• Disease
  • Ventricular
  • Ventricular Fibrillation
  • William J Mandel

    Prominent publications by William J Mandel

    KOL Index score: 17100

    BACKGROUND: The upper limit of vulnerability is the stimulus strength above which electrical stimulation cannot induce ventricular fibrillation even when the stimulus occurs during the vulnerable period of the cardiac cycle. The purpose of this study was to test the hypothesis that the upper limit of vulnerability can accurately predict the defibrillation threshold in patients undergoing implantable cardioverter-defibrillator (ICD) implantation using nonthoracotomy lead systems.

    METHODS ...

    Also Ranks for: Defibrillation Threshold |  upper limit vulnerability |  peak wave |  ventricular fibrillation |  icd implantation
    KOL Index score: 15073

    OBJECTIVES: The goals of this study were to determine the probability of successful defibrillation at the upper limit of vulnerability and to evaluate a minimal safety margin for implantable cardioverter-defibrillator first shocks based solely on the upper limit of vulnerability.

    BACKGROUND: The upper limit of vulnerability is the strength at or above which ventricular fibrillation is not induced when a stimulus is delivered during the vulnerable phase of the cardiac cycle. It has been ...

    Also Ranks for: Upper Limit Vulnerability |  shock strength |  implantable cardioverter |  defibrillation threshold |  ventricular fibrillation
    KOL Index score: 13621

    Critical conduction delay has been shown to be the important factor in reentrant arrhythmias. To determine the causal relation between conduction delay and spontaneous ischemic ventricular fibrillation, conduction delay of induced premature ventricular impulses in the ischemic and the border zones of ventricular myocardium was investigated in 23 dogs. There were 8 control dogs, 9 dogs that manifested ventricular fibrillation within 30 minutes of ligation of the distal left anterior ...

    Also Ranks for: Ventricular Fibrillation |  conduction delay |  premature impulses |  ischemic zone |  acute myocardial
    KOL Index score: 13540

    OBJECTIVES: The study examined the activations in the pulmonary veins (PVs) and the vein of Marshall (VOM) during atrial fibrillation (AF) in dogs with congestive heart failure (CHF).

    BACKGROUND: The patterns of activation within the PVs and the VOM during AF in CHF are unclear.

    METHODS: We induced CHF in nine dogs by rapid ventricular pacing. The patterns of activation during induced AF were studied one week after ceasing ventricular pacing.

    RESULTS: The duration of induced AF averaged ...

    Also Ranks for: Atrial Fibrillation |  pulmonary vein |  heart failure |  chf dogs |  canine model
    KOL Index score: 12991

    Background: The upper limit of vulnerability (ULV) is the stimulus strength above which ventricular fibrillation cannot be induced, even when the stimulus occurs during the vulnerable period of the cardiac cycle. Determination of ULV using T-wave shocks during ventricular pacing has been shown to closely correlate with the defibrillation threshold (DFT) at ICD implantation. However, there are no data correlating ULV determined in sinus rhythm at ICD implantation, with DFT determined at ...

    Also Ranks for: Ulv Dft |  defibrillation threshold |  icd implantation |  ventricular fibrillation |  upper limit vulnerability
    KOL Index score: 12841

    OBJECTIVES: The goal of this study was to determine the incidence and clinical significance of underdetection in 125 patients treated with a tiered-therapy cardioverter-defibrillator, the Medtronic PCD.

    BACKGROUND: Underdetection, distinct from undersensing, is a unique, potential complication of new algorithms that enhance specificity in tiered-therapy cardioverter-defibrillators. These algorithms may delay or prevent recognition of ventricular tachycardia even though electrograms are ...

    Also Ranks for: Ventricular Tachycardia |  atrial fibrillation |  cardioverter defibrillators |  new algorithms |  12 patients
    KOL Index score: 12813

    BACKGROUND: According to the spiral wave hypothesis of reentry, the core of functional reentry remains excitable but not excited. We sought to determine whether the core remains excitable and whether excitation of the core by an outside wave front leads to termination of the reentry in the atrium.

