• Axonal Transport
    • Aaron G Filler
    • Aaron G Filler: Influence Statistics

      Aaron G Filler

      Aaron G Filler

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      Society for Brain Mapping and Therapeutics (SBMT), Los Angeles, CA, USA. | Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. | Institute for Nerve ...

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      Aaron G Filler:Expert Impact

      Concepts for whichAaron G Fillerhas direct influence:Axonal transport,Magnetic resonance,Magnetic resonance neurography,Resonance neurography,Computed imaging,Cervical radiculopathy,Peripheral nerves,Peripheral nerve.

      Aaron G Filler:KOL impact

      Concepts related to the work of other authors for whichfor which Aaron G Filler has influence:Magnetic resonance,Sciatic nerve,Piriformis syndrome,Brachial plexus,Carpal tunnel,Peripheral nervous,Pudendal neuralgia.

      KOL Resume for Aaron G Filler


      Society for Brain Mapping and Therapeutics (SBMT), Los Angeles, CA, USA.


      Molecular Synthetics LTD, Babraham Hall, Babraham Research Campus, Cambridge, CB22 3AT, UK

      Division of Neurosurgery, UCLA School of Medicine, Center for Health Sciences, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA


      Institute for Nerve Medicine, Santa Monica, California


      Department of Neurosurgery, Cedars Sinai Medical Center, Institute for Spinal Disorders, Los Angeles Institute for Nerve Medicine, Santa Monica, CA


      Department of Anthropology, Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts, United States of America

      Institute for Spinal Disorders, Cedars-Sinai Medical Center, Los Angeles, California, USA.


      Institute for Spinal Disorders, Cedars Sinai Medical Center, Los Angeles, California, USA.


      Institute for Nerve Medicine, 2716 Ocean Park Blvd., Suite 3082, Santa Monica, CA 90405, USA


      From the Division of Neurosurgery, Department of Surgery, School of Medicine, University of California at Los Angeles, Los Angeles, California.


      Department of Radiology, University of Utah, Salt Lake City, Utah; Department of Neurological Surgery, UCLA Medical Center, Los Angeles; and Department of Radiology, University of Washington, Seattle


      Department of Neurological Surgery, University of Washington, Seattle, USA.

      Division of Neurological Surgery, University of California, Los Angeles Medical Center, Los Angeles, California


      Department of Neurological Surgery, University of Washington, ZA‐86, 325 Ninth Ave, Seattle, WA 98104

      The author is a director and shareholder in a recently formed start‐up company. It is expected that rights to a patent application concerning axonal transport contrast agents will be transferred from St George's Hospital Medical School. London, England, to the company, SynGenix Ltd, in the near future


      Department of Neurological Surgery, University of Washington, Seattle, Washington, U.S.A.


      Atkinson Morley's Hospital, London, United Kingdom

      Department of Neurosurgery, University of Washington, Seattle, Washington 98109

      CRC Biomedical Magnetic Resonance Research Group, Division of Biochemistry, St. George's Hospital Medical School, London, SW17 ORE, England

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      Sample of concepts for which Aaron G Filler is among the top experts in the world.
      Concept World rank
      clinical imaging science #1
      priorities forgotten advances #1
      mrn prospective basis #1
      robert tiels presentation #1
      battles nobel #1
      seconds incisional #1
      room electromyographic #1
      prospective 5000 #1
      clinically tracked #1
      cylindrical imri #1
      types pne #1
      dti steady #1
      entrapment syndromes diagnosis #1
      percutaneous configuration #1
      3 incisional surgery #1
      computed medical imaging #1
      achievement computed #1
      dyadic tensor concept #1
      dti steady series #1
      progress human terms #1
      benefits electromyography #1
      pne syndromes #1
      imri cycle #1
      category pointcounterpoint discussion #1
      steady series advances #1
      piriformis muscle spasm #1
      piriformis entrapment syndromes #1
      drama remarkable #1
      pelvic sciatic syndromes #1
      humans injections piriformis #1
      incisional surgery imri #1
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      dti nobel prizes #1
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      fallacy humans injections #1
      magnetadjacent procedures #1
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      patent priority litigations #1
      incisional configuration #1
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      prospective basis methods #1
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      neurological diagnosis neurosurgery #1
      priority litigations #1
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      Prominent publications by Aaron G Filler

      KOL-Index: 11931

      OBJECT: Because lumbar magnetic resonance (MR) imaging fails to identify a treatable cause of chronic sciatica in nearly 1 million patients annually, the authors conducted MR neurography and interventional MR imaging in 239 consecutive patients with sciatica in whom standard diagnosis and treatment failed to effect improvement.

