• Disease
  • Burkitt
  • Burkitt Lymphoma
  • Ian T Magrath

    Prominent publications by Ian T Magrath

    KOL Index score: 14899

    Nasal NK/T-cell lymphoma is a unique form of lymphoma highly associated with Epstein-Barr virus (EBV). These lymphomas are rare in Western populations and much more prevalent in some Asian and Latin American countries. Although there are several sizable studies from Asian countries, the same is not true from South America. The aim of this study was to analyze a series of 32 cases of nasal T-cell lymphoma from Peru and to further extend the characterization of this disease. ...

    Also Ranks for: Cell Lymphoma |  nasal nk |  p53 overexpression |  cases cd56 |  asian countries
    KOL Index score: 13905

    BACKGROUND: Childhood-cancer survival is dismal in most low-income countries, but initiatives for treating paediatric cancer have substantially improved care in some of these countries. The My Child Matters programme was launched to fund projects aimed at controlling paediatric cancer in low-income and mid-income countries. We aimed to assess baseline status of paediatric cancer care in ten countries that were receiving support (Bangladesh, Egypt, Honduras, Morocco, the Philippines, ...

    Also Ranks for: Paediatric Oncology |  child matters |  cancer countries |  descriptive study |  5year survival
    KOL Index score: 12316

    We have investigated the frequency of p53 mutations in B- and T-cell human lymphoid malignancies, including acute lymphoblastic leukemia, the major subtypes of non-Hodgkin lymphoma, and chronic lymphocytic leukemia. p53 exons 5-9 were studied by using genomic DNA from 197 primary tumors and 27 cell lines by single-strand conformation polymorphism analysis and by direct sequencing of PCR-amplified fragments. Mutations were found associated with (i) Burkitt lymphoma (9/27 biopsies; 17/27 ...

    Also Ranks for: P53 Mutations |  chronic lymphocytic |  cell leukemia |  lymphoid malignancies |  burkitt lymphoma
    KOL Index score: 12106

    The functional maturity of T and B lymphocyte populations from human newborns was evaluated using a reverse hemolytic plaque assay to detect immunoglobulin-secreting cells generated in in vitro cultures stimulated with pokeweed mitogen (PWM), a T cell-dependent polyclonal activator, and the Epstein-Barr virus (EBV), a T cell-independent B cell activator. Cord blood lymphocytes failed to produce immunoglobulin in response to PWM, but did respond with immunoglobulin synthesis to ...

    Also Ranks for: Blood Lymphocytes |  human cord |  adult cells |  cell differentiation |  ebv pwm
    KOL Index score: 12070

    Early initiation of empiric antibiotic therapy in febrile cancer patients has become established practice, but the appropriate duration of antibiotic therapy when no infectious source can be identified is unknown. The complications of broad-spectrum antibiotics argue for brief treatment, but the risk of an inadequately treated infection in the granulocytopenic patient favors longer therapy. We prospectively studied 306 episodes of fever and granulocytopenia in 143 patients with leukemia ...

    Also Ranks for: Antibiotic Therapy |  granulocytopenic patient |  unknown origin |  fever granulocytopenia |  500 mm3
    KOL Index score: 11360

    Publisher This chapter discusses the evidence that deregulation of c-myc is a critical component of the pathogenesis of Burkitt's lymphoma, and consideration is given to the potential pathogenetic role of Epstein–Barr virus (EBV). The clinical and epidemiological observations pertinent to the pathogenesis of this tumor are also presented. A consideration of the structural changes in c-myc provides strong, though indirect evidence that a major element in the pathogenesis of Burkitt's ...

    Also Ranks for: Human Pair |  burkitts lymphoma |  proteins myc |  14 chromosomes |  proto oncogene
    KOL Index score: 11096

    Primary effusion lymphoma (PEL) selectively involves the serous body cavities, occurs predominantly in immunodeficient patients and is infected consistently by human herpesvirus type-8. PEL is also frequently infected by Epstein–Barr virus (EBV). The precise pathogenetic role of EBV coinfection in PEL is not fully understood. The lymphoma fails to express the EBV transforming proteins EBNA-2 and LMP-1, whereas it expresses EBNA-1 (latency I phenotype). Some studies have hypothesized that ...