    METHODS AND RESULTS: In nine isolated canine right endocardial atrial tissues (3.8 by 3.2 cm wide), reentry was induced by a premature point stimulus (S2). The isochronal activation maps and ...

    Also Ranks for: Functional Reentry |  spontaneous termination |  isolated canine |  excitation core |  reentrant wave
    KOL Index score: 12639

    OBJECTIVES: The study was performed to document that atrioventricular node reciprocating tachycardia (AVNRT) can be associated with eccentric retrograde left-sided activation, masquerading as tachycardia using a left accessory pathway.

    BACKGROUND: The eccentric retrograde left-sided activation during tachycardia is thought to be diagnostic of the presence of a left free wall accessory pathway. However, it is not known whether AVNRT can occur with eccentric retrograde left-sided ...

    Also Ranks for: Accessory Pathway |  reciprocating tachycardia |  patients avnrt |  atrioventricular node |  catheter ablation
    KOL Index score: 12567

    Twenty patients with inducible, sustained ventricular tachycardia (VT) were prospectively evaluated to determine whether the response to intravenous procainamide administration, as assessed by programmed ventricular stimulation, predicted the response to oral procainamide and oral quinidine treatment. Six patients (30%) responded to intravenous procainamide (fewer than 10 beats of inducible VT). Ten of 20 patients (50%) responded to oral quinidine and 5 (25%) responded to oral ...

    Also Ranks for: Oral Procainamide |  electropharmacologic testing |  ventricular tachycardia |  quinidine patients |  response intravenous
    KOL Index score: 12563

    Oxidative stress with hydrogen peroxide (H(2)O(2)) readily promotes early afterdepolarizations (EADs) and triggered activity (TA) in isolated rat and rabbit ventricular myocytes. Here we examined the effects of H(2)O(2) on arrhythmias in intact Langendorff rat and rabbit hearts using dual-membrane voltage and intracellular calcium optical mapping and glass microelectrode recordings. Young adult rat (3-5 mo, N = 25) and rabbit (3-5 mo, N = 6) hearts exhibited no arrhythmias when perfused ...

    Also Ranks for: Oxidative Stress |  aged hearts |  ventricular fibrillation |  increased susceptibility |  fibrosis eads
    KOL Index score: 11628

    INTRODUCTION: Shocks during the vulnerable period of the cardiac cycle induce ventricular fibrillation (VF) if their strength is above the VF threshold (VFT) and less than the upper limit of vulnerability (ULV). However, the range of shock strengths that constitutes the vulnerable zone and the corresponding range of coupling intervals have not been defined in humans. The ULV has been proposed as a measure of defibrillation because it correlates with the defibrillation threshold (DFT), ...

    Also Ranks for: Vf Ulv |  wave shocks |  coupling interval |  weakest shock |  defibrillation threshold dft
    KOL Index score: 10627

    OBJECTIVES: We sought to evaluate the characteristics of wave fronts during ventricular fibrillation (VF) in human hearts with dilated cardiomyopathy (DCM) and to determine the role of increased fibrosis in the generation of reentry during VF.

    BACKGROUND: The role of increased fibrosis in reentry formation during human VF is unclear.

    METHODS: Five hearts from transplant recipients with DCM were supported by Langendorff perfusion and were mapped during VF. A plaque electrode array with ...

    Also Ranks for: Human Hearts |  ventricular fibrillation |  wave fronts |  dilated cardiomyopathy |  transplant recipients
    KOL Index score: 10350

    BACKGROUND: The cellular mechanism by which a point strong premature stimulus (S2) induces reentry is unknown. We hypothesized that cellular graded responses induced by an S2 mediate and control tissue vulnerability to reentry.

