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Aaron G Filler: Influence Statistics

OBJECT: Because lumbar magnetic resonance (MR) imaging fails to identify a treatable cause of chronic sciatica in nearly 1 million patients annually, the authors conducted MR neurography and interventional MR imaging in 239 consecutive patients with sciatica in whom standard diagnosis and treatment failed to effect improvement.

METHODS: After performing MR neurography and interventional MR imaging, the final rediagnoses included the following: piriformis syndrome (67.8%), distal ...

OBJECTIVE: We describe the clinical application and utility of high-resolution magnetic resonance neurography (MRN) techniques to image the normal fascicular structure of peripheral nerves and its distortion by mass lesions or trauma in the lower extremity.

METHODS: MRN images were obtained using a standard 1.5 Tesla magnet and custom built phased-array coils. Patients were imaged using T1-weighted spin echo without and with gadolinium, T2-weighted fast spin echo with fat peripheral ...

STUDY DESIGN: A clinical series of patients with unilateral radiculopathy treated with the anterior cervical foraminotomy procedure.

OBJECTIVE: To establish procedural techniques and clinical and radiologic outcomes for the anterior cervical foraminotomy procedure.

SUMMARY OF BACKGROUND DATA: Cervical radiculopathy is typically caused by unilateral disc herniation or uncovertebral osteophytes that compress the ventral aspect of the nerve. Direct removal of a cervical lesion causing ...

Recent advances in the technology of MR imaging are beginning to transform the fundamental methodology of diagnostic evaluations in neuromuscular disorders. When properly implemented, MR neurography is capable of providing high-quality information about nerve compression, nerve inflammation, nerve trauma, systemic neuropathies, nerve tumors, and recovery of nerve from pathologic states. Muscle MR imaging can identify denervation on a precise anatomic basis, document the progression of ...

Currently, diagnosis and management of disorders involving nerves are generally undertaken without images of the nerves themselves. The authors evaluated whether direct nerve images obtained using the new technique of magnetic resonance (MR) neurography could be used to make clinically important diagnostic distinctions that cannot be readily accomplished using existing methods. The authors obtained T2-weighted fast spin-echo fat-suppressed (chemical shift selection or inversion recovery) ...

OBJECTIVE: Methods were invented that made it possible to image peripheral nerves in the body and to image neural tracts in the brain. The history, physical basis, and dyadic tensor concept underlying the methods are reviewed. Over a 15-year period, these techniques-magnetic resonance neurography (MRN) and diffusion tensor imaging-were deployed in the clinical and research community in more than 2500 published research reports and applied to approximately 50,000 patients. Within this ...

OBJECT: Thoracoscopic discectomy is a minimally invasive procedure simulating a thoracotomy and is an alternative to the costotransversectomy and transpedicular approaches. In recent studies authors have concluded that thoracoscopic discectomy is the preferred procedure; however, relative historical comparisons were difficult to interpret. The authors conducted a prospective nonrandomized study in which they compared data on 36 patients undergoing thoracoscopic discectomy with eight ...

BACKGROUND: Targeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal. Currently, systemic methods are generally used for delivery of pain medications, anti-virals for treatment of dermatomal infections, anti-spasmodics, and neuroprotectants. Systemic side effects or undesirable effects on parts of the CNS that are not involved in the pathology limit efficacy and limit clinical utility for many classes of ...

OBJECT: To improve diagnostic accuracy and achieve high levels of treatment success in patients with pudendal nerve entrapment (PNE) syndromes, the author of this study applied advanced technology diagnostics in distinguishing the various syndrome types according to the different entrapment locations and evaluated new minimal access surgical techniques to treat each subtype.

METHODS: Two hundred cases were prospectively evaluated using a standardized set of patient-completed functional ...

We have made cross-sectional image "neurograms" in which peripheral nerve has a greater signal intensity than that of other tissue. Neurographic images of the rabbit forelimb were obtained using a spin-echo magnetic resonance imaging (MRI) technique that combines fat suppression and diffusion weighting. After fat suppression the nerve shows up in relative isolation and is brighter than the surrounding tissue due to its longer T2 relaxation time of approximately 50 ms compared to ...

A magnetic resonance imaging sequence, combining fat and flow suppression with T2 weighting, has been used to produce high conspicuity images of the median nerve within the carpal tunnel. Standard maximum intensity projection techniques were then used to produce three-dimensional (3D) reconstructions of the nerve. Comparison of 3D projections with the wrist in a neutral position and wrist flexed at 45 degrees depicted changes in the shape and course of the median nerve through the carpal ...

Magnetic resonance neurography was used to directly image cervical spinal nerves in patients with clinical and radiographic evidence of cervical radiculopathy. A magnetic resonance imaging phased-array coil system was used to obtain high-resolution coronal T1-weighted spin echo, coronal/axial T2-weighted fast spin echo with fat saturation, and coronal/axial fast short tau inversion recovery weighted images of the cervical spine and spinal nerves. Three patients with neck and upper ...

BACKGROUND: Despite the rising interest in homeotic genes, little has been known about the course and pattern of evolution of homeotic traits across the mammalian radiation. An array of emerging and diversifying homeotic gradients revealed by this study appear to generate new body plans and drive evolution at a large scale.

METHODOLOGY/PRINCIPAL FINDINGS: This study identifies and evaluates a set of homeotic gradients across 250 extant and fossil mammalian species and their antecedents ...

Reverse transcription is a key aspect of the retroviral life cycle. The enzyme reverse transcriptase requires divalent cations, manganese or magnesium, for function. In some cation-dependent systems substitution of a physiological metal by a nonphysiological metal has been shown to work. We investigated the effect of different cations on HIV reverse transcriptase activity. The studies established reaction conditions for assaying different cations. A variety of transition metals were used ...

Nerve entrapment syndromes involving the pudendal nerve have been challenging for the neurologist and neurosurgeon relative to other nerve entrapment syndromes because of the nature of the presenting symptoms and the technically demanding aspects of specific diagnosis. Further, effective treatment options have been few. Recently however, there have been a series of advances in diagnosis and treatment. Application of magnetic resonance neurography imaging and the use of open magnetic ...