• Disease
  • Vasa
  • Vasa Previa
  • Dwight R Cordero

    Prominent publications by Dwight R Cordero

    KOL Index score: 8756

    From an architectural point of view, the forebrain acts as a framework upon which the middle and upper face develops and grows. In addition to serving a structural role, we present evidence that the forebrain is a source of signals that shape the facial skeleton. In this study, we inhibited Sonic hedgehog (Shh) signaling from the neuroectoderm then examined the molecular changes and the skeletal alterations resulting from the treatment. One of the first changes we noted was that the ...

    Also Ranks for: Forebrain Shh Expression |  molecular interactions |  skeletal elements |  facial ectoderm |  frontonasal prominence
    KOL Index score: 7105

    One of the most perplexing questions in clinical genetics is why patients with identical gene mutations oftentimes exhibit radically different clinical features. This inconsistency between genotype and phenotype is illustrated in the malformation spectrum of holoprosencephaly (HPE). Family members carrying identical mutations in sonic hedgehog (SHH) can exhibit a variety of facial features ranging from cyclopia to subtle midline asymmetries. Such intrafamilial variability may arise from ...

    Also Ranks for: Sonic Hedgehog |  shh activity |  craniofacial development |  critical periods |  gene mutations
    KOL Index score: 6946

    While next-generation sequencing has accelerated the discovery of human disease genes, progress has been largely limited to the "low hanging fruit" of mutations with obvious exonic coding or canonical splice site impact. In contrast, the lack of high-throughput, unbiased approaches for functional assessment of most noncoding variants has bottlenecked gene discovery. We report the integration of transcriptome sequencing (RNA-seq), which surveys all mRNAs to reveal functional impacts of ...

    Also Ranks for: Transcriptome Sequencing |  noncoding variants |  micromelia syndrome |  male mice mice |  dna replication
    KOL Index score: 6177

    INTRODUCTION: Preeclampsia is a disorder of pregnancy, characterized by hypertension and proteinuria after 20 weeks of gestation. Here, we evaluated the role of aspirin triggered-lipoxin A(4) (ATL, 15-epi-LXA(4)) on the modulation of the adhesion of human polymorphonuclear neutrophils (PMN) to endothelial cells initiated by preeclamptic plasma.

    MATERIALS AND METHODS: Plasma from preeclamptic, normotensive pregnant, and non-pregnant women were analyzed for factors involved in regulating ...

    Also Ranks for: Endothelial Cells |  preeclamptic plasma |  aspirin preeclampsia |  20 weeks |  cell adhesion
    KOL Index score: 5483

    Caudal regression syndrome represents a continuum of congenital malformations ranging from agenesis of the lumbosacral spine to the most severe cases of sirenomelia with lower extremities fusion and major visceral anomalies. The etiology of this syndrome is not well known. Maternal diabetes, genetic predisposition, and vascular hypoperfusion have been suggested as possible causative factors. The degree of associated anomalies usually parallels the severity of the primary defect. ...

    Also Ranks for: Caudal Regression Syndrome |  fetal spine |  gestational age |  maternal diabetes |  vascular hypoperfusion
    KOL Index score: 5075

    Congenital genital abnormalities have a diverse spectrum from hypospadias to cloacal anomalies. The molecular events in the normal and abnormal development of the genital tubercle (GT) are still obscure. Genetically engineered mice with specific gene deletions that affect genital anatomy are a useful tool to better understand the etiology of genital abnormalities. In this study, we compared the genital tubercle anatomy of the androgen receptor (AR) deficient, fibroblastic growth factor ...

    Also Ranks for: Genital Tubercle |  fibroblast growth |  androgen receptor |  molecular events |  sonic hedgehog
    KOL Index score: 4078

    The frontonasal prominence of the developing avian embryo contains an organizing center, defined by juxtaposition of the Sonic hedgehog (Shh) and Fibroblast growth factor 8 (Fgf8) expression domains. This molecular interface presages any detectable growth of the frontonasal prominence, and experiments involving transplantation of this boundary epithelium have demonstrated it is a source of dorsal-ventral and rostral-caudal patterning information for the neural crest-derived mesenchyme of ...

    Also Ranks for: Developmental Hedgehog Proteins |  sonic hedgehog |  fgf8 shh |  fibroblast growth |  factor 8
    KOL Index score: 3800

    No region of our anatomy more powerfully conveys our emotions nor elicits more profound reactions when disease or genetic disorders disfigure it than the face. Recent progress has been made towards defining the tissue interactions and molecular mechanisms that control craniofacial morphogenesis. Some insights have come from genetic manipulations and others from tissue recombinations and biochemical approaches, which have revealed the molecular underpinnings of facial morphogenesis. ...

    Also Ranks for: Craniofacial Morphogenesis |  gene expression regulation |  molecular mechanisms |  neural crest |  body patterning
    KOL Index score: 3765

    The craniofacial region is assembled through the active migration of cells and the rearrangement and sculpting of facial prominences and pharyngeal arches, which consequently make it particularly susceptible to a large number of birth defects. Genetic, molecular, and cellular processes must be temporally and spatially regulated to culminate in the three-dimension structures of the face. The starting constituent for the majority of skeletal and connective tissues in the face is a ...

