship between microorganisms and immune cells in the tumor microenvironment is needed. Experimental evidence suggests that Fusobacterium nucleatum may promote colonic neoplasia development by downregulating antitumor T cell-mediated adaptive ...

      Known for Colorectal Carcinoma | Fusobacterium Nucleatum | Tumor Tissue | Cd3 Cells | Adaptive Immunity
      KOL-Index: 16889

      OBJECTIVE: Given the importance of inflammation in acute kidney injury and the relationship between vitamin D and inflammation, we sought to elucidate the effect of vitamin D on acute kidney injury. We hypothesized that deficiency in 25-hydroxyvitamin D prior to hospital admission would be associated with acute kidney injury in the critically ill.

      DESIGN: Two-center observational study of patients treated in medical and surgical intensive care units.

      SETTING: Two hundred nine medical and ...

      Known for Acute Kidney Injury | 25 Hydroxyvitamin | Adjusted Odds Ratio | Hospital Admission | Aged Odds
      KOL-Index: 16849

      CONTEXT: Alterations of the WNT signaling pathway and cadherin-associated protein β 1 (CTNNB1 or β-catenin) have been implicated in colorectal carcinogenesis and metabolic diseases.

      OBJECTIVE: To test the hypothesis that CTNNB1 activation in colorectal cancer modifies prognostic associations of body mass index (BMI) and level of postdiagnosis physical activity.

      DESIGN, SETTING, AND PATIENTS: Two US prospective cohort studies (Nurses' Health Study and the Health Professionals Follow-up ...

      Known for Colorectal Cancer | Nuclear Ctnnb1 | Postdiagnosis Physical Activity | Body Mass Bmi | Obese Patients
      KOL-Index: 16699

      Importance: Prolonged sitting, particularly watching television or videos, has been associated with increased risk of multiple diseases and mortality. However, changes in sedentary behaviors over time have not been well described in the United States.

      Objective: To evaluate patterns and temporal trends in sedentary behaviors and sociodemographic and lifestyle correlates in the US population.

      Design, Setting, and Participants: A serial, cross-sectional analysis of the US nationally ...

      Known for Sedentary Behavior | 95 Trend | Adults Aged | Sitting Time | Watching Television
      KOL-Index: 16693

      CONTEXT: Randomized trials of short-term aspirin use for prevention of recurrent colorectal adenoma have provided compelling evidence of a causal relationship between aspirin and colorectal neoplasia. However, data on long-term risk of colorectal cancer according to dose, timing, or duration of therapy with aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) remain limited.

      OBJECTIVE: To examine the influence of aspirin and NSAIDs in prevention of colorectal cancer.

      DESIGN, ...

      Known for Colorectal Cancer | Nonsteroidal Anti | Women Aspirin | 14 Tablets Week | Dose Risk
      KOL-Index: 16678

      BACKGROUND & AIMS: Endoscopic screening reduces incidence and mortality of colorectal cancer (CRC) because precursor lesions, such as conventional adenomas or serrated polyps, are removed. Individuals with polypectomies are advised to undergo colonoscopy surveillance to prevent CRC. However, guidelines for surveillance intervals after diagnosis of a precursor lesion, particularly for individuals with serrated polyps, vary widely, and lack sufficient supporting evidence. Consequently, ...

      Known for Serrated Polyps | Conventional Adenomas | Colorectal Cancer | Crc Individuals | Nurses Health Study
      KOL-Index: 16652

      BACKGROUND: Fruits and vegetables rich in antioxidants have been proposed to reduce the risk of renal cell cancer. However, few prospective studies have examined the intakes of fruits, vegetables, and antioxidant vitamins in relation to the risk of renal cell cancer.

      METHODS: We prospectively examined the associations between the intakes of fruits, vegetables, vitamins A, C, and E, and carotenoids and risk of renal cell cancer in women and men. We followed 88,759 women in the Nurses' ...

      Known for Renal Cell Cancer | Fruits Vegetables | Fruit Vegetable Consumption | Acid Carcinoma | Cell Carotenoids

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      Edward Luciano Giovannucci">:Expert Impact

      Concepts for whichEdward Luciano Giovannucci">has direct influence:Colorectal cancer,  Prostate cancer,  Pancreatic cancer,  Cancer risk,  Colon cancer,  Physical activity,  United states,  Colorectal adenoma.

      Edward Luciano Giovannucci">:KOL impact

      Concepts related to the work of other authors for whichfor which Edward Luciano Giovannucci"> has influence:Prostate cancer,  Physical activity,  Cardiovascular disease,  Alcohol consumption,  Metabolic syndrome,  Blood pressure,  Type 2 diabetes.



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      Department of Nutrition, Harvard T.H. School of Public Health, Boston, MA, USA 02115 | Harvard T.H. Chan School of Public Health, Boston, MA, United States | Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts |

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