• Disease
  • Central
  • Central Nervous
  • Antonio Gaetano Tavoni

    Prominent publications by Antonio Gaetano Tavoni

    KOL Index score: 11690

    OBJECTIVE: To develop valid instruments for the assessment of disease-related damage and disease activity in Sjögren's syndrome (SS).

    METHODS: Data on 206 patients with primary SS were collected in 12 Italian centers. Each patient was scored by 1 investigator, on the basis of a global assessment of the degree of disease damage and disease activity. Patients judged to have active disease at the time of enrollment underwent a second evaluation after 3 months. Univariate and multivariate ...

    Also Ranks for: Disease Damage |  activity ssdai |  sjögrens syndrome |  salivary glands |  humans italy
    KOL Index score: 10706

    OBJECTIVE: Mixed cryoglobulinemia syndrome (MCs) is a systemic vasculitis characterized by multiple organ involvement due to the vascular deposition of immune-complexes, mainly the cryoglobulins. B-lymphocyte expansion represents the underlying pathological alteration frequently triggered by hepatitis C virus (HCV) infection. The treatment of MCs syndrome is generally based on antiviral drugs and/or immunosuppressors, among which rituximab, an anti-CD20 monoclonal antibody, has been ...

    Also Ranks for: Mixed Cryoglobulinemia Syndrome |  hcv infection |  rituximab patients |  complete remission |  cryoglobulinemic vasculitis
    KOL Index score: 10556

    BACKGROUND: Even when treated with current protocols, 25 to 30% of systemic lupus erythematosus (SLE) patients with diffuse proliferative glomerulonephritis (DPGN) evolve to end-stage renal disease (ESRD). The occurrence of renal flares is considered to be an important risk factor for the evolution to ESRD. The aim of this retrospective study was to evaluate the incidence and prognostic significance of renal flares in SLE patients with DPGN and to identify predictors for the occurrence ...

    Also Ranks for: Renal Flares |  sle patients |  serum creatinine |  diffuse proliferative |  systemic lupus
    KOL Index score: 9990

    The objective of this work was to evaluate the clinical and serological profiles of patients with undifferentiated connective tissue diseases (UCTD) who had been followed for at least 1 year. The retrospective analysis (197495) was based on UCTD patients diagnosed on the basis of clinical manifestations suggestive of a connective tissue disease, and the presence of at least one non-organ-specific autoantibody. A total of 91 patients were evaluated. The condition of 79 remained stable ...

    Also Ranks for: Connective Tissue |  1 year |  antiro ssa |  uctd patients |  lupus erythematosus
    KOL Index score: 9393

    OBJECTIVE: To conduct a long-term, prospective, randomized controlled trial evaluating rituximab (RTX) therapy for severe mixed cryoglobulinemia or cryoglobulinemic vasculitis (CV).

    METHODS: Fifty-nine patients with CV and related skin ulcers, active glomerulonephritis, or refractory peripheral neuropathy were enrolled. In CV patients who also had hepatitis C virus (HCV) infection, treatment of the HCV infection with antiviral agents had previously failed or was not indicated. Patients ...

    Also Ranks for: Cryoglobulinemic Vasculitis |  rtx treatment |  hcv infection |  antibodies monoclonal |  randomized controlled
    KOL Index score: 8355

    BACKGROUND/AIM: The IgG4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect almost any organ, often associated with eosinophilia and increased levels of IgE and IgG4. Overexpression in tissues of Th2-related cytokines but also of IFN-γ has been reported. Given the major role of Il-1 family cytokines in inducing and regulating inflammation, and the paucity of data so far available in IgG-RD, we performed a comprehensive analysis of IL-18, related IL-1 family ...

    Also Ranks for: Il1 Cytokines |  soluble receptors |  igg4related disease |  fibroinflammatory condition |  comprehensive analysis
    KOL Index score: 7249

    OBJECTIVE: The aims of this study were to describe the clinical presentation of primary SS (pSS) in a large cohort of patients by assessing the prevalence of the patient subgroups at high risk for severe extraglandular manifestations and to explore the influence of the patients' serological profile on disease severity and on immunosuppressive drug utilization.

    METHODS: Cumulative demographic, clinical, serological, histological and therapeutic data of 1115 pSS patients were ...

    Also Ranks for: Large Cohort |  clinical presentation |  primary sjögren |  pss patients |  serological profile
    KOL Index score: 6994

    Undifferentiated connective tissue disease (UCTD) is a group of systemic autoimmune conditions not fulfilling the classification criteria for a definite connective tissue disease (CTD). While an average of 20% of UCTD patients develop a defined CTD during follow-up, the remaining patients maintain an undefined disease. Since pregnancy is considered to be an important factor that may alter the course of autoimmune diseases, we examined 25 pregnancies in 20 UCTD patients being followed at ...

