• Disease
  • Confocal
  • Confocal Microscopy
  • Jianjiang Xu

    Prominent publications by Jianjiang Xu

    KOL Index score: 22074

    PURPOSE: To compare intraocular pressure (IOP) measurements obtained using the Topocon noncontact tonometer (NCT), the Goldmann applanation tonometer (GAT), and the Corvis ST (CST), a newly developed tonometer with features of visualization and measurement of the corneal deformation response to an air impulse. A secondary objective was to assess the agreement among the devices.

    METHODS: Fifty-nine participants, including glaucoma patients (36 cases) and control volunteers (23 cases), ...

    Also Ranks for: Cst Nct |  goldmann applanation |  iop measurements |  gat corvis |  mm hg
    KOL Index score: 15483

    PURPOSE: To compare the postoperative measurements of intraocular pressure (IOP) using the Corvis ST Tonometer (CST), ocular response analyzer (ORA), and Goldmann applanation tonometry (GAT) in eyes undergoing laser in situ keratomileusis (LASIK), as well as to analyze the relationship between the corneal biomechanical parameters of the CST and the ORA.

    METHODS: Fifty participants who had undergone LASIK to treat myopia in the previous 3 months were enrolled. Postoperative IOP ...

    Also Ranks for: Postoperative Iop |  cst gat |  laser situ keratomileusis |  corvis tonometer |  corneal biomechanical
    KOL Index score: 13623

    PURPOSE: To evaluate changes of anterior chamber angle (ACA) by anterior-segment optical coherence tomography (AS-OCT) in patients with primary angle closure glaucoma (PACG) following phacoemulsification (phaco) with or without goniosynechialysis (GSL).

    METHODS: Patients with PACG recruited into 2 randomized controlled trials comparing phaco-GSL versus phaco were pooled for analysis. Images of ACA were obtained by AS-OCT before surgery, and at 1 and 2 weeks, and 1, 3, and 6 months after ...

    Also Ranks for: Angle Closure |  optical coherence |  anterior chamber |  phacogsl phaco |  patients pacg
    KOL Index score: 13556

    PURPOSE: Nerve growth factor (NGF) plays an important role in promoting the healing of corneal wounds. However, the molecular mechanism by which NGF functions is unknown. We investigated the possible effects of NGF on phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and mitogen activated protein kinase (MAPK)/extracellular signal-regulated kinase (Erk) pathways and cell growth in human corneal epithelial cells (HCECs).

    METHODS: We examined the effect of NGF on cell cycle and ...

    Also Ranks for: Epithelial Cells |  cell cycle |  pi3k akt |  human corneal |  kinase erk
    KOL Index score: 12869

    PURPOSE: The activation of ROS-NLRP3-IL-1β signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis. The current study aims to investigate whether calcitriol, the active metabolite of vitamin D3, could protect cells against HS-induced inflammation through modulating this critical step.

    METHODS: Human corneal epithelial cells (iHCECs) were cultured in hyperosmotic medium (450 mOsM) with various ...

    Also Ranks for: Hyperosmotic Stress |  epithelial cells |  nlrp3 activation |  human corneal |  calcitriol inhibits
    KOL Index score: 12102

    PURPOSE: To investigate the features of corneal epithelial thickness topography with Fourier-domain optical coherence tomography (OCT) in dry eye patients.

    METHODS: In this cross-sectional study, 100 symptomatic dry eye patients and 35 normal subjects were enrolled. All participants answered the ocular surface disease index questionnaire and were subjected to OCT, corneal fluorescein staining, tear breakup time, Schirmer 1 test without anesthetic (S1t), and meibomian morphology. Several ...

    Also Ranks for: Dry Eye |  epithelial thickness |  corneal epithelium |  questionnaires tears tomography |  normal subjects
    KOL Index score: 11722

    PURPOSE: To evaluate in vivo features of Schlemm's canal (SC) in patients with primary open-angle glaucoma (POAG) with spectral-domain optical coherence tomography (SD-OCT) and to investigate the relationship of SC size with intraocular pressure (IOP) and glaucoma severity.

