 | Derek C Angus |
Prominent publications by Derek C Angus
Renal failure in the ICU: Comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes
[ PUBLICATION ]
BACKGROUND: Acute renal failure (ARF) is associated with a persistent high mortality in critically ill patients in intensive care units (ICUs). Most studies to date have focused on patients with established, intrinsic ARF or relatively severe ARF due to multiple factors. None have examined outcomes of dialysis-dependent chronic renal failure [end-stage renal disease (ESRD)] patients in the ICU. We examined the incidence and outcomes of ARF in the ICU using a standard definition and ...
| Also Ranks for: Renal Failure | patients arf | icu outcomes | dialysis mortality |
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
[ PUBLICATION ]
OBJECTIVE: To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004.
DESIGN: Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. This process was conducted ...
| Also Ranks for: Septic Shock | sepsis campaign | international guidelines | fluid resuscitation 1c | antibiotic therapy |
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
[ PUBLICATION ]
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008.
DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout. The ...
| Also Ranks for: Septic Shock | international guidelines | sepsis campaign | tissue hypoperfusion | ards patients |
Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
[ PUBLICATION ]
IMPORTANCE: The Third International Consensus Definitions Task Force defined sepsis as "life-threatening organ dysfunction due to a dysregulated host response to infection." The performance of clinical criteria for this sepsis definition is unknown.
OBJECTIVE: To evaluate the validity of clinical criteria to identify patients with suspected infection who are at risk of sepsis.
DESIGN, SETTINGS, AND POPULATION: Among 1.3 million electronic health record encounters from January 1, 2010, to ...
| Also Ranks for: Clinical Criteria | predictive validity | sofa sirs | suspected infection | validation cohort |
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008.
DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout. The ...
| Also Ranks for: Sepsis Campaign | septic shock | ards 1b | tissue hypoperfusion | recommendations patients |
IMPORTANCE: Protocolized sedation improves clinical outcomes in critically ill adults, but its effect in children is unknown.
OBJECTIVE: To determine whether critically ill children managed with a nurse-implemented, goal-directed sedation protocol experience fewer days of mechanical ventilation than patients receiving usual care.
DESIGN, SETTING, AND PARTICIPANTS: Cluster randomized trial conducted in 31 US pediatric intensive care units (PICUs). A total of 2449 children (mean age, 4.7 ...
| Also Ranks for: Acute Respiratory Failure | protocolized sedation | pediatric patients | mechanical ventilation | usual duration |
IMPORTANCE: Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination.
OBJECTIVE: To evaluate and, as needed, update definitions for sepsis and septic shock.
PROCESS: A task force (n = 19) with expertise in sepsis pathobiology, clinical ...
| Also Ranks for: Septic Shock | definitions sepsis | clinical criteria | task force | organ dysfunction |
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19
[ PUBLICATION ]
Importance: Effective therapies for patients with coronavirus disease 2019 (COVID-19) are needed, and clinical trial data have demonstrated that low-dose dexamethasone reduced mortality in hospitalized patients with COVID-19 who required respiratory support.
Objective: To estimate the association between administration of corticosteroids compared with usual care or placebo and 28-day all-cause mortality.
Design, Setting, and Participants: Prospective meta-analysis that pooled data from 7 ...
| Also Ranks for: Usual Placebo | systemic corticosteroids | association mortality | covid19 administration | critically patients |
IMPORTANCE: Septic shock currently refers to a state of acute circulatory failure associated with infection. Emerging biological insights and reported variation in epidemiology challenge the validity of this definition.
OBJECTIVE: To develop a new definition and clinical criteria for identifying septic shock in adults.
DESIGN, SETTING, AND PARTICIPANTS: The Society of Critical Care Medicine and the European Society of Intensive Care Medicine convened a task force (19 participants) to ...
| Also Ranks for: Clinical Criteria | new definition | septic shock | serum lactate level | 2 mmol |
Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014
[ PUBLICATION ]
Importance: Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time.
Objective: To estimate the US national incidence of sepsis and trends using detailed clinical data from the electronic health record (EHR) systems of diverse hospitals.
Design, Setting, and Population: ...
| Also Ranks for: Claims Data | incidence sepsis | clinical criteria | outcomes trends | septic shock |
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
[ PUBLICATION ]
OBJECTIVE: To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004.
