María García-Bonilla

María García-Bonilla

Departamento De Biología Celular, Genética Y Fisiología, Universidad De Málaga, Campus De Teatinos, 29071, Malaga, Spain Instituto De Investigación Biomédica De Málaga ...

Direct Impact

Concepts for which María García-Bonilla has direct influence:

congenital hydrocephalus
hyh mouse
neurodegenerative conditions
tumour necrosis factor alpha
metabolite profile
growth factor
white matter

External impact

Concepts related to the work of other authors for which María García-Bonilla has influence:

congenital hydrocephalus
hyh mouse
tumour necrosis factor alpha
neurodegenerative conditions
metabolite profile
growth factor
diffusion mri

Prominent publications by María García-Bonilla

KOL-Index: 70 BACKGROUND: Periventricular extracellular oedema, myelin damage, inflammation, and glial reactions are common neuropathological events that occur in the brain in congenital hydrocephalus. The periventricular white matter is the most affected region. The present study aimed to identify altered molecular and cellular biomarkers in the neocortex that can function as potential therapeutic ...
Known for
Hyh Mouse Model | Cerebral White Matter | Oligodendrocyte Differentiation | Oedema Conditions
KOL-Index: 25 In congenital hydrocephalus, cerebrospinal fluid accumulation is associated with increased intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage, and astrocytic reaction. The aim of this study was to identify whether a metabolite profile revealing tissue responses according to the severity of hydrocephalus can be detected. The hyh mutant mouse used for this ...
Known for
Cerebrospinal Fluid Accumulation | 2 Progressions | Key Histopathological Markers | Differential Astrocytic
KOL-Index: 24 BackgroundIn obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial reactions in the neocortex. The viability and short time effects of a therapy based on bone marrow-derived mesenchymal stem cells (BM-MSC) have been evaluated in ...
Known for
Hyh Mice | Severe Congenital Hydrocephalus | Astrocyte Reaction | Msc Conditions
KOL-Index: 19 AIMS: Here, we tested the hypothesis that glial responses via the production of cytokines such as transforming growth factor-beta 1 (TGFβ1) and tumour necrosis factor alpha (TNFα), which play important roles in neurodegenerative diseases, are correlated with the severity of congenital hydrocephalus in the hyh mouse model. We also searched for evidence of this association in human cases of ...
Known for
Astrocyte Reaction | Neurodegenerative Processes | Glial Responses | Growth Factor‐beta
KOL-Index: 8 Hydrocephalic hyh mutant mice undergo a programmed loss of the neuroepithelium/ependyma followed by a reaction of periventricular astrocytes, which form a new cell layer covering the denuded ventricular surface. We present a comparative morphological and functional study of the newly formed layer of astrocytes and the multiciliated ependyma of hyh mice. Transmission electron microscopy, ...
Known for
Layer Astrocytes

Departamento de Biología Celular, Genética y Fisiología, Universidad de Málaga, Campus de Teatinos, 29071, Malaga, Spain Instituto de Investigación Biomédica de Málaga (IBIMA), Malaga, Spain

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