Prominent publications by Jiang Chang

KOL Index score: 17477

Importance: The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, is serious and has the potential to become an epidemic worldwide. Several studies have described typical clinical manifestations including fever, cough, diarrhea, and fatigue. However, to our knowledge, it has not been reported that patients with COVID-19 had any neurologic manifestations.

Objective: To study the neurologic manifestations of patients with COVID-19.

Design, Setting, and Participants: This is ...

Also Ranks for: Neurologic Manifestations |  severe infection |  wuhan china |  hospitalized patients |  impaired consciousness
KOL Index score: 13133

Plasma lipid levels are important risk factors for cardiovascular disease and are influenced by genetic and environmental factors. Recent genome wide association studies (GWAS) have identified several lipid-associated loci, but these loci have been identified primarily in European populations. In order to identify genetic markers for lipid levels in a Chinese population and analyze the heterogeneity between Europeans and Asians, especially Chinese, we performed a meta-analysis of two ...

Also Ranks for: Lipid Levels |  chinese population |  genome wide |  common variants |  genetic loci
KOL Index score: 12157

Background: The outbreak of coronavirus disease 2019 (COVID-19) from Wuhan China is serious and has the potential to become epidemic unfortunately worldwide. We aimed to describe the neurological manifestations of patients with COVID-19. Methods: In this retrospective, observational study, we enrolled two hundred fourteen hospitalized patients with laboratory confirmed diagnosis of severe acute respiratory syndrome from coronavirus 2 (SARS-CoV-2) infection in three designated COVID-19 ...

Also Ranks for: Neurological Manifestations |  hospitalized patients |  covid19 wuhan |  impaired consciousness |  neurologic symptoms
KOL Index score: 11174

Background: Epirubicin combined with docetaxel is the cornerstone of neoadjuvant chemotherapy(NAC) for breast cancer. The efficacy of NAC for luminal A breast cancer patients is very limited, and single nucleotide polymorphism is one of the most important factor that influence the efficacy. Our study aimed to explore genetic markers for the efficacy of epirubicin combined with docetaxel for NAC in patients with luminal A breast cancer.Methods: A total of 421 patients with two stages of ...

Also Ranks for: Breast Cancer |  epirubicin docetaxel |  efficacy nac |  abtb2 regulatory variant |  genetic variations
KOL Index score: 11059

APOBEC3s are a family of cytidine deaminases involved in innate cellular immunity against virus including hepatitis B virus (HBV). A germline deletion across APOBEC3A and APOBEC3B (A3B) genes results in complete removal of the A3B coding region and destroys A3B expression. To determine whether this deletion affects susceptibility to HBV infection and HBV-related hepatocellular carcinoma (HCC), A3B genotypes were analyzed in 1124 individuals with HCC, 510 individuals with persistent HBV ...

Also Ranks for: Hepatocellular Carcinoma |  hbv infection |  gene deletion |  hepatitis virus |  hcc cells
KOL Index score: 10559

Genome-wide association studies (GWASs) have identified multiple susceptibility loci of colorectal cancer (CRC), however, causative polymorphisms have not been fully elucidated. Long non-coding RNAs (lncRNAs) are a recently discovered class of non-protein coding RNAs that involved in a wide variety of biological processes. We hypothesized that single nucleotide polymorphisms (SNPs) in lncRNA may associate with the CRC risk by influencing lncRNA functions. To evaluate the effects of SNPs ...

Also Ranks for: Colorectal Cancer |  functional polymorphism |  crc risk |  mirna binding |  case control
KOL Index score: 10058

Genome-wide association studies (GWAS) of colorectal cancer have identified several common susceptible variants in gene regulatory regions. However, low-frequency or rare coding risk variants have not been systematically investigated in patients with colorectal cancer from Chinese populations. In this study, we performed an exome-wide association analysis with 1,062 patients with colorectal cancer and 2,184 controls from a Chinese population. Promising associations were further ...

Also Ranks for: Colorectal Cancer |  myc enhancer |  missense variant |  chinese population |  functional analysis
KOL Index score: 10052

BACKGROUND & AIMS: Known genetic factors explain only a small fraction of genetic variation in colorectal cancer (CRC). We conducted a genome-wide association study to identify risk loci for CRC.

METHODS: This discovery stage included 8027 cases and 22,577 controls of East-Asian ancestry. Promising variants were evaluated in studies including as many as 11,044 cases and 12,047 controls. Tumor-adjacent normal tissues from 188 patients were analyzed to evaluate correlations of risk ...