    METHODS AND RESULTS: Reentry is induced in normal canine ventricular epicardial slices (30x38x2 mm, n=30) by an S2 at intervals shorter than the effective refractory period. The S1 is applied at the edge and the S2 at the center of the tissue. The line connecting ...

    Also Ranks for: Graded Responses |  ventricular vulnerability |  premature stimulus |  reentry induced |  refractory period
    KOL Index score: 10283

    The efficacy of retrograde coronary venous delivery of procainamide for the management of spontaneous and inducible sustained ventricular tachycardia was evaluated and compared with systemic intravenous procainamide administration in 22 conscious dogs with permanent left anterior descending coronary artery occlusion. Selective retrograde injection of procainamide was achieved through an autoinflatable balloon catheter placed in the great cardiac vein, with the tip positioned in the ...

    Also Ranks for: Myocardial Infarction |  ventricular tachycardia |  coronary venous retroinfusion |  inducible sustained |  great cardiac vein


    William J Mandel: Influence Statistics

    Sample of concepts for which William J Mandel is among the top experts in the world.
    Concept World rank
    border ischemia #1
    concentration levels agent #1
    accessory atrioventricular report #1
    verapamil adult arrhythmias #1
    bretylium conduction #1
    entry atrioventricular #1
    verapamil effects svt #1
    twosite protocol #1
    standard protocol induction #1
    carotid hypersensitivity #1
    minimal subthreshold current #1
    nifedipine conduction delay #1
    patients artificial electrophysiology #1
    spontaneous cardiac rhythmicity #1
    diltiazem diagonal branch #1
    pathway subthreshold #1
    30 180 seconds #1
    delta wave procaine #1
    smvt risk #1
    electrophysiologic study lidocaine #1
    svt verapamil adult #1
    basic clinical subsets #1
    δ 95 exercise #1
    features fatal arrhythmias #1
    ventricular pacing stimulation #1
    terminating reciprocating #1
    epguided therapy rate #1
    myocardial conduction delay #1
    experimentally induced block #1
    control vf groups #1
    standard protocol sustained #1
    delay blockers #1
    management young woman #1
    induction risk patients #1
    aeh intervals #1
    propranolol wolff #1
    diastolic threshold stimulation #1
    prolongation cholinergic blockade #1
    30 minute infusions #1
    anterograde node pathway #1
    1 104 effects #1
    tachycardia instances #1
    lidocaine peripheral hemodynamics #1
    cardiac benzofurans death #1
    conduction delay #1
    extrastimuli twosite protocol #1
    20year electrocardiographic evidence #1
    electrophysiologic testing terms #1
    short tolong protocol #1
    disopyramide 1 104 #1

    Key People For Ventricular Fibrillation

    Top KOLs in the world
    Douglas P Zipes
    ventricular tachycardia atrial fibrillation cardiac death
    ventricular fibrillation biphasic waveforms transmembrane potential
    Leonard A Cobb
    cardiac arrest ventricular fibrillation chest compression
    Alfred P Hallstrom
    cardiac arrest ventricular fibrillation myocardial infarction
    atrial fibrillation ambulatory dogs myocardial infarction
    Hein J J Wellens
    ventricular tachycardia atrial fibrillation accessory pathway

    William J Mandel:Expert Impact

    Concepts for whichWilliam J Mandelhas direct influence:Ventricular fibrillation,  Conduction delay,  Ventricular tachycardia,  Atrial fibrillation,  Sinus rhythm,  Defibrillation threshold,  Atrial pacing,  Myocardial infarction.

    William J Mandel:KOL impact

    Concepts related to the work of other authors for whichfor which William J Mandel has influence:Atrial fibrillation,  Ventricular tachycardia,  Myocardial infarction,  Sinus node,  Heart failure,  Catheter ablation,  Sudden death.



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    Translational Arrhythmia Research Section, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. | Translational Arrhythmia Research Section, Cardiovascular Research Laboratory, Division of