Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland | Center for Neuroprosthetics and Brain Mind ...
KOL Resume for Laura McCracken
Department of Clinical Neuroscience, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Laura McCracken: Influence Statistics
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Prominent publications by Laura McCracken
The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of Ngn3 protein is largely unexplored. Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple serine-proline sites. Replacing wild-type protein with a phosphomutant form of Ngn3 increases α cell generation, the earliest endocrine cell type to be formed in the developing pancreas. Moreover, ...
|Known for Endocrine Differentiation | Neurogenin3 Phosphorylation | Ngn3 Protein | Insulinsecreting Cells Islets | Developing Pancreas|
Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis
[ PUBLICATION ]
Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal column of the spinal cord. Here, we hypothesized that an arrangement of electrodes targeting the ensemble of dorsal roots involved in leg and trunk movements would result in superior efficacy, restoring more diverse motor activities ...
|Known for Spinal Cord | Complete Paralysis | Sci Ees | Motor Functions | Electrical Stimulation|
Key People For Complete Paralysis
Laura McCracken:Expert Impact
Concepts for whichLaura McCrackenhas direct influence:Complete paralysis, Sci ees, Endocrine differentiation, Ees sci, Insulinsecreting cells islets, Pancreatic endocrine, Ngn3 protein, Neurogenin3 phosphorylation.
Laura McCracken:KOL impact
Concepts related to the work of other authors for whichfor which Laura McCracken has influence:Muscle synergies, Pancreas development, Islet function, Gait rehabilitation, Pancreatic organoids, Proneural genes, Aldh1b1 expression.
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