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    • Andrew P Bush

      Andrew P Bush

      National Heart and Lung Institute, Imperial College London. | Dept of Paediatric Respiratory Medicine, Imperial Centre for Paediatrics and Child Health, National Heart and ...



      KOL Resume for Andrew P Bush


      National Heart and Lung Institute, Imperial College London.

      Imperial Centre for Paediatrics and Child Health, Imperial College, London, UK

      Royal Brompton Hospital, London, United Kingdom

      European Respiratory Society, Lausanne, Switzerland


      National Heart and Lung Institute, Imperial College London, London, UK

      European Respiratory Society Guidelines Working Group, Switzerland

      Imperial College and Royal Brompton Hospital, London, United Kingdom.

      Paediatric Respiratory Department, Royal Brompton and Harefield Hospitals, London, United Kingdom


      Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, England, United Kingdom

      Division of Medicine, and National Heart and Lung Institute, Imperial College, London, UK.

      COPSAC (Copenhagen Prospective Studies on Asthma I Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark

      Imperial College and Royal Brompton Hospital, London, UK



      Andrew P Bush: Influence Statistics

      Sample of concepts for which Andrew P Bush is among the top experts in the world.
      Concept World rank
      children respiration #1
      common international approach #1
      hrct children #1
      aged 616 years #1
      adherence track #1
      plethysmography hrct abnormalities #1
      inhalers facilitators #1
      load bal samples #1
      respiratory disease lci05 #1
      epoprostenol vasodilator #1
      hbd2 airway infection #1
      csld ll37 #1
      noncolonized children #1
      posts inhaler treatment #1
      pcd clinical findings #1
      children curvilinearity #1
      peak exhaled #1
      cystic fibrosis lcfc #1
      difficult asthma services #1
      differences feno #1
      pcd health impact #1
      ciliary dyskinesia feno #1
      atopic median #1
      viral wheeze evidence #1
      epoprostenol life #1
      rsv psw #1
      cardiopulmonary bypass ped #1
      feno response exacerbations #1
      interstitial collagen rbm #1
      vitamin aat expression #1
      ultrastructural groups #1
      balf hbd2 ll37 #1
      rbm thickness children #1
      maltophilia acquisition #1
      intervention electronic reminders #1
      wheeze outcomes evidence #1
      preschool cost life #1
      attacks asthmatic agents #1
      psw egfr #1
      cystic fibrosis paradigm #1
      immunofluorescence pcd #1
      bal eosinophils npv #1
      malinosculation #1
      bal microbiology cytology #1
      symptoms bronchoscopy #1
      subjects mbl2 #1
      fvcpr #1
      social stigma asthma #1
      matrix asthmatics #1
      bronchial biopsies pbecs #1


      Prominent publications by Andrew P Bush

      KOL-Index: 14154

      BACKGROUND: The pathology of pediatric severe therapy-resistant asthma (STRA) is little understood.

      OBJECTIVES: We hypothesized that STRA in children is characterized by airway eosinophilia and mast cell inflammation and is driven by the T(H)2 cytokines IL-4, IL-5, and IL-13.

      METHODS: Sixty-nine children (mean age, 11.8 years; interquartile range, 5.6-17.3 years; patients with STRA, n = 53; control subjects, n = 16) underwent fiberoptic bronchoscopy, bronchoalveolar lavage (BAL), and ...

      Known for Th2 Cytokines | Children Stra | Bal Fluid | Pediatric Severe Asthma | Airway Eosinophilia
      KOL-Index: 14039

      BACKGROUND: There are several potential physiological differences between the atriopulmonary (AP) and the total cavopulmonary connection (TCPC) Fontan circulations. Studies suggest that the TCPC reduces energy loss due to turbulence and may have more dependence on respiratory movement for pulmonary blood flow. We compared cardiopulmonary physiology during rest and exercise in patients who had undergone the AP Fontan procedure with those who had undergone the TCPC Fontan ...

      Known for Fontan Procedure | Total Cavopulmonary Connection | Stroke Volume | Cardiopulmonary Adaptation | Minute Ventilation
      KOL-Index: 13409

      RATIONALE: Structural alterations to airway smooth muscle (ASM) are a feature of asthma and cystic fibrosis (CF) in adults.

      OBJECTIVES: We investigated whether increase in ASM mass is already present in children with chronic inflammatory lung disease.

