Else A Tolner: Influence Statistics

Else A Tolner

Else A Tolner

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands | Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands | ...

Else A Tolner: Expert Impact

Concepts for which Else A Tolner has direct influence: Cortical spreading depression , Chronic epileptic rats , Cortical spreading , Spreading depression , Subplate neurons , Fatal seizures , Entorhinal cortex .

Else A Tolner: KOL impact

Concepts related to the work of other authors for which for which Else A Tolner has influence: Mass spectrometry , Temporal lobe epilepsy , Entorhinal cortex , Febrile seizures , Status epilepticus , Sudden unexpected death , Cortical spreading depression .

KOL Resume for Else A Tolner


Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands


Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands.


Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands


Departments of Human Genetics,

Neurology, Leiden University Medical Center, 2300 RC Leiden, Netherlands, and


Departments of Neurology and Human Genetics, Leiden University Medical Center, Leiden, The Netherlands


Department of Neurology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.


Leiden University Medical Center Department of Neurology Leiden The Netherlands


Department of Neurology, Leiden University Medical Centre, The Netherlands


Leiden Univ. Medical Ctr. (Netherlands)


Migraine Research Group, Leiden University Medical Centre, Leiden, the Netherlands


Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland, and


Department of Biosciences, University of Helsinki


Department of Biosciences, University of Helsinki, Helsinki, Finland


Department of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland


Institute of Neurophysiology, Charité Universitätsmedizin Berlin, Humboldt Universität, Tucholskystr. 2, D-10117 Berlin, Germany


Institute of Physiology, Charité, Berlin, Germany


Swammerdam Institute of Life Sciences, Center for Neuroscience, University of Amsterdam, Graduate School of Neurosciences, 1098 SM Amsterdam, The Netherlands.


Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 SM Amsterdam, The Netherlands


Swammerdam Institute of Life Sciences, Section of Neurobiology, University of Amsterdam, Graduate School of Neurosciences Amsterdam, 1098 SM, Amsterdam, The Netherlands

