Prominent publications by Freddie H Fu

KOL Index score: 21366

BACKGROUND: The function of the anterolateral capsule of the knee has not been clearly defined. However, the contribution of this region of the capsule to knee stability in comparison with other anterolateral structures can be determined by the relative force that each structure carries during loading of the knee. Purpose/Hypothesis: The purpose of this study was to determine the forces in the anterolateral structures of the intact and anterior cruciate ligament (ACL)-deficient knee in ...

Also Ranks for: Anterolateral Capsule |  fibrous tissue |  internal tibial torque |  structures knee |  acl response
KOL Index score: 21208

PurposeThe purpose of this study was to reveal the correlation between the size of the native anterior cruciate ligament (ACL) footprint and the size of the lateral wall of femoral intercondylar notch.MethodsEighteen non-paired human cadaver knees were used. All soft tissues around the knee were resected except the ACL. The ACL was cut in the middle, and the femoral bone was cut at the most proximal point of the femoral notch. The ACL was carefully dissected, and the periphery of the ACL ...

Also Ranks for: Lateral Wall |  femoral intercondylar notch |  acl footprint |  height area |  correlation size
KOL Index score: 20019

BACKGROUND: The role of the anterolateral capsule (ALC) as a secondary restraint to quantitative rotatory laxity of patients with an anterior cruciate ligament (ACL) injury is currently debated.

PURPOSE/HYPOTHESIS: The purpose was to determine the influence of concomitant ALC injuries as well as injuries to other soft tissue structures on rotatory knee laxity in patients with an ACL injury. It was hypothesized that a concomitant ALC injury would be associated with increased rotatory knee ...

Also Ranks for: Knee Laxity |  ligament injuries |  acl injury |  lateral meniscus |  anterior cruciate
KOL Index score: 20006

BACKGROUND: Cells that express bone morphogenetic protein-2 (BMP-2) can now be prepared by transduction with adenovirus containing BMP-2 cDNA. Skeletal muscle tissue contains cells that differentiate into osteoblasts on stimulation with BMP-2. The objectives of this study were to prepare BMP-2-expressing muscle-derived cells by transduction of these cells with an adenovirus containing BMP-2 cDNA and to determine whether the BMP-2-expressing muscle-derived cells would elicit the healing ...

Also Ranks for: Derived Cells |  bone morphogenetic |  bmp2 healing |  scid muscle |  situ hybridization
KOL Index score: 19454

The anterior cruciate ligament has a complex fiber anatomy and is not considered to be a uniform structure. Current anterior cruciate ligament reconstructions succeed in stabilizing the knee, but they neither fully restore normal knee kinematics nor reproduce normal ligament function. To improve the outcome of the reconstruction, it may be necessary to reproduce the complex function of the intact anterior cruciate ligament in the replacement graft. We examined the in situ forces in nine ...

Also Ranks for: Situ Forces |  anterior cruciate ligament |  posterolateral bundle |  tibial loads |  15 degrees
KOL Index score: 19231

PurposeThe purpose of this study was to: (1) define the relationship between the ACL and PCL in normal knees; (2) determine whether ACL–PCL impingement occurs in native knees; and (3) determine whether there is a difference in impingement between double-bundle reconstructed and native knees.MethodsEight subjects were identified (age 20–50; 6 females, 2 males). All were at least 1-year status postanatomic double-bundle ACL reconstruction (allograft; AM = 8 mm; PL = 7 mm) and had no ...

Also Ranks for: Intercondylar Notch |  acl pcl |  resonance imaging |  cruciate ligament |  double bundle
KOL Index score: 19027

PURPOSE: To study how well an anterior cruciate ligament (ACL) graft fixed at the 10 and 11 o'clock positions can restore knee function in response to both externally applied anterior tibial and combined rotatory loads by comparing the biomechanical results with each other and with the intact knee.

TYPE OF STUDY: Biomechanical experiment using human cadaveric specimens.

METHODS: Ten human cadaveric knees (age, 41+/-13 years) were reconstructed by placing a bone-patellar tendon-bone graft ...

Also Ranks for: Knee Stability |  30 degrees |  graft function |  cruciate ligament |  oclock position
KOL Index score: 18809

BACKGROUND: A clinically meaningful change in patient-reported outcome (PRO) may not be associated with an acceptable state that corresponds to "feeling well," also known as the patient acceptable symptom state (PASS). The PASS thresholds for the International Knee Documentation Committee Subjective Knee Form (IKDC-SKF) and the Knee injury and Osteoarthritis Outcome Score (KOOS) have not been determined for individuals after anterior cruciate ligament (ACL) reconstruction.


Also Ranks for: Acl Reconstruction |  patient acceptable |  symptom state |  ikdcskf koos |  pass thresholds
KOL Index score: 18736

PurposeThe purpose of this study was to report the potential differences associated with graft maturity measured on magnetic resonance imaging (MRI) between quadriceps tendon with bone block and hamstring tendon autografts 6 months after ACL reconstruction.MethodsTwenty-six patients (15 male, 11 female; mean age 29.4 ± 17 years, range 13–46 years) who had undergone anatomic SB ACL reconstruction with either hamstring or quadriceps tendon with bone block autografts and had postoperative ...

