• Disease
  • Congenital
  • Congenital Diaphragmatic
  • Congenital Diaphragmatic Hernia
  • Dick Tibboel

    Prominent publications by Dick Tibboel

    KOL Index score: 18094

    OBJECTIVE: To assess the value of antenatally determined observed to expected fetal lung area to head circumference ratio (LHR) in the prediction of postnatal survival in isolated, congenital diaphragmatic hernia (CDH).

    METHODS: Two groups of fetuses were examined. The first group included 650 normal fetuses at 12-32 weeks' gestation, and the data collected were used to establish a normal range of observed to expected LHR with gestational age. The second group included the data of a ...

    Also Ranks for: Circumference Ratio |  cdh lhr |  expected lung |  survival fetuses |  isolated diaphragmatic hernia
    KOL Index score: 15610

    INTRODUCTION: The lung-to-head ratio (LHR), measured by ultrasound, and the fetal lung volume (FLV), measured by MRI, are both used to predict survival and need for extra corporeal membrane oxygenation (ECMO) in infants with congenital diaphragmatic hernia (CDH). The aim of this study is to determine whether MRI measurements of the FLV, in addition to standard ultrasound measurements of the LHR, give better prediction of chronic lung disease, mortality by day 28 and need for ...

    Also Ranks for: Ecmo Therapy |  chronic lung disease |  congenital diaphragmatic hernia |  fetal mri |  membrane oxygenation
    KOL Index score: 15412

    BACKGROUND: Recent trials have questioned the benefit of early parenteral nutrition in adults. The effect of early parenteral nutrition on clinical outcomes in critically ill children is unclear.

    METHODS: We conducted a multicenter, randomized, controlled trial involving 1440 critically ill children to investigate whether withholding parenteral nutrition for 1 week (i.e., providing late parenteral nutrition) in the pediatric intensive care unit (ICU) is clinically superior to providing ...

    Also Ranks for: Late Parenteral Nutrition |  critically children |  early parenteral |  icu stay |  1 week
    KOL Index score: 15353

    The vagal neural crest adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives. Ganglionic derivatives are the neurons and supportive cells of the enteric nervous system (ENS), cardiac, and dorsal root ganglia. Ectomesenchymal derivatives are cells in the cardiac outflow tract and the mesenchymal components of thymus and parathyroids. Ectomesenchymal derivatives are formed by a segment of the vagal neural crest, from the level of the otic vesicle ...

    Also Ranks for: Vagal Neural Crest |  enteric ganglia |  hindgut neural |  adjacent somites |  chick embryo
    KOL Index score: 15183

    BACKGROUND: Pulmonary hypoplasia and persistent pulmonary hypertension (PPH) are the principal causes of the ongoing mortality in congenital diaphragmatic hernia (CDH) presenting with respiratory insufficiency within 6 hours after birth. Endothelin-1 (ET-1) is an endothelial-derived vasoconstrictor, which could play an important role in modulating pulmonary vascular tone in PPH. ET-1 exerts its role in controlling vascular tone through two different subtype receptors, endothelin-A ...

    Also Ranks for: Pulmonary Vasoconstriction |  congenital diaphragmatic hernia |  endothelin receptor |  gene expression |  eta etb
    KOL Index score: 14586

    OBJECTIVE: To compare the pharmacodynamics and pharmacokinetics of IV morphine after cardiac surgery in two groups of children-those with and without Down syndrome.

    DESIGN: Prospective, single-center observational trial.

    SETTING: PICU in a university-affiliated pediatric teaching hospital.

    PATIENTS: Twenty-one children with Down syndrome and 17 without, 3-36 months old, scheduled for cardiac surgery with cardiopulmonary bypass.

    INTERVENTIONS: A loading dose of morphine (100 μg/kg) was ...

    Also Ranks for: Cardiac Surgery |  children syndrome |  pharmacokinetics morphine |  cardiopulmonary bypass |  24 hours
    KOL Index score: 14339

    BACKGROUND: Pulmonary hypoplasia accompanied by pulmonary hypertension resistant to treatment is an important feature of congenital diaphragmatic hernia (CDH). The pathogenesis of the pulmonary vascular abnormalities in CDH remains to be elucidated at the molecular level. Vascular endothelial growth factor (VEGF), an endothelial cell specific mitogen, is known to play a role in pulmonary angiogenesis and vascular remodelling but there are no data on VEGF expression in patients with ...