      METHODS: Fiberoptic bronchoscopy was performed in 78 children (median age [IQR], 11.3 [8.5-13.8] yr): 24 with asthma, 27 with CF, 16 with non-CF bronchiectasis (BX), and 11 control children without lower respiratory tract disease. ...

      Known for Children Asthma | Smooth Muscle | Cystic Fibrosis | Increased Airway | Asm Mass
      KOL-Index: 12638

      RATIONALE: High resolution computed tomography (HRCT) is a more sensitive tool for detecting early cystic fibrosis (CF) lung disease than either spirometry or plain radiography, but its relationship to other measures of lung function has not been established in young children.

      OBJECTIVES: (1) To assess whether the lung clearance index (LCI) derived from multiple breath inert-gas washout (MBW) is as effective as HRCT in identifying pulmonary abnormalities; and (2) explore the ...

      Known for Young Children | Lung Clearance | Hrct Spirometry | Abnormal Lci | Computed Tomography
      KOL-Index: 12135

      BACKGROUND: Rhinovirus infections are the dominant cause of asthma exacerbations, and deficient virus induction of IFN-α/β/λ in asthmatic patients is important in asthma exacerbation pathogenesis. Mechanisms causing this interferon deficiency in asthmatic patients are unknown.

      OBJECTIVE: We sought to investigate the expression of suppressor of cytokine signaling (SOCS) 1 in tissues from asthmatic patients and its possible role in impaired virus-induced interferon induction in these ...

      Known for Cytokine Signaling | Asthmatic Patients | Virus Induction | Asthma Exacerbations | Mice Socs1
      KOL-Index: 12026

      RATIONALE: Newborn screening (NBS) for cystic fibrosis (CF) allows early intervention. Design of randomised controlled trials (RCT) is currently impeded by uncertainty regarding evolution of lung function, an important trial end point in such infants.

      OBJECTIVE: To assess changes in pulmonary function during the first year of life in CF NBS infants.

      METHODS: Observational longitudinal study. CF NBS infants and healthy controls were recruited between 2009 and 2011. Lung Clearance Index ...

      Known for Lung Function | 1 Year | Cystic Fibrosis | 3 Months | Nbs Infants
      KOL-Index: 12021

      RATIONALE: Little is known about vitamin D status and its effect on asthma pathophysiology in children with severe, therapy-resistant asthma (STRA).

      OBJECTIVES: Relationships between serum vitamin D, lung function, and pathology were investigated in pediatric STRA.

      METHODS: Serum 25-hydroxyvitamin D [25(OH)D(3)] was measured in 86 children (mean age, 11.7 yr): 36 with STRA, 26 with moderate asthma (MA), and 24 without asthma (control subjects). Relationships between 25(OH)D(3), the ...

      Known for Serum Vitamin | Airway Remodeling | Children Stra | Lung Function | Asthma Control
      KOL-Index: 11999

      BACKGROUND: Lung clearance index (LCI), a measure of ventilation inhomogeneity derived from the multiple-breath inert gas washout (MBW) technique, has been shown to detect abnormal lung function more readily than spirometry in preschool children with cystic fibrosis, but whether this holds true during infancy is unknown.

      OBJECTIVES: To compare the extent to which parameters derived from the MBW and the raised lung volume rapid thoraco-abdominal compression (RVRTC) techniques identify ...

      Known for Cystic Fibrosis | Early Detection | Breath Washout | Raised Volume | Mbw Lci
      KOL-Index: 11942

      BACKGROUND: TH2 cytokines are not responsible for the ongoing symptoms and pathology in children with severe therapy-resistant asthma (STRA). IL-33 induces airway hyperresponsiveness, but its role in airway remodeling and steroid resistance is unknown.

      OBJECTIVE: We sought to investigate the relationship between IL-33 and airway remodeling in pediatric patients with STRA.

      METHODS: IL-33 levels were quantified in neonatal mice given inhaled house dust mite (HDM), and the effect of ...

      Known for Airway Remodeling | Children Stra | Inbred Balb Mice | Resistant Asthma | Il33 Levels
      KOL-Index: 11928

      OBJECTIVE: To explore the barriers and facilitators to inhaled asthma treatment in adolescents with asthma.

