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    • Tao‐Yun Ji

      Tao‐Yun Ji

      Department of Pediatrics, Peking University First Hospital, Beijing, China | Pediatric Epilepsy Center, Peking University First Hospital, No. 1 Xi'an Men Street, Xicheng ...



      KOL Resume for Tao‐Yun Ji


      Department of Pediatrics, Peking University First Hospital, Beijing, China


      Department of Pediatrics, Peking University First Hospital, No. 1 Xi'an Men Street, Xicheng District, Beijing, 100034, China


      Department of Pediatrics, Peking University First Hospital, No. 1 of Xian Men Street, Xicheng District, 100034, Beijing, China


      Department of Pediatrics, Peking University First Hospital, 100034, China; Pediatric Epilepsy Center, Peking University First Hospital, 100034, China.


      Department of Pediatrics, Peking University First Hospital, No.1 Xi’an Men Street, West District, Beijing, China


      Department of Pediatrics, Peking University First Hospital, Beijing, China -


      Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.


      Department of Pediatrics, Peking University First Hospital, 100034, Beijing, China



      Tao‐Yun Ji: Influence Statistics

      Sample of concepts for which Tao‐Yun Ji is among the top experts in the world.
      Concept World rank
      central cortex disconnection #5
      subtotal hemispherotomy hemiparesis #5
      hemiparesis subtotal #5
      seizure outcomes disconnection #5
      disconnection central operculum #5
      hemiparesis subtotal hemispherotomy #5
      disconnection poor #5
      lesional hemispheric #5
      central operculum insula #5
      subtotal hemispherotomy children #5
      patients remote programming #6
      intractable lesional #6
      20 children time #7
      disconnection central #7
      hemispherotomy hemispheric #7
      genetic diagnosis 789 #8
      ncl gosr2 #8
      case causing gene #8
      pme children ncl #8
      ncl gosr2 pme #8
      pme seizure #8
      clear 789 #8
      789 pme #8
      gosr2 pme cohort #8
      genetic pme patients #8
      case gosr2 #8
      789 pme patients #8
      case gosr2 pme #8
      pme cohort #8
      lipofuscinoses causing #8
      rars chinese patients #9
      heterogeneity 119 #9
      outpatient programming #9
      disorders chinese population #9
      polr3a rars #9
      genetic pme #9
      119 patients disorders #9
      rars chinese #9
      1 hypomyelinating #9
      features hypomyelinating #9
      disorders 119 patients #9
      genes 15 variants #10
      11 hlds #10
      15 causative variants #10
      mutation pme #10
      genes tubb4a #10
      20 patients hlds #10
      wes hlds #10
      leukodystrophy trio #10
      triobased wes hlds #10


      Prominent publications by Tao‐Yun Ji

      KOL-Index: 9334

      BackgroundWe attempted to determine whether the inflammatory pathway HMGB1-TLR4 and the downstream pro-inflammatory cytokines is upregulated in focal cortical dysplasia (FCD) type II and whether there is a correlation between the TLR4 upregulation and disease duration or frequency of epileptic seizures.MethodsFCD type II and peri-FCD paired tissues resected from eight children with refractory epilepsy were collected. Through real-time qPCR, Western blot, and co-immunoprecipitation, we ...

      Known for Focal Cortical Dysplasia | Hmgb1 Tlr4 | Epileptic Seizures | Cortical Development | Fcd Type
      KOL-Index: 8725

      BACKGROUND: Subtelomeric imbalance is widely accepted as related to developmental delay/mental retardation (DD/MR). Fine mapping of aberrations in gene-enriched subtelomeric regions provides essential clues for localizing critical regions, and provides a strategy for identifying new candidate genes. To date, no large-scale study has been conducted on subtelomeric aberrations in DD/MR patients in mainland China.

      METHODS: This study included 451 Chinese children with moderate to severe ...

      Known for Subtelomeric Aberrations | Chinese Patients | Mental Retardation | Deletions Duplications | Detection Rate
      KOL-Index: 7743

      While pathogenic copy number variations (CNVs) in 15q11.2 were recently identified in Caucasian patients with idiopathic generalized epilepsies (IGEs), the epilepsy-associated gene(s) in this region is/are still unknown. Our study investigated whether the CNVs in 15q11.2 are associated with childhood absence epilepsy (CAE) in Chinese patients and whether the selective magnesium transporter NIPA2 gene affected by 15q11.2 microdeletions is a susceptive gene for CAE. We assessed IGE-related ...

      Known for Cae Nipa2 | Childhood Absence | Chinese Patients | Copy Variations | 15 Dna
      KOL-Index: 6598

      BACKGROUND: Some studies have reported clinical features of relapsing MOG-IgG-associated CNS demyelination principally in Caucasians children. It is not clear whether Chinese children share the same phenotype.

      OBJECTIVE: To delineate the clinical characteristics in Chinese children with relapsing MOG-IgG-associated demyelination.

      METHODS: A follow-up study on 23 Children with relapsing MOG-IgG-associated demyelination from two Chinese tertiary hospitals was performed. Phenotypic features ...

      Known for Chinese Children | Adem Common Phenotype | Disease Onset | Clinical Characteristics | Mog Igg
      KOL-Index: 6219

      BackgroundRecent clinical observations have reported the potential benefit of vagus nerve stimulation (VNS) as an adjunctive therapy for pediatric epilepsy. Preliminary evidence suggests that VNS treatment is effective for seizure reduction and mental development in young participants between 3 and 6 years of age who suffer from intractable epilepsy. However, robust clinical evidence for quantifying the difference of the efficacy and safety of VNS treatment in this specific patient ...

