• Disease
  • Esophageal
  • Esophageal Atresia
  • Lewis Spitz

    Prominent publications by Lewis Spitz

    KOL Index score: 13950

    HYPOTHESIS: Primary anastomosis following intestinal resection is a valid surgical option in the treatment of infants with necrotizing enterocolitis (NEC) who weigh less than 1000 g.

    DESIGN: Retrospective case series.

    SETTING: Tertiary neonatal surgery referral center.

    PATIENTS: All infants with confirmed NEC weighing less than 1000 g admitted to our intensive care unit over 4 years.

    INTERVENTION: For infants requiring laparotomy and intestinal resection, primary anastomosis was ...

    Also Ranks for: Primary Anastomosis |  necrotizing enterocolitis |  infants nec |  intestinal resection |  newborn infant
    KOL Index score: 13049

    Recurrence of gastro-oesophageal reflux (GOR) following redo Nissen fundoplication represents a significant clinical problem. The aim of this study was to identify factors predicting failure of redo Nissen fundoplication. The notes of children who underwent redo Nissen fundoplication for recurrent GOR in a single institution between June 1994 and May 2005 were reviewed. Data are reported as median (range), or as numbers of cases. Multiple logistic regression analysis, using type of first ...

    Also Ranks for: Nissen Fundoplication |  neurological impairment |  failure redo |  oesophageal atresia |  postoperative complications
    KOL Index score: 11868

    BACKGROUND/PURPOSE: Surgical neonates are at risk of sepsis-associated liver dysfunction. Hydrogen peroxide (H(2)O(2)) and nitric oxide (NO) are important mediators of sepsis, which impair neonatal hepatic metabolism. Glutamine has been shown to have beneficial effects on hepatocyte metabolism during neonatal sepsis. However, the molecular basis of these effects are unknown. The aim of this study was to test the hypotheses that (1) glutamine and its dipeptides counteract the inhibitory ...

    Also Ranks for: Effects Glutamine |  neonatal hepatocytes |  glutathione synthesis |  amino acids |  hydrogen peroxide h2o2
    KOL Index score: 11855

    Multisystem organ failure represents a major cause of mortality in intestinal ischemia and reperfusion (I/R), and oxidative stress plays a key role in its pathogenesis. Hypothermia is beneficial in I/R injury, but its effects on systemic oxidative stress have not been elucidated. The aim of this study was to evaluate the effects of moderate hypothermia on systemic oxidative stress after intestinal I/R injury. Anaesthetized adult rats (n = 10 per group) underwent 60 min of intestinal ...

    Also Ranks for: Oxidative Stress |  intestinal ischemia |  moderate hypothermia |  reperfusion injury |  ileum lungs
    KOL Index score: 11677

    BACKGROUND/PURPOSE: A small proportion of infants born with oesophageal atresia in which the gap between the 2 ends of the oesophagus is too great for an end-to-end anastomosis will require oesophageal replacement. Since 1981 the author's procedure of choice for oesophageal replacement has been gastric transposition. The long-term functional outcome appears to be satisfactory, but the quality of life of these patients has not been investigated formally. This report assesses the ...

    Also Ranks for: Gastric Transposition |  oesophageal atresia |  quality life |  qol patients |  surgical procedures
    KOL Index score: 11521

    PURPOSE: The aim of this study was to characterize the type and incidence of complications related to colostomy formation in newborn infants with anorectal anomalies.

    METHODS: The authors reviewed a 5-year (1994 to 1999) experience of a single institution in the management of neonates with high and intermediate anorectal anomalies who required colostomy at birth. Patients with colostomy still in place have been excluded from the study to maximize the chances of detecting ...

    Also Ranks for: Colostomy Formation |  anorectal anomalies |  incidence complications |  urinary tract |  rectal fistula
    KOL Index score: 10577

    OBJECTIVE: To evaluate whether critically ill children with systemic inflammatory response syndrome (SIRS) or sepsis have altered resting energy expenditure (REE) and substrate utilization.

    SUMMARY BACKGROUND DATA: Studies in adults with sepsis have shown increased energy expenditure and mobilization of endogenous fat. In infants and children, energy metabolism and substrate utilization during sepsis have not been characterized.

