• Disease
  • Cell
  • Cell Lymphoma
  • Falko Fend

    Prominent publications by Falko Fend

    KOL Index score: 16435

    The signal transducer and activator of transcription molecules (Stats) play key roles in cytokine-induced signal transduction. Recently, it was proposed that constitutively activated Stat 3 (Stat 3 phosphorylated) contributes to the pathogenesis of multiple myeloma (MM) by preventing apoptosis and inducing proliferation. The study aim was to investigate Stat 3 activation in a series of multiple myeloma (MM) cases and its effect on downstream targets such as the anti-apoptotic proteins ...

    Also Ranks for: Cyclin D1 |  signal transducer |  multiple myeloma |  transcription 3 |  proliferation rate
    KOL Index score: 15889

    Depending on geographic location and patient age Hodgkin's disease (HD) is associated with Epstein-Barr virus (EBV), mostly type A EBV, in 20% to 100%. The highest prevalence occurs in children of developing countries. Molecular analysis of the oncogene coding for the latent membrane protein 1 (LMP-1) revealed a 30-base pair (bp) deletion in up to 46% of EBV-positive HD. We investigated the presence of EBV in a series of Mexican classical HD (n = 57) and reactive lymphoid tissues (n = ...

    Also Ranks for: Barr Virus |  1 gene |  type ebv |  latent membrane protein |  molecular analysis
    KOL Index score: 15757

    Nasal NK/T-cell lymphoma is a unique form of lymphoma highly associated with Epstein-Barr virus, and with a characteristic geographic distribution. Recently, we showed that p53 is overexpressed in a high percentage of nasal NK/T-cell lymphomas. The aim of this study was to analyze the status of the p53 gene, and correlate it with the expression of p53 protein and its downstream target, the cyclin-dependent kinase inhibitor p21, in a series of 25 cases of well-characterized nasal ...

    Also Ranks for: P53 Mutations |  cell lymphoma |  advanced disease |  natural killer |  nasal nk
    KOL Index score: 15472

    p27 is a cyclin-dependent kinase inhibitor that plays a critical role in regulating G(1)/S progression, and whose activity is, in part, regulated through interactions with D-type cyclins. Mantle cell lymphoma (MCL) is characterized by the t(11;14) translocation resulting in deregulated cyclin D1. We previously showed that p27 expression in MCL, as assessed by immunohistochemistry (IHC), does not show the usual inverse relationship to proliferate seen in most other lymphomas that do not ...

    Also Ranks for: Cyclin D1 |  mantle cell |  human pair |  kinase inhibitor |  p27 protein
    KOL Index score: 15317

    p27Kip1 is a cyclin-dependent kinase inhibitor that regulates the decision to enter S phase or withdraw from the cell cycle. In resting cells, the level of p27Kip1 provides an inhibitory threshold above which G1 cyclin D/E/cyclin-dependent kinases accumulate before activation; however, in cycling cells, p27Kip1 protein is sequestered by high levels of active cyclin D/cyclin-dependent kinase 4 complexes. As a group, the cyclin-dependent kinase inhibitors have been proposed to act as tumor ...

    Also Ranks for: Cell Lymphomas |  dependent kinase |  p27kip1 expression |  proliferation rate |  blastic variant
    KOL Index score: 15120

    Epidermal growth factor receptor (EGFR) overexpression and activation are hallmarks of non-small cell lung carcinoma (NSCLC). Although EGFR-targeted therapies are used, the prognosis of NSCLC remains poor. ADAM17 induces activation of the EGFR through ligand cleavage. However, we show that inhibition or knockdown of ADAM17 markedly reduces tumorigenesis and survival to a large part independently from EGFR ligand shedding in NSCLC cells. These findings strongly indicate additional ...

