• Disease
  • Influenza
  • Influenza Virus
  • George Fu Gao

    Prominent publications by George Fu Gao

    KOL Index score: 31747

    BACKGROUND: Although several COVID-19 vaccines have been developed so far, they will not be sufficient to meet the global demand. Development of a wider range of vaccines, with different mechanisms of action, could help control the spread of SARS-CoV-2 globally. We developed a protein subunit vaccine against COVID-19 using a dimeric form of the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein as the antigen. We aimed to assess the safety and immunogenicity of this vaccine, ...

    Also Ranks for: 2 Trials |  phase 1 |  subunit vaccine |  50 μg |  spike glycoprotein
    KOL Index score: 20645

    BACKGROUND: China has undergone rapid demographic and epidemiological changes in the past few decades, including striking declines in fertility and child mortality and increases in life expectancy at birth. Popular discontent with the health system has led to major reforms. To help inform these reforms, we did a comprehensive assessment of disease burden in China, how it changed between 1990 and 2010, and how China's health burden compares with other nations.

    METHODS: We used results of ...

    Also Ranks for: Global Burden |  health transition |  risk factors china |  ylds dalys |  leading death
    KOL Index score: 18299

    Avian influenza virus A of the novel H7N9 reassortant subtype was recently found to cause severe human respiratory infections in China. Live poultry markets were suspected locations of the human H7N9 infection sources, based on the cases' exposure histories and sequence similarities between viral isolates. To explore the role of live poultry markets in the origin of the novel H7N9 virus, we systematically examined poultry and environmental specimens from local markets and farms in ...

    Also Ranks for: H9n2 Virus |  influenza h7n9 |  chickens china |  live poultry markets |  genome viral
    KOL Index score: 16799

    Since its emergence in 2013, the H7N9 low-pathogenic avian influenza virus (LPAIV) has been circulating in domestic poultry in China, causing five waves of human infections. A novel H7N9 highly pathogenic avian influenza virus (HPAIV) variant possessing multiple basic amino acids at the cleavage site of the hemagglutinin (HA) protein was first reported in two cases of human infection in January 2017. More seriously, those novel H7N9 HPAIV variants have been transmitted and caused ...

    Also Ranks for: H7n9 Influenza |  highly pathogenic |  human infections |  chickens mice |  hemagglutinin glycoproteins
    KOL Index score: 16424

    BACKGROUND: The avian influenza A H7N9 virus has caused infections in human beings in China since 2013. A large epidemic in 2016-17 prompted concerns that the epidemiology of the virus might have changed, increasing the threat of a pandemic. We aimed to describe the epidemiological characteristics, clinical severity, and time-to-event distributions of patients infected with A H7N9 in the 2016-17 epidemic compared with previous epidemics.

    METHODS: In this epidemiological study, we ...

    Also Ranks for: H7n9 Virus |  mainland china |  epidemiological study |  avian influenza |  human beings
    KOL Index score: 16024

    The surface transmembrane glycoprotein is responsible for mediating virion attachment to cell and subsequent virus-cell membrane fusion. However, the molecular mechanisms for the viral entry of coronaviruses remain poorly understood. The crystal structure of the fusion core of mouse hepatitis virus S protein, which represents the first fusion core structure of any coronavirus, reveals a central hydrophobic coiled coil trimer surrounded by three helices in an oblique, antiparallel manner. ...

    Also Ranks for: Fusion Core |  hepatitis virus |  crystal structure |  spike protein |  structural basis
    KOL Index score: 15595

    BACKGROUND: In late December, 2019, patients presenting with viral pneumonia due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was subsequently identified as the causative pathogen, provisionally named 2019 novel coronavirus (2019-nCoV). As of Jan 26, 2020, more than 2000 cases of 2019-nCoV infection have been confirmed, most of which involved people living in or visiting Wuhan, and human-to-human transmission has been confirmed.

    METHODS: We did ...

    Also Ranks for: Virus Humans |  viral receptors |  receptor binding |  phylogenetic analysis |  2019 ncov
    KOL Index score: 15300

    BACKGROUND: On March 30, 2013, a novel avian influenza A H7N9 virus that infects human beings was identified. This virus had been detected in six provinces and municipal cities in China as of April 18, 2013. We correlated genomic sequences from avian influenza viruses with ecological information and did phylogenetic and coalescent analyses to extrapolate the potential origins of the virus and possible routes of reassortment events.

    METHODS: We downloaded H7N9 virus genome sequences from ...

    Also Ranks for: Avian Influenza |  h7n9 viruses |  coalescent analyses |  causing human |  phylogenetic trees
    KOL Index score: 15246

    Innate cytokine response provides the first line of defense against influenza virus infection. However, excessive production of cytokines appears to be critical in the pathogenesis of influenza virus. Interferon lambdas (IFN-λ) have been shown to be overproduced during influenza virus infection, but the precise pathogenic processes of IFN-λ production have yet to be characterized. In this report, we observed that influenza virus induced robust expression of IFN-λ in alveolar epithelial ...

    Also Ranks for: Influenza Virus |  excessive production |  interferon lambda |  inbred balb mice |  ifn λ
    KOL Index score: 15240

    The recently identified H7N9 influenza A virus has caused severe economic losses and worldwide public concern. Genetic analysis indicates that its six internal genes all originated from H9N2 viruses. However, the H7N9 virus is more highly pathogenic in humans than H9N2, which suggests that the internal genes of H7N9 have mutated. To analyze which H7N9 virus internal genes contribute to its high pathogenicity, a series of reassortants was generated by reverse genetics, with each virus ...