    METHODS: Metabolic studies were performed in 21 critically ...

    Also Ranks for: Energy Metabolism |  sirs sepsis |  inflammatory response |  infants children |  fat utilization
    KOL Index score: 10323

    PURPOSE: The purpose of this study was to analyze the outcome in 173 children (104 M, 69 F) undergoing transposition since 1981.

    METHODS: The most common indications for esophageal replacement included failed repair of different varieties of esophageal atresia (127), caustic injury (23), and peptic strictures (8). A total of 81% of the patients were referred from other hospitals (50% from other countries). Age at operation ranged from 7 days to 17 years. The gastric transposition was ...

    Also Ranks for: Gastric Transposition |  patients outcome |  esophageal replacement |  caustic injury |  graft failures
    KOL Index score: 9860

    This was a qualitative research study of parental perceptions of gastrostomy feeding before surgery using an in-depth interview in the parental home to examine the factors parents consider when gastrostomy feeding is recommended and to identify the need for support. Participants were a subgroup of families taking part in a larger research study evaluating gastrostomy placement in children with severe neurodevelopmental disabilities at a major paediatric centre in the UK between 1998 and ...

    Also Ranks for: Gastrostomy Feeding |  neurodevelopmental disabilities |  parents children |  cerebral palsy |  qualitative study
    KOL Index score: 9790

    BACKGROUND: Before 1999, infants born in the UK with suspected biliary atresia were investigated in regional centres, and, if confirmed, a Kasai operation was done there. Since 1999, all infants with suspected biliary atresia in England and Wales, UK, have been referred to one of three designated centres where both the Kasai operation and liver transplantation (if necessary) could be done.

    METHODS: We assessed clearance of jaundice (bilirubin <20 micromol/L) as an early outcome in all ...

    Also Ranks for: Biliary Atresia |  england wales |  native liver |  kasai operation |  transplantation portoenterostomy
    KOL Index score: 9478

    Necrotizing enterocolitis (NEC) is the most common surgical emergency in the newborn. Up to half of babies with NEC develop advanced disease requiring surgical intervention. Options include peritoneal drainage under local anaesthetic, enterostomy only, resection and enterostomies, and resection with primary anastomosis. Resection with enterostomies is favoured by many paediatric surgeons but management of neonatal enterostomies can be difficult. The outcome of 26 infants undergoing ...

    Also Ranks for: Primary Anastomosis |  necrotizing enterocolitis |  infants nec |  peritoneal drainage |  surgical intervention
    KOL Index score: 9467

    PURPOSE: The aim of this study was to evaluate the clinical significance of low platelet count in the surgical management of neonates with necrotizing enterocolitis (NEC).

    METHODS: The clinical course of 58 consecutive neonates with advanced NEC (Bell's stages II or III) treated in the authors' hospital between 1995 and 1998 was reviewed. NEC in neonates who required operation was classified as isolated, multifocal, or pan-intestinal. Severe thrombocytopenia was defined as platelet count ...

    Also Ranks for: Platelet Count |  clinical significance |  enterocolitis nec |  severe thrombocytopenia |  surgical management
    KOL Index score: 9272

    PURPOSE: The aim of this study was to evaluate the results of surgical treatment of necrotizing enterocolitis (NEC) according to the extent of disease and to establish if resection of the ileocecal valve represents a poor prognostic factor.

    METHODS: The authors reviewed all cases of NEC (n = 161) treated in our hospital during the last 11 years; of these, 83 required surgical intervention. Definitions used by the authors include isolated, disease in a single intestinal segment; ...

    Also Ranks for: Surgical Treatment |  necrotizing enterocolitis |  neonates nec |  extent disease |  primary anastomosis
    KOL Index score: 9068

    OBJECTIVE: To determine the accuracy of prenatal and postnatal echocardiography in delineating the degree of cardiac fusion, intracardiac anatomy (ICA), and ventricular function of 23 sets of conjoined twins with thoracic level fusion presenting to a single centre over a 20 year period.