    Also Ranks for: Cell Lung |  growth factor |  notch1 nsclc |  egfr expression |  adam17 activation
    KOL Index score: 15018

    Background:Overexpression of the ERG protein is highly prevalent in prostate cancer (PCa) and commonly results from gene fusions involving the ERG gene. Recently, N-terminal epitope-targeted mouse and a C-terminal epitope-targeted rabbit monoclonal anti-ERG antibody (ERG-MAbs) have been introduced for the detection of the ERG protein. Independent studies reported that immunohistochemistry (IHC) with both ERG-MAbs highly correlates with the underlying ERG gene rearrangement status. ...

    Also Ranks for: Erg Protein Expression |  prostate cancer |  situ hybridization |  rearrangement status |  monoclonal antibodies
    KOL Index score: 14727

    BACKGROUND: Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is characterized by the t(2;5) chromosomal translocation, resulting in the expression of a fusion protein formed of nucleophosmin (NPM) and ALK. Recently, we reported the abnormal expression of the transcription factor CCAAT/enhancer binding protein-beta (C/EBPbeta) in ALK-positive anaplastic large cell lymphomas, and demonstrated its dependence on NPM-ALK activity.

    DESIGN AND METHODS: In this study, the ...

    Also Ranks for: Cell Proliferation |  anaplastic large |  expression alk |  erk1 2 |  stat3 signaling
    KOL Index score: 14663

    Identification of specific somatic gene alterations is crucial for the insight into the development, progression, and clinical behavior of individual cancer types. The recently discovered recurrent ERG rearrangement in prostate cancer might represent a prostate cancer-specific alteration that has not been systematically assessed in tumors other than prostate cancer. Aim of this study was to assess, whether the ERG rearrangement and the distinct deletion site between TMPRSS2 and ERG, both ...

    Also Ranks for: Erg Rearrangement |  prostate cancer |  situ hybridization |  oncogene proteins |  gene deletion
    KOL Index score: 14340

    Mutations of components of the mitogen-activated protein kinase pathway, mainly BRAF, are common in serous ovarian borderline tumors, whereas high-grade serous ovarian carcinomas rarely show this feature. With the advent of specific kinase inhibitors active against BRAF-mutated cancers, rapid and sensitive detection of the BRAF V600E, by far the most common mutation of this gene, is of great practical relevance. Currently, BRAF mutations are detected by DNA-based techniques. Recently, a ...

    Also Ranks for: V600e Mutation |  serous ovarian |  detection braf |  monoclonal antibody |  sequence analysis
    KOL Index score: 13020

    AIMS: To evaluate the expression of αv-series integrins in brain metastases. Inhibitors targeting these integrins are being tested for their therapeutic potential.

    MATERIAL AND METHOD: The extracellular regions of the αvβ3, αvβ5, αvβ6, αvβ8, the cytoplasmic domain of β3, the αv-chain, and the ECM molecules fibronectin and fibrinogen were studied immunohistochemically in a series of 122 carcinoma and 60 melanomas metastatic to the central nervous system. In addition, 38 matched primary ...

    Also Ranks for: Brain Metastases |  integrins αvβ3 |  αvβ5 αvβ8 |  primary tumors |  cytoplasmic domain
    KOL Index score: 13019

    This study describes the clinicopathologic features of 5 patients who developed a fulminant Epstein-Barr virus (EBV)-positive clonal T-cell lymphoproliferative disorder (LPD) after acute EBV infection. One additional patient developed a similar disorder in the setting of long-standing chronic active EBV infection. Detailed immunophenotyping, in situ hybridization for EBV early RNA-1 (EBER1) and polymerase chain reaction (PCR) analyses for immunoglobulin (Ig) heavy chain and T-cell ...

    Also Ranks for: Ebv Infection |  cell lymphoproliferative |  liver spleen |  situ hybridization |  2 cases
    KOL Index score: 12787

    Aims/hypothesisObesity-linked ectopic fat accumulation is associated with the development of type 2 diabetes. Whether pancreatic and liver steatosis impairs insulin secretion is controversial. We examined the crosstalk of human pancreatic fat cells with islets and the role of diabetogenic factors, i.e. palmitate and fetuin-A, a hepatokine released from fatty liver.MethodsHuman pancreatic resections were immunohistochemically stained for insulin, glucagon, somatostatin and the ...