    DESIGN: Prospective, comparative study.

    PARTICIPANTS: Fifty Chinese patients with newly diagnosed POAG who had not undergone surgery and 50 normal Chinese subjects from a population-based, cross-sectional study in ...

    Also Ranks for: Diameter Area |  optical coherence |  angle glaucoma |  intraocular pressure iop |  eyes poag
    KOL Index score: 11361

    PURPOSE: To measure corneal and limbal epithelial thickness (ET) in normal subjects and to evaluate its variation with age by using anterior segment optical coherence tomography (AS-OCT).

    METHODS: A total of 180 normal subjects (180 healthy eyes) were enrolled and divided into four groups according to age: A (0-20 years), B (21-40 years), C (41-60 years), and D (>60 years). Cornea and limbus were imaged with OCT. Corneal ET (CET) was obtained automatically by the built-in analysis ...

    Also Ranks for: Optical Coherence |  anterior segment |  epithelial thickness |  corneal epithelium |  groups age
    KOL Index score: 11253

    PURPOSE: To map the corneal epithelial thickness in vivo with Fourier-domain optical coherence tomography in long-term soft contact lens (SCL) wearers.

    METHODS: This is a cross-sectional observational study. Forty eyes from 40 normal subjects who had never worn SCL and 40 eyes from 40 SCL wearers who had worn lenses for more than 2 years were enrolled. Corneal epithelium over the entire cornea was topographically imaged using a novel optical coherence tomography system. An epithelial ...

    Also Ranks for: Epithelial Thickness |  contact lenses |  corneal epithelium |  term soft |  normal eyes
    KOL Index score: 10792

    BACKGROUND: The aims of the study were to investigate limbal epithelial thickness in subjects with limbal stem cell deficiency and to evaluate the correlation between the palisades of Vogt and limbal epithelial thickness.

    DESIGN: Cross-sectional observational study.

    PARTICIPANTS: Twenty-four subjects (39 eyes) with limbal stem cell deficiency and 20 normal controls (20 eyes).

    METHODS: Anterior segment optical coherence tomography and laser scanning confocal microscopy were performed to ...

    Also Ranks for: Epithelial Thickness |  limbal stem |  cell deficiency |  palisades vogt |  confocal microscopy
    KOL Index score: 10749

    PURPOSE: To observe morphologic changes and the distribution of dendritic cells in pterygium using in vivo laser scanning confocal microscopy (LSCM).

    DESIGN: Prospective comparative study.

    METHODS: Twenty-six eyes of 26 patients with pterygium and 17 eyes of 17 healthy subjects were recruited. Using LSCM, in vivo images of the pterygium and adjacent clear cornea were captured. The density of basal corneal epithelial cells and keratocytes in the anterior and posterior stroma and the ...

    Also Ranks for: Dendritic Cells |  vivo confocal |  controls density |  adjacent clear cornea |  microscopy lscm
    KOL Index score: 10366

    BACKGROUND: Dry eye syndrome (DES) is a common ocular disorder occurring in general population. The purpose of this study is to evaluate the impact of DES on vision-related quality of life (QoL) in a non-clinic-based general population.

    METHODS: This population-based cross-sectional study enrolled subjects older than 40 years, who took part in an epidemiological study on dry eye in Sanle Community, Shanghai. Apart from the collection of sociodemographics, dry eye symptoms, and other ...

    Also Ranks for: Dry Eye |  ocular pain |  mental health |  illness surveys |  composite score
    KOL Index score: 9641

    PURPOSE: To compare the dynamic changes in lower tear meniscus area (TMA) and height after instillation of artificial tears in patients with dry eye and healthy controls.

    METHODS: Twenty-two eyes of 11 patients with dry eye and twenty eyes of 10 age- and sex-matched healthy subjects were included. The inferior tear meniscus height and area measurements were taken before and after instillation of 35 μL carboxymethyl cellulose (CMC) 0.5% and 1.0% (Allergan, Irvine, CA) on 2 consecutive ...