      Known for Intractable Epilepsy | Vagus Nerve Stimulation | Vns Treatment | Seizure Reduction | Drug Resistant
      KOL-Index: 5364

      Background and purpose: We retrospectively analyzed the clinical characteristics of children with autoimmune encephalitis (AE) in two Chinese tertiary pediatric neurology centers. We also compared anti-NMDAR encephalitis with and without co-positive MOG antibody, as well as specific autoantibody-positive AE and autoantibody-negative but probable AE. Methods: A retrospective study of children (0-18 years old) with AE in Peking University First Hospital and Children's Hospital Affiliated ...

      Known for Autoimmune Encephalitis | Mog Antibody | Anti Nmdar | Prognosis Children | Clinical Characteristics
      KOL-Index: 5319

      Objective: To evaluate the efficacy and safety of ketogenic diet (KD) in patients with Dravet syndrome (DS). Methods: 60 DS patients receiving treatment of KD for more than 12 weeks from 2009 to 2018 were analyzed retrospectively. Modified Johns Hopkins protocol was used to initiate KD. Seizure frequency, electroencephalogram (EEG), cognition, language, and motor function of the patients were assessed. Side effects were monitored and adjusted accordingly. SPSS 23.0 software was used for ...

      Known for Ketogenic Diet | Dravet Syndrome | Kd Treatment | Seizure Frequency | 12 Months
      KOL-Index: 4971

      Jacobsen syndrome (JBS) is a haploinsufficiency syndrome caused by partial deletion of the long arm of chromosome 11. It is characterized by developmental delay (DD)/mental retardation (MR), physical growth retardation, facial dysmorphism, visceral malformations and thrombocytopenia. We report two JBS patients from China out of a total of 451 patients with unexplained DD/MR. The genotypes of these patients were compared with earlier reported patients in North America and Europe. Both ...

      Known for Distal 11q | Developmental Delay | Jacobsen Syndrome | Chromosome Deletion | Critical Region
      KOL-Index: 4921

      This study aimed to evaluate the efficacy, adverse events and expense burden of outpatient versus remote programming for vagus nerve stimulation (VNS) in children with epilepsy. A total of 46 children with drug-resistant epilepsy, who underwent VNS at the Pediatric Epilepsy Center, Peking University First Hospital between March 2017 and June 2018, were enrolled into the study. Participants were assigned (non-randomized) into an outpatient programming group or remote programming group ...

      Known for Remote Programming | June 2018 | Patients Living
      KOL-Index: 4622

      OBJECTIVE: Hypomyelinating disorders are a group of clinically and genetically heterogeneous diseases characterized by neurological deterioration with hypomyelination visible on brain MRI scans. This study was aimed to clarify the clinical and genetic features of HMDs in Chinese population.

      METHODS: 119 patients with hypomyelinating disorders in Chinese population were enrolled and evaluated based on their history, clinical manifestation, laboratory examinations, series of brain MRI with ...

      Known for Gm1 Gangliosidosis | Hypomyelinating Leukodystrophy | Basal Ganglia | Patients Mutations | Merzbacher Disease
      KOL-Index: 4390

      Background The unfolded protein response (UPR) includes three cascade pathways, which are responsible for the elimination of overload protein that is accumulated in the endoplasmic reticulum (ER). We hypothesize that mutations in connexin 47 (Cx47) lead to abnormal retain of the protein in the ER lumen, which causes Pelizaeus–Merzbacher-like disease (PMLD), a hypomyelinating leukodystrophic disorder.

      Methods In this study, the influence of mutant Cx47 on the three UPR ...

      Known for Protein Response | Activation Upr | Endoplasmic Reticulum | Merzbacher Disease | Gap Junction
      KOL-Index: 4163

      Objective To identify the pathogenic gene variants and clinical phenotype features of 26 children with progressive myoclonic epilepsy (PME). Methods In this cross-sectional study, 26 PME children (11 boys and 15 girls) sent to neurological outpatient clinics and admitted to wards of the Department of Pediatrics, Peking University First Hospital were enrolled prospectively from January 2014 to October 2018. The pathogenic gene variants of PME children and their parents were identified ...

      Known for Progressive Myoclonic Epilepsy | Clinical Phenotype | Pme Children | 3 Months | Variants Identified
      KOL-Index: 3864

      Objective To assess the effectiveness and safety of rituximab in Chinese children with autoimmune diseases of the nervous system. Method An ambispective cohort study enrolled patients with refractory and(or) relapse autoimmune diseases of nervous system from June 2010 to June 2016 in Peking University First Hospital.These patients failed to respond to steroids and(or)intravenous immunoglobulin (IVIG) were treated with rituximab and seen for follow-up visits once every 3 months.The ...

      Known for Safety Rituximab | Humans Immunologic | Factors Male | Autoimmune Encephalitis

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      Tao‐Yun Ji:Expert Impact

      Concepts for whichTao‐Yun Jihas direct influence:Developmental delay,  Remote programming,  Chinese children,  Intractable epilepsy,  Subtotal hemispherotomy,  Ketogenic diet,  Refractory epilepsy,  Vagus nerve stimulation.

      Tao‐Yun Ji:KOL impact

      Concepts related to the work of other authors for whichfor which Tao‐Yun Ji has influence:Intellectual disability,  Autoimmune encephalitis,  Ketogenic diet,  Dravet syndrome,  Developmental delay,  Farber disease,  Status epilepticus.



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      Department of Pediatrics, Peking University First Hospital, Beijing, China | Pediatric Epilepsy Center, Peking University First Hospital, No. 1 Xi'an Men Street, Xicheng District, Beijing 100034, China; Department of Pediatrics, Peking University Fir

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