• Disease
  • Nodular
  • Nodular Melanoma
  • Riccardo Bono

    Prominent publications by Riccardo Bono

    KOL Index score: 13305

    BACKGROUND: Over the past decade numerous epiluminescence microscopy (ELM) criteria and algorithmic methods have been developed to improve the diagnosis of cutaneous melanocytic lesions.

    OBJECTIVE: Our purpose was to compare the sensitivity, specificity, and diagnostic accuracy of 3 algorithmic methods (pattern analysis, ABCD rule of dermoscopy, and the 7-point checklist) on a series of highly atypical melanocytic lesions. We also determined the diagnostic value of distinct ELM ...

    Also Ranks for: Melanocytic Lesions |  sensitivity specificity |  structureless areas |  pattern analysis |  algorithmic methods
    KOL Index score: 13110

    BACKGROUND: Amelanotic malignant melanoma is a subtype of cutaneous melanoma with little or no pigment on visual inspection. It may mimic benign and malignant variants of both melanocytic and nonmelanocytic lesions.

    OBJECTIVES: To evaluate whether dermoscopy is also a useful technique for the diagnosis of amelanotic/hypomelanotic melanoma (AHM).

    METHODS: We conducted a retrospective clinical study of 151 amelanotic/hypomelanotic skin lesions from 151 patients with a mean age of 47 years ...

    Also Ranks for: Hypomelanotic Melanoma |  dermoscopic features |  vascular patterns |  irregular pigmentation |  regression structures
    KOL Index score: 9556

    OBJECTIVE: To determine the predictive dermoscopic features of amelanotic and hypomelanotic melanoma.

    DESIGN: A total of 105 melanomas (median Breslow thickness, 0.76 mm), 170 benign melanocytic lesions, and 222 nonmelanocytic lesions lacking significant pigment (amelanotic, partially pigmented, and light colored) were imaged using glass-plate dermoscopy devices and scored for 99 dermoscopic features. Diagnostic models were derived from and tested on independent randomly selected ...

    Also Ranks for: Dermoscopic Evaluation |  hypomelanotic melanoma |  sensitivity specificity |  benign lesions |  differential humans
    KOL Index score: 8918

    IMPORTANCE: Nodular melanoma (NM) is a rapidly progressing potentially lethal skin tumor for which early diagnosis is critical.

    OBJECTIVE: To determine the dermoscopy features of NM.

    DESIGN: Eighty-three cases of NM, 134 of invasive non-NM, 115 of nodular benign melanocytic tumors, and 135 of nodular nonmelanocytic tumors were scored for dermoscopy features using modified and previously described methods. Lesions were separated into amelanotic/hypomelanotic or pigmented to assess ...

    Also Ranks for: Nodular Melanoma |  pigmented nm |  dermoscopic evaluation |  bluewhite veil |  pink color
    KOL Index score: 8096

    BACKGROUND: The negative pigment network (NPN) is seen as a negative of the pigmented network and it is purported to be a melanoma-specific structure.

    OBJECTIVES: We sought to assess the frequency, sensitivity, specificity, and odds ratios (ORs) of NPN between melanoma cases and a group of control lesions.

    METHODS: Digitalized images of skin lesions from 679 patients with histopathological diagnosis of dermatofibroma (115), melanocytic nevus (220), Spitz nevus (139), and melanoma (205) ...

    Also Ranks for: Negative Pigment Network |  spitz nevus |  diagnosis melanoma |  multicomponent pattern |  skin lesions
    KOL Index score: 7021

    Although the long experience acquired with the widespread use of dermoscopy has allowed the establishment of criteria for the recognition of benign and malignant skin lesions, very few data are available on cutaneous melanoma metastases. As the characteristic clinical aspects are multiform and even histological evaluation may sometimes be difficult, we have studied and characterized the patterns of cutaneous melanoma metastases in dermoscopy. In this paper, we report dermoscopic data on ...