    Also Ranks for: Pulmonary Hypertension |  vascular endothelial |  congenital diaphragmatic hernia |  growth factor |  enhanced expression
    KOL Index score: 13557

    CONTEXT: Newborns admitted to neonatal intensive care units (NICUs) undergo a variety of painful procedures and stressful events. Because the effect of continuous morphine infusion in preterm neonates has not been investigated systematically, there is confusion regarding whether morphine should be used routinely in this setting.

    OBJECTIVE: To evaluate the effects of continuous intravenous morphine infusion on pain responses, incidence of intraventricular hemorrhage (IVH), and poor ...

    Also Ranks for: Preterm Newborns |  routine morphine infusion |  randomized controlled trial |  ventilatory support |  severe ivh
    KOL Index score: 13382

    Congenital diaphragmatic hernia (CDH) is a major cause of refractory respiratory failure in the newborn. Pulmonary hypoplasia often limits survival. Vitamin A (Vit A) is an important signal for lung growth. We hypothesized that antenatal treatment with Vit A would stimulate lung growth and decrease mortality in experimental CDH induced in rats by ingestion of the herbicide nitrofen (2, 4-dichlorophenyl-p-nitrophenyl ether). Nitrofen was administered to pregnant rats on day 12 of ...

    Also Ranks for: Vit Day |  diaphragmatic hernias |  lung growth |  incidence cdh |  induced congenital
    KOL Index score: 13281

    The aim of the present study was to compare the architecture and alveolar epithelial cell composition of the pulmonary acinus in hypoplastic and normal fetal rat lungs. For this purpose, a rat model of pulmonary hypoplasia in association with congenital diaphragmatic hernia (CDH) induced by Nitrofen (100 mg on day 10 of pregnancy) was studied. Sections (5 microns) from lungs of control and Nitrofen-exposed fetal Sprague Dawley rats with or without CDH aged 18-22 days (vaginal plug on day ...

    Also Ranks for: Pulmonary Hypoplasia |  congenital diaphragmatic hernia |  rat model |  alveolar epithelial |  type cells
    KOL Index score: 13247

    The molecular basis of the pathogenesis of pulmonary hypertension (PH) associated with congenital diaphragmatic hernia (CDH) is poorly understood. Variation in responses to therapeutic strategies such as nitric oxide (NO) inhalation and extracorporeal membrane oxygenation (ECMO) in patients with CDH remains a major problem in pediatric critical care. We investigated the expression pattern of NO-generating enzyme nitricoxide synthase (NOS) (both endothelial [eNOS] and inducible [iNOS] ...

    Also Ranks for: Pulmonary Hypertension |  oxide synthase |  congenital diaphragmatic hernia |  inos patients |  cdh cases
    KOL Index score: 12933

    Finding the optimal pharmacological treatment of a patent ductus arteriosus (PDA) in preterm neonates remains challenging. There is a growing interest in paracetamol as a new drug for PDA closure. In this prospective observational cohort study, we evaluated the effectiveness of intravenous paracetamol in closing a PDA in very low birth weight infants with a hemodynamically significant PDA who either did not respond to ibuprofen or had a contraindication for ibuprofen. They received ...

    Also Ranks for: Intravenous Paracetamol |  patent ductus arteriosus |  birth weight |  pda closure |  newborn infant
    KOL Index score: 12906

    BACKGROUND: Remifentanil has been associated with increased acute and potentially chronic postoperative pain. The objective of this prospective randomized controlled trial was to investigate the influence of intraoperative remifentanil on acute and chronic postoperative pain after cardiac surgery.

    METHODS: Patients (N = 126) receiving standardized anesthesia with propofol and intermittent intravenous fentanyl at predetermined times for cardiac surgery were randomized to intraoperatively ...