    Also Ranks for: Crest Cells |  cranial neural |  craniofacial development |  pharyngeal arches |  birth defects
    KOL Index score: 3693

    Craniofacial anomalies are some of the most variable and common defects affecting the population. Herein, we examine a group of craniofacial disorders that are the result of defects in primary cilia; ubiquitous, microtubule-based organelles that transduce molecular signals and facilitate the interactions between the cell and its environment. Based on the frequent appearance of craniofacial phenotypes in diseases born from defective primary cilia (ciliopathies) we propose a new class of ...

    Also Ranks for: Craniofacial Disorders |  primary cilia |  ciliopathic conditions |  molecular signals |  proteins animals
    KOL Index score: 3679

    Women heterozygous for mutations at the ornithine transcarbamylase (OTC) locus may be at risk for hyperammonaemia and its untoward effects including coma and death in the postpartum period. We present the case of a pregnant woman heterozygous for OTC deficiency (McKusick 311250) whose past medical history was significant for two prior pregnancies complicated by postpartum hyperammonaemic coma. In the index pregnancy, increased levels of serum ammonium were noted during labour. Postpartum ...

    Also Ranks for: Ornithine Transcarbamylase |  pregnancy women |  otc deficiency |  postpartum period |  female heterozygote
    KOL Index score: 3506

    Holoprosencephaly-Polydactyly (HPS) or Pseudotrisomy 13 syndrome are names conferred to clinically categorize patients whose phenotype is congruent with Trisomy 13 in the context of a normal karyotype. The literature suggests that this entity may be secondary to submicroscopic deletions in holoprosencephaly (HPE) genes; however, a limited number of investigations have been undertaken to evaluate this hypothesis. To test this hypothesis we studied a patient with HPE, polydactyly, and ...

    Also Ranks for: Polydactyly Syndrome |  normal karyotype |  mutational analysis |  nuclear proteins |  transcription factors
    KOL Index score: 3100

    Ingesting multiple packets of drugs ("body packing") is a well-described method of smuggling. Although older reports suggested that body packers were mostly young men, the demographics of this group may be changing because children, older patients, and pregnant women may be involved. Pregnant patients represent a challenge in management, particularly in the event of package rupture. Modification of standard management protocols, which were developed for nonpregnant body packers, may be ...

    Also Ranks for: Body Packing |  foreign bodies |  gastrointestinal tract |  cocaine crime |  pregnant women


    Dwight R Cordero: Influence Statistics

    Sample of concepts for which Dwight R Cordero is among the top experts in the world.
    Concept World rank
    new studies fish #2
    craniofacial morphogenesis region #2
    fowl attest #2
    heart evolutionary adaptation #2
    elicits profound reactions #2
    fowl attest findings #2
    profound reactions disease #2
    fish fowl attest #2
    findings craniofacial development #2
    elicit hpe #3
    insights craniofacial #3
    craniofacial form cyclopia #3
    hpe environmental #3
    area intense sustained #3
    developmental disorder holoprosencephaly #3
    hpe astounding variation #3
    molecular medicine holoprosencephaly #3
    death postpartum period #3
    intense sustained possibility #3
    hpe environmental agents #3
    possibility disease prevention #3
    etiopathologies holoprosencephaly #3
    holoprosencephaly common malformation #3
    cyclopia hpe #3
    hpe fabio candotti #3
    early intervention editors #3
    head new insights #4
    isolated entity terms #5
    seclusion axioms #5
    temporal developmental events #5
    complexity simplicity interactions #5
    facial features reflection #5
    anatomy emotions #5
    profound reactions #5
    culmination interactions #5
    axioms craniofacial development #5
    artistic intricacy #5
    interactions planar tissue #5
    brain culmination #5
    insights genetic manipulations #5
    upper beak ontogeny #6
    signaling neuroectoderm #6
    frontonasal prominence experiments #6
    growth middle upper #6
    shh bromodeoxyuridine chick #6
    prominence proximodistal #6
    middle upper addition #6
    prominence frontonasal #6
    facial ectoderm shh #6
    shh frontonasal ectoderm #6

    Key People For Vasa Previa

    Top KOLs in the world
    VAL A Catanzarite
    vasa previa prenatal diagnosis respiratory failure
    Yinka Oyelese
    vasa previa placental abruption perinatal mortality
    John C Smulian
    united states placenta previa gestational age
    Morey Schachter
    vasa previa gnrh antagonist insulin resistance
    Yosi Tovbin
    vasa previa prenatal diagnosis separation cases
    Federico Prefumo
    pregnant women hellp syndrome birth weight

    Dwight R Cordero:Expert Impact

    Concepts for whichDwight R Corderohas direct influence:Vasa previa,  Craniofacial disorders,  Craniofacial development,  Craniofacial ciliopathies,  Caudal regression syndrome,  Sonic hedgehog,  Craniofacial morphogenesis,  Genital tubercle.

    Dwight R Cordero:KOL impact

    Concepts related to the work of other authors for whichfor which Dwight R Cordero has influence:Neural crest,  Craniofacial development,  Vasa previa,  Sonic hedgehog,  Cleft lip,  Caudal regression syndrome,  Primary cilia.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. | Modesto Perinatal Associates, Modesto, California | Department of Obstetrics, Gynecology and R