      METHODS: After performing MR neurography and interventional MR imaging, the final rediagnoses included the following: piriformis syndrome (67.8%), distal ...

      Known for Piriformis Syndrome | Magnetic Resonance | Interventional Imaging | Nerve Entrapment | Patients Sciatica
      KOL-Index: 8434

      OBJECTIVE: We describe the clinical application and utility of high-resolution magnetic resonance neurography (MRN) techniques to image the normal fascicular structure of peripheral nerves and its distortion by mass lesions or trauma in the lower extremity.

      METHODS: MRN images were obtained using a standard 1.5 Tesla magnet and custom built phased-array coils. Patients were imaged using T1-weighted spin echo without and with gadolinium, T2-weighted fast spin echo with fat peripheral ...

      Known for Peripheral Nerve | Magnetic Resonance | Lower Extremity | Mrn Images | Mass Lesions
      KOL-Index: 8247

      STUDY DESIGN: A clinical series of patients with unilateral radiculopathy treated with the anterior cervical foraminotomy procedure.

      OBJECTIVE: To establish procedural techniques and clinical and radiologic outcomes for the anterior cervical foraminotomy procedure.

      SUMMARY OF BACKGROUND DATA: Cervical radiculopathy is typically caused by unilateral disc herniation or uncovertebral osteophytes that compress the ventral aspect of the nerve. Direct removal of a cervical lesion causing ...

      Known for Anterior Cervical | Unilateral Radiculopathy | Uncovertebral Osteophytes | Radicular Symptoms | Background Data
      KOL-Index: 8100

      Recent advances in the technology of MR imaging are beginning to transform the fundamental methodology of diagnostic evaluations in neuromuscular disorders. When properly implemented, MR neurography is capable of providing high-quality information about nerve compression, nerve inflammation, nerve trauma, systemic neuropathies, nerve tumors, and recovery of nerve from pathologic states. Muscle MR imaging can identify denervation on a precise anatomic basis, document the progression of ...

      Known for Peripheral Nerves | Muscle Imaging | Nerve Compression | Nervous Diseases | Image Findings
      KOL-Index: 7795

      Currently, diagnosis and management of disorders involving nerves are generally undertaken without images of the nerves themselves. The authors evaluated whether direct nerve images obtained using the new technique of magnetic resonance (MR) neurography could be used to make clinically important diagnostic distinctions that cannot be readily accomplished using existing methods. The authors obtained T2-weighted fast spin-echo fat-suppressed (chemical shift selection or inversion recovery) ...

      Known for Peripheral Nerve | Magnetic Resonance Neurography | Surgical Repair | Inversion Recovery | Resonance Imaging
      KOL-Index: 7172

      OBJECTIVE: Methods were invented that made it possible to image peripheral nerves in the body and to image neural tracts in the brain. The history, physical basis, and dyadic tensor concept underlying the methods are reviewed. Over a 15-year period, these techniques-magnetic resonance neurography (MRN) and diffusion tensor imaging-were deployed in the clinical and research community in more than 2500 published research reports and applied to approximately 50,000 patients. Within this ...

      Known for Tensor Imaging | Resonance Neurography | Clinical Impact | Peripheral Nerves | Physical Basis
      KOL-Index: 6340

      OBJECT: Thoracoscopic discectomy is a minimally invasive procedure simulating a thoracotomy and is an alternative to the costotransversectomy and transpedicular approaches. In recent studies authors have concluded that thoracoscopic discectomy is the preferred procedure; however, relative historical comparisons were difficult to interpret. The authors conducted a prospective nonrandomized study in which they compared data on 36 patients undergoing thoracoscopic discectomy with eight ...

      Known for Thoracoscopic Discectomy | Patients Thoracotomy | Blood Loss | Intervertebral Disc | Neurological Function
      KOL-Index: 6319

      BACKGROUND: Targeted delivery of pharmaceutical agents into selected populations of CNS (Central Nervous System) neurons is an extremely compelling goal. Currently, systemic methods are generally used for delivery of pain medications, anti-virals for treatment of dermatomal infections, anti-spasmodics, and neuroprotectants. Systemic side effects or undesirable effects on parts of the CNS that are not involved in the pathology limit efficacy and limit clinical utility for many classes of ...