    Also Ranks for: Fatty Liver |  insulin secretion |  metabolic crosstalk |  pancreatic adipocytes |  palmitate fetuina
    KOL Index score: 12766

    We report three cases of nodal peripheral T-cell lymphoma (PTCL) with Reed-Sternberg-like (RS-like) cells of B-cell pheno- and/or genotype. Histologic analysis in all cases revealed diffuse nodal effacement by atypical lymphoid cells of variable size. Two of the three cases had features of angioimmunoblastic T-cell lymphoma (AILT). Large mononuclear and binucleated cells with prominent eosinophilic nucleoli and abundant cytoplasm resembling classic RS cells and mononuclear variants were ...

    Also Ranks for: Barr Virus |  cell lymphoma |  neoplasm diagnosis |  ptcl antigens |  hodgkins disease


    Falko Fend: Influence Statistics

    Sample of concepts for which Falko Fend is among the top experts in the world.
    Concept World rank
    sts aspp2 #1
    sarcomagenesis therapy resistance #1
    mpn trephine biopsy #1
    cd56 potential marker #1
    t1418 t1418q32q21 #1
    treatment modalities mf #1
    dlbcl mzbl #1
    14 aepc #1
    adhesion formation mcc #1
    nsclc cb #1
    peritoneal waterjet #1
    european cases #1
    vaccination prolongation #1
    myeloproliferative neoplasms morphology #1
    technique lcm #1
    multivariate analysis cd11c #1
    oncogenic isoform migration #1
    endometriosis surgical resection #1
    largecell components #1
    hashimotopritzker cases #1
    pcr bnhl #1
    il‐2‐ #1
    monopolar contact #1
    areas extranodal mzbl #1
    cd56 hgsocs #1
    background translocation #1
    generalized pngd #1
    organ microthrombi #1
    lymphoma extent #1
    mzbl malt type #1
    activating mutations kras #1
    bnhl pcr #1
    peritoneal elevation saline #1
    cd147 cd147 bsg #1
    cmml immunohistochemistry leukemia #1
    thymic hd #1
    elevation thermal ablation #1
    biclonal lymphomas #1
    aspp2κ sarcomagenesis #1
    systemic alk #1
    carcinomas synaptophysin #1
    heterogeneous presence #1
    coagulation mcc #1
    embedded trephine #1
    dlbcl areas #1
    thymic hodgkin #1
    immunohistochemistry blymphocyte graft #1
    organoids comparison #1
    conclusionsdiagnosis #1
    aspp2 aspp2κ #1

    Key People For Cell Lymphoma

    Top KOLs in the world
    Elaine S Jaffe
    cell lymphoma lymphoid neoplasms situ hybridization
    Randy D Gascoyne
    cell lymphoma diffuse large gene expression
    Nancy Lee Harris
    cell lymphoma abdominal pain cyclin d1
    Elı́as Campo
    cell lymphoma chronic lymphocytic leukemia cyclin d1
    Dennis D Weisenburger
    cell lymphoma bone marrow situ hybridization
    James Olen Armitage
    cell lymphoma bone marrow complete remission

    Falko Fend:Expert Impact

    Concepts for whichFalko Fendhas direct influence:Cell lymphoma,  Situ hybridization,  Cyclin d1,  Bone marrow,  Follicular lymphoma,  Prostate cancer,  Mantle cell lymphoma,  Multiple myeloma.

    Falko Fend:KOL impact

    Concepts related to the work of other authors for whichfor which Falko Fend has influence:Cell lymphoma,  Prostate cancer,  Multiple myeloma,  Gene expression,  Cyclin d1,  Situ hybridization,  Bone marrow.



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    Department of Pathology, University Hospital Tübingen, Tübingen, Germany | Institute for Pathology and Neuropathology, University Hospital of Tuebingen, Liebermeisterstraße 8, 72076 Tuebingen, Germany. | Institute of Pathology and Neuropathology and