      DESIGN: Qualitative analysis of posts about inhaler treatment in adolescents from an online forum for people with asthma. Analysis informed by the Perceptions and Practicalities Approach.

      PARTICIPANTS: Fifty-four forum participants (39 adolescents ≥16 years, 5 parents of adolescents, 10 adults with asthma) identified using search terms 'teenager inhaler' and 'adolescent ...

      Known for Adolescents Asthma | Online Forum | Barriers Facilitators | Medication Adherence | Administration Inhalation
      KOL-Index: 11926

      STUDY OBJECTIVES: The noninvasive assessment and monitoring of airway inflammation could be important in respiratory disease. The pH of exhaled breath condensate (EBC) is a promising marker. Although pH has been measured in the EBC of adults with inflammatory airway diseases, no study has measured this in children.

      DESIGN: This study aimed to assess whether there is a change in pH in the EBC of children with cystic fibrosis (CF) and asthma, and to try to determine whether pH could be ...

      Known for Airway Inflammation | Cystic Fibrosis | Children Asthma | Breath Condensate | Noninvasive Marker
      KOL-Index: 11821

      BACKGROUND: Daily recombinant human deoxyribonuclease (rhDNase) is an established but expensive treatment in cystic fibrosis. Alternate-day treatment, if equally effective, would reduce the drug cost. Hypertonic saline improved lung function to the same degree as rhDNase in short-term studies. We compared the effectiveness of daily rhDNase, hypertonic saline, and alternate-day rhDNase in children with cystic fibrosis.

      METHODS: In an open cross-over trial, 48 children were allocated in ...

      Known for Hypertonic Saline | Cystic Fibrosis | Daily Rhdnase | Randomised Trial | Alternate Day
      KOL-Index: 11806

      Much of the morbidity and mortality seen in cystic fibrosis (CF) is related to chronic infection of the respiratory tract with Pseudomonas aeruginosa. Some studies have attributed the strong relationship between CF and Pseudomonas colonization to the presence of increased numbers of specific cell-surface receptors, although other work suggests that this relates to the presence of mucus. Several groups are now assessing the use of gene transfer as a novel form of treatment for CF. We have ...

      Known for Gene Transfer | Pseudomonas Aeruginosa | Respiratory Epithelium | Fibrosis Cystic | Epithelial Cells
      KOL-Index: 11747

      The aim of the present study is to determine the prevalence of asthma and allergic diseases among schoolchildren aged 6-14 years in the State of Qatar, based on a questionnaire designed by the International Study of Asthma and Allergy in Childhood (ISAAC). A cross-sectional study of 3,283 school children living in both urban and rural areas (average age, 9.03 +/- 1.99 years; 52.3% boys and 47.7% girls) was conducted between February 2003-February 2004. The population sample had a high ...

      Known for International Study | Prevalence Asthma | Allergic Rhinitis | Qatari Population | Surveys Questionnaires
      KOL-Index: 11644

      Exhaled breath condensate analysis for noninvasive quantification of airway inflammation in asthma is a potentially useful research tool in children. There is an imbalance between T-helper (Th)-2 cells, which secrete interleukin (IL)-4, and Th1 cells, which secrete interferon (IFN)-gamma, in asthma. We measured concentrations of IL-4 and IFN-gamma in breath condensates of 37 children (11 normal, 12 steroid-naive, and 14 steroid-treated children with asthma). Exhaled IFN-gamma was ...

      Known for Children Asthma | Exhaled Breath | Th2 Cells | Ifn Gamma | Airway Inflammation

      Key People For Cystic Fibrosis

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      Andrew P Bush:Expert Impact

      Concepts for whichAndrew P Bushhas direct influence:Cystic fibrosis,  Lung function,  Severe asthma,  Primary ciliary dyskinesia,  Difficult asthma,  Ciliary dyskinesia,  Airway inflammation,  Lung disease.

      Andrew P Bush:KOL impact

      Concepts related to the work of other authors for whichfor which Andrew P Bush has influence:Cystic fibrosis,  Severe asthma,  Lung function,  Nitric oxide,  Primary ciliary dyskinesia,  Pseudomonas aeruginosa,  Airway inflammation.



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      National Heart and Lung Institute, Imperial College London. | Dept of Paediatric Respiratory Medicine, Imperial Centre for Paediatrics and Child Health, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, UK | Imp

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