Prominent publications by Else A Tolner

KOL-Index: 13692 . Sudden unexpected death in epilepsy (SUDEP) is a fatal complication of epilepsy in which brainstem spreading depolarization may play a pivotal role, as suggested by animal studies. However, patiotemporal details of spreading depolarization occurring in relation to fatal seizures have not been investigated. In addition, little is known about behavioural and neurophysiological features that ...
Known for Fatal Seizures | Spreading Depolarization | Cacna1as218l Mice | Epilepsy Sudep
KOL-Index: 11193 . Mossy fiber sprouting (MFS) in the hippocampal dentate gyrus is thought to play a critical role in the hyperexcitability of the hippocampus in temporal lobe epilepsy patients. The composition of molecular signals that is needed to direct this sprouting response has not yet been elucidated to a great extent. In the present study we investigated the expression profile of Sema3A mRNA and the ...
Known for Mossy Fiber | Rat Model | Temporal Lobe | Status Epilepticus
KOL-Index: 10797 . We investigated the potential of 4-AP (50-100 microM) to induce seizure-like events (SLEs) in combined entorhinal cortex-hippocampal slices from Sprague Dawley rats which developed spontaneous limbic seizures following kainic acid induced status epilepticus. Slices from control rats (n=8) displayed SLEs in the entorhinal and perirhinal cortex upon application of 50 or 100 microM 4-AP. By ...
Known for Entorhinal Cortex | Epileptic Rats | Reduced Ictogenic Potential | Sles Slices
KOL-Index: 9872 . Immunocytochemical markers of specific rat hippocampal interneuron subpopulations, including the calcium binding proteins parvalbumin (PV), and calretinin (CR) were examined in relation to the evolution of spontaneous seizures after electrically induced status epilepticus (SE). PV/CR/NeuN immunoreactive neurons were counted in the hippocampal formation at different time intervals after SE ...
Known for Hippocampal Formation | Specific Regions | Inhibitory Interneurons | Temporal Lobe Epilepsy
KOL-Index: 9845 . It is not fully understood how seizures terminate and why some seizures are followed by a period of complete brain activity suppression, postictal generalized EEG suppression. This is clinically relevant as there is a potential association between postictal generalized EEG suppression, cardiorespiratory arrest and sudden death following a seizure. We combined human encephalographic seizure ...
Known for Postictal Generalized | Seizure Termination | Eeg Suppression | Sudden Electroencephalography
KOL-Index: 9313 . OBJECTIVE: The mechanisms whereby birth asphyxia leads to generation of seizures remain unidentified. To study the possible role of brain pH changes, we used a rodent model that mimics the alterations in systemic CO(2) and O(2) levels during and after intrapartum birth asphyxia. METHODS: Neonatal rat pups were exposed for 1 hour to hypercapnia (20% CO(2) in the inhaled gas), hypoxia (9% ...
Known for Birth Asphyxia | Brain Alkalosis | Seizure Burden | Graded Restoration
KOL-Index: 8878 . MALDI mass spectrometry can simultaneously measure hundreds of biomolecules directly from tissue. Using essentially the same technique but different sample preparation strategies, metabolites, lipids, peptides and proteins can be analyzed. Spatially correlated analysis, imaging MS, enables the distributions of these biomolecular ions to be simultaneously measured in tissues. A key ...
Known for Mass Spectrometry | Spreading Depression | Brain Tissue | Substantial Metabolite
KOL-Index: 8407 . Patterned neuronal activity such as spindle bursts in the neonatal cortex is likely to promote the maturation of cortical synapses and neuronal circuits. Previous work on cats has shown that removal of subplate neurons, a transient neuronal population in the immature cortex, prevents the functional maturation of thalamocortical and intracortical connectivity. Here we studied the effect of ...
Known for Subplate Neurons | Spindle Bursts | Somatosensory Cortex | Neonatal Rat
KOL-Index: 7814 . Seizure-related apnea is common and can be lethal. Its mechanisms however remain unclear and preventive strategies are lacking. We postulate that brainstem spreading depolarization (SD), previously associated with lethal seizures in animal models, initiates apnea upon invasion of brainstem respiratory centers. To study this, we assessed effects of brainstem seizures on brainstem function ...
Known for Spreading Depolarization | Fatal Seizures | Mice Apnea | Animal Models
KOL-Index: 7785 . Cortical spreading depression, which plays an important role in multiple neurological disorders, has been studied primarily with experimental models that use highly invasive methods. We developed a relatively non-invasive optogenetic model to induce cortical spreading depression by transcranial stimulation of channelrhodopsin-2 ion channels expressed in cortical layer 5 neurons. ...
Known for Cortical Spreading Depression | Freely Behaving | Optogenetic Induction | Anesthetized Mice
KOL-Index: 7610 . In order to reveal axonal rewiring in the hippocampal and parahippocampal regions after status epilepticus, we investigated the temporal evolution of growth-associated protein-43 (GAP-43) mRNA and protein expression in two rat models of mesial temporal lobe epilepsy (MTLE). Status epilepticus (SE) was induced by electrical stimulation of the angular bundle or by intraperitoneal kainic acid ...
Known for Status Epilepticus | Gap43 Protein | Messenger Rats | Mrna Expression
KOL-Index: 7418 . The characteristic cell loss in layer III of the medial entorhinal area (MEA-III) in human mesial temporal lobe epilepsy is reproduced in the rat kainate model of the disease. To understand how this cell loss affects the functional properties of the MEA, we investigated whether projections from the presubiculum (prS), providing a main input to the MEA-III, are altered in this epileptic rat ...
Known for Epileptic Rats | Entorhinal Cortex | Superficial Layers | Prs Mea
KOL-Index: 7212 . PURPOSE: We investigated whether the functional network properties of the medial entorhinal area (MEA) of the entorhinal cortex were altered in a rat model of chronic epilepsy that is characterized by extensive cell loss in MEA layer III. METHODS: Responses were evoked in the entorhinal cortex by electrical stimulation of the subiculum in anesthetized chronic epileptic rats, 2-4 months ...
Known for Chronic Epileptic Rats | Entorhinal Cortex | Superficial Layers | Cell Loss
KOL-Index: 7132 . Mesial temporal lobe epilepsy patients often display shrinkage of the entorhinal cortex, which has been attributed to neuronal loss in medial entorhinal cortex layer III (MEC-III). MEC-III neuronal loss is reproduced in chronic epileptic rats after kainate-induced (KA) status epilepticus. Here we examined, in vitro, functional changes in superficial entorhinal cortex layers. Alterations in ...
Known for Entorhinal Cortex | Superficial Layers | Synaptic Responses | Neural Pathways
KOL-Index: 6584 . Migraine is a common brain disorder characterized by recurrent attacks of severe headaches and other neurological symptoms. In one-third of patients headaches are accompanied by auras, which consist of transient visual and sensory disturbances, believed to be caused by cortical spreading depression (CSD). CSD is characterized by a wave of neuronal and glial depolarization with concomitant ...
Known for Capillary Electrophoresis | Cortical Spreading Depression | Hemiplegic Migraine | Mouse Model

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Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands | Department of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands | Department of Human Genetics, Leiden University Medical Center, Leiden, The