Prominent publications by You‐Chan Kim

KOL Index score: 11780

Both acquired bilateral nevus of Ota-like macules (ABNOM) and nevus of Ota are characterized by the presence of dermal melanocytes. There are no differences in the method of treatment, however, postinflammatory hyperpigmentation (PIH) develops more often in ABNOM than in nevus of Ota following treatment. We investigated the differences in the development of PIH after treatment between ABNOM and nevus of Ota, and the histopathologic differences in the PIH. A total of 82 patients with ...

Also Ranks for: Nevus Ota |  treatment abnom |  acquired bilateral |  therapeutic outcome |  dermal melanocytes
KOL Index score: 9971

Photodynamic therapy (PDT) is known to be effective in the photorejuvenation of photoaged skin. However, the molecular mechanisms of rejuvenation by PDT remain elusive. In this study, we aimed to understand the molecular events occurring during the photorejuvenation after PDT in dermal fibroblasts in vitro. First, we found that PDT conditions resulted in an increased fibroblast proliferation and motility in vitro. Under this condition, cells had increased intracellular reactive oxygen ...

Also Ranks for: Dermal Fibroblasts |  photodynamic therapy |  skin rejuvenation |  matrix metalloproteinase |  fibroblast proliferation
KOL Index score: 9092

BACKGROUND: Melasma is a commonly acquired symmetrical hypermelanosis on sun-exposed areas of the skin. The development of melasma appears to be associated with increased levels of oestrogen, exposure to sunlight and a genetic predisposition. Several in vitro studies have partially clarified the effects of oestrogen and progesterone on melasma. However, oestrogen receptor (ER) and progesterone receptor (PR) expression in melasma-affected skin has not been investigated to date, except for ...

Also Ranks for: Receptor Expression |  melasma skin |  genetic predisposition |  oestrogen progesterone |  sunexposed areas
KOL Index score: 8981

BACKGROUND: Epstein-Barr virus (EBV)-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in Western countries.

AIM: To elucidate the possible association of EBV with CD30+ anaplastic large cell lymphoma (ALCL) involving the skin and lymphomatoid papulosis (LyP) in South Korea.

METHODS: In situ hybridization for EBV-encoded small RNA (EBER) and immunohistochemistry including viral latent membrane protein-1 (LMP-1) were performed on formalin-fixed, ...

Also Ranks for: Barr Virus |  lymphomatoid papulosis |  cell lymphoma |  anaplastic large |  situ hybridization
KOL Index score: 8620

Toxic epidermal necrolysis (TEN) is a severe adverse drug reaction involving extensive keratinocyte death in the epidermis. Histologically, the skin from TEN patients exhibits separation at the dermo-epidermal junction and accompanying necrosis of epidermal keratinocytes. Receptor-interacting protein kinase-3 (RIP3 or RIPK3) is an essential part of the cellular machinery that executes "programmed", or "regulated", necrosis and has a key role in spontaneous cell death and inflammation in ...

Also Ranks for: Toxic Epidermal Necrolysis |  rip3 expression |  programmed necrosis |  cell death |  epidermal keratinocytes
KOL Index score: 8342

PURPOSE: Recent studies indicated that the autoimmunity of vitiligo exerts effects on cells other than melanocytes, which confer reduced risks of both melanoma and nonmelanoma skin cancers in patients with vitiligo. However, the risk of internal malignancy in patients with vitiligo has not been elucidated.

PATIENTS AND METHODS: We conducted a population-based retrospective cohort study using data from the Korean National Health Insurance claims database obtained from January 2007 to ...

Also Ranks for: Internal Malignancies |  reduced risk |  patients vitiligo |  based cohort |  nationwide population
KOL Index score: 8243

Cell-mediated immune response to herpes simplex virus (HSV) may be important in the pathogenesis of herpes keratitis, erythema multiforme or Behcet's disease. We examined whether herpesvirus infection regulates the expression of cell adhesion molecules on cultured human dermal microvascular endothelial cells (HDMEC) and the regulation of T-lymphocytes binding to HDMEC. The expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), or E-selectin ...

Also Ranks for: Cell Adhesion |  icam1 vcam1 |  microvascular endothelial |  hdmec treatment |  simplex virus
KOL Index score: 8199

Importance: Narrowband UV-B (NBUVB) phototherapy has been the mainstay in the treatment of vitiligo, but its long-term safety in terms of photocarcinogenesis has not been established.

Objectives: To investigate the risks of skin cancer and precancerous lesions among patients with vitiligo undergoing NBUVB phototherapy, based on the number of NBUVB phototherapy sessions.

Design, Setting, and Participants: This nationwide population-based retrospective cohort study enrolled 60 321 patients ...

Also Ranks for: Skin Cancer |  patients vitiligo |  phototherapy sessions |  actinic keratosis |  retrospective studies
KOL Index score: 7935

The follicular helper T cells (TFH) seemed to be expressed in several subsets of T-cell lymphomas. However, their expression in cutaneous T-cell lymphomas (CTCLs) has been rarely described. We investigated the clinical features, histopathological morphology, and expression of TFH markers in CTCLs. Forty-nine patients (24 men and 25 women) diagnosed with CTCL were examined, 25 patients with mycosis fungoides (MF) and 24 with other CTCLs. Immunohistochemical staining for CD10, Bcl-6, ...

