Department of Neurosurgery, Washington University in St. Louis School of Medicine, 63110, St. Louis, MO, USA | Department of Cell Biology, Genetics, and Physiology, Facultad ...
KOL Resume for María García‐Bonilla
Department of Neurosurgery, Washington University in St. Louis School of Medicine, 63110, St. Louis, MO, USA
Department of Cell Biology, Genetics, and Physiology, Facultad de Ciencias, Universidad de Málaga, Campus de Teatinos, 29071 Malaga, Spain
Departamento de Biología Celular, Genética y Fisiología, Universidad de Málaga, Campus de Teatinos, 29071, Malaga, Spain
Instituto de Investigación Biomédica de Málaga (IBIMA), Malaga, Malaga, Spain
University of Malaga Department of Cell Biology, Genetics, and Physiology Faculty of Sciences Malaga Spain
Departamento de Biología Celular, Genética y Fisiología, Universidad de Málaga, Campus Universitario de Teatinos, 29071 Málaga, Spain
María García‐Bonilla: Influence Statistics
|opcs ng2 antigen||#5|
|common neuropathological events||#5|
|mass spectrometry opcs||#5|
|hereditary hydrocephalus hydrocephalus||#5|
|opcs hydrocephalic mice||#5|
|hydrocephalus cerebral grey||#5|
|hydrocephalic mice opcs||#5|
|hyh mouse model||#6|
|illness neurodegenerative conditions||#8|
|differential profile metabolites||#8|
|neurodegenerative conditions icp||#8|
|key histopathological markers||#8|
|hydrocephalus neurodegenerative conditions||#8|
|severely hydrocephalic mice||#8|
|congenital hydrocephalus tnfα||#8|
|human foetuses hydrocephalus||#8|
|astrocytic reaction metabolites||#8|
|severity congenital hydrocephalus||#8|
|hyh mice hydrocephalus||#8|
|tnfαr1 mrna levels||#8|
|tnfαr1 normal mice||#8|
|hyh mouse tnfα||#8|
|tnfα tnfαr1 immunoreactivity||#8|
|neurodegenerative conditions severity||#8|
|cell death pvwm||#9|
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Prominent publications by María García‐Bonilla
Astrocytes acquire morphological and functional characteristics of ependymal cells following disruption of ependyma in hydrocephalus
[ PUBLICATION ]
Hydrocephalic hyh mutant mice undergo a programmed loss of the neuroepithelium/ependyma followed by a reaction of periventricular astrocytes, which form a new cell layer covering the denuded ventricular surface. We present a comparative morphological and functional study of the newly formed layer of astrocytes and the multiciliated ependyma of hyh mice. Transmission electron microscopy, immunocytochemistry for junction proteins (N-cadherin, connexin 43) and proteins involved in ...
|Known for Hyh Mice | Electron Microscopy | Animal Ependyma | Humans Hydrocephalus | Junction Proteins|
Increased levels of tumour necrosis factor alpha (TNFα) but not transforming growth factor‐beta 1 (TGFβ1) are associated with the severity of congenital hydrocephalus in the hyh mouse
[ PUBLICATION ]
AIMS: Here, we tested the hypothesis that glial responses via the production of cytokines such as transforming growth factor-beta 1 (TGFβ1) and tumour necrosis factor alpha (TNFα), which play important roles in neurodegenerative diseases, are correlated with the severity of congenital hydrocephalus in the hyh mouse model. We also searched for evidence of this association in human cases of primary hydrocephalus.
METHODS: Hyh mice, which exhibit either severe or compensated long-lasting ...
|Known for Congenital Hydrocephalus | Necrosis Factor | Hyh Mice | Neurodegenerative Diseases | Mouse Model|
A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus
[ PUBLICATION ]
In congenital hydrocephalus, cerebrospinal fluid accumulation is associated with increased intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage, and astrocytic reaction. The aim of this study was to identify whether a metabolite profile revealing tissue responses according to the severity of hydrocephalus can be detected. The hyh mutant mouse used for this study exhibits 2 different forms of hydrocephalus, severe and moderate. In a comprehensive ...
|Known for Congenital Hydrocephalus | Neurodegenerative Conditions | Ischemia Hypoxia | Cerebrospinal Fluid Accumulation | Intracranial Pressure|
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells
[ PUBLICATION ]
BackgroundIn obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial reactions in the neocortex. The viability and short time effects of a therapy based on bone marrow-derived mesenchymal stem cells (BM-MSC) have been evaluated in such pathological conditions in the hyh mouse model.MethodsBM-MSC obtained from mice expressing ...
|Known for White Matter | Glial Reactions | Congenital Hydrocephalus | Hyh Mouse Model | Neurodegenerative Conditions|
Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter
[ PUBLICATION ]
BackgroundHydrocephalus is a neurological disease with an incidence of 80–125 per 100,000 births in the United States. Neuropathology comprises ventriculomegaly, periventricular white matter (PVWM) alterations, inflammation, and gliosis. We hypothesized that hydrocephalus in a pig model is associated with subventricular and PVWM cellular alterations and neuroinflammation that could mimic the neuropathology described in hydrocephalic infants.MethodsHydrocephalus was induced by ...
|Known for White Matter|
Key People For Congenital Hydrocephalus
María García‐Bonilla:Expert Impact
Concepts for whichMaría García‐Bonillahas direct influence:Congenital hydrocephalus, Subventricular zone, Neurodegenerative conditions, Hyh mouse, Metabolite profile, Hyh mice, Acquired hydrocephalus, Hyh mouse model.
María García‐Bonilla:KOL impact
Concepts related to the work of other authors for whichfor which María García‐Bonilla has influence:Subventricular zone, Cerebrospinal fluid, Ependymal cells, Lateral ventricles, Congenital hydrocephalus, Ventricular wall, Brain parenchyma.
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