    Also Ranks for: Internal Genes |  h7n9 virus |  pathogenicity mice |  humans influenza |  h9n2 subtype
    KOL Index score: 14321

    Hepatitis B virus (HBV) causes chronic infection in about 350 million people worldwide. Given the important role of the most abundant liver-specific microRNA, miR-122, in hepatic function and liver pathology, here we investigated the potential role and mechanism of miR-122 in regulating HBV replication. We found that miR-122 expression in liver was significantly down-regulated in patients with HBV infection compared with healthy controls, and the miR-122 levels were negatively correlated ...

    Also Ranks for: Cyclin G1 |  hbv replication |  mir122 expression |  virus hepatitis |  chronic infection
    KOL Index score: 13977

    H5 influenza viruses containing a motif of multiple basic amino acids at the hemagglutinin (HA) cleavage site (HACS) are highly pathogenic in chicken but display different virulence phenotypes in mammals. Previous studies have shown that multiple basic amino acids of H5N1 influenza virus are a prerequisite for lethality in mice. However, it remains unclear which specific residue at the cleavage site affects the pathogenicity of H5N1 in mammals. A comprehensive genetic analysis of the ...

    Also Ranks for: Influenza Virus |  cleavage site |  amino acid |  virulence h5n1 |  hemagglutinin glycoproteins
    KOL Index score: 13796

    Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, ...

    Also Ranks for: Influenza Virus |  public health |  h5n6 avian |  southern china |  phylogenetic analysis
    KOL Index score: 13441

    More than 350 million people worldwide are chronically infected with hepatitis B virus (HBV). Broad repertoire and strong magnitude of HBV-specific T cell responses are thought to play key roles for virus control and clearance. Previous studies together with ours showed that heat shock protein gp96 as adjuvant induces antigen specific T cell responses, yet little is known for its anti-viral properties. Here, we investigated the role of gp96 mediated cellular and humoral immunity in ...

    Also Ranks for: Transgenic Mice |  cell responses |  heat shock |  protein gp96 |  hepatitis virus
    KOL Index score: 13434

    The presentation of viral epitopes to cytotoxic T lymphocytes (CTLs) by swine leukocyte antigen class I (SLA I) is crucial for swine immunity. To illustrate the structural basis of swine CTL epitope presentation, the first SLA crystal structures, SLA-1 0401, complexed with peptides derived from either 2009 pandemic H1N1 (pH1N1) swine-origin influenza A virus (S-OIV(NW9); NSDTVGWSW) or Ebola virus (Ebola(AY9); ATAAATEAY) were determined in this study. The overall peptide-SLA-1 0401 ...

    Also Ranks for: Crystal Structure |  epitope peptides |  major histocompatibility |  structural basis |  influenza virus


    George Fu Gao: Influence Statistics

    Sample of concepts for which George Fu Gao is among the top experts in the world.
    Concept World rank
    taiwan 2 2013 #1
    h9n2 subtype mice #1
    bacterial mobile resistome #1
    sequential reassortments #1
    infected erythrocytes expression #1
    h9n2 subtypes #1
    epidemics mainland china #1
    suis enolase #1
    enfpeg #1
    allele cytotoxic #1
    peptide presentation sla #1
    lpm workers #1
    pa104r dna #1
    apoptosis sarscov #1
    lpms china #1
    lpm environments resistomes #1
    virus replication arhgap21 #1
    mobile resistome #1
    pandemic sars cov2 #1
    140th anniversary #1
    vrbjsy07 #1
    hbc l60v variation #1
    intertwined loop #1
    distinct protections #1
    2 strain 05zyh33 #1
    single dose mrnarbd #1
    virus minks #1
    hiv1 y135f #1
    coreceptors cd8 #1
    ataaateay #1
    h17n10 bats #1
    diurnal rhythm disruptions #1
    presentation strategy #1
    heavy chain conformation #1
    inactive vaccines #1
    ebov np npbp #1
    n7 n6 structures #1
    h7n9 #1
    functional modules protein #1
    clade 2321c #1
    sarscov2 varied species #1
    marv np #1
    human herpesvirus epha2 #1
    jdh10n8 #1
    5 years mabs #1
    m1 sld5 #1
    virulence factors stss #1
    essential attachment factor #1
    paralysis zikv #1
    mice adc7rbdtr2 #1

    Key People For Influenza Virus

    Top KOLs in the world
    Robert Gordon Webster
    influenza virus hong kong monoclonal antibodies
    Yoshihiro Yoshihiro
    influenza virus hong kong amino acid
    Peter Palese
    influenza virus neutralizing antibodies ns1 protein
    Yanfang Guan
    influenza virus hong kong southern china
    Adolfo GarcíaSastre
    influenza virus ns1 protein neutralizing antibodies
    Albert 'D M E Osterhaus
    influenza virus monoclonal antibodies west nile

    George Fu Gao:Expert Impact

    Concepts for whichGeorge Fu Gaohas direct influence:Influenza virus,  Crystal structure,  Zika virus,  Avian influenza,  Monoclonal antibodies,  Neutralizing antibodies,  Fusion core,  Molecular basis.

    George Fu Gao:KOL impact

    Concepts related to the work of other authors for whichfor which George Fu Gao has influence:Influenza virus,  Spike protein,  Neutralizing antibodies,  Respiratory syndrome,  Sarscov2 infection,  Clinical characteristics,  Public health.



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    NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; liujun@ivdc.chinacdc.cn zycdchp@sina.com gaofu@chinacdc.cn. | CAS Key Laboratory of Patho