Also Ranks for: Quadriceps Tendon |  bone block |  graft maturity |  anterior cruciate |  6 months
KOL Index score: 18411

BACKGROUND: High tunnel placement is common in single- and double-bundle anterior cruciate ligament (ACL) reconstructions. Similar nonanatomic tunnel placement may also occur in ACL augmentation surgery.

PURPOSE: In this study, in situ forces and knee kinematics were compared between nonanatomic high anteromedial (AM) and anatomic AM augmentation in a knee with isolated AM bundle injury.

STUDY DESIGN: Controlled laboratory study.

METHODS: Seven fresh-frozen cadaver knees were used (age, ...

Also Ranks for: Situ Force |  knee kinematics |  anterior cruciate |  bundle augmentation |  ° flexion
KOL Index score: 18158

Platelet-rich plasma (PRP) containing hepatocyte growth factor (HGF) and other growth factors are widely used in orthopaedic/sports medicine to repair injured tendons. While PRP treatment is reported to decrease pain in patients with tendon injury, the mechanism of this effect is not clear. Tendon pain is often associated with tendon inflammation, and HGF is known to protect tissues from inflammatory damages. Therefore, we hypothesized that HGF in PRP causes the anti-inflammatory ...

Also Ranks for: Injured Tendons |  hgf prp |  inflammatory effects |  tendon inflammation |  growth factors
KOL Index score: 17989

BACKGROUND: An anterior cruciate ligament (ACL) injury greatly increases the risk for premature knee osteoarthritis (OA). Improved diagnosis and staging of early disease are needed to develop strategies to delay or prevent disabling OA.

PURPOSE: Novel magnetic resonance imaging (MRI) ultrashort echo time (UTE)-T2(*) mapping was evaluated against clinical metrics of cartilage health in cross-sectional and longitudinal studies of human participants before and after ACL reconstruction ...

Also Ranks for: Anterior Cruciate |  magnetic resonance |  ligament reconstruction |  imaging ute |  cmfc pmfc
KOL Index score: 17288

BACKGROUND: The objective of this study was to evaluate the effectiveness of reconstructions of the anterior cruciate ligament to resist anterior tibial and rotational loads. We hypothesized that current reconstruction techniques, which are designed mainly to provide resistance to anterior tibial loads, are less effective in limiting knee instability in response to combined rotational loads.

METHODS: Twelve fresh-frozen young human cadaveric knees (from individuals with a mean age [and ...

Also Ranks for: Anterior Tibial |  cruciate ligament |  patellar tendon |  cadaveric study |  situ forces
KOL Index score: 17251

BACKGROUND: The role of the anterolateral capsule in knee stability has recently been advocated by studies reporting that a distinct ligament exists in this area. Defining the structural properties of the anterolateral capsule can provide insight into its contribution to joint stability. The structural properties of the iliotibial band also need to be determined, as it is a common graft used for extra-articular tenodesis.

PURPOSE/HYPOTHESIS: The purpose of this study was to determine the ...

Also Ranks for: Anterolateral Capsule |  iliotibial band |  structural properties |  gerdy tubercle |  ultimate load
KOL Index score: 17158

PURPOSE: Various techniques are used to produce the pivot shift phenomenon after anterior cruciate ligament (ACL) injury. In particular, the amount of applied axial tibial torque varies among examiners. Thus, the objective of this study was to determine the effect of the magnitude and direction of axial tibial torque in combination with valgus torque on the resulting knee kinematics during such a simulated pivot shift test.

TYPE OF STUDY: This was a biomechanical study that used ...

Also Ranks for: Tibial Torque |  biomechanical study |  pivot shift |  anterior cruciate |  10 nm

Key People For Cruciate Ligament

Top KOLs in the world
Freddie * **
cruciate ligament acl reconstruction gene therapy
Frank * *****
cruciate ligament acl reconstruction female athletes
Russell * ******
rotator cuff cruciate ligament shoulder arthroplasty
Christopher ******* ******
cruciate ligament acl reconstruction situ forces
Lars ******* ***********
cruciate ligament acl reconstruction knee function
Savio *** ***
anterior cruciate ligament situ forces knee flexion

Freddie H Fu:Expert Impact

Concepts for whichFreddie H Fuhas direct influence:Cruciate ligament,  Anterior cruciate,  Anterior cruciate ligament,  Acl reconstruction,  Ligament reconstruction,  Gene therapy,  Knee flexion,  Knee kinematics.

Freddie H Fu:KOL impact

Concepts related to the work of other authors for whichfor which Freddie H Fu has influence:Cruciate ligament,  Acl reconstruction,  Knee joint,  Articular cartilage,  Femoral tunnel,  Stem cells,  Tissue engineering.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

UPMC Freddie Fu Sports Medicine Center, University of Pittsburgh, 3200 South Water Street, 15203, Pittsburgh, PA, USA | Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. | Department of Orthopa