Prominent publications by Ananda N Nisalak

KOL Index score: 16326

It has been reported that the severe complication of dengue virus infection, dengue hemorrhagic fever (DHF) is much more commonly observed during secondary dengue virus infections than primary infections. In order to elucidate the role of T lymphocytes in the pathogenesis of DHF, we attempted to determine whether T lymphocytes are activated in vivo during dengue virus infections, by examining the levels of soluble IL-2 receptor (sIL-2R), soluble CD4 (sCD4), soluble CD8 (sCD8), ...

Also Ranks for: Soluble Cd8 |  dengue virus infections |  ifn gamma |  patients dhf |  levels sil2r
KOL Index score: 13123

BACKGROUND: Chikungunya virus (CHIKV) is a globally re-emerging arbovirus for which previous studies have indicated the majority of infections result in symptomatic febrile illness. We sought to characterize the proportion of subclinical and symptomatic CHIKV infections in a prospective cohort study in a country with known CHIKV circulation.

METHODS/FINDINGS: A prospective longitudinal cohort of subjects ≥6 months old underwent community-based active surveillance for acute febrile ...

Also Ranks for: Prospective Cohort |  chikungunya virus |  neutralizing antibodies |  chikv infections |  female genotype
KOL Index score: 12775

A rapid (<7-min) immunochromatographic test for immunoglobulin M (IgM) and IgG antibodies to dengue viruses was evaluated by using hospital admission and discharge sera from 124 patients. The reference laboratory diagnosis was based on the results of virus isolation, hemagglutination-inhibition assay (HAI), and enzyme immunoassay (EIA). By the standard assays, patients experienced primary dengue virus infection (n = 30), secondary dengue virus infection (n = 48), Japanese encephalitis ...

Also Ranks for: Dengue Virus |  igm igg |  rapid test |  immunoglobulin sensitivity |  positive patients
KOL Index score: 12441

BACKGROUND: Transmission of dengue viruses (DENV), the leading cause of arboviral disease worldwide, is known to vary through time and space, likely owing to a combination of factors related to the human host, virus, mosquito vector, and environment. An improved understanding of variation in transmission patterns is fundamental to conducting surveillance and implementing disease prevention strategies. To test the hypothesis that DENV transmission is spatially and temporally focal, we ...

Also Ranks for: Denv Transmission |  thai villages |  positive clusters |  dengue virus |  temporal clustering
KOL Index score: 12195

The severe complications of dengue virus infections, hemorrhagic manifestations and shock, are more commonly observed during secondary dengue virus infections than during primary infections. It has been speculated that these complications are mediated by cross-reactive host-immune responses. We have begun to analyze human T cell responses to dengue antigens in vitro to explain the possible role of T lymphocytes in the pathogenesis of these complications. Dengue antigens induce ...

Also Ranks for: Cell Responses |  dengue antigens |  ifn gamma |  cd8 phenotypes |  severe complications
KOL Index score: 11903

Immunoglobulin M (IgM) and IgG antibodies to Japanese encephalitis virus (JEV) were detected in acute-phase cerebrospinal fluid (CSF) specimens from patients with acute encephalitis by using a solid-phase radioimmunoassay of the antibody capture type. Of 12 patients with JEV infections subsequently proven by hemagglutination inhibition serology, 11 had JEV IgM antibodies, as measured by antibody capture radioimmunoassay, in the first CSF specimen (geometric mean titer, 1:2,500) compared ...

Also Ranks for: Antibody Capture |  cerebrospinal fluid |  encephalitis virus |  jev igg |  immunoglobulin antibodies
KOL Index score: 11893

BACKGROUND: Dengue virus infection causes a spectrum of clinical manifestations, usually classified according to the World Health Organization (WHO) guidelines into dengue fever (DF) and dengue hemorrhagic fever (DHF). The ability of these guidelines to categorize severe dengue illness has recently been questioned.