      Known for Axonal Transport | Drug Delivery | Tripartite Complex | Central Nervous | Aminobutyric Acid
      KOL-Index: 6256

      OBJECT: To improve diagnostic accuracy and achieve high levels of treatment success in patients with pudendal nerve entrapment (PNE) syndromes, the author of this study applied advanced technology diagnostics in distinguishing the various syndrome types according to the different entrapment locations and evaluated new minimal access surgical techniques to treat each subtype.

      METHODS: Two hundred cases were prospectively evaluated using a standardized set of patient-completed functional ...

      Known for Nerve Entrapment | Pne Syndromes | Ischial Spine | Sacrotuberous Ligament | Surgical Procedures
      KOL-Index: 4604

      We have made cross-sectional image "neurograms" in which peripheral nerve has a greater signal intensity than that of other tissue. Neurographic images of the rabbit forelimb were obtained using a spin-echo magnetic resonance imaging (MRI) technique that combines fat suppression and diffusion weighting. After fat suppression the nerve shows up in relative isolation and is brighter than the surrounding tissue due to its longer T2 relaxation time of approximately 50 ms compared to ...

      Known for Magnetic Resonance | Nerve Tissue | Fat Suppression | Echo Time | Image Enhancement
      KOL-Index: 4600

      A magnetic resonance imaging sequence, combining fat and flow suppression with T2 weighting, has been used to produce high conspicuity images of the median nerve within the carpal tunnel. Standard maximum intensity projection techniques were then used to produce three-dimensional (3D) reconstructions of the nerve. Comparison of 3D projections with the wrist in a neutral position and wrist flexed at 45 degrees depicted changes in the shape and course of the median nerve through the carpal ...

      Known for Median Nerve | Magnetic Resonance | Carpal Tunnel | Normal Volunteers | Imaging Male
      KOL-Index: 4414

      Magnetic resonance neurography was used to directly image cervical spinal nerves in patients with clinical and radiographic evidence of cervical radiculopathy. A magnetic resonance imaging phased-array coil system was used to obtain high-resolution coronal T1-weighted spin echo, coronal/axial T2-weighted fast spin echo with fat saturation, and coronal/axial fast short tau inversion recovery weighted images of the cervical spine and spinal nerves. Three patients with neck and upper ...

      Known for Magnetic Resonance | Cervical Spine | Spinal Nerve | Radicular Symptoms | Phasedarray Coils
      KOL-Index: 3772

      BACKGROUND: Despite the rising interest in homeotic genes, little has been known about the course and pattern of evolution of homeotic traits across the mammalian radiation. An array of emerging and diversifying homeotic gradients revealed by this study appear to generate new body plans and drive evolution at a large scale.

      METHODOLOGY/PRINCIPAL FINDINGS: This study identifies and evaluates a set of homeotic gradients across 250 extant and fossil mammalian species and their antecedents ...

      Known for Humans Lumbar | Animals Biological | Evolution Fossils | Vertebrae Mammals | Mammalian Radiation
      KOL-Index: 2958

      Reverse transcription is a key aspect of the retroviral life cycle. The enzyme reverse transcriptase requires divalent cations, manganese or magnesium, for function. In some cation-dependent systems substitution of a physiological metal by a nonphysiological metal has been shown to work. We investigated the effect of different cations on HIV reverse transcriptase activity. The studies established reaction conditions for assaying different cations. A variety of transition metals were used ...

      Known for Reverse Transcriptase | Divalent Cations | Immunodeficiency Virus | Hiv1 Humans | Activation Hiv
      KOL-Index: 2950

      Nerve entrapment syndromes involving the pudendal nerve have been challenging for the neurologist and neurosurgeon relative to other nerve entrapment syndromes because of the nature of the presenting symptoms and the technically demanding aspects of specific diagnosis. Further, effective treatment options have been few. Recently however, there have been a series of advances in diagnosis and treatment. Application of magnetic resonance neurography imaging and the use of open magnetic ...

      Known for Pudendal Nerve | Entrapment Syndromes | Specific Diagnosis | Surgical Techniques | Resonance Neurography

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      Society for Brain Mapping and Therapeutics (SBMT), Los Angeles, CA, USA. | Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. | Institute for Nerve Medicine, Santa Monica, CA, USA. | Molecular Synthetics LTD, Babraham Hall

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