Prominent publications by Michael George Fehlings

KOL Index score: 20219

Objective. —To compare the efficacy of methylprednisolone administered for 24 hours with methyprednisolone administered for 48 hours or tirilazad mesylate administered for 48 hours in patients with acute spinal cord injury.Design. —Double-blind, randomized clinical trial.Setting. —Sixteen acute spinal cord injury centers in North America.Patients. —A total of 499 patients with acute spinal cord injury diagnosed in National Acute Spinal Cord Injury Study (NASCIS) centers within 8 hours of ...

Also Ranks for: 48 Hours |  tirilazad mesylate |  injury patients |  acute spinal |  6 weeks
KOL Index score: 18416

The International Campaign for Cures of Spinal Cord Injury Paralysis (ICCP) supported an international panel tasked with reviewing the methodology for clinical trials in spinal cord injury (SCI), and making recommendations on the conduct of future trials. This is the first of four papers. Here, we examine the spontaneous rate of recovery after SCI and resulting consequences for achieving statistically significant results in clinical trials. We have reanalysed data from the Sygen trial to ...

Also Ranks for: Spontaneous Recovery |  spinal cord injury |  sci trials |  iccp panel |  ais patients
KOL Index score: 17408

BACKGROUND: Although there is a strong biological rationale for early decompression of the injured spinal cord, the influence of the timing of surgical decompression for acute spinal cord injury (SCI) remains debated, with substantial variability in clinical practice. We aimed to objectively evaluate the effect of timing of decompressive surgery for acute SCI on long-term neurological outcomes.

METHODS: We did a pooled analysis of individual patient data derived from four independent, ...

Also Ranks for: Surgical Decompression |  acute spinal |  individual patient data |  pooled analysis |  1 year
KOL Index score: 16944

BACKGROUND: Surgery for symptomatic spinal metastases aims to improve quality of life, pain, function, and stability. Complications in the postoperative period are not uncommon; therefore, it is important to select appropriate patients who are likely to benefit the greatest from surgery. Previous studies have focused on predicting survival rather than quality of life after surgery.

OBJECTIVE: To determine preoperative patient characteristics that predict postoperative quality of life and ...

Also Ranks for: Spinal Metastases |  quality life |  survival surgery |  surgical treatment |  tumor type
KOL Index score: 16905

BACKGROUND: There is convincing preclinical evidence that early decompression in the setting of spinal cord injury (SCI) improves neurologic outcomes. However, the effect of early surgical decompression in patients with acute SCI remains uncertain. Our objective was to evaluate the relative effectiveness of early (<24 hours after injury) versus late (≥ 24 hours after injury) decompressive surgery after traumatic cervical SCI.

METHODS: We performed a multicenter, international, ...

Also Ranks for: Surgical Timing |  acute spinal |  delayed decompression |  cord injury |  late surgery
KOL Index score: 16874

STUDY DESIGN: Systematic review and survey.

OBJECTIVE: To perform an evidence synthesis of the literature and obtain information from the global spine care community assessing the frequency, timing, and predictors of symptom development in patients with radiographical evidence of cervical spinal cord compression, spinal canal narrowing, and/or ossification of posterior longitudinal ligament (OPLL) but no symptoms of myelopathy.

SUMMARY OF BACKGROUND DATA: Evidence for a marker to predict ...

Also Ranks for: Cord Compression |  cervical spinal |  longitudinal ligament |  myelopathy development |  neurological dysfunction
KOL Index score: 16044

Spinal cord injury leads to many forms of autonomic dysfunction including autonomic dysreflexia, a condition involving recurrent episodes of paroxysmal hypertension and associated bradycardia. This hypertension may reach intensities that are life-threatening. We investigated autonomic dysreflexia and the sprouting of central processes of primary afferent neurons (a potential mechanism for autonomic dysreflexia) in a clinically-relevant calibrated clip-compression model of spinal cord ...

Also Ranks for: Autonomic Dysreflexia |  spinal cord |  2 weeks |  primary afferent |  colon distension
KOL Index score: 15731

To characterize the changes in axonal function in the motor and somatosensory tracts of the cord after spinal cord injury (SCI) and to correlate these changes with spinal cord blood flow (SCBF), the relationships among the severity of SCI, motor and somatosensory evoked potentials (MEPs and SSEPs) and SCBF were examined. Fifteen rats received a 1.5 g (n = 5), 20 g (n = 5) or 56 g (n = 5) clip compression injury of the cord at C8. SCBF at the injury site was measured by the hydrogen ...