    Also Ranks for: Cardiac Surgery |  chronic pain |  randomized controlled trial |  intraoperative remifentanil |  3 months
    KOL Index score: 12777

    In embryological terms, pathogenesis of congenital diaphragmatic hernia (CDH) associated with pulmonary hypoplasia is still unclear. However, it is known since 1971 that Nitrofen (2,4-dichloro-phenyl-p-nitrophenyl ether) can induce anatomical malformations in rats including diaphragmatic hernias. On order to establish an animal model of the embryogenesis of CDH, the effect of Nitrofen on the developing diaphragm was studied. Thirty-three pregnant female rats were exposed to Nitrofen. ...

    Also Ranks for: Diaphragmatic Hernias |  animal model |  nitrofen day |  pregnancy rats |  hernia cdh
    KOL Index score: 12763

    BACKGROUND: Descriptions of the pharmacokinetics and metabolism of morphine and its metabolites in young children are scant. Previous studies have not differentiated the effects of size from those related to age during infancy.

    METHODS: Postoperative children 0-3 yr old were given an intravenous loading dose of morphine hydrochloride (100 micro g kg(-1) in 2 min) followed by either an intravenous morphine infusion of 10 micro g h(-1) kg(-1) (n=92) or 3-hourly intravenous morphine boluses ...

    Also Ranks for: Young Children |  developmental pharmacokinetics |  elimination clearance |  morphine metabolites |  newborn male models


    Dick Tibboel: Influence Statistics

    Sample of concepts for which Dick Tibboel is among the top experts in the world.
    Concept World rank
    lh 1000 births #1
    tsa method limits #1
    pain sedation #1
    cdh findings #1
    diaphragmatic hernias cdh #1
    hazard rescue morphine #1
    nava patient comfort #1
    dxa outcome children #1
    14cmicrodosing #1
    dxa outcome #1
    opioids picu admission #1
    conclusiondecisions #1
    children creation #1
    studies sedation level #1
    mortality intravenous sildenafil #1
    children intellectually #1
    fragile spirituality #1
    term age size #1
    mabp pph #1
    prenatal diagnosis diagnosis #1
    delivery liveborn infants #1
    picu stay iqr #1
    hypertension cdh #1
    etiology tef #1
    postmortem biopsy #1
    pain sensitivity offspring #1
    clindamycin cpb systems #1
    increase plasma cortisol #1
    smc ecmo #1
    propofol concentration caai #1
    cdh patient #1
    ratios infants #1
    iqr pretest period #1
    neuroprognostication comatose children #1
    stenosis atresia #1
    ecmo cdhecmo #1
    cell proliferation recombinants #1
    term propacetamol doses #1
    objectivesfrom #1
    small intestinal muc2 #1
    bps nrs #1
    partners sox2 #1
    codinos trial protocol #1
    respiratory support 24 #1
    urogenital digestive tract #1
    pao2 analysis #1
    developmental association cdh #1
    pediatric covariate model #1
    agenesis trachea #1
    newborn surgical patient #1

    Key People For Congenital Diaphragmatic Hernia

    Top KOLs in the world
    Dick Tibboel
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    Jay M Wilson
    congenital diaphragmatic hernia lung growth novo variants
    Michael R Harrison
    fetal surgery congenital diaphragmatic hernia hyaluronic acid
    N Scott Adzick
    fetal surgery congenital diaphragmatic hernia prenatal diagnosis
    Kevin Patrick Lally
    congenital diaphragmatic hernia ventricular dysfunction defect size
    Jan A Deprest
    congenital diaphragmatic hernia fetal surgery gestational age

    Dick Tibboel:Expert Impact

    Concepts for whichDick Tibboelhas direct influence:Congenital diaphragmatic hernia,  Diaphragmatic hernia,  Diaphragmatic hernias,  Congenital diaphragmatic,  Cardiac surgery,  Pulmonary hypertension,  Esophageal atresia,  Extracorporeal membrane.

    Dick Tibboel:KOL impact

    Concepts related to the work of other authors for whichfor which Dick Tibboel has influence:Congenital diaphragmatic hernia,  Preterm infants,  Esophageal atresia,  Newborn infant,  Pulmonary hypertension,  Pain management,  Gestational age.



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    Intensive Care and Department of Pediatric Surgery, Erasmus MC University Medical Center, Rotterdam, Netherlands | Department of Pediatric Surgery and Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands | Intensive Care and