    Also Ranks for: Cutaneous Melanoma Metastases |  dermoscopic patterns |  male melanoma |  skin neoplasms |  80 dermoscopy
    KOL Index score: 6565

    BACKGROUND: Nodular melanoma (NM), representing 10-30% of all melanomas, plays a major role in global mortality related to melanoma. Nonetheless, the literature on dermoscopy of NM is scanty.

    OBJECTIVES: To assess odds ratios (ORs) to quantify dermoscopic features of pigmented NM vs. pigmented superficial spreading melanoma (SSM), and pigmented nodular nonmelanocytic and benign melanocytic lesions.

    METHODS: To assess the presence or absence of global patterns and dermoscopic criteria, ...

    Also Ranks for: Nodular Melanoma |  dermoscopic features |  multivariate analysis |  dermoscopy diagnosis |  skin lesions
    KOL Index score: 6164

    BACKGROUND: Whether timing of sentinel lymph node biopsy (SLNB) in cutaneous melanoma improves survival is not yet clear. The aim of this study was to investigate if the timing of SLNB influences long-term melanoma mortality.

    METHODS: A 10-year retrospective cohort study was conducted on 748 cutaneous melanoma patients who underwent excision of the SLN. Hazard ratios and 95% confidence intervals were estimated from Cox proportional hazards models.

    RESULTS: After adjusting for sex, age, ...

    Also Ranks for: Lymph Node |  cutaneous melanoma |  retrospective studies |  early slnb |  aged neoplasm
    KOL Index score: 5455

    BACKGROUND: Differential diagnosis of melanoma from melanocytic nevi is often not straightforward. Thus, a growing interest has developed in the last decade in the automated analysis of digitized images obtained by epiluminescence microscopy techniques to assist clinicians in differentiating early melanoma from benign skin lesions.

    PURPOSE: The aim of this study was to evaluate diagnostic accuracy provided by different statistical classifiers on a large set of pigmented skin lesions ...

    Also Ranks for: Melanoma Nevus |  aided diagnosis |  pigmented reproducibility |  skin lesions |  automated analysis
    KOL Index score: 5247

    BACKGROUND/PURPOSE: The relationship between diseases and alterations of the airborne chemicals emitted from the body has been found in many different pathologies and in particular for various forms of cancer. Metabolism of cancer cells is greatly altered during their lifetime; then, modification of chemicals is supposed to be large around cancer tissues. Positive hints in this direction were provided, as an example, on studying the breath composition of lung cancer-affected subjects. ...

    Also Ranks for: Gas Sensor Array |  chemical composition |  cancer cells |  skin surface |  melanoma biomarkers
    KOL Index score: 5189

    Amelanotic melanoma (AM) is a rare subtype of melanoma with little or no clinically visible pigment; it is more difficult to diagnose than pigmented melanoma (PM), and has a worse prognosis. In the attempt to find a genetic explanation for the distinction between AM and PM, we conducted a case-case study, matching AM and PM patients, and testing them for germline mutations in high- (p16INK4A, p14ARF, CDK4) and low-penetrance (MC1R) melanoma susceptibility genes. Similar CDKN2A mutations ...

    Also Ranks for: Amelanotic Melanoma |  cdkn2a mutations |  female genetic predisposition |  mc1r variants |  pigmentation genes
    KOL Index score: 4968

    Table of contentsMELANOMA BRIDGE 2015KEYNOTE SPEAKER PRESENTATIONSMolecular and immuno-advancesK1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanomaVashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. DaviesK2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistanceGennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita ...

    Also Ranks for: Treatment Melanoma |  mek inhibitors |  cells tumor |  immune checkpoint |  response braf
    KOL Index score: 4715

    BACKGROUND: The morphologic capillary microscopy (capillaroscopy) pattern of acrocyanosis is characterized by hemorrhages, pericapillary edema, and widened capillaries. These findings can result in a difficult differential diagnosis with systemic sclerosis (SSc).