    METHODS: 13 thoracopagus, 5 thoraco-omphalopagus, and 5 parapagus pairs presenting to the authors' institution between 1985 and 2004 inclusive were assessed. Echocardiographic data were analysed together ...

    Also Ranks for: Conjoined Twins |  echocardiographic assessment |  cardiac fusion |  congenital humans infant |  separate hearts
    KOL Index score: 8949

    BACKGROUND/PURPOSE: Secondary organ damage to the lungs is an important consequence of intestinal ischaemia reperfusion (IIR) injury. Moderate hypothermia ameliorates gut necrosis and liver energy failure after IIR but potential beneficial effects on lung neutrophil infiltration after reperfusion of ischaemic bowel have not been investigated.

    METHODS: Adult Sprague-Dawley rats underwent 60 minutes intestinal ischaemia followed by 120 minutes of reperfusion. The animals were maintained at ...

    Also Ranks for: Intestinal Ischaemia |  moderate hypothermia |  reperfusion injury |  neutrophil infiltration |  sham normothermia


    Lewis Spitz: Influence Statistics

    Sample of concepts for which Lewis Spitz is among the top experts in the world.
    Concept World rank
    atresia follow #1
    gas abdominal radiographs #1
    tracheooesophageal fistula atresia #1
    lymphatic vessels submucosa #1
    fecal toxin positivity #1
    separation variations #1
    separation procedure stages #1
    vertebral 17 #1
    children symptomatic tracheomalacia #1
    primary anastomosis infants #1
    thirty fullterm infants #1
    irretrievable esophageal damage #1
    esophageal replacement improvement #1
    emergency ligation fistula #1
    pyopagus conjoined twins #1
    complication rates 51 #1
    bethanechol treatment hypogammaglobulinaemia #1
    1960s genesis #1
    infants anomalies #1
    cytopathic toxin faeces #1
    transposition esophageal #1
    lipiodol hepatoblastoma cells #1
    combination morbidity #1
    caustic oesophageal strictures #1
    gastric transposition gt #1
    diagnosis atresia #1
    unit tca #1
    surgery emetic reflex #1
    conjoined united kingdom #1
    35 18 #1
    uptake radioconjugates #1
    ruptured omphalocele #1
    250000 live births #1
    treated hepatoblastoma #1
    costeffectiveness gastrostomy placement #1
    thirteen infants haematemesis #1
    twins ica #1
    management 45 years #1
    nec lymphatic occlusion #1
    comparable isolation rates #1
    adhesion obstruction cent #1
    surgical challenge gastrostomy #1
    cardia treatment options #1
    details modern #1
    surgical intervention dilatations #1
    iiselfevident intervention #1
    aluminium 2 children #1
    initial enterostomy #1
    abdominoperineal pullthrough #1

    Key People For Esophageal Atresia

    Top KOLs in the world
    Lewis Spitz
    esophageal atresia conjoined twins gastric transposition
    Edward Matthew Kiely
    esophageal atresia primary anastomosis conjoined twins
    Risto Juhana Rintala
    anorectal malformations bowel function esophageal atresia
    Harry G Lindahl
    esophageal atresia anorectal malformations fecal continence
    Roger James Brereton
    esophageal atresia intestinal malrotation neonatal surgical unit
    Frédéric Gottrand
    european adolescents physical activity healthy lifestyle

    Lewis Spitz:Expert Impact

    Concepts for whichLewis Spitzhas direct influence:Esophageal atresia,  Oesophageal atresia,  Conjoined twins,  Gastric transposition,  Primary anastomosis,  Moderate hypothermia,  Nissen fundoplication,  Esophageal replacement.

    Lewis Spitz:KOL impact

    Concepts related to the work of other authors for whichfor which Lewis Spitz has influence:Esophageal atresia,  Conjoined twins,  Hirschsprung disease,  Newborn infant,  Necrotizing enterocolitis,  Anorectal malformations,  Parenteral nutrition.



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    Specialist Neonatal and Paediatric Surgery, Great Ormond Street Hospital for Children; Stem Cells and Regenerative Medicine section, Developmental biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health. Electronic address: l.