    Also Ranks for: Tear Meniscus |  dry eye |  30 minutes instillation |  optical coherence |  10 minutes
    KOL Index score: 8809

    In vivo laser scanning confocal microscopy (LSCM) has been widely used to evaluate the alterations caused by ocular surface diseases at a cellular level in the living eye. In this review, we focus on its use in the diagnosis of pterygium, meibomian gland (MG) disease, and chemical burns. Histopathologic changes occurring in pterygium can be examined in situ using in vivo LSCM. Alterations at the junction of the pterygium and the cornea, which cannot be observed in excised tissue samples, ...

    Also Ranks for: Ocular Surface |  confocal microscopy |  meibomian gland |  vivo laser |  application evaluation
    KOL Index score: 8520

    PURPOSE: To compare the impact of dry eye syndrome (DES) on vision-related quality of life (VR-QoL) between outpatients and general populations.

    METHODS: This cross-sectional comparative study enrolled 154 participants, 77 outpatients and 77 general participants, all of whom met the diagnostic criteria of DES. Apart from the collection of sociodemographic and clinical data, the Chinese version of 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) and Ocular ...

    Also Ranks for: Dry Eye Syndrome |  osdi score |  life vrqol |  visionrelated quality |  vision ocular


    Jianjiang Xu: Influence Statistics

    Sample of concepts for which Jianjiang Xu is among the top experts in the world.
    Concept World rank
    agerelated cataracts location #1
    recipient mice atra #1
    cds chinese population #1
    mirna‑494 ngf #1
    snp rs10831500 #1
    ics limbus #1
    term pgas #1
    vrqol outpatients #1
    average cet #1
    mirna‑494 cyclin d1 #1
    post injury eyes #1
    thickness dry #1
    vkc infiltration #1
    decade keratoconus #1
    impact conjunctivochalasis #1
    quadrant correlation #1
    801 candidate genes #1
    keratograph fdoct #1
    current study calcitriol #1
    pinguecula female humans #1
    groups 534 ± #1
    keratoplasty repeat #1
    cet values #1
    corneal ecd eyes #1
    nikav keratograph #1
    carbomer eye #1
    controls central cornea #1
    pgas gcs density #1
    patients tears vitro #1
    ros generation ngf #1
    nonglaucomatous subjects fdoct #1
    worseseeing eye duration #1
    palmitate carbomer gel #1
    kc susceptibility #1
    keratoconus decade #1
    cch ocular #1
    cyclin d1 orf #1
    5303 ±367 μm #1
    confusion matrices similarities #1

    Key People For Confocal Microscopy

    Top KOLs in the world
    Milind M Rajadhyaksha
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    Salvador González
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    Roger Yonchien Tsien
    fluorescent proteins living cells protein kinase
    Watt W Webb
    multiphoton microscopy fluorescence correlation cell surface
    Pellacani Pellacani
    confocal microscopy actinic keratosis basal cell
    Caterina Longo
    confocal microscopy basal cell carcinoma melanocytic lesions

    Jianjiang Xu:Expert Impact

    Concepts for whichJianjiang Xuhas direct influence:Confocal microscopy,  Dry eye,  Eastern china,  Vivo laser,  Vivo confocal microscopy,  Tear meniscus,  Corneal epithelium,  Chemical burns.

    Jianjiang Xu:KOL impact

    Concepts related to the work of other authors for whichfor which Jianjiang Xu has influence:Dry eye,  Ocular surface,  Tear film,  Confocal microscopy,  Infectious keratitis,  Contact lens,  Optical coherence.



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    Key Laboratory of Myopia, Chinese Academy of Medical Science, 83 Fenyang Road, Shanghai 200031, China | Shanghai Key Laboratory of Visual Impairment and Restoration, (Fudan University), Shanghai, China. | NHC Key Laboratory of Myopia, Fudan Universit