    OBJECTIVE: We sought to quantify the characteristics of the capillaroscopy pattern that distinguishes patients with acrocyanosis from patients with SSc and control subjects.

    METHODS: A videomicroscope with fiberoptic ...

    Also Ranks for: Systemic Sclerosis |  patients acrocyanosis |  capillary microscopy |  giant capillaries |  diagnosis differential
    KOL Index score: 4388

    BACKGROUND: The clinical and dermoscopic differentiation between lentigo maligna (LM) and solar lentigo (SL)/initial seborrheic keratosis (SK) may be difficult.

    OBJECTIVE: Our aim was to identify digital epiluminescence microscopy (DELM)-specific criteria that can be helpful in distinguishing LM from SL/SK and to propose a new model of LM dermoscopic progression based on a study of DELM-histopathological correlation.

    METHODS: A total of 167 consecutive doubtful pigmented lesions of the ...

    Also Ranks for: Lentigo Maligna |  seborrheic keratosis |  skin neoplasms |  hutchinson melanotic |  dermoscopy diagnosis


    Riccardo Bono: Influence Statistics

    Sample of concepts for which Riccardo Bono is among the top experts in the world.
    Concept World rank
    curves melanomas #2
    steady enhancement increase #2
    melanomas dynamic imaging #2
    melanomas dynamic #2
    naevi type #2
    milky pink #2
    minute naevi #2
    enhancement rate minute #2
    dermoscopic practice #4
    nevus global #4
    nevi global patterns #4
    prevalent minor pattern #4
    patients normal moles #4
    common dermoscopic profiles #4
    gd dtpa administration #4
    50 homogeneous pattern #4
    lesions linear classifier #4
    melanoma computeraided diagnosis #4
    study linear classifier #4
    nevi minor #4
    color specific structures #4
    patients acrocyanosis #4
    95 nearest #4
    205 nevi #4
    reticular global pattern #4
    391 melanomas #4
    dermoscopic global #4
    95 knearestneighbor classifier #4
    dermoscopic global pattern #4
    40 minor pattern #4
    knearestneighbor classifier sensitivity #4
    analyzers db #5
    analyzer evaluates #5
    objective melanoma progression #5
    interpret identify #5
    italian dermatology centers #5
    withinlesion analysis #5
    dermoscopy analyzers #5
    iii wash #5
    324month observation period #5
    metastases dermoscopy #5
    evaluates 49 #5
    cutaneous melanoma dermoscopy #5
    blue multicomponent #5
    ast dermoscopic #6
    dermatoscopic analysis #6
    melanoma volatile fingerprint #6
    ambulatory dermatology clinics #6
    19 lowvolume centers #6
    wash signal #6

    Key People For Nodular Melanoma

    Top KOLs in the world
    John William Kelly
    cutaneous melanoma melanocytic nevi shave biopsy
    John F Thompson
    melanoma patients node biopsy sentinel lymph
    Martin C Mihm
    malignant melanoma skin neoplasms clinical stage
    Charles M Balch†
    melanoma patients surgical oncology lymph node
    Alexander J Chamberlain
    nodular melanoma earlier detection distinct entity
    Alfred W Kopf
    malignant melanoma tumor conference basal cell

    Riccardo Bono:Expert Impact

    Concepts for whichRiccardo Bonohas direct influence:Nodular melanoma,  Digital dermoscopy analysis,  Early diagnosis,  Cutaneous melanoma metastases,  Dermoscopic features,  Skin lesions,  Lentigo maligna,  Hypomelanotic melanoma.

    Riccardo Bono:KOL impact

    Concepts related to the work of other authors for whichfor which Riccardo Bono has influence:Electronic nose,  Skin cancer,  Confocal microscopy,  Amelanotic melanoma,  Dermoscopic features,  Visual inspection,  Melanocytic lesions.



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    Istituto Dermopatico Dell’Immacolata Concezione, IDIIRCCS, Rome, Italy | Istituto Dermopatico Immacolata, IRCCS, Rome, Italy | Melanoma Unit, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione Luigi