Also Ranks for: Mf Cases |  cell markers |  follicular helper |  pd1 expression |  mycosis fungoides
KOL Index score: 7229

BACKGROUND: The pathogenesis of melasma is not yet fully understood. Previous studies indicate that dermal environment such as fibroblasts may have an important role in the development of melasma. Recently, it has been suggested that interactions between the cutaneous vasculature and melanocytes might have an influence on the development of pigmentation.

OBJECTIVES: We investigated the vascular characteristics in melasma lesions. The expression of vascular endothelial growth factor ...

Also Ranks for: Melasma Vegf |  lesional skin |  increased vascularity |  development pigmentation |  cutaneous vasculature
KOL Index score: 6835

Basal cell carcinoma (BCC) can show a variety of routes of differentiation, but myoepithelial differentiation has rarely been described. We describe a case of BCC showing histologic and immunohistochemical features of myoepithelial differentiation. Histologically, the lesion showed well-demarcated tumor nodules composed of two different components. One component was typical of BCC, and the other component was composed of tumor cells containing abundant cytoplasm, eccentric nuclei, and no ...

Also Ranks for: Basal Cell Carcinoma |  signet ring |  tumor cells |  myoepithelial differentiation |  s100 protein
KOL Index score: 6783

BACKGROUND: Repeated exposure to ultraviolet radiation from the sun results in premature photoaging. Photodynamic therapy (PDT) has been shown to be effective for treatment of photoaging, although the data from most studies have been based on clinical observation.

OBJECTIVES: We investigated whether 5-aminolevulinic acid (ALA)-PDT induced histologic changes suggesting photorejuvenation.

METHODS: Fourteen patients with one to three actinic keratoses on the face were treated twice with ...

Also Ranks for: Actinic Keratosis |  aminolevulinic acid |  photodynamic therapy |  pdt treatment |  transforming growth
KOL Index score: 6641

Psoriasis is a relatively common disorder in children and can be triggered by an upper respiratory tract infection. The aim of this study was to compare the clinical features of psoriasis in children and adult. In addition, we evaluated the relationship between anti-streptolysin O (ASO) titers and the clinical features of psoriasis. A total of 30 childhood psoriasis patients and 30 adult psoriasis patients were evaluated. Childhood psoriasis had a facial predominance when compared with ...

Also Ranks for: Children Psoriasis |  aso titers |  streptococcal infections |  antibodies bacterial |  streptococcus streptolysins
KOL Index score: 6624

BACKGROUND/PURPOSE: A relatively long incubation time is needed for photosensitizer absorption in conventional photodynamic therapy (PDT) for actinic keratosis (AK). The use of ablative CO2 fractional lasers (AFXLs) to increase drug delivery could shorten the incubation time. Here, we aimed to compare the efficacy between AFXL-assisted PDT with a short incubation time and conventional PDT for AK.

METHODS: Patients with histopathologically confirmed facial AK were randomly divided into ...

Also Ranks for: Actinic Keratosis |  conventional pdt |  incubation time |  carbon dioxide |  photodynamic therapy
KOL Index score: 6609

Sarcoidosis is a multisystem disease of unknown etiology. The demonstration of polarizable foreign bodies in cutaneous granulomas is generally thought to exclude a diagnosis of sarcoidosis. Nevertheless. some investigators have reported systemic sarcoidosis with cutaneous manifestations in which polarizable particles were associated with granuloma formation in the skin. We searched the biopsy specimens of granulomatous lesions from 50 patients with cutaneous sarcoidosis using ...

Also Ranks for: Foreign Bodies |  cutaneous sarcoidosis |  biopsy specimens |  granuloma formation |  skin lesions

Key People For Photodynamic Therapy

Top KOLs in the world
Thomas * *********
photodynamic therapy hematoporphyrin derivative malignant tumors
Johan ******* ****
photodynamic therapy topical application aminolevulinic acid
Michael ******* *******
photodynamic therapy wound healing blue light
David * ******
photodynamic therapy apoptotic response lysosomal photodamage
Barbara * *********
photodynamic therapy fluence rate light dose
Tayyaba *****
photodynamic therapy pancreatic cancer singlet oxygen

You‐Chan Kim:Expert Impact

Concepts for whichYou‐Chan Kimhas direct influence:Photodynamic therapy,  Nipple eczema,  Male melasma,  Palmoplantar keratoderma,  Immunohistochemical study,  Atopic dermatitis,  Pyoderma gangrenosum,  Actinic keratosis.

You‐Chan Kim:KOL impact

Concepts related to the work of other authors for whichfor which You‐Chan Kim has influence:Photodynamic therapy,  Granuloma annulare,  Actinic keratosis,  Cranial fasciitis,  Ecthyma gangrenosum,  Tranexamic acid,  Cell lymphoma.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Department of Dermatology, Ajou University School of Medicine, Suwon, Korea | Department of Dermatology, Ajou University Hospital School of Medicine, Suwon, Korea | Department of Dermatology, Ajou University School of Medicine, Suwon, Republic of Kor