    Also Ranks for: Pregnancy Outcome |  connective tissue |  uctd patients |  defined ctd |  autoimmune diseases
    KOL Index score: 6783

    Chronic glucocorticoid (GC) therapy is associated with an increased risk of developing cataracts and glaucoma, and recommendations have been developed for monitoring these side effects in patients with rheumatic diseases. The aim of this study was to assess the prevalence of cataracts and glaucoma and the adherence to the existing recommendations for monitoring eye toxicity of chronic GC therapy among systemic lupus erythematosus (SLE) patients in routine clinical practice. Clinical ...

    Also Ranks for: Systemic Lupus |  sle patients |  rheumatic diseases |  monitoring eye |  female glaucoma
    KOL Index score: 6163

    Lung function was assessed in 20 patients with primary Sjögren's syndrome (SS) and in a group of patients with SS associated with a variety of connective tissue diseases. Signs of small airway disease and of altered diffusion capacity, together with chest x-ray features of mild interstitial involvement, were the most common findings in primary SS. On the whole, lung involvement was more frequent and severe in patients with the secondary form of the syndrome. In both primary and secondary ...

    Also Ranks for: Lung Involvement |  syndrome patients |  secondary form |  connective tissue |  diffusion capacity
    KOL Index score: 5992

    Rituximab (RTX) represents a milestone in the treatment of mixed cryoglobulinemic vasculitis (MCV). Despite usually well-tolerated, RTX may induce different types of adverse drug reactions, including exacerbation of vasculitis. Recently, RTX biosimilar CT-P10 has been approved in Europe for the treatment of rheumatoid arthritis, but no data are available about effectiveness and safety of CT-P10 in the treatment of MCV. In this multicenter open-label study, we analyzed the safety of ...

    Also Ranks for: Rituximab Biosimilar |  cryoglobulinemic vasculitis |  originator rtx |  monoclonal murine |  humans italy


    Antonio Gaetano Tavoni: Influence Statistics

    Sample of concepts for which Antonio Gaetano Tavoni is among the top experts in the world.
    Concept World rank
    rituximab favorable outcome #1
    bcdt option #1
    refractory potential #1
    bcdt cases #1
    potential controlled trials #1
    active refractory patients #1
    unknown origin aorta #1
    view bcdt #1
    aggressive cytotoxic regimens #2
    death cryoglobulinemia #2
    cases renal manifestations #2
    fibromyalgia double #2
    dsa pacns #2
    sunlight igg4related disease #2
    pacns central nervous #2
    igg4rkd consequence #2
    igg4rkd glomerular disease #2
    ribavirin mixed #2
    central nervous mra #2
    aggressive modalities cases #2
    weakness arthralgias #2
    827 intracranial stenoses #2
    igg4related disease sunlight #2
    vasculitis chronic humans #2
    renal manifestations review #2
    cases lifethreatening conditions #2
    002 italian #2
    treatment prevailing symptom #2
    pacns patients dsa #2
    postrenal ureteral obstruction #2
    igg4rd frequent presentation #2
    storiform fibrosis kidney #2
    frequent presentation igg4rkd #2
    dsa pacns patients #2
    spondylitis paget #2
    italian evaluating test #3
    drw52 extraglandular manifestations #3
    serological variables #3
    class alloantigens patients #3
    italian sjögren #3
    dr2 drw52 alloantigens #3
    syndrome dr3 #3
    review igg4rd #3
    report pathological event #3
    mc discovery #3

    Key People For Central Nervous

    Top KOLs in the world
    Hans P Lassmann
    multiple sclerosis central nervous autoimmune encephalomyelitis
    Richard M Ransohoff
    multiple sclerosis central nervous chemokine receptors
    Fred H Gage
    stem cells dentate gyrus adult neurogenesis
    Cedric S Raine
    multiple sclerosis central nervous autoimmune encephalomyelitis
    Wolfgang Brück
    multiple sclerosis central nervous wallerian degeneration
    Ben Anthony Barres
    schwann cells oligodendrocyte differentiation astrocyte activation

    Antonio Gaetano Tavoni:Expert Impact

    Concepts for whichAntonio Gaetano Tavonihas direct influence:Central nervous,  Renal flares,  Mixed cryoglobulinemia,  Italian patients,  Primary angiitis,  Parotid sialography,  Hypersensitivity reactions,  Biological agents.

    Antonio Gaetano Tavoni:KOL impact

    Concepts related to the work of other authors for whichfor which Antonio Gaetano Tavoni has influence:Sjögren syndrome,  Lupus nephritis,  Takayasu arteritis,  Systemic sclerosis,  Renal involvement,  Rheumatoid arthritis,  Mixed cryoglobulinemia.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Department of Clinical Immunology, University of Pisa, Pisa, Italy | Clinical Immunology and Allergy Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy | Clinical Immunology Unit, Department of Clinical and Experi