DESIGN: Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. This process was conducted ...
| Also Ranks for: Septic Shock | sepsis campaign | international guidelines | antibiotic therapy | fluid resuscitation |
The Association of Sepsis Syndrome and Organ Dysfunction With Mortality in Emergency Department Patients With Suspected Infection
[ PUBLICATION ]
STUDY OBJECTIVE: The critical care community has used standard criteria for defining the sepsis syndromes and organ dysfunction for more than 15 years; however, these criteria are not well validated in the emergency department (ED) setting. The study objectives in our ED population of patients admitted to the hospital are to determine the prevalence of the sepsis syndromes, quantify inhospital mortality and 1-year survival associated with the sepsis syndromes, and assess the inhospital ...
| Also Ranks for: Suspected Infection | organ dysfunction | emergency department | sepsis sirs | inhospital mortality |
The chromatin-binding factor high-mobility group box 1 (HMGB1) functions as a proinflammatory cytokine and late mediator of mortality in murine endotoxemia. Although serine phosphorylation of HMGB1 is necessary for nucleocytoplasmic shuttling before its cellular release, the protein kinases involved have not been identified. To investigate if calcium/calmodulin-dependent protein kinase (CaMK) IV serine phosphorylates and mediates the release of HMGB1 from macrophages (Mphi) stimulated ...
| Also Ranks for: Protein Kinase | hmgb1 release | nucleocytoplasmic shuttling | cells camkiv | sto609 lps |
Importance: The quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score has not been well-evaluated in low- and middle-income countries (LMICs).
Objective: To assess the association of qSOFA with excess hospital death among patients with suspected infection in LMICs and to compare qSOFA with the systemic inflammatory response syndrome (SIRS) criteria.
Design, Settings, and Participants: Retrospective secondary analysis of 8 cohort studies and 1 randomized clinical trial ...
| Also Ranks for: Hospital Mortality | qsofa score | quick sequential | sirs criteria | suspected infection |
Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
[ PUBLICATION ]
BACKGROUND: Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. It is considered a major cause of health loss, but data for the global burden of sepsis are limited. As a syndrome caused by underlying infection, sepsis is not part of standard Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) estimates. Accurate estimates are important to inform and monitor health policy interventions, allocation of resources, and clinical ...
| Also Ranks for: Global Burden | sepsis incidence | death data | subsaharan africa | health loss |
Derek C Angus: Influence Statistics
| Concept | World rank |
|---|---|
| health respiration icu | #1 |
| surrogates familysupport intervention | #1 |
| respiratory failure hrql | #1 |
| 2 amcs | #1 |
| validation anns | #1 |
| survivors pac | #1 |
| patients early reversal | #1 |
| higher severe | #1 |
| early reversal 7 | #1 |
| arf icu admission | #1 |
| feasibility internal validity | #1 |
| phenotype membership | #1 |
| mphi kn93 | #1 |
| costs longterm outcomes | #1 |
| highrisk patients psihr | #1 |
| equivalence bamlanivimab etesevimab | #1 |
| attitude immune | #1 |
| vignettes decision making | #1 |
| nonreferral hospitals triage | #1 |
| estimated difference p0001 | #1 |
| curb65 psihr | #1 |
| stay artificial apache | #1 |
| sensitivity analyses hospital | #1 |
| organisational guidelines | #1 |
| international comparisons critical | #1 |
| bamlanivimab monoclonal | #1 |
| predictive validity sepsis | #1 |
| hospital deaths england | #1 |
| atherosclerosis sepsis | #1 |
| egdt startup costs | #1 |
| sepsis lmics | #1 |
| time sofa score | #1 |
| akd 7 | #1 |
| future supply demand | #1 |
| ards trial designs | #1 |
| severe sepsis prowessshock | #1 |
| discharges deaths | #1 |
| coordinated regional regions | #1 |
| hospital theoretical sensitivity | #1 |
| esld outcome | #1 |
| lowest quartile income | #1 |
| intensive length | #1 |
| protocolbased standard therapy | #1 |
| premeasures | #1 |
| 1 prescriptions metformin | #1 |
| arms clinical trials | #1 |
| undertriage proportion | #1 |
| genims | #1 |
| pneumonia hospitalization hospitalization | #1 |
| antibiotics fluids | #1 |
Key People For Severe Sepsis
Derek C Angus:Expert Impact
Concepts for whichDerek C Angushas direct influence:Severe sepsis, United states, Septic shock, Critical illness, Drotrecogin alfa, Mechanical ventilation, Hospital mortality, Trauma triage.
Derek C Angus:KOL impact
Concepts related to the work of other authors for whichfor which Derek C Angus has influence:Septic shock, Severe sepsis, Acute kidney injury, Critical illness, Intensive unit, Emergency department, Mechanical ventilation.
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