    Also Ranks for: Barr Virus |  effusion lymphoma |  tumor cells |  ebna1 gene |  regulation viral
    KOL Index score: 10920

    PURPOSE: Langerhans cell histiocytosis (LCH) is a disorder of unknown etiology involving the proliferation and accumulation of cells with the phenotype of a bone marrow-derived antigen-presenting cell of the skin, the Langerhans cell. We have studied p53 expression, an element in the control of cell proliferation, to determine whether it plays a role in the pathogenesis of LCH.

    PATIENTS AND METHODS: LCH lesions from 10 patients with either localized (n = 5) or multisystem disease (n = 5) ...

    Also Ranks for: P53 Expression |  langerhans cell |  preschool genes |  histiocytosis lch |  multisystem disease
    KOL Index score: 10783

    About one fourth of patients with Hodgkin's disease relapse after therapy. The mechanisms that lead to resistance to treatment in these patients are poorly understood. The authors describe the differential protein expression of p53, proliferating cell nuclear antigen (PCNA), and p21 at initial presentation and relapse, and discuss their role in disease progression and resistance to therapy. Thirty-four patients with Hodgkin's disease who had relapsed after standard chemotherapy and ...

    Also Ranks for: Cell Nuclear Antigen |  p53 pcna |  presentation relapse |  resistance therapy |  hodgkin disease


    Ian T Magrath: Influence Statistics

    Sample of concepts for which Ian T Magrath is among the top experts in the world.
    Concept World rank
    pioneer investigators #1
    14 burkitt #1
    chromosome q34 #1
    lymphoma burkitt #1
    blineage patients survival #1
    aya higher fraction #1
    pancreatitis list #1
    endemic ebl #1
    afbl frequent complaints #1
    lymphoma 814 #1
    marginated heterochromatin #1
    mcp842 protocol #1
    india all1 #1
    albert cook #1
    thirdgeneration protocols #1
    leukemia mab panels #1
    highest isoenzyme activities #1
    initially center #1
    therapy fraction #1
    years burkitt #1
    existing delays therapy #1
    pathologists african #1
    nasopharynx initial sites #1
    hodgkins disease wagner #1
    virus pathogenetic role #1
    treatment burkitts lymphoma #1
    unique additional mechanism #1
    oropharyngeal genital sites #1
    chemotherapy aids‐related malignancies #1
    renal lymphoma hydronephrosis #1
    regulation oncogene transcription #1
    consisting ifosfamide #1
    relapse frequencies #1
    africa burkitt #1
    tumour advantage #1
    nb african #1
    age burkitt lymphoma #1
    african tumors expression #1
    rapid tumor lysis #1
    cancers aya #1
    common antigen common #1
    cancer aya age #1
    patients aidsa #1
    cocultures blood #1
    immunoglobulins nucleic #1
    ldh uric #1
    rfc controls #1
    chd cases ebvassociation #1
    presentation relapse samples #1
    revealed disease #1

    Key People For Burkitt Lymphoma

    Top KOLs in the world
    Elaine S Jaffe
    cell lymphoma lymphoid neoplasms situ hybridization
    Ian T Magrath
    burkitt lymphoma cell lines developing countries
    Martine M Raphaël
    burkitt lymphoma hiv infection barr virus
    Wyndham Hopkins Wilson
    cell lymphoma moxetumomab pasudotox diffuse large
    Louis Michael Staudt
    cell lymphoma gene expression diffuse large
    Harald Stein†
    cell lymphoma monoclonal antibodies situ hybridization

    Ian T Magrath:Expert Impact

    Concepts for whichIan T Magrathhas direct influence:Burkitt lymphoma,  Cell lines,  Developing countries,  Burkitts lymphoma,  Barr virus,  Coding region,  P53 mutations,  Intensive chemotherapy.

    Ian T Magrath:KOL impact

    Concepts related to the work of other authors for whichfor which Ian T Magrath has influence:Burkitt lymphoma,  Barr virus,  Cell lines,  Bone marrow,  Childhood cancer,  P53 gene,  Acute lymphoblastic leukemia.



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    International Network for Cancer Treatment and Research, Oxford OX2 7HT, UK. | Eduardo Cazap, Latin American and Caribbean Society of Medical Oncology, Buenos Aires, Argentina; Ian Magrath, International Network for Cancer Treatment and Research, Bru