Also Ranks for: Susceptibility Loci |  risk variants |  colorectal cancer |  genetic factors |  transcription factor eb
KOL Index score: 9985

OBJECTIVE: Tumour biomarkers are used as indicators for cancer screening and as predictors for therapeutic responses and prognoses in cancer patients. We aimed to identify genetic loci that influence concentrations of cancer antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA) and α fetoprotein (AFP), and investigated the associations between the significant single nucleotide polymorphisms (SNPs) with risks of oesophageal squamous cell (OSCC), pancreatic and hepatocellular ...

Also Ranks for: Cancer Risk |  carcinoembryonic antigen |  genetic loci |  genome wide |  hepatocellular carcinoma
KOL Index score: 9698

BACKGROUND: Recent genome-wide association studies have identified 10 single nucleotide polymorphisms (SNP) associated with colorectal cancer (CRC) in Caucasians. This study evaluated the effects of these newly identified SNPs in a Chinese population.

METHODS: We assessed the associations of these 10 SNPs with CRC in a case-control study that consisted of 2,124 cases and 2,124 controls. Odds ratios (OR) and 95% confidence intervals were computed by logistic regression, and cumulative ...

Also Ranks for: Chinese Population |  colorectal cancer |  risk crc |  genome wide |  genetic variants
KOL Index score: 9390

BACKGROUND AND PURPOSE: COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Apart from respiratory complications, acute cerebrovascular disease (CVD) has been observed in some patients with COVID-19. Therefore, we described the clinical characteristics, laboratory features, treatment and outcomes of CVD complicating SARS-CoV-2 infection.

MATERIALS AND METHODS: Demographic and clinical characteristics, laboratory findings, treatments ...

Also Ranks for: Acute Cerebrovascular Disease |  patients cvd |  clinical characteristics |  laboratory findings |  single center
KOL Index score: 9307



To study the neurological manifestations of patients with coronavirus disease 2019 (COVID-19).


Retrospective case series


Three designated COVID-19 care hospitals of the Union Hospital of Huazhong University of Science and Technology in Wuhan, China.


Also Ranks for: Neurological Manifestations |  hospitalized patients |  neurologic symptoms |  wuhan china |  impaired consciousness
KOL Index score: 9248

Genetic variations in microRNAs (miRNA) that affect control of their target genes may alter individual susceptibilities to cancer. In this study, we took an in silico approach to identify single-nucleotide polymorphisms (SNP) within the 3'-untranslated region (UTR) of miRNA genes deregulated in human small-cell lung cancer (SCLC), and then investigated their associations with SCLC susceptibility in 666 SCLC patients and 758 controls. Odds ratios (OR) were estimated by multivariate ...

Also Ranks for: Cell Lung |  genetic variation |  binding site |  mirna genes |  sclc susceptibility
KOL Index score: 9075

The TGF-β pathway plays an essential role in regulating cell proliferation and differentiation. GWASs and candidate approaches have identified a battery of genetic variants in the TGF-β pathway contributing to colorectal cancer (CRC). However, most of the significant variants are common variants and their functions remain ambiguous. To identify causal variants with low-frequency in the TGF-β pathway contributing to CRC susceptibility in Chinese population, we performed targeted ...

Also Ranks for: Chinese Population |  colorectal cancer |  crc risk |  genetic variants |  β signaling
KOL Index score: 8935

BACKGROUND & AIMS: We performed a screen for genes whose expression correlates with invasiveness of esophageal squamous cell carcinoma (ESCC) cells. We studied the effects of overexpression and knockdown of these genes in cell lines and expression levels in patient samples.

METHODS: We selected genes for analysis from 11 loci associated with risk of ESCC. We analyzed the effects of knocking down expression of 47 of these genes using RNA interference on-chip analysis in ESCC cells and ...

Also Ranks for: Expression Brap |  esophageal squamous |  escc cells |  cell carcinoma |  inbred balb mice

Key People For Colorectal Cancer

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Jiang Chang:Expert Impact

Concepts for whichJiang Changhas direct influence:Colorectal cancer,  Chinese population,  Crc risk,  Genetic variants,  Chinese populations,  Pancreatic cancer,  Cell carcinoma,  Common variants.

Jiang Chang:KOL impact

Concepts related to the work of other authors for whichfor which Jiang Chang has influence:Lung cancer,  Neurological manifestations,  Ischemic stroke,  Sarscov2 infection,  Chinese population,  Hepatocellular carcinoma,  Coronavirus disease covid19.



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Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, Wuhan, 430030, China; School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, 430030, China. | Department of Epid