METHODS: We evaluated dengue case definitions in a prospective study at a pediatric hospital in Bangkok, Thailand, during 1994-2005. One thousand thirteen children were ...

Also Ranks for: Dengue Hemorrhagic Fever |  severe cases |  sensitivity specificity |  case definition |  health organization
KOL Index score: 11869

The performances of the MRL dengue fever virus immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) and the PanBio Dengue Duo IgM capture and IgG capture ELISA were compared. Eighty sera from patients with dengue virus infections, 24 sera from patients with Japanese encephalitis (JE), and 78 sera from patients with nonflavivirus infections, such as malaria, typhoid, leptospirosis, and scrub typhus, were used. The MRL test showed superior sensitivity for dengue virus ...

Also Ranks for: Dengue Virus |  immunosorbent assay |  southeast asia |  japanese encephalitis |  sensitivity specificity
KOL Index score: 11730

Encephalitis caused by Japanese encephalitis virus occurs in annual epidemics throughout Asia, making it the principal cause of epidemic viral encephalitis in the world. No currently available vaccine has demonstrated efficacy in preventing this disease in a controlled trial. We performed a placebo-controlled, blinded, randomized trial in a northern Thai province, with two doses of monovalent (Nakayama strain) or bivalent (Nakayama plus Beijing strains) inactivated, purified Japanese ...

Also Ranks for: Japanese Encephalitis |  inactivated vaccines |  immunization schedule |  vaccine efficacy |  dengue hemorrhagic fever
KOL Index score: 11700

BACKGROUND: Japanese encephalitis (JE) is presumed to be endemic throughout Asia, yet only a few cases have been reported in tropical Asian countries such as Indonesia, Malaysia and the Philippines. To estimate the true disease burden due to JE in this region, we conducted a prospective, hospital-based surveillance with a catchment population of 599,120 children less than 12 years of age in Bali, Indonesia, from July 2001 through December 2003.

METHODS: Balinese children presenting to ...

Also Ranks for: Japanese Encephalitis |  bali indonesia |  based surveillance |  children age |  cerebrospinal fluid
KOL Index score: 11684

Japanese encephalitis (JE) causes at least 10 000 deaths each year. Death is presumed to result from infection, dysfunction and destruction of neurons. There is no antiviral treatment. Seizures and raised intracranial pressure (ICP) are potentially treatable complications, but their importance in the pathophysiology of JE is unknown. Between 1994 and 1997 we prospectively studied patients with suspected CNS infections referred to an infectious disease referral hospital in Ho Chi Minh ...

Also Ranks for: Intracranial Pressure |  patients seizures |  poor outcome |  severe sequelae |  japanese encephalitis
KOL Index score: 11667

BACKGROUND: Although plasma leakage is the major cause of mortality and morbidity in patients with dengue hemorrhagic fever (DHF), a detailed assessment of the natural course of this process is still lacking. We employed serial ultrasound examination to delineate the locations and the timing of plasma leakage and to evaluate the usefulness of ultrasound in detecting plasma leakage in DHF.

METHOD: Daily ultrasound examinations of the abdomen and right thorax were performed in 158 ...

Also Ranks for: Plasma Leakage |  dengue hemorrhagic fever |  dhf cases |  pleural effusions |  gallbladder wall

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Ananda N Nisalak:Expert Impact

Concepts for whichAnanda N Nisalakhas direct influence:Dengue virus,  Japanese encephalitis,  Dengue viruses,  Kamphaeng phet,  Dengue hemorrhagic fever,  Dengue infection,  Hemorrhagic fever,  Japanese encephalitis virus.

Ananda N Nisalak:KOL impact

Concepts related to the work of other authors for whichfor which Ananda N Nisalak has influence:Dengue virus,  Japanese encephalitis,  Neutralizing antibodies,  Denv infection,  Aedes aegypti.



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Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand | Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand | Department of Virology, Armed Forces Research Institute of Medical Sciences, Ban