Also Ranks for: Cord Injury |  somatosensory evoked |  blood flow |  sci scbf |  mep ssep
KOL Index score: 15727

OBJECT: Rates of complications associated with the surgical treatment of cervical spondylotic myelopathy (CSM) are not clear. Appreciating these risks is important for patient counseling and quality improvement. The authors sought to assess the rates of and risk factors associated with perioperative and delayed complications associated with the surgical treatment of CSM.

METHODS: Data from the AOSpine North America Cervical Spondylotic Myelopathy Study, a prospective, multicenter study, ...

Also Ranks for: Surgical Treatment |  perioperative complications |  spondylotic myelopathy |  north america |  cervical vertebrae decompression
KOL Index score: 15659

BACKGROUND: Cervical spondylotic myelopathy (CSM) is the most common cause of spinal cord dysfunction in older individuals. Controversy remains in terms of the optimal timing and indications for surgical intervention. In this context, it would be of benefit to define clinical and magnetic resonance imaging (MRI) predictors of outcome after intervention for CSM.

OBJECTIVE: We studied subjects with clinically documented cervical myelopathy to evaluate the relationship among preoperative ...

Also Ranks for: Surgical Intervention |  t1wi t2wi |  cervical spondylotic myelopathy |  patients csm |  mri signal
KOL Index score: 15356

STUDY DESIGN: Prospective, blinded validation study of an objective, quantitative measure to assess maximum canal compromise (MCC) and maximum spinal cord compression (MSCC) in individuals with acute cervical spinal cord injury (SCI).

OBJECTIVE: To examine the intraobserver and interobserver reliability of MCC and MSCC in individuals with acute traumatic cervical SCI.

SUMMARY OF BACKGROUND DATA: To date, few quantitative reliable radiologic methods for assessing the extent of spinal cord ...

Also Ranks for: Cord Compression |  cervical spinal |  mcc mscc |  maximum canal compromise |  acute traumatic
KOL Index score: 15311

The transplantation of neural stem/progenitor cells (NPCs) is a promising therapeutic strategy for spinal cord injury (SCI). However, to date NPC transplantation has exhibited only limited success in the treatment of chronic SCI. Here, we show that chondroitin sulfate proteoglycans (CSPGs) in the glial scar around the site of chronic SCI negatively influence the long-term survival and integration of transplanted NPCs and their therapeutic potential for promoting functional repair and ...

Also Ranks for: Growth Factors |  functional repair |  chronic sci |  spinal cord |  synergistic effects
KOL Index score: 15099

PURPOSE: Vertebral compression fractures (VCFs) are increasingly observed after spine stereotactic body radiation therapy (SBRT). The aim of this study was to determine the risk of VCF after spine SBRT and identify clinical and dosimetric factors predictive for VCF. The analysis incorporated the recently described Spinal Instability Neoplastic Score (SINS) criteria.

METHODS AND MATERIALS: The primary endpoint of this study was the development of a de novo VCF (ie, new endplate fracture ...

Also Ranks for: Predictive Factors |  compression fracture |  vcf sbrt |  stereotactic body |  spinal neoplasms
KOL Index score: 15082

BACKGROUND: Despite decades of research, there are no national estimates of the incidence or prevalence of spinal cord injury (SCI) in Canada. Our objective was to utilize the best available data to estimate the incidence and prevalence of traumatic SCI (TSCI) and non-traumatic SCI (NTSCI) in Canada for 2010.

METHODS: Initial incidence (number of TSCIs at injury scene) and discharge incidence (number discharged into the community) were calculated using published TSCI rates from Alberta ...

Also Ranks for: Incidence Prevalence |  sci canada |  spinal cord |  injuries young

Key People For Spinal Cord

Top KOLs in the world
Michael ****** ********
spinal cord degenerative cervical myelopathy surgical decompression
Michael * *******
spinal cord cell death data sharing
Jacqueline * *********
spinal cord cell death data commons
Charles * *****
spinal cord conservative management blood flow
Martin ***** ******
spinal cord functional recovery neurite growth
D ******* *****
spinal cord locomotor recovery pet dogs

Michael George Fehlings:Expert Impact

Concepts for whichMichael George Fehlingshas direct influence:Spinal cord,  Spinal cord injury,  Cord injury,  Degenerative cervical myelopathy,  Cervical spondylotic myelopathy,  Spinal metastases,  Cervical myelopathy,  Surgical decompression.

Michael George Fehlings:KOL impact

Concepts related to the work of other authors for whichfor which Michael George Fehlings has influence:Spinal cord,  Stem cells,  Functional recovery,  Cervical spine,  Injury sci,  Surgical treatment,  Central nervous.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. | Division of Neurosurgery and Spinal Program, Department of Surgery, University of Toronto, Toronto, ON, Canada. | Division of Neurosurgery, Department of Surgery, Univer