Krista F. Huybrechts

Krista F. Huybrechts

Brigham And Women’s Hospital, Harvard Medical School. 1620 Tremont Street, Suite 3030. Boston, Ma 02120. Usa. Khuybrechts@bwh.harvard.edu

Direct Impact

Concepts for which Krista F Huybrechts has direct influence:

congenital malformations
pregnant women
oral clefts
vaginal delivery
postpartum hemorrhage
pregestational diabetes
nursing homes

External impact

Concepts related to the work of other authors for which Krista F Huybrechts has influence:

birth defects
pregestational diabetes
pregnant women
congenital malformations
persistent opioid
depressive symptoms
parental age

Prominent publications by Krista F. Huybrechts

KOL-Index: 61 BACKGROUND: Despite the prevalence and negative impact of posttraumatic stress disorder (PTSD), there are few medications approved by the U.S. Food and Drug Administration for treatment, and approved medications do not work well enough. We leveraged large-scale electronic health record data to identify existing medications that may be repurposed as PTSD treatments. METHODS: We constructed a ...
Known for
Large-Scale Electronic Record | 20-Year Period | Food Drug Administration-Approved Medications | Established Ptsd Treatments
KOL-Index: 54 Premarketing studies typically exclude pregnant women and children, although new regulations have promoted their inclusion in clinical trials. Thus, usage of medicines off‐label and off‐evidence in these vulnerable populations remains common, and pharmacoepidemiology has an important role in supplying critical missing evidence about the beneficial and harmful effects of drugs in these ...
Known for
Children Members | Designs Methodologic
KOL-Index: 49 OBJECTIVE: To assess whether maternal calcium channel blocker exposure during late pregnancy is independently associated with neonatal seizures after carefully controlling for confounding factors. METHODS: Data were derived from the Medicaid Analytic eXtract for the years 2000-2007 and included 2,529,636 completed pregnancies. We compared the risk of neonatal seizures among neonates who were ...
Known for
Exposure Late | Neonatal Complication | Null Finding | Unexposed Women
KOL-Index: 46 OBJECTIVE: There is inconsistent evidence that zidovudine use during pregnancy increases overall, cardiac, and male genital malformations. DESIGN: We conducted a systematic review and meta-analysis of zidovudine use and malformations and, using Bayesian methods, combined it with data from a cohort study of mother-infant pairs in the nationwide Medicaid Analytic eXtract (MAX). METHODS: Using ...
Known for
Art Bayesian | Zidovudine-Exposed | Methods Max | Malformations Cardiac
KOL-Index: 46 INTRODUCTION: Preterm birth is a major contributor to neonatal morbidity and mortality and its rate has been increasing over the past two decades. Antidepressant medication use during pregnancy has also been rising, with rates up to 7.5% in the US. The objective was to systematically review the literature to determine the strength of the available evidence relating to a possible association ...
Known for
Birth Women | Antidepressants Pregnancy | Increased Preterm
KOL-Index: 37 OBJECTIVE: To examine the risk of congenital malformations associated with exposure to oral fluconazole at commonly used doses in the first trimester of pregnancy for the treatment of vulvovaginal candidiasis. DESIGN: Population based cohort study. SETTING: A cohort of pregnancies publicly insured in the United States, with data from the nationwide Medicaid Analytic eXtract 2000-14. ...
Known for
Azoles Oral | Commonly Doses | Exposed Topical | Menstrual Period
KOL-Index: 37 Importance: Concerns exist that use of selective serotonin reuptake inhibitors (SSRIs) increases the risk of developing type 2 diabetes (T2D) in adults, but evidence in children and adolescents is limited. In the absence of a randomized clinical trial, evidence must be generated using real-world data. Objective: To evaluate the safety of SSRI use in children and adolescents with respect to ...
Known for
Psychotherapy Exposure | T2d Publicly | Fluoxetine Hydrochloride | Ssri Increased
KOL-Index: 33 AIM: To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. METHODS: Individually linked health data in Denmark (2000-2012), Finland (2005-2014), Iceland (2004-2017), Norway (2005-2015), Sweden (2006-2015), Germany (2006-2015), Australia (New South Wales, 2004-2012), Hong Kong (2001-2015), UK (2006-2016), and the US ...
Known for
Commonly Typical | Antipsychotic Prochlorperazine | 2006 Australia | 2004 2012
KOL-Index: 33 Previous reviews have shown that changes in prescription drug insurance benefits can affect medication use and adherence. We conducted a systematic review of the literature to identify studies addressing the association between prescription drug coverage and health outcomes. Studies were included if they collected empirical data on expansions or restrictions of prescription drug coverage and ...
Known for
Prescription Drug Insurance Benefits | Expansions | State-Based Insurance
KOL-Index: 32 OBJECTIVE: To examine the association between first-trimester angiotensin-converting enzyme (ACE) inhibitor exposure and the risk of overall major congenital, cardiac, and central nervous system malformations. METHODS: We used a cohort of completed pregnancies linked to liveborn neonates derived from Medicaid claims from 2000 to 2010. We examined the risk of malformations associated with ...
Known for
Inhibitor Exposure | Unexposed Unadjusted | Maternal Demographics | Completed Pregnancies

Brigham and Women’s Hospital, Harvard Medical School. 1620 Tremont Street, Suite 3030. Boston, MA 02120. USA. khuybrechts@bwh.harvard.edu

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